• 가정∙방문간호학회지
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• 제22권2호
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• pp.196-205
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• 2015

Purpose: This study investigated evidence for the effects of community-based cognitive rehabilitation programs for demented elderly. Methods: The literature review covered studies between 2004 and 2014, and searched international databases including Ovid-MEDLINE, EMBASE, and the Cochrane Library. The Risk of Bias Assessment Tool for Non-Randomized Studies was used by two reviewers to evaluate independently the quality of the selected articles. Results: Eighteen studies were selected through a systematic search of the literature. About three quarters of the studies showed that the community-based cognitive rehabilitation programs provided by nurses were significantly effective in enhancing cognition among elderly individuals with dementia. Conclusion: Based on these results, we suggest that nurse is an appropriate profession to manage cognitive rehabilitation or cognitive enhancement programs for demented elderly individuals. Therefore, the current system in which caregivers provide cognitive rehabilitation programs for demented elderly individuals must be reformed.

• BMB Reports
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• 제29권1호
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• pp.52-57
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• 1996

A specific DNA fragment from Korean radish (Raphanus sativus L.) was amplified by performing PCR with oligonucleotide primers which correspond to the highly conserved regions of plant peroxidases. The size of the PCR product was ca. 400 bp, as expected from the known plant peroxidase genes. Comparison of the nucleotide and deduced amino acid sequences of the PCR product to those of other plant peroxidase-encoding genes revealed that the amplified fragment corresponded to the highly conserved region I and III of plant peroxidases. By screening a genomic library of Korean radish using the amplified fragment as a probe, two positive clones, named prxK1 and prxK2, were isolated. Restriction mapping studies indicated that the 5.2 kb Sail fragment of the prxK1 clone and the 4.0 kb EcoRI fragment of the prxK2 clone encode separate isoperoxidase genes. Analyses of the promoter region of the prxK1 clone shows that putative CAAT box, CMT box, and TGA1b binding sequence (5' TGACGT) are present 718 bp upstream from the start codon.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 춘계학술대회
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• pp.1234-1239
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• 2003

In the product design process computer-aided engineering and optimization tools are widely utilized in order to reduce the total development time and cost. Since several simulation tools are involved in the process, information losses, omissions, or errors are common and the importance of seamless information exchange among the tools has been increased. In this study ISO STEP standards are adopted to represent the neutral format for CAE/CAO information exchange. The schema of AP209 is used to define the information of finite element analysis and the new schema is proposed to describe the information of structural optimization based on the STEP methodology. The schema is implemented by EXPRESS, information modeling language, and ST-Developer is employed to generate C++ classes and STEP Rose Library by using the schema denoted. To substantiate the proposed approach, the information access interfaces of the finite element modeling software (FEMAP), structural optimization software (GENESIS) and in-house topology optimization program are developed. Examples of the size optimization of a three-bar truss and topology optimization of a MBB beam are shown to validate the information exchange of finite element analysis and structural optimization using STEP standards.

• 대한기계학회논문집
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• 제19권3호
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• pp.639-646
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• 1995

The objective of this study is to minimize the weight of a damped anisotropic roto-bearing system considering whirl natural frequency and stability. The system is modeled as an assemblage of rigid disks, flexible shafts and discrete bearings. The system design variables are the crosssectional areas of shaft elements and the properties of bearings. To analyze the system, the polynomial method which is derived by rearranging the calculations performed by a transfer matrix method is adopted. For the optimization, the optimization software IDOL (Integrated Design Optimization Library) which is based on the Augmented Lagrange Multiplier (ALM) method is employed. Also, an analytical design sensitivity analysis of the system is used for high accuracy and efficiency. To demonstrate the usefulness of the proposed optimal design program incorporating analysis, design sensitivity analysis, and optimization modules, a damped anisotropic rotor-bearing system is optimized to obtain 34$ weight reduction.

• The Journal of Korean Physical Therapy
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• 제32권1호
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• pp.21-28
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• 2020

Purpose: This study identified the effects of physical therapists on the quality of life when applying exercise-based movement techniques to breast cancer survivors. Methods: To conduct meta-analysis, 186 RCT studies were searched in five databases (RISS, Pubmed, CINAHL, Medline, and Cochrane Library), without limitation, for the year of publication, and papers published in April 2018 were selected. Four studies met the inclusion criteria and were selected for meta-analysis based on the risk of bias. The basic demographic data, athletic characteristics, and outcome data were extracted from all included clinical trials. The data were analyzed using the RevMan 5.2 program. Results: As a result of meta-analysis, exercise-based movement techniques applied by the control group (Pilates, yoga, tai chi, and qigong) or physical therapists showed no significant difference in the impact on the quality of life of breast cancer survivors. Conclusion: In this study, exercise-based movement techniques mediated by control groups or physical therapists showed no significant difference in the quality of life of breast cancer survivors, but the types and duration of exercise in each study varied, and the number of subjects was small. Considering randomized studies, more randomized studies will be needed to draw conclusions.

