• Title/Summary/Keyword: Life-science industries

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A Concept Design Study for Mini Sporty Utility Vehicle (소형 SUB 컨셉카 디자인 연구)

  • 이명기
    • Archives of design research
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    • v.12 no.4
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    • pp.109-118
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    • 1999
  • In the respect of automobile history, the tendency to the development of automobiles for the latest 100 years has been leaded by technical performances. Especially, with the rapid growth of the newest electronic industry, the technical know-hows of automobiles improved in short terms have brought about outstanding results. The differences of the technical know-hows are little between some of the famous automobile manufacturing industries and the rising. So, now, the automobile design became a basis in selecting a car. The latest tendency to automobile style in accordance with the improvement of a universal life quality has been changed to a characteristic design meeting various needs of customers. RV, UV, MPV(and so forth ) meeting their needs made an appearance, or a characteristic model derived from them respectively appeared. We tried to study a new mini SUV-typed-concepcar design with a touch of the next concept. The whole design process from our researches to the end hard model was performed at the Design Center, Daewoo Automobile, based on the automobile design processes. Especially, We styled an automobile concept as inexpensive, characteristic, new one to have a car easily at the young and made an analysis of customers' responses for referring to this study in generating the next SUV-typed-automobile.

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Big Wave in R&D in Quantum Information Technology -Quantum Technology Flagship (양자정보기술 연구개발의 거대한 물결)

  • Hwang, Y.;Baek, C.H.;Kim, T.;Huh, J.D.
    • Electronics and Telecommunications Trends
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    • v.34 no.1
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    • pp.75-85
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    • 2019
  • Quantum technology is undergoing a revolution. Theoretically, strange phenomena of quantum mechanics, such as superposition and entanglement, can enable high-performance computing, unconditionally secure communication, and high-precision sensing. Such theoretical possibilities have been examined in the last few decades. The goal now is to apply these quantum advantages to daily life. Europe, where quantum mechanics was born a 100 years ago, is struggling to be placed at the front of this quantum revolution. Thus, the European Commission has decided to invest 1 billion EUR over 10 years and has initiated the ramp-up phase with 20 projects in the fields of communication, simulation, sensing and metrology, computing, and fundamental science. This program, approved by the European Commission, is called the "Quantum Technology Flagship" program. Its first objective is to consolidate and expand European scientific leadership and excellence in quantum research. Its second objective is to kick-start a competitive European industry in quantum technology and develop future global industrial leaders. Its final objective is to make Europe a dynamic and attractive region for innovative and collaborative research and business in quantum technology. This program also trains next-generation quantum engineers to achieve a world-leading position in quantum technology. However, the most important principle of this program is to realize quantum technology and introduce it to the market. To this end, the program emphasizes that academic institutes and industries in Europe have to collaborate to research and develop quantum technology. They believe that without commercialization, no technology can be developed to its full potential. In this study, we review the strategy of the Quantum Europe Flagship program and the 20 projects of the ramp-up phase.

Assessment of Evaporation Rates from Litter of Duck House (오리사 바닥재의 수분 증발량 평가)

  • Lee, Sang-Yeon;Lee, In-Bok;Kim, Rack-Woo;Yeo, Uk-Hyeon;Decano, Cristina;Kim, Jun-gyu;Choi, Young-Bae;Park, You-Me;Jeong, Hyo-Hyeog
    • Journal of The Korean Society of Agricultural Engineers
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    • v.61 no.5
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    • pp.101-108
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    • 2019
  • The domestic duck industry is the sixth-largest among the livestock industries. However, 34.3% of duck houses were the duck houses arbitrarily converted from plastic greenhouses. This type of duck house was difficult to properly manage internal air temperature and humidity environment. Humidity environment inside duck houses is an important factor that directly affects the productivity and disease occurrence of the duck. Although the humidity environments of litters (bedding materials) affect directly the inside environment of duck houses, there are only few studies related to humidity environment of litters. In this study, evaporation rates from litters were evaluated according to air temperature, relative humidity, water contents of litters, and wind speed. The experimental chamber was made to measure evaporation rates from litters. Temperature and humidity controlled chamber was utilized during the conduct of the laboratory experiments. Using the measured data, a multi linear regression analysis was carried out to derive the calculation formula of evaporation rates from litters. In order to improve the accuracy of the multi linear regression model, the partial vapor pressure directly related to evaporation was also considered. Variance inflation factors of air temperature, relative humidity, partial vapor pressure, water contents of litters, and wind speed were calculated to identify multicollinearity problem. The Multiple $R^2$ and adjusted-$R^2$ of regression model were calculated at 0.76 and 0.71, respectively. Therefore, the regression models were developed in this study can be used to estimate evaporation rates from the litter of duck houses.

