• Journal of Periodontal and Implant Science
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• 제30권4호
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• pp.895-913
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• 2000

It is becoming increasingly clear that human gingival fibroblasts(HGF) may play a role in regulating immune responsiveness in inflammatory periodontal lesions. Stimulation of HGF with locally-secreted T cell cytokine $IFN_{\gamma}$ induces human leukocyte antigen class II(HLA II) expression on HGF, which is one of the characteristic feature of professional antigen presenting cells(pAPC). However, $IFN_{\gamma}$-treated HGF and other nonprofessional antigen presenting cells(npAPC) are known to be ineffective or less effective antigen presenter to resting T cells. This study, therefore, was undertaken in an effort to elucidate the differences in expression of cell surface molecules between npAPC in periodontal tissues, such as HGF and periodontal ligament fibroblasts(PDLF), and pAPC such as monocytes/macrophages. Using flow cytometry, the levels of cell surface expression of HLA-D, ICAM-1, LFA-3, and B7-1, which are involved in antigen presentation, were determined in HGF, PDLF and human myelomonocytic cell line THP-1. $IFN_{\gamma}$ clearly induced HLA-D expression on both of fibroblasts and monocytes dose dependently. However, expression level on monocytes were 4 to 5 times higher than that on fibroblasts, and induction rate was faster in monocytes than in fibroblasts. The levels of ICAM-1 expression on fibroblasts and monocytes were enhanced by $IFN_{\gamma}$ in a dose dependent manner. On the other hand, the expression of LFA-3 molecule, which could be detected in fibroblasts and monocytes without cytokine stimulation, was no more enhanced by addition of $IFN_{\gamma}$. B7-1, important costimulatory molecule in T cell activation and proliferation, was not detected on both of fibroblasts and monocytes even when stimulated with $IFN_{\gamma}$, except on monocytes fully differentiated by pretreatment of PMA and treated by $IFN_{\gamma}$. These results suggest that delayed expression of HLA-D and absence of B7-1 on $IFN_{\gamma}$ - treated fibroblasts may at least in part be involved in the ineffectiveness of fibroblasts as primary APC. And it is postulated that although periodontal fibroblasts may not serve as primary APC in normal periodontium, sustained expression of HLA II on ubiquitous fibroblasts in inflammatory lesions may perpetuate immune responses and produce chronic inflammation and tissue injury.

• 대한정형외과스포츠의학회지
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• 제2권2호
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• pp.163-167
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• 2003

목적: 본 연구는 인 라인 스케이트를 타다가 발생한 다양한 형태의 손상에 대해 기 술하고 그 원인과 예 방 방법을 찾고자 하였다. 대상 및 방법: 인 라인 스케이트를 타던 중 수상 후 본원 및 인근 병원에 내원하여 치료를 받은 환자 57예를 조사하였다 이 중 남자 37명 , 여 자20명이었으며 평균 연령 은 9세 9개월 (범위 , 6$\~$40세)이었다 수상 부위 및 인 라인 스케이트를 즐겨 타던 장소, 수상 당시 보호 장비의 착용 여부, 그리고 수상 기전 등을 조사하였다. 결과: 수상 형 태로는 골절 50예 슬관절 연골판 파열 1예 , 슬관절 내측 측부 인대 손상 2예 , 좌상 및 염 좌 4예였으며 골절의 부위로는 원위부 요-척골 골절 33예(66$\%$) , 주관절부 골절 5예(10$\%$) , 상완골 간부 골절 3예(6$\%$) 등으로 나타났다. 수상 당시의 장소는 복잡한 아파트 단지 22예 (39$\%$) , 좁은 골목길 19예 (33$\%$) , 공원 16예 (28$\%$)였다 보호장비 착용 여부로는 단 5예에서만 부분적으로 보호장비를 착용하였으며 슬관절 보호대만을 착용한 경우 2예, 슬관절 및 주관절 보호대 1예, 슬관절 , 주관절 및 완관절 보호대 2예였고, 헬멧을 착용한 경우는 없었다 결론: 인 라인 스케이트를 타다가 발생하는 손상을 줄이 기 위해서 는 적절한 보호장비의 착용 및 안전한 장소의 선택이 필요하며 , 인 라인 스케이트를 타는 방법에 대 하여 동호회 등을 통한 지속적 이고 효과적 인 교육이 중요하다고 사료되었다

• 한국운동역학회지
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• 제27권3호
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• pp.189-195
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• 2017

Objective: The aim of this study was to examine the effect of foot landing type (forefoot vs. rearfoot landing) on kinematics, kinetics, and energy absorption of hip, knee, and ankle joints. Method: Twenty-five healthy men performed single-leg landings with two different foot landing types: forefoot and rearfoot landing. A motion-capture system equipped with eight infrared cameras and a synchronized force plate embedded in the floor was used. Three-dimensional kinematic and kinetic parameters were compared using paired two-tailed Student's t-tests at a significance level of .05. Results: On initial contact, a greater knee flexion angle was shown during rearfoot landing (p < .001), but the lower knee flexion angle was found at peak vertical ground reaction force (GRF) (p < .001). On initial contact, ankles showed plantarflexion, inversion, and external rotation during forefoot landing, while dorsiflexion, eversion, and internal rotation were shown during rearfoot landing (p < .001, all). At peak vertical GRF, the knee extension moment and ankle plantarflexion moment were lower in rearfoot landing than in forefoot landing (p = .003 and p < .001, respectively). From initial contact to peak vertical GRF, the negative work of the hip, knee, and ankle joint was significantly reduced during rearfoot landing (p < .001, all). The contribution to the total work of the ankle joint was the greatest during forefoot landing, whereas the contribution to the total work of the hip joint was the greatest during rearfoot landing. Conclusion: These results suggest that the energy absorption strategy was changed during rearfoot landing compared with forefoot landing according to lower-extremity joint kinematics and kinetics.

