• 구강회복응용과학지
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• 제38권2호
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• pp.71-80
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• 2022

다양한 치과용 도재가 개발되고 있으나 현재 단일구조 보철물로 사용할 수 있는 수준의 기계적, 광학적 성질을 보이는 도재는 반투명 지르코니아와 리튬디실리케이트 결정화유리가 대표적이다. 기계적 성질의 경우 지르코니아가, 광학적 성질은 리튬디실리케이트가 상대적으로 더 우수하다고 알려져 있으나 물성개선을 통해 보다 다양한 증례에 보철물을 적용할 수 있게 되었다. 그 결과 반투명 지르코니아와 리튬디실리케이트 보철물의 적응증이 서로 중복되는 경우가 발생하고 있다. 그러나 두 도재는 유리질(glass matrix) 포함여부뿐만 아니라 강화기전, 탄성계수 등이 서로다르다. 이에 본 문헌고찰에서는 두 단일구조 치과용 도재의 물성을 평가한 다양한 연구결과들을 살펴보고 특히 가공치가 포함된 고정성 보철물의 디자인 시 고려사항에 대해 알아보고자 한다.

• 대한치과보철학회지
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• 제61권1호
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• pp.82-89
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• 2023

혀는 대표적인 구강암 호발 부위 중 하나로, 현재 설암 치료의 표준은 외과적 절제술로 알려져 있다. 그러나 설암으로 인해 혀 절제술을 받은 환자의 경우 혀의 가동성이 저하되어 연하와 발음 같은 정상적인 구강기능을 수행하는 데 어려움을 겪을 수 있다. 따라서 이러한 환자들의 보철 수복 시에는 손상된 혀의 기능을 보완하기 위한 추가적인 고려가 필요하다. 구개증대보철물은 구개 연마면의 위치를 낮추어 혀-구개 접촉을 도움으로써 혀의 움직임이 제한된 환자의 구강기능을 개선할 수 있다. 본 증례에서는 설암으로 인한 혀의 좌측 부분 절제술 및 피판 재건술 이후 혀의 가동성이 감소된 상하악 완전 무치악 환자를 대상으로 구개증대보철물로써의 상악 총의치와 전통적인 하악 총의치를 제작하였으며, 최종 보철물을 통해 저작과 연하 및 발음 기능이 개선되어 환자와 술자 모두 만족하는 결과를 얻었기에 이를 보고하고자 한다.

• Journal of Periodontal and Implant Science
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• 제43권6호
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• pp.251-261
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• 2013

A paradigm shift is taking place in medicine and dentistry from using synthetic implants and tissue grafts to a tissue engineering approach that uses degradable porous three-dimensional (3D) material hydrogels integrated with cells and bioactive factors to regenerate tissues such as dental bone and other oral tissues. Hydrogels have been established as a biomaterial of choice for many years, as they offer diverse properties that make them ideal in regenerative medicine, including dental applications. Being highly biocompatible and similar to native extracellular matrix, hydrogels have emerged as ideal candidates in the design of 3D scaffolds for tissue regeneration and drug delivery applications. However, precise control over hydrogel properties, such as porosity, pore size, and pore interconnectivity, remains a challenge. Traditional techniques for creating conventional crosslinked polymers have demonstrated limited success in the formation of hydrogels with large pore size, thus limiting cellular infiltration, tissue ingrowth, vascularization, and matrix mineralization (in the case of bone) of tissue-engineered constructs. Emerging technologies have demonstrated the ability to control microarchitectural features in hydrogels such as the creation of large pore size, porosity, and pore interconnectivity, thus allowing the creation of engineered hydrogel scaffolds with a structure and function closely mimicking native tissues. In this review, we explore the various technologies available for the preparation of macroporous scaffolds and their potential applications.

• 구강회복응용과학지
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• 제25권3호
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• pp.287-292
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• 2009

최근에는 임플란트를 이용한 치료가 예측 가능한 치료로 자리 잡고 있다. 충분한 골질과 골량은 임플란트의 성공에 중요한 역할을 한다. 10 mm 이하의 임플란트의 사용은 골질이 불충분할 때 부가적인 수술의 대안이 될 수 있다. 이 논문은 길이 10 mm 이하의 임플란트와 관련된 생역학적 관점과 발표된 임상결과들을 리뷰하고 사용 예지성을 제시하고자 하였다. 임플란트의 초기고정여부, 시술자의 learning curve, 사용한 임플란트의 표면처리, 환자의 골질들을 적절히 고려한 후 짧은 길이의 임플란트를 사용한다면 부가적인 수술 필요성의 대안이 될 수 있을 것이다.

