• Clinical and Experimental Pediatrics
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• v.58 no.11
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• pp.421-426
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• 2015

Purpose: The vancomycin dosage regimen is regularly modified according to the patient's glomerular filtration rate (GFR). In the present study, we aimed to assess the usefulness of serum cystatin C (Cys-C) concentration, compared with serum creatinine (SCr) concentration, for predicting vancomycin clearance (CLvcm) in neonates. Methods: We retrospectively analyzed the laboratory data of 50 term neonates who were admitted to the neonatal intensive care unit and received intravenous vancomycin, and assessed the pharmacokinetic profiles. Creatinine clearance (CLcr) and GFR based on Cys-C (GFRcys-c) were estimated using the Schwartz and Larsson formulas, respectively. Results: The mean CLvcm (${\pm}$standard deviation) was $74.52{\pm}31.17L/hr$, the volume of distribution of vancomycin was $0.67{\pm}0.14L$, and vancomycin half-life was $9.16{\pm}17.42hours$. The SCr was $0.46{\pm}0.25mg/dL$ and serum Cys-C was $1.43{\pm}0.34mg/L$. The peak and trough concentrations of vancomycin were $24.65{\pm}14.84$ and $8.10{\pm}5.35mcg/mL$, respectively. The calculated GFR based on serum creatinine concentration (GFR-Cr) and GFRcys-c were $70.2{\pm}9.45$ and $63.6{\pm}30.18mL/min$, respectively. The correlation constant for CLvcm and the reciprocal of Cys-C (0.479, P=0.001) was significantly higher than that for CLvcm and the reciprocal of SCr (0.286, P=0.044). GFRcys-c was strongly correlated with CLvcm (P=0.001), and the correlation constant was significantly higher than that for CLvcm and CLcr (0.496, P=0.001). Linear regression analysis showed that only GFRcys-c was independently and positively correlated with CLvcm (F=41.9, P<0.001). Conclusion: The use of serum Cys-C as a marker of CLvcm could be beneficial for more reliable predictions of serum vancomycin concentrations, particularly in neonates.

• Microbiology and Biotechnology Letters
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• v.32 no.4
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• pp.334-340
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• 2004

This study was initially performed to obtain fundamental data on lichen distribution depending on environmental condiLichens distributed on coastal rocks atleast 20 m far away from the coast were also investigated. Analyof morphological characteristics and rDNA ITS clones revealed that lichens containing 9 families and 15 genera were distributed in coastal rocks of V-do, while lichens containing 10 families and 14 genera were in field rocks, demonstrating little difference of diversity between both sites. Foliose lichens such as PhaeophysPhyscia, Pyxine belonging to the family Physciaceae were representatives distributed in coastal rocks of V-do, along with Xanthoparmelia belonging to Parmeliaceae, fruticose lichens such as Ramalina to Ramaliand crustose lichen Lecanora to Lecanoraceae. In contrast, foliose lichen Cladonia belonging to the family Cladoniaceae, fruitcose lichen Stereocaulon to Streocaulaceae, and crustose lichen Porpidia to Porpidwere found only on the surface of field rocks. Crustose lichens containing genera Caloplaca, CanDirinaria, Graphis, Rhizocarpon, and Pertusaria were rarely distributed in coastal rocks, and most of them were also found in field rocks.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.12 no.6
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• pp.86-98
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• 2009

This study was carried out to investigate vegetation structure and soil properties of Adenophora racemosa population distributed in Jeombongsan, Seoraksan, Odaesan and Dutasan in Gangwon-do, Korea. From August 2007 until September 2009, $2m{\times}2m$ quadrate was established in native area of Adenophora racemosa in order to record a dominants and coverage, and soil factors at 22 sites. It was found that the altitude in the distributed areas for Angelica gigas population was 800 m or more. Adenophora racemosa population was classified into Rhododendron mucronulatum dominant population, Geranium var. hirsutum dominant population, Caret siderosticta dominant population and Aruncus dioicus var. kamtschaticus dominant population. In the site of study, soil pH, electrical conductivity, soil organic matter, available phosphorous, and exchangeable potassium, exchangeable calcium, exchangeable magnesium, exchangeable sodium concentration and total nitrogen were ranged from 5.0~7.1, 0.06~0.65dS/m, 0.96~8.94%, 12.3~32.8mg/kg, 0.12~0.89cmol+/kg, 0.34~10.08cmol+/kg, 0.1~l.4cmol+/kg, 0.02~0.29cmol+/kg and 0~8.4% respectively. According to the results of DCCA, Adenophora racemosa population were distributed in the high available phosphorous and exchangeable potassium, and Rhododendron mucronulatum dominant population was situated on low available potassium and high slope degree, Geranium var. hirsutum dominant population was high altitude, electrical conductivity and exchange magnesium, and Carex siderosticta dominant population and Aruncus dioicus var. kamtschaticus were distributed on high total nitrogen, organic matter, available phosphorous.

