• 대한간호학회지
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• 제52권1호
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• pp.24-35
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• 2022

Purpose: This study investigated the incidence and risk factors of cataract in people with diabetes mellitus (DM) using data from Ansan cohort of the Korean Genome and Epidemiology Study (KoGES). Methods: Data from a total of 329 patients with type 2 DM without cataract who participated in Ansan cohort of the KoGES from baseline survey (2001-2002) to fifth follow-up visit (2011-2012) were examined. The characteristics of the subjects were analyzed with frequency and percentage, and mean and standard deviation. Cataract incidence was measured as incidence proportion (%). For risk factors of cataract, hazard ratio (HR) and 95% confidence interval (CI) were obtained using the Cox proportional hazard model. Results: The cataract incidence over a 10-year follow-up period was 19.1% (15.1 in males and 25.8 in females), and mean age at the incidence of cataract was 63.48 years (61.58 years in males and 65.31 years in females). Age (HR=1.09, 95% CI=1.05-1.13) and HbA1c (HR=1.21, 95% CI=1.07-1.37) or the duration of DM (HR=1.05, 95% CI=1.00-1.09) were found to be independently associated with cataract development. Conclusion: Cataract development in people with DM is common, and its likelihood increases with age, HbA1c, and the duration of DM. Considering negative effect of cataract on their quality of life and economic burden, nurses should identify people with DM at a higher risk of cataract development, and plan individual eye examination programs to detect cataract development as early as possible.

• 한국환경농학회지
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• 제30권1호
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• pp.43-51
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• 2011

국내 15 지점의 폐광산 주변 지역에서 재배 생산된 백미 중 총 비소 오염도를 조사하였고, 연령과 성별에 따른 평균일 일노출량(ADD)을 산정하여 발암위해확률 및 비발암독성영향을 평가하였다. 광산 인근에서 재배 생산된 백미 중 총 비소의 평균 농도는 0.09 mg/kg으로 조사되었다. ADD값은 총 비소 함량에 무기 비소의 비율을 고려하여 산정하였으며, FAO/WHO에서 정한 2.1 ${\mu}g/kg$ b.w.-day의 PTDI 값을 초과하지 않았다. 그러나 광산 지역 인근에서 재배한 백미를 섭취했을 경우, 연령 및 성별 인구집단의 발암위해확률은 허용수준인 $10^{-6}{\sim}10^{-4}$ 범위를 초과하였고, 특히 6세 이하 유아의 경우 평균 10,000 명당 5인 이상의 높은 발암위해확률이 있는 것으로 산정되었다. 비발암독성위험값 (HQ)은 모든 연령 및 성별 인구집단에서 1.0을 초과하지 않았으며, 따라서 폐광산 주변 지역에서 재배 생산된 백미를 장기간 섭취하더라도 비소에 의한 인체 독성이 나타날 가능성은 없는 것으로 판단된다.

• Journal of Preventive Medicine and Public Health
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• 제32권4호
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• pp.526-537
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• 1999

Objectives : It is known that the prevalence of diabetes mellitus(DM) appears to be rapidly increasing in recent times in Korea, presumably due to a westernized diet and change of life style followed by rapid economic growth. Based on the Seoul male cohort which was constructed in 1993, this study was conducted to estimate the annual incidence rates of DM through 4 years' follow up and to determine which factors are associated with DM risk in Korean middle-aged men. Methods : Among 14,533 men recruited at baseline, 559 were excluded because they reported a history of diabetes or were found to be diabetes at 1992 routine health examination. During 4 years' follow-up, 237 incident DM cases were ascertained through chart reviews and telephone contacts for those who have ever visited hospitals or clinics under suspicion of DM during 1993-1996 and the biennial routine health examinations in 1994 and 1996. Results : In this study the annual incidence of DM among the study population was estimated to be 0.5 per 100. This study showed that fasting glucose level at initial baseline examination was a powerful predictor of risk for diabetes several years later(fasting blood glucose of $\geq$ 110 mg/dl compared with $\leq$ 80 mg/dl, Hazard Ratio[HR]:15.6, 95% Confidence interval[CI]=9.1-26.6) after considering potential covariates such as age, family history, smoking and alcohol history, body mass index, physical activity, total energy intake, and total fiber intake. Adjusted hazard ratios of family history of diabetes was 1.95(95% CI=1.38-2.75); of obesity as measured by BMI(BMI $\geq$ 25.3 compared with $\leq$ 21.3) was 7.19(95% CI=3,75-13.8); of weight change during middle life(>10kg compared with $\leq$ 5) was 1.77(95% CI=1.16-2.69); of smoking(current vs none) was 1.93(95% CI=1.06-3.51); and fat intake(upper fertile compared with lower fertile) was 1.88(95% CI=1.01-3.49), while fiber intake was associated with the reduced risk(HR=0.36, 95% CI=0.19-0.67). Conclusion : The factors identified in this study indicate that the greatest reduction in risk of diabetes might be achieved through population-based efforts that promote fiber intake and reduce obesity, smoking, and fat intake.