Molecular Cloning, Characterization, and Application of Organic Solvent-Stable and Detergent-Compatible Thermostable Alkaline Protease from Geobacillus thermoglucosidasius SKF4

  • Suleiman D Allison;Nur AdeelaYasid;Fairolniza Mohd Shariff; Nor'Aini Abdul Rahman
    • Journal of Microbiology and Biotechnology
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    • v.34 no.2
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    • pp.436-456
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    • 2024
  • Several thermostable proteases have been identified, yet only a handful have undergone the processes of cloning, comprehensive characterization, and full exploitation in various industrial applications. Our primary aim in this study was to clone a thermostable alkaline protease from a thermophilic bacterium and assess its potential for use in various industries. The research involved the amplification of the SpSKF4 protease gene, a thermostable alkaline serine protease obtained from the Geobacillus thermoglucosidasius SKF4 bacterium through polymerase chain reaction (PCR). The purified recombinant SpSKF4 protease was characterized, followed by evaluation of its possible industrial applications. The analysis of the gene sequence revealed an open reading frame (ORF) consisting of 1,206 bp, coding for a protein containing 401 amino acids. The cloned gene was expressed in Escherichia coli. The molecular weight of the enzyme was measured at 28 kDa using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The partially purified enzyme has its highest activity at a pH of 10 and a temperature of 80℃. In addition, the enzyme showed a half-life of 15 h at 80℃, and there was a 60% increase in its activity at 10 mM Ca2+ concentration. The activity of the protease was completely inhibited (100%) by phenylmethylsulfonyl fluoride (PMSF); however, the addition of sodium dodecyl sulfate (SDS) resulted in a 20% increase in activity. The enzyme was also stable in various organic solvents and in certain commercial detergents. Furthermore, the enzyme exhibited strong potential for industrial use, particularly as a detergent additive and for facilitating the recovery of silver from X-ray film.

Magnetron Sputter Coating of Inner Surface of 1-inch Diameter Tube

  • Han, Seung-Hee;An, Se-Hoon;Song, In-Seol;Lee, Keun-Hyuk;Jang, Seong-Woo
    • Proceedings of the Korean Vacuum Society Conference
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    • 2015.08a
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    • pp.135-135
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    • 2015
  • Tubes are of extreme importance in industries as for fluid channels or wave guides. Furthermore, some weapon systems such as cannons use the tubes as gun barrels. To increase the service life of such tubes, a protective coating must be applied to the tubes' inner surface. However, the coating methods applicable to the inner surface of the tubes are very limited due to the geometrical restriction. A small-diameter cylindrical magnetron sputtering gun can be used to deposit coating layers on the inner surface of the large-bore tubes. However, for small-bore tubes with the inner diameter of one inch (~25 mm), the magnetron sputtering method can hardly be accommodated due to the space limitation for permanent magnet assembly. In this study, a new approach to coat the inner surface of small-bore tubes with the inside diameter of one inch was developed. Instead of using permanent magnets for magnetron operation, an external electro-magnet assembly was adopted around the tube to confine the plasma and to sustain the discharge. The electro-magnet was operated in pulse mode to provide the strong axial magnetic field for the magnetron operation, which was synchronized with the negative high-voltage pulse applied to the water-cooled coaxial sputtering target installed inside the tube. By moving the electro-magnet assembly along the tube's axial direction, the inner surface of the tube could be uniformly coated. The inner-surface coating system in this study used the tube itself as the vacuum chamber. The SS-304 tube's inner diameter was 22 mm and the length was ~1 m. A water-cooled Cu tube (sputtering target) of the outer diameter of 12 mm was installed inside of the SS tube (substrate) at the axial position. The 50 mm-long electro-magnet assembly was fed by a current pulse of 250 A at the frequency and pulse width of 100 Hz and 100 usec, respectively. The calculated axial magnetic field strength at the center was ~0.6 Tesla. The central Cu tube was synchronously driven by a HiPIMS power supply at the same frequency of 100 Hz as the electro-magnet and the applied pulse voltage was -1200 V with a pulse width of 500 usec. At 150 mTorr of Ar pressure, the Cu deposition rate of ~10 nm/min could be obtained. In this talk, a new method to sputter coat the inner surface of small-bore tubes would be presented and discussed, which might have broad industrial and military application areas.