• Clinics in Shoulder and Elbow
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• 제10권1호
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• pp.131-135
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• 2007

23세 남환에서 발생한 요골 두 급성 전방 탈구를 경험하였기에 이를 보고하고자 한다. 수상 당시 전완부는 회내전, 주관절은 약간 굴곡되어 있었고, 손이 지면에 닿아 체중이 실리면서 주관절의 갑작스런 과도한 회내전이 발생하였다. 요골 두는 상완근의 외측 근육 다발에 의해 감돈 되었고, 윤상인대가 척골의 후방 부착부에서 견열되어 요골 두와 소두 사이에 끼어 정복을 방해하였다. 관혈적 정복을 시행하였다. 12개월간 추시 관찰을 하였으며 요골 두의 정복은 잘 유지되고 있었고 주관절의 운동제한은 없었다.

• 대한관절경학회지
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• 제14권1호
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• pp.25-28
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• 2010

대부분의 반월상 연골의 양동이 손잡이형 파열은 전방 십자인대와 동반하여 발생하며, 전방십자 인대의 급성 손상 시는 외측 반월상 연골의 양동이 손잡이형 파열이 흔한 반면 만성 전방 십자인대 손상 시는 내측에서 흔히 발생한다고 보고된다. 저자들은 전방십자 인대의 불안정성과 동반 된 내,외측 반월상 연골의 동시적 양동이 손잡이형 파열에 대해 보고하고자 한다.저자들은 전방십자 인대의 불안정성과 동반 된 내,외측 반월상 연골의 동시적 양동이 손잡이형 파열의 발생 가능성에 대한 인식을 높이고자 하였으며, 추가적으로 본 손상의 발생기전, 임상증상, 자기공명영상 검사상 특이 소견 및 치료에 대해 문헌 고찰과 함께 보고하고자 한다.

• 한국운동역학회지
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• 제30권1호
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• pp.1-6
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• 2020

Objective: The incidence rate of elbow ulnar collateral ligament injuries is dependent on the throwing speed or pitching type, especially in adolescent baseball players. However, mixed results have been reported due to a lack of controlled biomechanical analysis. Thus, the purpose of this study was to investigate the biomechanical analysis of the elbow in relation to throwing speed and pitching type. Method: Four overhead type high-school baseball players were recruited for this study. The participants were asked to throw balls with different types of pitch and speed. While the throwing speeds were measured, each pitching moment of the elbow was recorded. Descriptive statistics, frequency analysis, mean comparison analysis, and Pearson's correlation analysis were performed in order to examine differences in peak varus and valgus moment during pitching motion in the elbow in all throwing speed and pitching types. Results: There was no significant difference in physical characteristics, throwing speed, and momentum variability among all players. The mean varus moments were 44.38±1.55 Nm, 48.83±1.66 Nm, and 48.94±0.95 Nm, and the moment gaps between varus and valgus were 7.36±3.25 Nm, 7.44±2.02 Nm, and 7.36±2.62 Nm in fastball, curveball, and slider ball, respectively. The varus moment was higher in the curved and slider balls than in the fastballs, and there was no significant differences between the varus moments regarding the pitching type. However, the increase in valgus moment and decrease in moment gap according to throwing speed was significantly increased in the slider ball (r=0.718 and -0.591, respectively). Conclusion: The possibility of elbow injury caused by the valgus moment or moment gapincreases more rapidly in slider balls as the speed increases. Based on our results, appropriate pitching guidelines should be suggested to prevent ulnarligament injuries, especially in adolescent baseball players.

• 대한족부족관절학회지
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• 제14권2호
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• pp.130-134
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• 2010