• Journal of Veterinary Clinics
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• v.23 no.2
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• pp.87-90
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• 2006

The aim of the present study was to investigate the disposition pharmacokinetics of roxithromycin in broilers. Roxithromycin was administered at a single dose of 20 mg/kg body weight by intravenous (i.v.) routes. Plasma concentrations of roxithromycin were determined by liquid chromatography/mass spectrometry. After a single i.v. dose plasma concentrations were best fitted to a two-compartment open model. The values of the pharmacokinetic parameters after i.v. administration were: elimination half-life = $5.83{\pm}1.79h$, mean residence time = $6.33{\pm}0.32h$, total body clearance = $0.55{\pm}0.15L/h/kg$, and volume of distribution at steady state = $3.47{\pm}0.84L/kg$. The pharmacokinetic interpretation of roxithromycin after i.v. administration revealed that the drug was well distributed throughout the body in broilers and slowly eliminated. More studies for the application of roxithromycin against poultry disease are needed to establish a suitable pharmaceutical formulation, propose optimum dosage regimens, investigate clinical efficacy and study the tolerability of repeated doses.

• Journal of Oriental Neuropsychiatry
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• v.23 no.4
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• pp.133-152
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• 2012

Objectives : The purpose of this study is to investigate the effect of Sihogayonggolmoryeo-tang on the anxiety of Hwa-byung. Methods : In this randomized, double blinded, placebo-controlled study, we planned to give Sihogayonggolmoryeo-tang or controlled medication for anxiety of Hwa-byung. Hamilton Anxiety Scale (HAM-A) was measured as the 1st evaluative instrument, and Korean State-Trait Anxiety Inventory (STAI-K), Likert scale for major symptom of Hwa-byung, Hwa-Byung Scale Score, Korean Beck's Depression Inventory (BDI-K), Korean State-Trait Anger Expression Inventory (STAXI-K), Insomnia severity Index (ISI), Instrument of Oriental Medical Evaluation for Hwa-Byung, WHO Quality of Life Avvreviated (WHOQOL-BREF), genral self-Efficacy Scale (GSES), Rosenberg Self-Esteem Inventory (SRE) and Heart Rate Variability (HRV) were also measured as the 2nd evaluative instrument before treatment. Results : Clinical characteristics-vital signs and demographic characteristics showed no significant difference between both groups. The characteristics of disease-chief complaint, pattern Identification, period, etiological factor, and etc, also showed similarity of distribution in both groups. The results of Chest PA, EKG and clinicopathologic examination showed no significant difference between both groups. There were no significant difference between both groups in all valuation scales; HAM-A was measured as the first evaluative instrument, and STAI-K, Likert scale for major symptom of Hwa-byung, Hwa-Byung Scale Score, BDI-K, STAXI-K, ISI, Instrument of Oriental Medical Evaluation for Hwa-Byung, WHOQOL-BREF, GSES, SRE and HRV. Conclusions : We considered that establishment of the experimental group and controlled group was objective and worth conducting this research. In addition, this methodology is expected to be applied to the subsequent research. Further, we hope to make up for this study through various study and discussion.

• Journal of Plant Biotechnology
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• v.43 no.3
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• pp.317-331
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• 2016

Development of disease resistant plant is one of the important objectives in rice breeding programs because biotic stresses can adversely affect rice growth and yield losses. This study was conducted to identify lines with multiple-resistance genes to biotic stress among 173 hybrid rice breeding lines and germplasms using DNA-based markers. Our results showed that one hybrid rice line [IR98161-2-1-1-k1-3 (IR86409-3-1-1-1-1-1/IRBB66)] possessed 5 bacterial blight resistance genes (Xa4, xa5, Xa7, Xa13 and Xa21) while two hybrid rice lines [IR98161-2-1-1-k1-2 (IR86409-3-1-1-1-1-1/IRBB66) and 7292s (IR75589-31-27-8-33S(S1)/IR102758B)] possessed 3 bacterial blight resistance genes (Xa4, Xa7 and Xa21, and Xa3, Xa4 and xa5). Molecular survey on rice blast disease revealed that most of these lines had two different resistant genes. Only 11 lines possessed Pib, Pi-5, and Pi-ta. In addition, we further surveyed the distribution of insect resistant genes, such as Bph1, Bph18(t), and Wbph. Three hybrid breeding lines [IR98161-2-1-1-k1-3 (IR86409-3-1-1-1-1-1/IRBB66), IR98161-2-1-1-k1-2 (IR86409-3-1-1-1-1-1/IRBB66), and 7292s (IR75589-31-27-8-33S(S1) /IR102758B)] contained all three resistance genes. Finally, we obtained four hybrid rice breeding lines and germplasms [IR98161-2-1-1-k1-2 (IR86409-3-1-1-1-1-1/IRBB66), Damm-Noeub Khmau, 7290s, and 7292s (IR75589-31-27-8-33S(S1)/IR102758B)] possessing six-gene combination. They are expected to provide higher level of multiple resistance to biotic stress. This study is important for genotyping hybrid rice with resistance to diverse diseases and pests. Results obtained in this study suggest that identification of pyramided resistance genes is very important for screening hybrid rice breeding lines and germplasms accurately for disease and pest resistance. We will expand their cultivation safely through bioassays against diseases, pests, and disaster in its main export countries.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.10
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• pp.1201-1206
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• 2013