• 환경생물
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• 제38권2호
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• pp.289-298
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• 2020

As part of the research program "2018 Rapid screening and identification of freshwater microorganisms using MALDI-TOF/MS library" freshwater samples were collected from a branch of the Nakdong River. Almost 300 antibiotic-resistant bacterial strains were isolated from freshwater samples and subsequently identified by 16S rRNA gene sequencing. Seventeen strains among the isolates shared high 16S rRNA gene sequence similarity (>99.0%) with known species that were not previously recorded in Korea, and each of the isolates also formed a robust phylogenetic clade with the closest species. These species were phylogenetically diverse, belonging to four phyla, seven classes, 10 orders, and 13 genera. At the genus and class level, the previously unrecorded species belonged to Rhodovarius, Xanthobacter, and Shinella of the class Alphaproteobacteria; Ottowia, Simplicispira, and Zoogloea of Betaproteobacteria; Pseudomonas, Acinetobacter, and Shewanella of Gammaproteobacteria; Arcobacter of Epsilonproteobacteria; Sphingobacterium of Sphingobacteriia; Trichococcus of Bacilli; and Leucobacter of Actinobacteria. The previously unrecorded species were further characterized by examining their gram-staining, colony and cell morphology, biochemical properties, and phylogenetic position.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2006년도 학술대회 2부
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• pp.518-523
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• 2006

As digital broadcasting process and information compressing technologies developed, digital technologies have been used extensively in many visual media such as movies and TV programs, and it is required to develop a new process for 3 dimensional digital programs. The study attempts to develop a new digital video-producing process through pre-simulation using a digital storytelling method, in order to increase the quality of broadcasting, reducing the producing time and improve efficiency. This system, supposed to be used to produce actual broadcasting, includes all tools needed for broadcasting in the program, so users can select an appropriate set among the pre-made library, which saves time for making sets. Also, it offers a storyboard making function by perfectly representing the functions of a virtual camera, and enables users to make the better storyboard, checking the real time movies. In addition, it recognizes objects though avatars, organizes the appropriate set for these avatars to act, and embodies a variety of avatar movements through which it reaffirms the camera's position and organization, minimizing errors and saving time and budget.

• 한국응용과학기술학회지
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• 제25권3호
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• pp.370-379
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• 2008

Akt, a serine/threonine protein kinase as a viral oncogene, is a critical regulator of PI3K-mediated cell proliferation and survival. On translocation, Akt is phosphorylated and activated, ultimately resulting in stimulation of cell growth and survival. As a part of our program toward the novel Akt1 inhibitors with potent activity over PI3K signaling pathway, we found primary hit compound 2 with an $IC_{50}$ value of $620\mu}M$ from protein kinase focused library. Based on the structural features of 2, new 1,3,4-thiadiazole derivatives were designed by the introduction of aromatic and heteroaromatic moieties onto thiadiazole nucleus. In this work, a series of 1,3,4-thiadiazole derivatives 1a-1 were synthesized and evaluated for Akt1 inhibitory activity.

• 한국압력기기공학회 논문집
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• 제15권2호
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• pp.58-63
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• 2019

This paper presents preliminary analysis and results on IASCC sensitivity of a core shroud in the reactor pressure vessel. First, neutron irradiation flux distribution of the reactor internals was calculated by using the Monte Carlo simulation code, MCNP6.1 and the nuclear data library, ENDF/B-VII.1. Second, based on the neutron irradiation flux distribution, temperature and stress distributions of the core shroud during normal operation were determined by performing finite element analysis using the commercial finite element analysis program, ABAQUS, considering irradiation aging-related degradation mechanisms. Last, IASCC sensitivity of the core shroud was assessed by using the IASCC sensitivity definition of EPRI MRP-211 and the finite element analysis results. As a result of the preliminary analysis, it was found that the point at which the maximum IASCC sensitivity is derived varies over operating time, initially moving from the shroud plate located in the center of the core to the top shroud plate-ring connection brace over operating time. In addition, it was concluded that IASCC will not occur on the core shroud even after 60 years of operation (40EFPYs) because the maximum IASCC sensitivity is less than 0.5.

• 한국정보과학회논문지:소프트웨어및응용
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• 제32권11호
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• pp.1036-1046
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• 2005

응집도는 모듈의 구성 요소들 사이의 관련성 정도를 나타내는 척도로서, 응집도가 높을수록 소프트웨어에 대한 이해 및 유지보수가 용이하다고 알려져 있다. 최근에 응집도의 개념을 객체지향 시스템의 클래스에 적용하기 위하여 많은 응집도 척도들이 제안되고 있다. 본 논문에서는 클래스 멤버 간의 쓰기 의존성의 영향을 고려함으로써 기존의 응집도 척도를 개선시킬 수 있음을 소개한다. 본 논문의 기법을 지원하는 도구를 개발하였으며 이 도구를 이용하여 C++ 클래스 라이브러리에 이 기법을 적용한 사례 결과를 소개한다.