• Journal of Pharmaceutical Investigation
• /
• v.28 no.2
• /
• pp.87-92
• /
• 1998

Kojic acid (KA) is an antimelanogenic agent which has been widely used in cosmetics to whiten the skin color. However, it has the drawbacks of the skin irritancy and the instability against the pH, temperature, and light. In order to overcome these problems, various topical gels and multiple emulsion creams which can control the release of active ingredient, KA, were formulated employing cream bases of mineral oil with caprylic capric triglyceride and hydrophilic polymers such as chitosan, carbopol. and pluronics. Using Franz diffusion cells mounted with a synthetic cellulose membrane (MWCO 12,000), drug release characteristics of the formulations were evaluated by the HPLC assay of KA concentration in the receptor compartment of pH 7.4 phosphate buffered saline solution. Drug release from chitosan-based gels (ChitoGel) obeyed to the first order kinetics with a rapid release especially in the initial period. However, pluronic-based gels (PluGel) and carbopol-based gels (CarboGel) revealed controlled release of drug to some extent, followed by the square root-time kinetics. Moreover, the release of KA was further controlled with the W/O/W multiple emulsion creams (MultiCream), showing the apparent zero order release kinetics by virtue of dynamic ratecontrolling membrane of the oil layer. The flux $(J,\;{\mu}g/cm^2/hr)$ of ChitoGel. CarboGel. PluGel. and MultiCream in the initial period of 6hr were 73.30, 28.67. 24.04 and 7.72, respectively. On the other hand, the skin irritancy score of ChitoGel and MultiCream were observed as 2.5 and 2.3 respectively, in the rabbit skin irritation test. Although there were insignificant differences at p<0.05 between those formulations, it was possible to conclude that the W/O/W multiple emulsion creams containing KA might be a good candidate for an antimelanogenic drug delivery system due to the controlled release of acidic drug molecules.

• 한국금형공학회:학술대회논문집
• /
• 2008.06a
• /
• pp.39-44
• /
• 2008

Magnesium alloys have given high attention to the industry of light-weigh as automobile and electronics with aluminium, titanium and composite alloys due to their high strength, low specific density and good damping characteristics. But the magnesium contained structures under high temperature have the problems related to creep deformation and rupture life, which is a reason of developing the new material against creep deformation to use them safely. The purpose of this study is to predict the creep deformation mechanism and rupture time of AZ31 magnesium alloy. For this, creep tests of AZ31 magnesium alloy were done under constant creep load and temperature with the equipment including automatic temperature controller with acquisition computer. The apparent activation energy Qc and the applied stress exponent n, rupture life have been determined during creep of AZ31 Mg alloy over the temperature range of $150^{\circ}C$ to $300^{\circ}C$. In order to investigate the creep behavior. Constant load creep tests were carried out in the equipment including automatic temperature controller, whose data are sent to computer. At around the temperature of $150^{\circ}C{\sim}300^{\circ}C$ the creep behavior obeyed a simple power-law relating steady state creep rate to applied stress and the activation energy for the creep deformation was nearly equal and a little low, respectively, to that of the self diffusion of Mg alloy.

• Journal of the Institute of Convergence Signal Processing
• /
• v.8 no.1
• /
• pp.78-83
• /
• 2007

Robot collects surrounding information to recognize tile unknown environment by using various sensors such as visual, infrared ray and ultra sonic sensors. Although visual sensor is the most popular one, it has some difficulties in collecting data in dark or too bright environment due to sensitivity of the light. It also requests significant amount of calculation on collecting data from certain images with marked, straight and curved ones. As an alternative, ultra sonic sensor can simply overcome this visual sensing system's flaw and easily be used. It is easier than visual system, especially in case of collecting data on object and distance in dark environment. Ultra sonic sensor can replace the expensive visual sensing system not only in avoiding obstacles but also in reaching to the target area smoothly. The purpose of this paper is to develop the algorithm to optimize the environmental recognition, path planning and free-ranging by minimizing errors caused by inaccurate information and by considering characteristics of the ultra sonic rays such as refraction and diffusion. This paper also realizes the system that can recognize the environment and make the appropriate path planning by applying the algorithm on this moving robot.

