• 대한화학회지
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• 제45권6호
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• pp.577-588
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• 2001

조합화학 기법을 적용하여 $YRO_4$ (R=As, Nb, P, V)계 모체에 Eu을 활성하여 적색형광체를 합성하였다. 합성된 형광체는 UV PL,VUV PL, 및 색좌표 분석을 하였고, 254nm 및 147nm 여기하에서의 발광세기 및 색좌표 사면체 라이브러리를 완성하였다. Eu이 0.1 mol 도핑된 적색 형광체는 254nm로 여기 시켰을 때 $YRO_4$를 중심으로 다른 중심으로 다른 성분이 미량 첨가되었을 때 가장 좋은 발광 세기를 나타내었으나. 147nm에서는 $YRO_4$를 중심으로 좋은 발광 세기가 나타났다. 합성된 형광체 중 $Y_{0.9}$(A$S_{0.06}$N$B_{0.06}$$P_{0.83}$$V_{0.06}$) $O_4$: $Eu_{0.1}$의 조성으로 1200$^{\circ}C$에서 소성하였을 때 상용 형광체와 대등한 발광세기가 색순도가 우수하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5907-5912
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• 2015

Purpose: To evaluate and update evidence for prognostic effects of kidney-sparing (KS) management and nephroureterectomy (NU) for upper tract urothelial carcinomas. Materials and Methods: Pubmed, Embase and the Cochrane Library were retrieved for the identification of comparative studies of kidney-sparing procedure and nephroureterectomy for upper tract urothelial carcinoma prior to December 2014. The data were extracted independently by 2 reviewers and the quality of the included studies was assessed. Review Manager 5.3 and STATA 13 were used to perform the meta-analysis. Results: Twenty-three observational studies including 1,587 KS and 3,996 NU were evaluated. The results of the meta-analysis showed that nephroureterectomy had no significant benefit with regard to intravesical recurrence (IRFS), metastasis (MFS), cancer specific survival (CSS) and overall survival (OS) except the total tumor recurrence (RFS) when compared with kidney sparing management. The respectively pooled outcomes were HR 1.36 (0.69-2.68, P=0.38) for IRFS, 1.09 (0.59-2.01, P=0.78) for MFS, 1.17 (0.77-1.79, P=0.47) for CSS, 1.50 (0.90-2.48, P=0.12) for OS and 1.61 (1.03-2.51, P=0.04) for RFS. Conclusions: On the whole, kidney-sparing management had equivalent prognostic effect on upper tract urothelial carcinoma as the standard nephroureterectomy except in tumor recurrence. However, the results should be interpreted with caution for lack of stage and grade stratification and multi-center randomized controlled trials are still needed to verify our results.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3369-3375
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• 2014

Background: C-reactive protein (CRP), considered as a prototypical inflammatory cytokine, has been proposed to be involved in tumor progression through inflammation. Recent studies have indicated CRP as a progostic predictor for urological cancers, but the results remain controversial. Materials and Methods: A systematic search of Medline, Scopus and the Cochrane Library was performed to identify eligible studies published between Jan 1, 2001 and Sep 1, 2013. Outcomes of interest were collected from studies comparing overall survival (OS), cancer-specific survival (CSS) and relapse-free survival (RFS) in patients with elevated CRP levels and those having lower levels. Studies were pooled, and combined hazard ratio (HR) of CRP with its 95% confidence interval (CI) for survival were used for the effect size estimate. Results: A total of 43 studies (7,490 patients) were included in this meta-analysis (25 for RCC, 10 for UC, and 8 for PC). Our pooled results showed that elevated serum CRP level was associated with poor OS (HR: 1.26, 95%CI: 1.22-1.30) and RFS (HR: 1.38 95%CI: 1.29-1.47), respectively. For CSS the pooled HR (HR: 1.33, 95%CI: 1.28-1.39) for higher CRP expression could strongly predict poorer survival in urological cancers. Simultaneously, elevated serum CRP was also significantly associated with poor prognosis in the subgroup analysis. Conclusions: Our pooled results demonstrate that a high serum level of CRP as an inflammation biomarker denotes a poor prognosis of patients with urological cancers. Further large prospective studies should be performed to confirm whether CRP, as a biomarker of inflammation, has a prognostic role in urological cancer progression.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3419-3424
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• 2014