• 한국전산구조공학회논문집
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• 제26권6호
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• pp.415-421
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• 2013

본 논문에서는 면진시스템이 원전에 적용될 경우 원전구조물의 생애주기 성능에 미치는 영향을 소개한다. 최근 내진설계와 더불어 강진발생 예상 지역에 적용을 목적으로 개발되는 면진시스템은 구조물을 장주기화하여 응답가속도를 줄이고 상대변위를 늘려줌으로써 구조물의 안전성을 증진시키는 것으로 알려져 있다. 따라서, 구조물의 안전성이 중요시되는 원전구조물에 면진시스템을 적용하기 위한 연구가 국내에서 진행 중에 있다. 본 연구에서는 원전구조물의 생애주기 성능분석에 있어서 특징을 분석하고, 면진시스템이 적용될 경우 원전구조물의 생애주기성능에 있어서 미치는 영향을 평가함으로써, 도출된 결과를 면진시스템 적용의 정량적인 타당성 평가에 활용할 수 있다.

• Annals of dermatology
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• 제30권6호
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• pp.668-675
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• 2018

Background: Drug survival, defined as the time until discontinuation, is a parameter reflecting real-world therapeutic effectiveness. Few studies have examined the influence of economic factors on the drug survival of biologic agents for psoriasis, particularly in Asian countries. Objective: To determine the drug survival for ustekinumab in real-life settings and investigate the factors affecting drug survival for psoriasis patients in Korea. Methods: We evaluated 98 psoriasis patients who were treated with ustekinumab at a single center. We analyzed the efficacy and drug survival of ustekinumab. Cox proportional hazard analysis and competing risk regression analysis were performed to reveal the factors affecting the drug survival of ustekinumab. Results: The overall mean drug survival was 1,596 days (95% confidence interval [CI], 904~2,288). Among the 39 cessations of ustekinumab treatment, 9 (23.1%) patients discontinued treatment after experiencing satisfactory results. Multivariate Cox proportional hazard analysis revealed that paying on patients' own expense was the major predictor for the discontinuation of ustekinumab (hazard ratio [HR], 9.696; 95% CI, 4.088~22.998). Competing risk regression analysis modeling of discontinuation because of factors other than satisfaction of an event also revealed that ustekinumab treatment at the patient's expense (HR, 4.138; 95% CI, 1.684~10.168) was a predictor of discontinuation rather than satisfaction. Conclusion: The results of our study revealed that the cost of biologics treatment affects the drug survival of ustekinumab and suggested that economic factors affect the drug survival of ustekinumab treatment in Korea.

• 해양환경안전학회지
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• 제30권2호
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• pp.200-208
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• 2024

승선 인원이 많은 실습선은 화재가 발생하는 경우 대형 인명피해로 확장될 수 있으며 이에 따라 선원법 및 Safety Life At Sea(SOLAS)에서는 퇴선 훈련에 대한 중요성을 강조해 왔다. 따라서 본 연구에서는 승선 인원이 많은 국립목포해양대학교의 세계로호를 대상선박으로 선정하여 preliminary hazard analysis(PHA) 정성적 위험성 평가 기법을 통해 각 deck의 화재 사고 위험빈도와 심각성에 대하여 예측하였다. 또한 위험성이 높은 구역에서의 화재를 가정 한 뒤, 그 위험성을 정량적으로 예측하기 위하여 대피 시간 및 인구 밀도에 대한 시뮬레이션을 수행하였다. 그 결과, 총 대피시간이 인구 분포가 한 구역에 집중되어 있던 식사 시간을 가정한 시나리오에서 501초로 가장 길게 예측되었으며 시나리오에 따라 일부 deck에서 1.4pers/m² 이상의 상대적으로 높은 인구밀도를 나타내며 대피 인원이 정체되는 현상을 보였다. 본 연구 결과는 다양한 피난 시나리오에 따른 대피시간 및 인구밀도를 정량화하여 실습선의 상황에 맞는 훈련 시나리오를 개발하기 위한 기초자료로서 사용될 것으로 보이며 추후 수학적 모델과 실험값의 비교를 통하여 연구를 확장할 수 있을 것으로 예상된다.