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Evaluation of Livestock Manure Utilization Rates as Agricultural Purpose in Developed OECD Countries by Using Nutrient Balances (OECD 양분수지를 이용한 축산선진국의 농경지 축산분뇨 이용실태 평가)

  • Kim, Pil-Joo;Lee, Yong-Bok;Lee, Youn;Yun, Hong-Bae;Lee, Kyung-Dong
    • Korean Journal of Environmental Agriculture
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    • v.27 no.4
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    • pp.337-342
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    • 2008
  • The nitrogen (N) and phosphorus (P) balances in Korea during 1985-2006, which calculated according to the surface balance method of the PARCOM guidelines, continually increased with the lapse of year, and then might keep the highest levels with about $250kg\;N\;ha^{-1}$ and $50kg\;P\;ha^{-1}$ in 2006 among OECD countries. National phosphorus balance of the developed OECD countries (Belgium, Denmark, Germany, The Netherlands) in the livestock feeding industries has significantly decreased, due to limit livestock feeding density and nutrient application level by using strong legislation. However, Korean P balance was not apparent decrease, since the number of livestock feeding heads has been increasing, irrespective with the decrease of chemical fertilizer consumption. Manure P portion to the total P input amount of the above four OECD Countries in nutrient balance has continuously inclined to 60-70%. Therefore, the large portion of livestock manure might be used as nutrient source in agricultural side in these countries. In particular, manure P application levels of Belgium and The Netherlands, which have relatively high P balance and manure P portion to total P input dose, was estimated to be $31-33\;kg\;p\;ha^{-1}$ in 2004, and it was similar level with that of Korea in 2006. The manure P application levels for agricultural purpose has continuously decreased in these two OECD countries. In contrast, our manure P application rate continuously increased, and therefore we need the strong political countermeasure to control livestock feeding density at the resonable level.

Ecotoxicological Test on Various Industrial Effluent Using Mayfly Egg, Ephemera orientalis (동양하루살이 알을 이용한 산업폐수 생태독성평가)

  • Mo, Hyoung-ho;Son, Jino;Jung, Jinho;Shin, Key-Il;Cho, Kijong
    • Korean Journal of Environmental Biology
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    • v.34 no.3
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    • pp.212-215
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    • 2016
  • We developed a new ecotoxicological test method using native test species, eggs of Ephemera orientalis, and five kinds of industrial wastewater were tested to validate the test method. The water samples were collected in Jun 2006 from the following industries: pesticide, metal plating, PCB, leather1, and leather2. Wastewater and effluent were diluted by distilled water, respectively, to prepare various concentrations, 100, 50, 25, 12.5, 6.3, 3.1, and 0%. For the egg bioassay, 20 freshly laid eggs (<24 h old) were exposed to test solutions in a Petri dish ($52{\times}12mm$) at $20^{\circ}C$ with photoperiod of 16 h light and 8 h dark for 14 days. The median egg hatching concentrations (EHC50) were estimated using Probit analysis. All EHC50s of wastewater were less than 3.1%, which meant very high ecotoxicity except for the wastewater of PCB industry having 6.1% of EHC50. Among the effluents, the least toxic effluent was from pesticide industry having 58% of EHC50, while the effluent of leather2 was the most toxic having 7.3% of EHC50.

A Study on the Improvement of Domestic Policies and Guidelines for Secure AI Services (안전한 AI 서비스를 위한 국내 정책 및 가이드라인 개선방안 연구)

  • Jiyoun Kim;Byougjin Seok;Yeog Kim;Changhoon Lee
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.33 no.6
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    • pp.975-987
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    • 2023
  • With the advancement of Artificial Intelligence (AI) technologies, the provision of data-driven AI services that enable automation and intelligence is increasing across industries, raising concerns about the AI security risks that may arise from the use of AI. Accordingly, Foreign countries recognize the need and importance of AI regulation and are focusing on developing related policies and regulations. This movement is also happening in Korea, and AI regulations have not been specified, so it is necessary to compare and analyze existing policy proposals or guidelines to derive common factors and identify complementary points, and discuss the direction of domestic AI regulation. In this paper, we investigate AI security risks that may arise in the AI life cycle and derive six points to be considered in establishing domestic AI regulations through analysis of each risk. Based on this, we analyze AI policy proposals and recommendations in Korea and validate additional issues. In addition, based on a review of the main content of AI laws in the US and EU and the analysis of this paper, we propose measures to improve domestic guidelines and policies in the field of AI.

