• Science of Emotion and Sensibility
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• v.7 no.4
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• pp.51-56
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• 2004

This study was to estimate human response to different color light stimulation by measuring physiological parameters of human behavior, For both stimulations we used color lights with 6 color filters such as red, yellow, green, blue, violet, and white. The experiment was performed in a soundproof chamber. 30 young male and female subjects participated in the experiment, For physiological parameters, we measured electroencephalogram (EEG), electr ocardiogram (ECG). The result of EEG analysis showed that the relative power of $\alpha$ wave ratio increased in blue and green, In case of HRV spectrum analysis, HF/LF ratio increased in green and blue. From these results, we knew that the physical response was affected by color environment and it might be an indicator in the design of a color environment.

• Journal of Radiation Protection and Research
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• v.42 no.1
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• pp.69-76
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• 2017

Background: Time-resolved optically stimulated luminescence (TR-OSL) is a very useful method for calculating the lifetimes of crystalline quartz and feldspar. Materials and Methods: A compact TR-OSL system was developed, comprising a heater assembly manufactured using Kanthal wire, 2 powerful blue light-emitting diodes (LED, LXHL-PB02) for optical stimulation equipped with VIS liquid light guides, and a photomultiplier tube combined with an optical filter for luminescence detection. A pulse generated from the data acquisition board (NI PCI 6250) was used to initiate on/off signals in LED and TR-OSL measurements. Results and Discussion: The TR-OSL and background signals measured using this TR-OSL system using quartz samples were very similar to those reported in a previous study. Additionally, the lifetimes of the build-up and TR-OSL signals were calculated as $27.4{\pm}2.2{\mu}s$ and $30.3{\pm}0.6{\mu}s$, respectively, in good agreement with the findings of a previous study. Conclusion: It was concluded that the developed TR-OSL system was very reliable for TR-OSL signal measurements and lifetime calculations.

• Journal of Acupuncture Research
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• v.24 no.5
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• pp.105-111
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• 2007

Objectives : The electroacupuncture(EA) was often used in Oriental medicine clinic and basic researches. However, there have been neither any national standard of acupuncture needles in Korea nor many studies about the property of acupuncture needles for applying electrical stimulations. Therefore we investigated the electrical corrosion property of acupuncture needles used for EA stimulation in clinic. Methods : We observed the occurrence of electrical corrosion like changes in the surface of acupuncture needles after EA stimulation with various parameters(electrical stimulation intensity, treatment duration, diameter of needle) under a light microscope. We performed EA stimulation on Baekhoe($GV_{20}$) or Joksamli($ST_{36}$) of rats with intensity of 0.025, 0.05, 0.075, 0.1, 0.25 or 0.5mA at a 10Hz frequency. Results : The electrical corrosion-like changes were found on the surface of needles when the EA stimulation was given over 0.05mA of intensity. When electrical stimulation was treated for 10min, the electrical corrosion-like changes were low, but the electrical corrosion-like changes gradually increased by the treatment duration(20, 30min). We also found that acupuncture needles of 0.2mm diameter were produced more extensive electrical corrosion-like changes than acupuncture needles of 0.3 or 0.4mm diameter by electrical stimulation. Conclusions: These results suggested that EA stimulation could produce electrical corrosion-like changes of acupuncture needles through intensity of current, duration of electric stimulation and/or diameter of needle.

• Journal of Korean Academy of Nursing
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• v.46 no.4
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• pp.475-489
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• 2016

Purpose: This study was a systematic review and meta-analysis designed to investigate the effects of stimulation-oriented interventions for behavioral problems among people with dementia. Methods: Based on the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), a literature search was conducted using seven electronic databases, gray literature, and other sources. Methodological quality was assessed using the Scottish Intercollegiate Guidelines Network (SIGN) for randomized controlled trials (RCTs). Data were analyzed using R with the 'meta' package and the Comprehensive Meta-Analysis (CMA 2.0) program. Results: Sixteen studies were included for meta-analysis to investigate the effect of stimulation-oriented interventions. The quality of individual studies was rated as '++' for eight studies and '+' for the rest. The effect sizes were analyzed according to three subgroups of interventions (light, music, and others); Hedges' g=0.04 (95% CI: -0.38~0.46), -0.23 (95% CI: -0.56~0.10), -0.34 (95% CI: -0.34~0.00), respectively. To explore the possible causes of heterogeneity ($I^2=62.8%$), meta-regression was conducted with covariates of sample size, number of sessions, and length of session (time). No moderating effects were found for sample size or number of sessions, but session time showed a significant effect (Z=1.96, 95% CI: 0.00~0.01). Finally, a funnel plot along with Egger's regression test was performed to check for publication bias, but no significant bias was detected. Conclusion: Based on these findings, stimulation-oriented interventions seem to have a small effect for behavioral problems among people with dementia. Further research is needed to identify optimum time of the interventions for behavioral problems among dementia pateints.

