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Progressive Dynamic Equinovarus Deformity in Hereditary Spastic Paraplegia - A Case Report- (유전성 연축성 양하지 마비 환자에서의 족부 진행성 동적 첨내반족 -1예 보고-)

  • Bae, Su-Young;Seo, In-Seock
    • Journal of Korean Foot and Ankle Society
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    • v.8 no.1
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    • pp.111-113
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    • 2004
  • In neurogenic equinovarus deformity, surgical intervention such as tendon transfer or osteotomy can be expected to improve symptoms. However, in rare cases of hereditary spastic paraplegia, the deformity and paralysis gradually progress. So limited operation and early post-operative rehabilitation are preferred to aggressive operation. We would like to report our clinical experience with one case of hereditary spastic paraplegia patient with reference review. A 40 year-old male, given tendon transfer of ankle and foot and tendo achilles lengthening 10 years ago, complained about aggravated spastic paraplegia which resulted in dynamic equinovarus and limited walking ability since his operation. Family history showed limited walking ability of his father with gradually progressing spastic paralysis and he was diagnosed as hereditary spastic paraplegia type I. We had performed a limited operation such as tendo achilles and tibialis posterior lengthening to induce plantigrade standing and walking with crutch. As a result, the patient was able to maintain a stabilized standing posture and walk after the operation. Hereditary spastic paraplegia presents with a progressive paralysis which limits rehabilitation after tendon transfer, and the symptoms can be aggravated. Therefore, considering potential hereditary neurogenic disorders in paients with equinovarus deformity and performing limited operative procedures seem to be important.

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Breeding of a New Silkworm Variety, Kumhwangjam, with a Sex-Limited Cocoon Color for Spring Rearing Season

  • Kang, Pil Don;Sohn, Bong Hee;Lee, Sang Uk;Kim, Mi Ja;Jung, I Yeon;Kim, Young Soon;Kim, Yung Dae;Lee, Heui Sam
    • International Journal of Industrial Entomology and Biomaterials
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    • v.9 no.1
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    • pp.89-93
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    • 2004
  • A new silkworm variety, Kumhwangjam, with a sex-limited cocoon color for spring rearing season is F$_1$ hybrid between Jam 309, a Japanese race bred from Y1/9153, and Jam 310, a Chinese race from Y1/8586. In the local adaptability test performed at 8 local areas in spring rearing season of 2003, major characteristics of Kumhwangjam were mainly similar to those of the check variety Kumokjam. The new silkworm variety, Kumhwangjam, showed a sex-limited cocoon color: yellow for female and white for male with elliptical cocoon shape. This sex-limited cocoon color can be used as a valuable marker for discrimination between female and male for various purposes.

Remote sensing and GIS technologies for route selection of 'West-East Nature Gas pipeline'

  • Zhu Xiaoge;Zhang Yaoyan;Zhang Yiming;Van Hu;Shihong Wang
    • Proceedings of the KSRS Conference
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    • 2004.10a
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    • pp.28-30
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    • 2004
  • The West-East Nature Gas Pipeline is a great project in China. Advanced remote sensing technology combined with GIS and GPS is used to select the favorable plan from various possible routes through interpreting the information of topographic landform, regional geology, disaster geology, traffic conditions and nature environment from remote sensing images. There are a lot of changes in geographical and environmental factors along such pipelines due to the rapid development in China. Image maps produced from new satellite data can identify these changes and be used successfully not only on route-selection studies but also on in situ investigation, together with GPS. Results from detail analysis provide necessary information and parameters for plan, design and construction of the pipeline and they are also the basic data for the pipeline database. The set of techniques has been applied on planning and designing several pipelines successfully.