• 영어영문학
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• 제57권6호
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• pp.1017-1041
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• 2011

This study investigates Korean EFL learners' awareness and use of the English existential there-construction by examining data collected from 54 Korean EFL learners of English by means of a pragmalinguistic judgment task and a controlled discourse completion task. The results of the judgment task reveal that lower proficiency learners rated canonical sentences and existentials with a preposed locative best in the communicative situations where the use of existentials would have been most appropriate. A comparison of the ratings by more proficient learners and native speakers shows that existentials received highest ratings by both groups where they are the most natural option, while canonical sentences received significantly higher ratings by the learners. With regard to the production data, learners tended to avoid existentials, but rather relied on canonical sentences. Existentials were rarely used by lower proficiency learners and not used productively even by more proficient learners in the situations where existentials would have been the most natural option. These results suggest that Korean learners' difficulty with the use of existentials is not merely a product of performance limitations, but attributable to limited knowledge about existentials and their syntactic alternatives in terms of contextual appropriateness. Lower proficiency learners lack such knowledge, and more proficient learners, while showing better awareness of the use of existentials, have problems as to the placement of new information when engaging in writing tasks that place lower level of demands on attention to the information status of noun phrases compared to communicative, oral tasks.

• 구강회복응용과학지
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• 제29권2호
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• pp.141-151
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• 2013

티타늄 산화막을 나노단위에서 변형시키는 방법은 다공성 표면을 강화하는 내부적 접근과 나노입자를 피복하는 외부적 접근으로 나눌 수 있다. 나노표면은 나노튜브, 나노피트, 나노노듈 및 다형구조 등 다양한 형태를 지닌다. 형성방법 및 형성재료에 따라 다른 표면이 생성되지만, 현재까지 표준화된 형성방법은 없다. 나노표면을 분석해 보면 마이크론 단위의 표면구조에는 영향을 미치지 않으며 전기화학적으로 안정적이다. 나노표면은 세포독성이 거의 없으며 조골세포의 증식과 분화를 모두 촉진하고, 섬유모세포의 증식을 저해하여 연조직 개재를 감소시키는 효과를 가진다. 또한 세포 및 단백질과 유사한 크기 및 형태를 가지기 때문에 조직과의 친화성이 우수하여 골유착을 증진시킨다. 하지만 그 작용이 미치는 범위는 극히 제한되어 있기 때문에 골조직과의 거리가 있는 경우에는 효과가 미미하다. 마이크론 단위의 표면과는 달리 나노표면은 광촉매효과로 인한 항균작용을 가지지만 지속시간이 짧아 실제 임상에서의 적용효과는 의문시 된다. 하지만 마이크론 단위의 표면거칠기가 가지는 단점을 배제할 수 있어 다양한 가능성을 가지기 때문에 더 많은 연구가 필요하다.

• 대한간호
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• 제33권5호
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• pp.63-75
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• 1995

The need of oriental nursing role is recently increasing. The implication of this trend is enormous not only for the need of independent of independent oriental nursing intervention. Hence, this study was designed to describe the characteristics of oriental nursing activity and identify the meaning of nursing activity in oriental hospital. A total of 24 nurses were selected by convenience sampling from eight units at one oriental hospital. A total of 168 data were collected using minute-by-minute recording during nurse s work shift. The data were analyzed using nova and scheffe method as post-hoc test The results of this study are as follows; 1. the category of nursing activity in oriental hospital 74.4% of nursing activity was the patient-oriented nursing care. The nursing activity included others (18.28%), the function-oriented nursing care (7.07%), and staff-oriented care (0.2%). 29.1 % of the patient-oriented nursing care was the direct care, and 24. 5 % of the patient-oriented nursing care was the indirect care. There was a lack of patient education and the communication patient. 2. Nursing activity in oriental hospital by characteristics 1) Nursing activity by unit For patient-oriented nursing care, there was a statistically significant difference among 8 units. In the critical care unit, the patient-oriented nursing care was mostly performed. For function-oriented nursing care, there was statistically significant difference among 8 units. In the physical therapy unit, the function-oriented nursing care was mostly performed. 2) Nursing activity in oriental hospital For all kinds of nursing activity, there was a statistically significant difference between shifts. In night shift patient-oriented nursing care, function-oriented nursing care, and other kinds of nursing care was mostly performed. Patient-oriented nursing care included indirect care, treatment set management, and the breaktime. In day shift, staff-oriented nursing care was performed. 3) Nursing activity in oriental hospital For all kinds of nursing activity, there was not a statistically significant difference by day. The day has not impact on nursing activity. 3. the meaning of activity in oriental hospital The results of this study show that the patient-oriented care was vital check, input! output check, medication, bedsore prevention, nasogastric feeding, oral care, catheterization care, perinatal care, nursing care associated with acupuncture and moxacautery, observation (fever, sweating), heat and cold application communication with patent and family, and patient room management In conclusion, two issues associated with the findings of the research appeated to be involved in the difficulty of nursing activity in hospital. The first issue was the nursing care in oriental hospital provided by nurses who have a limited understading of the principles of oriental medicine. The second issue was the deficiency of systematic guideling for oriental nursing activity. The findings suggest the need to develop the systematic guideline for oriental nursing activity. The need of continuing education for nurses who work in the oriental hospital, and the need of nursing education including oriental nursing are critical.