Purpose: The aim of this study was to evaluate the result of combined first metatarsal and calcaneal osteotomy for static cavovarus deformity of the foot. Materials and Methods: We performed a dorsal closing wedge $1^{st}$ metatarsal osteotomy and a lateral and upward displacement calcaneal osteotomy for 9 patients, 12 feet (6 male and 3 female). The mean age at the time of operation was 37 years and the mean followup period was 27 months. The causes of deformity were 2 poliomyelitis, 1 cerebral palsy, 1 Charcot-Marie-Tooth disease and 5 idiopathic type. Five lateral ligament reconstructions of the ankle and six percutaneous Achilles tendon lengthenings were added. The surgical results in terms of pain, function and alignment of the foot were evaluated by means of AOFAS ankle-hindfoot score and talo-$1^{st}$ metatarsal, calcaneus-$1^{st}$ metatarsal and calcaneal pitch angles were checked with weight bearing radiographs in lateral projection. Results: Talo-$1^{st}$ metatarsal and calcaneal pitch angles were reduced from the mean preoperative values of $21^{\circ}$ and $25^{\circ}$ to $12^{\circ}$ and $19^{\circ}$, respectively, at last followup. Also, calcaneus-$1^{st}$ metatarsal angle was increased from the mean $114^{\circ}$ to $114^{\circ}$. The mean AOFAS score was improved from 44.5 points preoperatively to 89.2 points at followup. There were 1 metatarso-cueiform joint nonunion, 1 sural nerve injury and 3 remaining symptomatic claw toes. Conclusion: Combined first metatarsal and calcaneal osteotomy appears to be an effective procedure for the treatment of adult static cavovarus foot.

• 대한두개안면성형외과학회지
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• 제9권2호
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• pp.93-96
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• 2008

Purpose: Sudoriferous cyst usually occurs on the face, and especially on the ear and scalp as a solitary cystic mass. It is derived from the sweat glands of Moll and results from the obstruction of excretory ducts with the retention of fluid. In the eyelid, it is usually seen as small and firm vesicle arising at the eyelid margin. If it rarely occurs on the orbit, it develops from orbital ectopic epithelial cells predetermined to form glands of Moll. We experienced a case of sudoriferous cyst on eyelid which was adhered to levator aponeurosis and it disappeared when patient closed eyes. Methods: A 55-year-old women suffered palpable mass on left upper eyelid without pain that had been present for 25 years. Orbital computed tomographic finding showed a oval mass($2.1{\times}0.6{\times}0.6cm$ size) inside upper eyelid and it invaded the orbit. The mass was completely excised under general anesthesia and histopathological examination was followed. Results: Cystic mass was purple color and it was located in superiorly to tarsal plate. The mass was adhered to levator aponeurosis and levator palpabrae superioris muscle between the fat layer of post-orbital septum and the Whitnall ligament. The mass was completely excised without injury of aponeurosis and muscle. Microscopically, the lesion was a solitary cyst lined by two layers of cuboidal epithelial cells and innermost cells displaying eosinophilic cytoplasm with apical expansions. Conclusion: Sudoriferous cyst usually occurs on eyelid margin. But in this case, cystic mass occurred on upper eyelid and disappeared when patient closed the eyes because it was partially adhered to levator aponeurosis and levator palpebrae superioris muscle. Therefore, if sudoriferous cyst occurs on eyelid, it is necessary to excised the mass carefully.

• 대한관절경학회지
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• 제11권2호
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• pp.134-138
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• 2007

Brodie 농양은 빈도가 흔하지 않고, 독성이 적은 원인균에 의해 발생하는 아급성 혹은 만성 골수염의 국소형으로 소아나 청소년의 하지 장골 특히 경골의 골간단과 골단 부위에 호발하나 성인에서도 발생할 수 있다. 수술적 치료시 병변의 위치가 근위 경골 골간단 후방에 위치한 경우 개방적 소파술로는 병소 접근이 어렵고 신경 혈관 손상 및 주위 조직 오염의 위험성이 있다. 본원 정형외과에서 48세 남자에서 발생한 경골 근위부 골간단 후방부의 Brodie 농양을 전방 십자 인대 재건술시 사용하는 표적 기구(Rigid fix system, Mitek, Johnson & Johnson, Norwood, MA)를 이용하여 병소에 손쉽고 정확하게 삽입구를 만들어 내시경 시야 하에서 염증 및 육아 조직을 제거하여 치료한 경험이 있어 이를 문헌 고찰과 함께 보고하고자 한다.

• 대한관절경학회지
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• 제7권1호
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• pp.92-95
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• 2003

34세 남자 환자로 등산중 실족으로 발생한 전방십자인대의 완전파열로 자가 슬괵건을 이용한 경핀 고정법으로 전방십자인대 재건술을 시행하였다. 술후 경과는 양호하였으나 술후 3개월째 굴신 신전 운동 시 슬부 후측면의 동통과 지속적인 관절내 부종 소견을 보였으며 수차례의 관절천자와 약물투여에도 반응이 없었다. 컴퓨터 단층 촬영 상후방 피질 골의 천공이 관찰되어 술후 6개월째 이차관절내시경 수술을 시행하였다. 내시경 소견상 경핀고정물의 전방부 1/3에 일치되는 투명한 이물질과 대퇴경골관절면의 연골의 손상이 관찰되었으며 이물 제거 후 증세는 호전되었다. 경핀 터널의 잘못된 위치가 실패의 원인이라고 생각되었으며 경핀고정법을 이용한 전방십자인대 재건술시, 슬관절 과굴곡 상태에서 예각의 대퇴 터널을 만들어 후방 피질 골을 두껍게 남기고, 핀 홀을 만들 때 경핀가이드를 횡상과축보다 $10\~20$도 외회전시켜야 대퇴골 후방피질골의 천공을 방지할 수 있어 조기 실패를 예방할 수 있다고 생각된다.