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The Clip Limit Decision of Contrast Limited Adaptive Histogram Equalization for X-ray Images using Fuzzy Logic (퍼지를 이용한 X-ray 영상의 대비제한 적응 히스토그램 평활화 한계점 결정)

  • Cho, Hyunji;Kye, Heewon
    • Journal of Korea Multimedia Society
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    • v.18 no.7
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    • pp.806-817
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    • 2015
  • The contrast limited adaptive histogram equalization(CLAHE) is an advanced method for the histogram equalization which is a common contrast enhancement technique. The CLAHE divides the image into sections, and applies the contrast limited histogram equalization for each section. X-ray images can be classified into three areas: skin, bone, and air area. In clinical application, the interest area is limited to the skin or bone area depending on the diagnosis region. The CLAHE could deteriorate X-ray image quality because the CLAHE enhances the area which doesn't need to be enhanced. In this paper, we propose a new method which automatically determines the clip limit of CLAHE's parameter to improve X-ray image quality using fuzzy logic. We introduce fuzzy logic which is possible to determine clip limit proportional to the interest of users. Experimental results show that the proposed method improve images according to the user's preference by focusing on the subject.

Externality Cost of Capital Investment in Limited Commitment (불완전한 금융계약하에서의 자본투자의 외부성에 관한 연구)

  • Chien, Yili;Lee, Junsang
    • KDI Journal of Economic Policy
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    • v.34 no.2
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    • pp.17-40
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    • 2012
  • We study externality costs of capital investment under limited commitment. We solve for the constrained efficient allocation with a limited commitment environment and find positive externality costs of capital investment provided that full-risk-sharing is not feasible. In a decentralized version of limited commitment environment, a one unit increase of capital investment by an agent increases all individuals' autarky values in the economy and generates externality costs in the economy. This externality cost provides a rationale for positive capital taxation even in the absence of government expenditure. In order to internalize this costs, the government use a positive rate of linear capital tax in the decentralized economy.

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Inelastic design of high-axially loaded concrete columns in moderate seismicity regions

  • Ho, Johnny Ching Ming
    • Structural Engineering and Mechanics
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    • v.39 no.4
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    • pp.559-578
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    • 2011
  • In regions of high seismic risk, high-strength concrete (HSC) columns of tall buildings are designed to be fully ductile during earthquake attack by providing substantial amount of confining steel within the critical region. However. in areas of low to moderate seismic risk, the same provision of confining steel is too conservative because of the reduced seismic demand. More critically, it causes problematic steel congestion in the beam-column joints and column critical region. This will eventually affect the quality of concrete placing owing to blockage. To relieve the problem, the confining steel in the critical region of HSC columns located in low to moderate seismicity regions can be suitably reduced, while maintaining a limited ductility level. Despite the advantage, there are still no guidelines developed for designing limited ductility HSC columns. In this paper, a formula for designing limited ductility HSC columns is presented. The validity of the formula was verified by testing half-scale HSC columns subjected to combined high-axial load and flexure, in which the confining steel was provided as per the proposed formula. From the test results, it is evident that the curvature ductility factors obtained for all these columns were about 10, which is the generally accepted level of limited ductility.

Speaker Verification with the Constraint of Limited Data

  • Kumari, Thyamagondlu Renukamurthy Jayanthi;Jayanna, Haradagere Siddaramaiah
    • Journal of Information Processing Systems
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    • v.14 no.4
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    • pp.807-823
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    • 2018
  • Speaker verification system performance depends on the utterance of each speaker. To verify the speaker, important information has to be captured from the utterance. Nowadays under the constraints of limited data, speaker verification has become a challenging task. The testing and training data are in terms of few seconds in limited data. The feature vectors extracted from single frame size and rate (SFSR) analysis is not sufficient for training and testing speakers in speaker verification. This leads to poor speaker modeling during training and may not provide good decision during testing. The problem is to be resolved by increasing feature vectors of training and testing data to the same duration. For that we are using multiple frame size (MFS), multiple frame rate (MFR), and multiple frame size and rate (MFSR) analysis techniques for speaker verification under limited data condition. These analysis techniques relatively extract more feature vector during training and testing and develop improved modeling and testing for limited data. To demonstrate this we have used mel-frequency cepstral coefficients (MFCC) and linear prediction cepstral coefficients (LPCC) as feature. Gaussian mixture model (GMM) and GMM-universal background model (GMM-UBM) are used for modeling the speaker. The database used is NIST-2003. The experimental results indicate that, improved performance of MFS, MFR, and MFSR analysis radically better compared with SFSR analysis. The experimental results show that LPCC based MFSR analysis perform better compared to other analysis techniques and feature extraction techniques.

