• Journal of Life Science
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• v.30 no.4
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• pp.331-342
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• 2020

The suppression of neuroinflammatory responses in microglial cells can be considered a key target for improving the progression of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). Asparagus cochinchinensis has traditionally been used as a medicine to treat fever, cough, kidney disease, breast cancer, inflammatory diseases, and brain diseases. In this study, we investigated the neuroprotective mechanism of an aqueous extract from A. cochinchinensis root (AEAC), particularly its anti-inflammatory effects on lipopolysaccharide (LPS)-activated BV-2 microglial cells. BV-2 cells were treated with four different concentrations of AEAC. No significant toxicity was detected in BV-2 cells treated with AEAC. Nitric oxide (NO), cyclooxygenase-2 (COX-2) mRNA, and inducible nitric oxide synthase (iNOS) mRNA levels were 21% lower in the AEAC+LPS group than in the Vehicle+LPS group. Lower proinflammatory (TNF-α and IL-1β) and anti-inflammatory cytokine (IL-6 and IL-10) levels were also detected in the AEAC+LPS group than in the Vehicle+LPS group, albeit at varying rates. Moreover, the phosphorylation of mitogen-activated protein kinase (MAPK) members after LPS treatment was significantly recovered in the AEAC-pretreated group compared to the Vehicle+LPS group, enhancement of the phosphorylation of mitogen-activated protein kinase (MAPK) members after LPS treatment was significantly recovered in the AEAC-pretreated group, while cell cycle arrest at the G2/M phase caused by LPS treatment was less severe in the AEAC+LPS group. The increase in reactive oxygen species (ROS) generation induced by LPS treatment was also lower in the AEAC-pretreated group than in the Vehicle+LPS group. This is the first study to show that AEAC exerts anti-neuroinflammatory activity against LPS stimulation by regulating the MAPK signaling pathway, the cell cycle, and ROS production.

• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.145-145
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• 2021

Water distribution networks (WDNs) are designed to satisfy water requirement of an urban community. One of the central issues in human history is providing sufficient quality and quantity of water through WDNs. A WDN consists of a great number of pipelines with different ages, lengths, materials, and sizes in varying degrees of deterioration. The available annual budget for rehabilitation of these infrastructures only covers part of the network; thus it is important to manage the limited budget in the most cost-effective manner. In this study, a novel pipe replacement scheduling approach is proposed in order to smooth the annual investment time series based on a life cycle cost assessment. The proposed approach is applied to a real WDN currently operating in South Korea. The proposed scheduling plan considers both the annual budget limitation and the optimum investment on pipes' useful life. A non-dominated sorting genetic algorithm is used to solve a multi-objective optimization problem. Three decision-making objectives, including the minimum imposed LCC of the network, the minimum standard deviation of annual cost, and the minimum average age of the network, are considered to find optimal pipe replacement planning over long-term time period. The results indicate that the proposed scheduling structure provides efficient and cost-effective rehabilitation management of water network with consistent annual budget.

• Land and Housing Review
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• v.10 no.4
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• pp.51-59
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• 2019

The government is encouraging the notice of obligatory reclaimed asphalt as a result of the economic and social positioning of green growth to reduce the amount of waste resources and to solve natural resource problems by recycling continuously generated waste resources. However, it is necessary to develop application guideline for each application to apply reclaimed asphalt to the site because quality control of the reclaimed asphalt is difficult and the specifications are ambiguous as well. Therefore, in this study, the mix design, quality test, performance test, and finite element analysis about reclaimed Asphalt Pavement were conducted to develop application guideline for reclaimed hot asphalt. The mix design was carried out for the comparative general hot mix asphalt mixture, the reclaimed hot mix asphalt mixture using the additive, and the reclaimed hot mix asphalt mixture without the additive. Indirect tensile strength and tensile strength ratio tests were used to characterize the reclaimed hot mix asphalt mixture. Using the results of dynamic modulus test and FWD test for KPRP analysis and finite element analysis, the performance life was evaluated for general pavement and pavement using recycled aggregate. Finally, the life cycle cost analysis was used to compare and analyze the economics of reclaimed asphalt concrete pavement.

• Proceedings of the Korean Institute of Resources Recycling Conference
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• 2001.05b
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• pp.69-73
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• 2001

• The Journal of the Korea Contents Association
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• v.21 no.5
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• pp.84-93
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• 2021

Each equipment has a durable life. The state of the equipment may change or fail until it is introduced, operated and disposed of. It is difficult for each organization to have a significant amount of these equipment and to understand each issue. Therefore, systematic life cycle management of equipment is more necessary than just for inventory purposes. In this paper, we design and implement an integrated management system for information assets. If it is an environment that can use the Internet based on the web, it can easily and easily access computerized information resource data through PCs, tablets, and smartphones. In addition, an integrated management system was established to limit the functions of higher and lower institutions through centralized management and user-level empowerment methods and to understand the overall status of resources.