• 구강회복응용과학지
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• 제26권2호
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• pp.145-156
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• 2010

치아 우식, 치주 질환, 치아 파절 등으로 다수의 구치가 상실된 환자의 경우 대합치의 정출, 잔존 치아의 과도한 교합 하중으로 인한 교합 외상의 문제가 발생된다. 대합치 정출이 발생된 경우 인접 조직의 성장도 이와 동시에 발생되고 보철을 위한 악간 공간의 상실을 동반하게 되며 교합 외상으로 인한 치아에 동요도 증가 및 교모에 의한 마모도 증가하게 된다. 이러한 구치의 다수 상실, 대합치 정출 및 잔존치의 교모 증가를 동반한 환자에 있어서는 적절한 치주 수술(치관 연장술, 골 절제술 등) 및 수직 교합 고경의 회복을 통한 잔존 치아와 상실된 치아의 수복이 필요하게 된다. 본 증례의 환자는 상실된 구치의 수복을 주소로 내원한 환자로 구치부 상실 및 잔존치의 마모된 치열을 지녀보철 수복을 위한 공간을 위해 수직고경을 증가시켜 치료한 치험예를 문헌 고찰과 함께 보고하고자 한다.

• Journal of Acupuncture Research
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• 제15권2호
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• pp.183-198
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• 1998

This study was done in order to present clinical trial method for safety of herb-acupuncture. The results were summerized as follow: In case of western medicine, clinical trial divides into four phase 1. Phase I: Investigate safety and drug movement for health people. 2. The first phase II: Investigate safety, effectiveness for the limited patient. The late phase II: Investigate propriety of an applicable disease, the way to use and dose. 3. Phase III: Through the comparative, public trial, investigate a final, applicable disease and side effect. 4. Phase IV: After NDA, investigate safety and effectiveness for the wide patients. In case of herb-acupuncture, we have to investigate the following for safety and effectiveness 1. Drug dose: Decide with 1/2 or 1/3 of oral dosage or a basis of animal's of maximum dosage or a ratio of man and animal. 2. Toxicity: Examine blood, urine, liver function, EKG, after herb-acupuncture during acertain period of time. 3. Regional response: Estimate response of swelling, redness, pruritus. etc 4. Treatment effectiveness: After exactly diagnosis, estimate effectiveness with a objective guide post.

• Journal of Periodontal and Implant Science
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• 제31권1호
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• pp.135-148
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• 2001

Gingival fibroblasts are major cellular component of gingiva. However, the molecular mechanisms of senescence of human gingival fibroblasts are unknown. Human fibroblasts undergo replicative senescence in vitro after a limited number of population doublings. A reduced rate of proliferation is a prominent phenomenon observed in senescent fibroblasts. This phenomenon is controled by cell cycle regulatory proteins. The purpose of present study was to investigate the effect of replicative senescence on cell cycle progression and to find out its molecular mechanisms in human gingival fibroblasts. Replicative senescence of gingival fibroblasts were induced by subsequent cultures that were repeated up to 18 passage. In the present study, I examined change of cell proliferation, cell activity, cell viability and cell cycle progression during the replicative process. Also, I examined expression of cell cycle regulatory proteins which was estimated by western blot analysis. Cell proliferation, cell activity and cell viability of gingival fibroblasts were notably decreased with increase of population doubling level(PDL). S phase was decreased and G1 phase was increased with increase of PDL. Western blot analysis showed that levels of P16, p21 and p53 of senescent gingival fibroblasts(PDL41, PDL58) were higher than young fibroblasts(PDL27) and cdk4 were lower than young fibroblasts(PDL27). In conclusion, these results suggest that proliferative function of human gingival fibroblasts may be decreased by replicative senescence and its molecular mechanisms may be activatied with p16, p21, p53 and pRB, and repressed wtih cdk4.