• Nuclear Engineering and Technology
• /
• v.22 no.4
• /
• pp.359-370
• /
• 1990

This study concerns with comparing low-dimensional reactor kinetics methods with a three-dimensional kinetics method to be used for safety analysis of light water reactors in order to suggest means of preparing input parameters required for low-dimensional methods. For this purpose a one-dimensional finite difference two-group diffusion theory code ODTRAN and a third-order Hermit polynomial-based point kinetics code POTRAN are developed and used to obtain low-dimensional solutions to the LRA-BWR kinetics benchmark problem. The results are compared with a three-dimensional modified Borresen's coarse-mesh solution of the kinetics problem by CMSNACK code. Through this comparison some simple but practical means of preparing input parameters of low-dimensional kinetics analysis methods are suggested.

• 한국태양에너지학회:학술대회논문집
• /
• 2011.11a
• /
• pp.34-39
• /
• 2011

Screen printing method is a common way to fabricate the crystalline silicon solar cell with low-cost and high-efficiency. The screen printing metallization use silver paste and aluminum paste for front and rear contact, respectively. Especially the rear contact between aluminum and silicon is important to form the back surface filed (Al-BSF) after firing process. BSF plays an important role to reduces the surface recombination due to $p^+$ doping of back surface. However, Al electrode on back surface leads to bow occurring by differences in coefficient of thermal expansion of the aluminum and silicon. In this paper, we studied the properties of mono crystalline silicon solar cell for rear electrode with aluminum and aluminum-boron in order to characterize bow and BSF of each paste. The 156*156 $m^2$ p-type silicon wafers with $200{\mu}m$ thickness and 0.5-3 ${\Omega}\;cm$ resistivity were used after texturing, diffusion, and antireflection coating. The characteristics of solar cells was obtained by measuring vernier callipers, scanning electron microscope and light current-voltage. Solar cells with aluminum paste on the back surface were achieved with $V_{OC}$ = 0.618V, JSC = 35.49$mA/cm^2$, FF(Fill factor) = 78%, Efficiency = 17.13%.

• Korean journal of food and cookery science
• /
• v.33 no.3
• /
• pp.256-263
• /
• 2017

Purpose: Essential oils are secondary metabolites of herbs and have antibacterial activities against foodborne pathogens. However, their applications for food protection are limited due to the hydrophobic and volatile natures of essential oils. Methods: In this study, essential oil nanoemulsions of rosemary and lavender were formulated with non-ionic surfactant Tween 80 and water using ultrasonic emulsification, and their antibacterial effects were determined. Results: The antibacterial activities of nanoemulsions were evaluated against 12 strains of 10 bacterial species, and significant antibacterial effects were observed against four Gram-positive and four Gram-negative bacteria but not against Streptococcus mutans and Shigella sonnei. In the disc diffusion test, the diameter of the inhibition zone proportionally increased with the concentration of nanoemulsions. Using cell turbidity measurement, minimum bactericidal concentration (MBC) of the nanoemulsions, which is the lowest concentration reducing viability of the initial bacterial inoculum by ${\geq}99.9%$, was significantly higher than the minimum inhibitory concentration (MIC) of the nanoemulsions. The largest bactericidal effects of lavender and rosemary essential oil nanoemulsions were observed against S. enterica and S. aureus, respectively. Conclusion: Nanoemulsion technique could improve antibacterial activity of essential oil nanoemulsions by increasing the solubility and stability of essential oils. Our findings shed light on the potential use of essential oil nanoemulsions as an alternative to chemical sanitizers in food protection.

• Journal of Pharmaceutical Investigation
• /
• v.36 no.5
• /
• pp.299-304
• /
• 2006