• Journal of Families and Better Life
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• v.10 no.1 s.19
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• pp.75-94
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• 1992

The purpose of this study was to provide for the appropriate conflict management strategies to employed wives by investigation casual relations of conflict, resources, home management behavior and managerial satisfaction by applying a system's approach. The data were collected through the questionnaire whose respondent were 388 employed wives. The data were analyzed by various statistical methods such as Frequency, Percentage, ANOVA, F-test, T-test, Pearsons' correlation analysis, Multiple Regression analysis, Path analysys. The results of this study are as follows : 1) Input variables, throughput variables, output variables had differences significantly according to the family life cycle. The employed wives' families which are former term of the family life cycle used more appropriate conflict management strategies than latter term of FLC. That is, the employed wives' families which are former term of FLC had more abundant resources such as cohesive power of family, interaction with relatives, social support, had higher planning score, used more frequent structural management strategies. But, the managerial satisfaction had no differences. 2) For the relation of input variables and throughput variables, the more resources, the lower conflict is the higher planning, implementing score, structural management score. For the relation of throughput variables, the higher planning, implementing, structural management score is the higher managerial satisfaction score. For the relation of input variables and output variables, the more resources, the lower conflict is the higher managerial satisfaction, besides objective and material resource, subjective and psychological resource had influence. 4) among all variables affecting the managerial satisfaction, the commition of housework, cohesive power of family, wives' occupational level had indirect effect on managerial satisfaction through structural managemenet. Only the income had direct effect on managerial satisfaction.

• Journal of the Korea Organic Resources Recycling Association
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• v.22 no.2
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• pp.35-43
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• 2014

The application of the Life Cycle Impact Assessment (LCIA) methodology to analyze the environmental burden of appling the digestates to corn field including different swine waste treatment systems was investigated. The first part of LCA is an inventory of parameters used to emissions released due to the system under investigation. In the following step, the Life Cycle Impact Assessment, the inventory data were analyzed and aggregated in order to finally get one index representing the each environmental burden. Each corn field applied with the aerobic and anaerobic digestates including different swine waste treatment systems was used as an example for the life cycle impact analysis. With analyzing the agricultural environmental burden, it observed that the effect of corn field applied aerobic digestate including digestion system was 7.6 times higher at eutrophication effects, but global warming potential effect was 0.9 times less than its applied anaerobic digestate.

• Journal of Korean Society of Environmental Engineers
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• v.29 no.6
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• pp.722-727
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• 2007

Life Cycle Assessment(LCA) is a tool that quantifies the inputs and outputs, md evaluates the potential environmental impacts during the entire life cycle of a product, material and/or service. Inputs and outputs encompass the consumption of natural resources and emission of pollutants to the environment. One of the deficiencies of the conventional LCA methodology is that it does not consider time explicitly. In addition, there are problems associated with the temporal boundary in the normalization step of LCA. The objective of this study is to propose a new life cycle assessment method that considers time in LCA as called 'Time Load LCA'. Basically Time Load LCA is a method that divides environmental load in each life cycle stage by time duration in each life cycle stage. Time consideration in the proposed method indicated that the new LCA method not only renders new perspective on the environmental impacts of a product system but also rectifies inconsistency in temporal dimension of the normalization step. Basic premise of the time load LCA method is that same amount of load over a shorter time period would affect more seriously on the environment than over a longer time period. therefore, load per time is necessary for the assessment of an impact of the inventory parameters on the environment.

• The Research Journal of the Costume Culture
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• v.6 no.2
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• pp.163-180
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• 1998

The purpose of this study is to investigate the main characteristics of the environment-friendly design expressed in Koran fashion. Environment-friendly design can be categorized into choice of material, extension of products life cycle, and recycling design. In this study, Korean fashion designers can be found having the conciousness of environment for fashion design since 1990. First, in choice of material, the designers used Natural fibers which are cotton, linen, wool, and etc, and used natural dyes. Some of the designers have moved from using real fur to using fake fur for animal welfare. But fake furs produced from synthetic or regenerated fibers have the environmental problems during textile production processes. Some of the designers used fake leather made from the skins of an edible fish which are otherwise going to waste. Secondly, Design for extension of products life cycle can economize the resources and energy. Design for extension of products life cycle are classified into reversible clothing, many function clothing, modular style, patina clothing, simple style, and layered look. Finally, recycling design are classified into recycling of daily necessaries and expression techniques of recycling design which are designer's works used patchwork, mash techniques, and handmade of knits or buttonhole stitch.

• Clean Technology
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• v.1 no.1
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• pp.34-46
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• 1995

Clean Technology goes beyond Clean-UP (or "End of PiPe) Technologies to include Pollution prevention, waste minimisation, and cleaner production. However, the concept of Clean Technology goes deeper than changes in technology, to ways in which human needs can be satisfied sustainably. In other words, Clean Technology, concentrates on delivering a human benefit rather than making a product. Introducing cleaner technology may therefore involve new commercial relationships as well as new technological practices. In some economic sectors, this involves leasing or providing a service rather than selling a product. Life Cycle Assessment (LCA) is an important tool in Clean Technology. LCA involves determining all the resources used and all the wastes and emissions produced in providing the human benefit. Use of LCA ensures that improved environmental performance in one part of the Life Cycle is not achieved merely at the expense of more environmental damage elsewhere. Going beyond LCA, the concepts of Life Cycle Design and "metabolised" use of materials are approaches to obtain maximum benefit from materials as they pass through the human economy. "Closed-loop" use can be a component of clean technology. Looking beyond simple re-use and recycling, a material may pass through a "cascade of uses". typically a series of applications with progressively lower performance specifications. Closed-loop use necessarily involves a change in commercial practice, because the material or product must be recovered after use.