• Korean Journal of Acupuncture
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• v.28 no.3
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• pp.113-126
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• 2011

Objectives : We have examined and analyzed patents regarding acupuncture point stimulating methods in order to understand the stimulation technology and research trends of acupuncture points. Methods : We searched and analyzed the total of 135 on-line DB based patents under time limit of Dec, 2010. Results : According to the analyzed results, non-invasive method is used more than invasive method. Electric stimulation is used more than any other method, such as magnetic, ionic, laser, light, ultrasonic, water, Far IR and thermal stimulation. There are numbers of cases such as rejected during screening procedure, waived before the screening, of failed to renew its registrational status which outnumber those patents registered and maintained. Conclusions : These data suggest that we need to move away from using one side method such as non-invasive and electrical method. Thus follow-up service is recommended.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.202-205
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• 2005

The purpose of this work is to identify the characteristic of eye movement for visual training of the elderly. This investigation is to examine the relationship between the head and the eye motor system for the localization of visual target direction in three-dimensional space. All experiments were performed in a soundproof chamber. Twenty-one red LEDs (Light-Emitting Diode, Brightness: 20cd/$m^2$) arrayed in three lines on a half circle-surrounding panel are used. LEDs are horizontally 30 degree apart and vertically 20 degree apart from each other. The condition of stimulation is random and anti-saccade. Physiological parameter such as EOG (Electro-Oculography) was measured by BIOPAC system. We measure the mean latency time, which is the time from the start of visual stimulation to the response of the human body. The result shows that the mean latency time is short in the case of the condition of anti-saccade, the fixed head and a quarter visual stimulation. This finding can be used in developing programs for various visual improvements for the elderly by analyzing the characteristic of eye movement.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2021.10a
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• pp.397-399
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• 2021

In this study, a basic study on the development of a multi-stimulation system was conducted to suppress lung cancer cell proliferation. Stimulation was applied to lung cancer cells using a photo-stimulating system and ultrasonic waves that generate a specific frequency, and the effect of inhibiting proliferation of cells was imaged and quantitatively evaluated. As a result of the experiment, when a single LED, single ultrasound stimulus were applied and ultrasound and LED stimuli were applied at the same time, meaningful results were shown in the proliferation rate of lung cancer cells.

• Journal of Plant Biology
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• v.19 no.3
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• pp.71-84
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• 1976

In order to observe the phosphate metabolism in chloroplast, the contents of inorganic phosphate and various compounds in chloroplast from spinach leaf tissues were investigated during the reaction in the light and dark in the reaction mixture and the turnover of phosphate in chloroplast was compared with that of whole cell system: 1. The phosphorus of DNA in chloroplast appears to be transferred from inorganic phosphate, while in whole cell system from phosphate pool. 2. $^{32}P-phosphate$ content of acid soluble fraction in chloroplast as well as in whole cell system was more increased in the light than dark during the reaction. It was noted to be caused by the stimulation of sugar phosphate synthesis in the light. 3. It was confirmed that polyphosphate exists in chloroplast as well as whole cell. Acid insoluble polyphosphate content in whole cell system was significantly decreased during the reaction and the similar tendency was also observed in chloroplst. It is, therefore, considered that acid insoluble polyphosphate also play an most important role as a phosphate pool respectively in chloroplast and in cytoplasm. 4. Protein and lipid phosphorus in chloroplast as well as whole cell system were transferred from acid insoluble polyphosphate.

• Molecules and Cells
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• v.42 no.11
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• pp.794-803
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• 2019

Ultraviolet light (UV)-induced cellular response has been studied by numerous investigators for many years. Long noncoding RNAs (lncRNAs) are emerging as new regulators of diverse cellular process; however, little is known about the role of lncRNAs in the cellular response to UV treatment. Here, we demonstrate that levels of lncRNA-HOTTIP significantly increases after UV stimulation and regulates the UV-mediated cellular response to UV through the coordinate activation of its neighboring gene Hoxa13 in GC-1 cells (spermatogonia germ cell line). UV-induced, G2/M-phase arrest and early apoptosis can be regulated by lncRNA-HOTTIP and Hoxa13. Furthermore, lncRNA-HOTTIP can up-regulate ${\gamma}-H_2AX$ and p53 expression via Hoxa13 in UV-irradiated GC-1 cells. In addition, p53 has the ability to regulate the expression of both lncRNA-HOTTIP and Hoxa13 in vitro and in vivo. Our results provide new data regarding the role lncRNAs play in the UV response in spermatogenic cells.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.35 no.3
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• pp.215-222
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• 2022

Artificial neuromorphic devices are considered the key component in realizing energy-efficient and brain-inspired computing systems. For the artificial neuromorphic devices, various material candidates and device architectures have been reported, including two-dimensional materials, metal-oxide semiconductors, organic semiconductors, and halide perovskite materials. In addition to conventional electrical neuromorphic devices, optoelectronic neuromorphic devices, which operate under a light stimulus, have received significant interest due to their potential advantages such as low power consumption, parallel processing, and high bandwidth. This article reviews the recent progress in optoelectronic neuromorphic devices using various active materials such as two-dimensional materials, metal-oxide semiconductors, organic semiconductors, and halide perovskites