The aim of this study was to investigate the effect of deformable liposomes with sodium cholate on the skin permeation and skin deposition of arbutin, a hydrophilic skin-whitening agent. Various compositions of liposomes were prepared by the extrusion method. Particle size distribution and entrapment efficiency were determined by the laser light scattering and the gel permeation chromatography, respectively. The in vitro rat skin permeation and deposition of arbutin in various skin layers were investigated using the Keshary-Chien diffusion cells at $37^{\circ}C$. The average particle size of the deformable liposomes ranged from 217.4 to 117.4 nm, depending on the composition. The entrapment efficiency was dependent on surfactant concentration and loading dose of arbutin. The permeation rate of 5% arbutin in deformable liposomes was $8.91({\pm}1.33){\mu}g/cm^2/h$, and was not significantly different from 5% arbutin aqueous solution $[9.82({\m}0.86){\mu}g/cm^2/h]$. The deposition of arbutin was $43.34({\pm}12.13)$ and $16.99({\pm}7.83){\mu}g/cm^2$ in stratum corneum layer and epidermis/dermis layer, respectively, after 12 h of permeation study. These results are consistent with several earlier studies for the localization effect of liposomal formulations in stratum corneum, and demonstrated the feasibility of the deformable liposomes as a promising carrier for the skin deposition of hydrophilic skin-whitening compounds.

• Proceedings of the Korean Society of Agricultural Engineers Conference
• /
• 1999.10c
• /
• pp.169-174
• /
• 1999

The reclamation area of Saemangeum (Kunsan) located between 126$^{\circ}$10' -126$^{\circ}$50'E and and 35$^{\circ}$35'N -36$^{\circ}$05'N at the western coast of Korea. The construction of the 33km sea dike is building in the Saemangeum area. When the construction of the sea dike in the coastal region takes plase, there exists a certain amount of soil which is diffused by the tidal current. Behavior of the soil diffusion usually depends on its intrinsic characteristics, bathymetry, construction method and used mchinery. The amount of soil at the construction acts as a pollutant which is the cause of changing the marine environment. When the soil material is diffused , it may form a layer which obstructs the light passing into the sea and causes the extinction or alteration of the living beings on the sea bottom. The settlement of soil material could change the sea bottom deposit. The purpose of MITIGATION is to harmonize the development and the conservation of environment, to restrict environmental destruction and to reproduce the enviroment damaged by the construction in the coastal region. The purpose of this study is to find the method by which we minimize the anti-function of development in the coastal region. Tide and tidal current are calculated using a two-dimensional numerical model before the construction of sea dike in Saemangeum Bay. The numerical results are compared well with field observations. On the basis of these results, we caculated the tide and tidal current after the construction of the sea dike in order to investigate the change of the tide and tidal current after the construction of the sea dike. Moreover, we calculated the tide and tidal current after the construction of submerged breakwater in order to preserve the enviornmental condition of creature habitat . We compared the tide and tidal current before and after the construction of submerbed breakwater, to investigate the possbility of MITIGATION in the fisheries.

• The Journal of the Korea Contents Association
• /
• v.15 no.2
• /
• pp.507-519
• /
• 2015

Along with the rapid diffusion of smart devices, smart learning has been taking place as a main pedagogy in education. Under these drastic changing circumstances, social presence and interaction between learners have been highlighted as key factors in educational research. In this light of rising importance, this study examined the effects of modality and smart device on users' perceived social presence and interaction experience in a smart learning environment. It conducted 2(text based interface vs. audio/video based interface) by 2(smartphone vs. tablet PC) between-subjects experiment. 80 participants were systematically recruited and randomly assigned to four conditions. The findings showed that social presence was higher in audio/video based interface condition than in text based interface condition. Modality also had a positive effect on learner's interaction experience. On the other hand, the effect of smart device is found to be statistically insignificant. Instead, interaction effect existed between modality and device on social presence. The result of this study suggests that the modality and characteristics of device should be considered seriously when designing interface of smart learning contents. The findings in this study provide future studies with heuristic implications by highlighting users' perceived cognition and experience.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.37 no.9
• /
• pp.1-6
• /
• 2000

Utilizing impurity free vacancy diffusion (IFVD) method, area selective intermixing of InGaAs/InGaAsP multi-quantum well (MQW) structure was done. After this, wavelength division demultiplexing waveguide type photodetectoers was integrated and measured. It showed large blue shift in bandgap due to intermixing of MQW. Photodetectors are based on typical p-i-n structure and devices having large and small bandgap areas line up linearly. Width of waveguide and length of each photodetector are 20 and 250 ${\mu}m$, respectively, TE/TM polarized light from tunable laser was butt-coupled to the photodetector and spectral response was measured. Photodetectors can demultiplexing 1480 and 1550 nm wavelength.