• 한국화재소방학회:학술대회논문집
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• 한국화재소방학회 2008년도 추계학술논문발표회 논문집
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• pp.223-228
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• 2008

Fire is recognized as a significant hazard in a service life of a structure. Therefore there is a clear need to provide an improved understanding of the performance of material and structures in fire and to provide clear design guidance in order to progress safety design especially high rise building. It is the aim of this study to investigates and analyze the study on the development of evaluation methods for fire risk analysis of high-rise building.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2001년도 춘계학술대회 논문집
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• pp.133-138
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• 2001

Formal safety assessment (FSA) is defined as a structured and systematic methodology aimed at enhancing maritime safety including protection of life, health, and the marine environment and property, by using risk and cost/benefit assessment or, more specifically, it is a process of identifying hazard, evaluating risk and deciding on course of action to control those risks. Emphasis is placed on the structural aspect of the failure of cargo hold. This study is expected to illustrate how a new methodology, i.e. the Formal Safety Assessment, can be applied to specific ship safety problems.

• Safety and Health at Work
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• 제9권3호
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• pp.290-295
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• 2018

Background: There is little information on the dose-response relationship between exposure to occupational carcinogenic agents and mesothelioma. This study aimed to investigate this association as well as the existence of agents other than asbestos that might cause mesothelioma. Methods: The Swedish component of the Nordic Occupational Cancer (NOCCA) study consists of 6.78 million individuals with detailed information on occupation. Mesothelioma diagnoses recorded in 1961-2009 were identified through linkage to the Swedish Cancer Registry. We determined cumulative exposure, time of first exposure, and maximum exposure intensity by linking data on occupation to the Swedish NOCCA job-exposure matrix, which includes 29 carcinogenic agents and corresponding exposure for 283 occupations. To assess the risk of mesothelioma, we used conditional logistic regression models to estimate hazard ratios and 95% confidence intervals. Results: 2,757 mesothelioma cases were identified in males, including 1,416 who were exposed to asbestos. Univariate analyses showed not only a significant excess risk for maximum exposure intensity, with a hazard ratio of 4.81 at exposure levels 1.25-2.0 fb/ml but also a clear dose-response effect for cumulative exposure with a 30-, 40-, and 50-year latency time. No convincing excess risk was revealed for any of the other carcinogenic agents included in the Swedish NOCCA job-exposure matrix. Conclusion: When considering asbestos exposure, past exposure, even for short periods, might be enough to cause mesothelioma of the pleura later in life.

• 한국화재소방학회논문지
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• 제32권3호
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• pp.8-13
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• 2018

여러 산업분야나 일상생활에서 다양하게 쓰이고 있는 플라스틱의 중요성과 효용성에 비해 화재 위험성에 관한 연구가 매우 부족하여 본 연구에서는 5종의 플라스틱 제품의 화재 위험성을 콘칼로리미터(ISO 5660-1)로 측정하였다. 그 결과, PVC판의 착화시간(TTI)은 196 s로 다른 플라스틱보다 연소시간이 가장 지연되었고, PS판은 19 s로 착화시간이 가장 짧았다. PS판의 총열방출열량(THR)은 가장 낮게 측정된 PVC판 보다 213.07% 높게 측정되었다. 또한 PS판의 CO는 다른 플라스틱에 비해 1.45~4.21배, $CO_2$는 1.77~6.97배 더 높게 나타나 불완전연소가 가장 높고 인명피해가 가장 많이 발생할 것으로 예측된다. 따라서 화재 위험성은 PS판이 가장 위험하고, PVC판이 가장 안전한 것으로 나타났다.