Substructural parameters and dynamic loading identification with limited observations

  • Xu, Bin;He, Jia
    • Smart Structures and Systems
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    • v.15 no.1
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    • pp.169-189
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    • 2015
  • Convergence difficulty and available complete measurement information have been considered as two primary challenges for the identification of large-scale engineering structures. In this paper, a time domain substructural identification approach by combining a weighted adaptive iteration (WAI) algorithm and an extended Kalman filter method with a weighted global iteration (EFK-WGI) algorithm was proposed for simultaneous identification of physical parameters of concerned substructures and unknown external excitations applied on it with limited response measurements. In the proposed approach, according to the location of the unknown dynamic loadings and the partially available structural response measurements, part of structural parameters of the concerned substructure and the unknown loadings were first identified with the WAI approach. The remaining physical parameters of the concerned substructure were then determined by EFK-WGI basing on the previously identified loadings and substructural parameters. The efficiency and accuracy of the proposed approach was demonstrated via a 20-story shear building structure and 23 degrees of freedom (DOFs) planar truss model with unknown external excitation and limited observations. Results show that the proposed approach is capable of satisfactorily identifying both the substructural parameters and unknown loading within limited iterations when both the excitation and dynamic response are partially unknown.

Optimized finite element model updating method for damage detection using limited sensor information

  • Cheng, L.;Xie, H.C.;Spencer, B.F. Jr.;Giles, R.K.
    • Smart Structures and Systems
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    • v.5 no.6
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    • pp.681-697
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    • 2009
  • Limited, noisy data in vibration testing is a hindrance to the development of structural damage detection. This paper presents a method for optimizing sensor placement and performing damage detection using finite element model updating. Sensitivity analysis of the modal flexibility matrix determines the optimal sensor locations for collecting information on structural damage. The optimal sensor locations require the instrumentation of only a limited number of degrees of freedom. Using noisy modal data from only these limited sensor locations, a method based on model updating and changes in the flexibility matrix successfully determines the location and severity of the imposed damage in numerical simulations. In addition, a steel cantilever beam experiment performed in the laboratory that considered the effects of model error and noise tested the validity of the method. The results show that the proposed approach effectively and robustly detects structural damage using limited, optimal sensor information.

Subchronic and Reproductive/Developmental Toxicity Studies of Tetrahydrocurcumin in Rats

  • Majeed, Muhammed;Natarajan, Sankaran;Pandey, Anjali;Bani, Sarang;Mundkur, Lakshmi
    • Toxicological Research
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    • v.35 no.1
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    • pp.65-74
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    • 2019
  • Tetrahydrocurcumin (THC) is a major metabolite of curcumin, which is obtained from Curcuma longa. THC has various benefits and overcomes the bioavailability issue of curcumin. To establish it as a pharmacologically active molecule, its safety profile has to be determined. Thus, the present study aimed to determine the preclinical safety profile of THC in a 90-day subchronic and reproductive/developmental toxicity study in Wistar rats. THC at oral doses of 100, 200, and 400 mg/kg was administered daily for 90 days. Rats in the recovery group were kept for 14 days after treatment termination. The animals were observed for treatment-related morbidity, mortality, and changes in clinical signs, clinical pathology, and histopathology. In the reproductive/developmental toxicity study, THC at 100, 200, and 400 mg/kg was administered orally to rats and the reproductive/developmental parameters in adult male and female rats and pups were observed. THC at up to 400 mg/kg/day of did not have any significant effect on all parameters in male and female rats in both toxicity studies. Thus, 400 mg/kg/day can be considered as the no-observed-adverse-effect-level of THC in rats.