Mechanisms for Anti-wrinkle Activities from Fractions of Black Chokeberries (블랙초크베리 분획물로부터의 주름억제 효과에 대한 작용기전)

  • Choi, Eun-Young;Kim, Eun-Hee;Lee, Jae-Bong;Do, Eun-Ju;Kim, Sang-Jin;Kim, Se-Hyeon;Park, Jeong-Yeol;Lee, Jin-Tae
    • Journal of Life Science
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    • v.26 no.1
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    • pp.34-41
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    • 2016
  • Black chokeberries (scientific name Aronia melanocarpa) have been reported to have major effects due to anti-oxidant, anti-inflammatory, and anti-cancer capabilities. In this study, we investigated the anti- wrinkle effects of A. melanocarpa, including collagenase inhibition effects and their molecular biological mechanisms, such as oxidative stress-induced matrix metalloproteinase (MMP), mitogen-activated protein (MAP) kinase, and activator protein (AP)-1 expression and/or phosphorylation. In collagenase inhibition activity, the ethyl acetate fraction of black chokeberry (AE) was 77.2% at a concentration of 500 μg/ml, which was a significant result compared to that of Epigallocatechin gallate (positive control, 83.9% in 500 μg/ml). In the reactive oxygen species (ROS) assay, the AE produced 78% of ROS in 10 μg/ml and 70% of ROS in 75 μg/ml, which was a much lower percentage than the ROS production of H2O2-induced CCRF S-180II cells. In the MTT assay, cell viability was increased dose-dependently with AE in H2O2-induced cells. In protein expression by western blot assay, the AE suppressed the expression and phosphorylation of MMPs (MMP-1, -3, -9), MAPK (ERK, JNK, and p38), and AP-1 (c-Fos and c-Jun), and expressed the pro-collagen type I in H2O2-induced cells. These results suggest that black chokeberries have anti-wrinkle and collagen-production effects, and they may be used in applications for material development in the functional food and cosmetic industries.

Mechanisms of Suppression of Matrix Metalloproteinases in UVB-Irradiated HaCaT Keratinocytes of Colored Rice Varieties (UVB에 조사된 HaCaT Keratinocytes에서의 유색미에 의한 Matrix Metalloproteinases 발현억제 메커니즘)

  • Choi, Eun-Young;Lee, Jae-Bong;Kim, Do-Hoon;Kwon, Yong-Sham;Cheon, Jung-Yoon;Lee, Jin-Tae
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.46 no.5
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    • pp.562-571
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    • 2017
  • In this study, we investigated the anti-oxidant activities [electron-donating ability (EDA), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging ability, and reactive oxygen species (ROS) inhibitory activity], anti-wrinkle activities [collagenase inhibitory activity, suppression and/or phosphorylation of matrix metalloproteinases (MMPs), and mitogen-activated protein (MAP) kinase activity], and mRNA expression levels using reverse transcription-polymerase chain reaction (RT-PCR) assay in ultraviolet (UV) B ray ($50mJ/cm^2$)-irradiated human keratinocyte HaCaT cells. Josaengheugchal, Sinneungheugchal (SE), Shintoheug rice, Heugjinju rice, and Heugseol (HE) among colored rice varieties were reported to have excellent antioxidant properties. In the EDA and ABTS radical scavenging assays, extracts of the five colored rice varieties had scavenging activities of 72% at concentrations higher $50{\mu}g/mL$. In the collagenase inhibition assay, ethanol extracts of the five colored rice varieties showed high inhibitory effects of about 60% at concentrations higher $25{\mu}g/mL$. In the ROS inhibition assay, ethanol extracts of HE and SE showed very excellent inhibition efficacies at all concentrations. We determined molecular biological mechanisms of MMPs (MMP-1, -3, -8, and -13) and mitogen-activated protein kinase (MAPK) with HE, and the results show that HE suppressed expression of MMPs and phosphorylation of MAPK and increased expression of pro-collagen type I in UVB-irradiated cells. It was also confirmed by RT-PCR that HE reduced expression of MMPs mRNA. Therefore, these results suggest that HE has anti-wrinkle and collagen production effects and may be used as a material in the development of functional food and cosmetic industries.