Defects that occur during the manufacturing process or operation of a wind turbine blade have a great influence on its life and safety. Typically, defects such as delamination, pore, wrinkle and matrix crack are found in a blade. In this study, the detectability of the pores, a type of defect that frequently occur during manufacturing, was examined from the full field strain distribution determined with the image correlation technique. Pore defects were artificially introduced in four-ply laminated GFRP composites with $0^{\circ}/{\pm}45^{\circ}$ fiber direction. The artificial pores were introduced in consideration of their size and location. Three different-sized pores with diameter of 1, 2 and 3 mm were located on the top and bottom surface and embedded. By applying static loads of 0-200 MPa, the strain distributions over the specimen with the pore defects were determined using image correlation technique. It was found the pores with diameter exceeding 2 mm can be detected in diameter.

• Korean Journal of Organic Agriculture
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• v.20 no.4
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• pp.503-518
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• 2012

Korean type of no-tillage cultivation method which was applied on this study used the ridge and the furrow and constantly recycling them as it was suitable for Korea's weather and farming conditions. This no-tillage cultivation was reported to have little negative impact such as reduction of production (Kwon et al., 1997). In addition, it was found to have a lot of benefits as it requires less agro-materials and energy costs as well as shortened working hours because tillage operation is not needed. (Yang et al., 2012). According to an analysis, no-tillage cultivation can reduce greenhouse gas emissions by $344.7kgCO^2$ (58%) in every 10a ($1,000m^2$) compared to ordinary pepper farming technique (Korea averages). Direct-indirect reduction effects from using fertilizer and using less amount of energy were 92% and 44% respectively both of which can be considered very high. Besides the direct effects of no-tillage cultivation, soil management using no-tillage technique raises carbon sequestration effect on soil as time goes on (West & Marland, 2002), that is why the technique is expected to have constant carbon emission reduction effect. For theses reasons, distribution and expansion of Korean type no-tillage cultivation are expected to play a role as major agro-green technologies for achieving our goal of reducing greenhouse gas emissions in agricultural sector.

• Journal of The Korean Society of Agricultural Engineers
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• v.57 no.5
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• pp.139-152
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• 2015

Along with climate change, it is reported that the scale and frequency of extreme climate events show unstable tendency of increase. Thus, to comprehend the change characteristics of precipitation data, it is needed to consider non-stationary. The main objectives of this study were to estimate future design floods for Wonpyeongcheon watershed based on RCP (Representative Concentration Pathways) scenario. Wonpyeongcheon located in the Keum River watershed was selected as the study area. Historical precipitation data of the past 35 years (1976~2010) were collected from the Jeonju meteorological station. Future precipitation data based on RCP4.5 were also obtained for the period of 2011~2100. Systematic bias between observed and simulated data were corrected using the quantile mapping (QM) method. The parameters for the bias-correction were estimated by non-parametric method. A non-stationary frequency analysis was conducted with moving average method which derives change characteristics of generalized extreme value (GEV) distribution parameters. Design floods for different durations and frequencies were estimated using rational formula. As the result, the GEV parameters (location and scale) showed an upward tendency indicating the increase of quantity and fluctuation of an extreme precipitation in the future. The probable rainfall and design flood based on non-stationarity showed higher values than those of stationarity assumption by 1.2%~54.9% and 3.6%~54.9%, respectively, thus empathizing the necessity of non-stationary frequency analysis. The study findings are expected to be used as a basis to analyze the impacts of climate change and to reconsider the future design criteria of Wonpyeongcheon watershed.

• The Korean Journal of Soil Zoology
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• v.10 no.1_2
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• pp.1-15
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• 2005

Tiger Beetles(Carabidae, Cicindelinae) were collected in the Province of Chollabukdo including some nearby islands from April 1997 to October 2002. The specimens of ca. 500 deposited in Sunchon National University, Chonbuk National University, the Jeju Folklore and Natural History Museum, and elsewhere were also examined. As a result, Korean Cicindelinae of 18 species from 10 subgenera is reported herein. Of these, Cicindela (Cylindera) obliquefasciata Adams, 1817 and Cicindeia (Cephalota) chiloleuca Fisher, 1820 are recorded newly in the Korean Peninsula. However, the distribution of C. japana is very doubtful in South Korea. This study also includes a key to the species, discussions on the habitats, distributions, and some ecological characteristics of Korean Cicindelinae.