Background: Our aim was to conduct a meta-analysis to compare the efficacy and safety of pemetrexed and docetaxel for non-small cell lung cancer (NSCLC). Materials and Methods: We systematically searched the Cochrane Library, PubMed, Embase, China Biology Medicine Database for randomized controlled trials (RCTs) comparing the efficacy and toxicities of pemetrexed versus docetaxel as a treatment for advanced NSCLC. We limited the languages to English and Chinese. Two reviewers independently screened articles to identify eligible trials according to the inclusion and exclusion criteria and assessed the methodological quality of included trials, and then extracted data. The meta-analysis was performed using STATA12.0. Results: Six RCTs involving 1,414 patients were identified. We found that there was no statistically significant differences in overall response rate, survival time, progression-free survival, disease control rate, and 1-2yr survival rate (p>0.050) but it is worthy of mention that patients in the pemetrexed arms had significantly higher 3-yr survival rate (P=0.002). With regard to the grade 3 or 4 hematological toxicity, compared with docetaxel, pemetrexed led to lower rate of grade 3-4 febrile neutropenia, neutropenia, and leukocyts toxicity (p<0.001). There was no significant difference in anemia between the two arms (p=0.08). In addition, pemetrexed led to higher rate of grade 3-4 thrombocytopenia toxicity (p=0.03). As for the non-hematological toxicities, compared with docetaxel, pemetrexed group had lower rate of grade 3-4 diarrhea and alopecia. Conclusions: Pemetrexed was almost as effective as docetaxel in patients with advanced NSCLC. At the same time, pemetrexed might increase the 3-yr survival rate. As for safety, pemetrexed led to lower rate of grade 3-4 febrile neutropenia, neutropenia, leukocytes, diarrhea and alopecia toxicity. However, it was associated with a higher rate of grade 3-4 thrombocytopenia.

• 한국산업정보학회논문지
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• 제24권6호
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• pp.43-53
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• 2019

최근 몇 년간 실내 환경에서 발생하는 대기 위험 물질에 관한 피해사례가 많이 있었으며, 이에 대해 빠른 대처를 하지 못하여 큰 피해가 발생하곤 했다. 이에 관해 본 시스템은 대기 위험 물질 농도 안전 수치 초과시 사용자의 Mobile에 Push Message로 전송하는 시스템을 구축하고자 한다. 본 시스템은 아두이노(Arduino), 라즈베리 파이(Raspberry PI)와 같은 IoT System으로 데이터를 추출하고 Cloud Computing System에 구현된 MongoDB, MySQL을 통하여 Database를 구축하였다. 해당 Database는 NodeJS를 이용한 Application Server를 통해 데이터를 가져오며, Application에 전송하여 시각화하였다. 또한, IoT System에서 위험 상황에 관한 신호를 받으면 Google FCM 라이브러리를 이용하여 Push Message를 보낸다. Mobile Application은 Android Web View를 이용하여 개발하며, Web View에 들어갈 Page는 HTML5 (HTML, Javascript CSS)를 이용하여 개발한다. 본 시스템의 Application을 통하여 사용자가 실내 대기 위험 물질을 실시간 모니터링하며, 위험 상황 시 사용자의 Mobile에 실내/외 검출 위치와 농도에 대한 실시간 정보를 Push Message로 전송하여 사용자의 빠른 대처에 도움이 될 것이라 기대할 수 있다.

• 대한지리학회지
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• 제50권6호
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• pp.717-734
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• 2015

일본 최대의 한국본 고서 소장 도서관 중의 하나인 동양문고에는 풍부한 지리 관련 자료가 소장되어 있다. 지리지(地理志)의 편찬과 개선방안을 기록한 "기인한상량 杞人間商量"을 비롯해 다수의 군현읍지들, 조선후기 도로와 유통의 발달을 반영한 도로망을 기록한 "해동도리표" 등 다양한 조선시대의 지리 자료들이 소장되어 있다. 동양문고 소장 지도와 지리지 중에는 한국에 소장본이 확인되지 않은 유일본들이 다수 포함되어 있어 중요한 지리학적 가치를 지닌다. 특히 지도 중에는 고산자 김정호의 "대동여지도" 6종을 비롯해 매우 중요한 고지도들이 소장되어 있다. 마에마 교사쿠(前間恭作)의 소장인이 찍힌 고산자 김정호의 "대동여지도"와 "수선전도", 시데하라 다이라(幣原坦) 소장본이었던 20리 방안지도인 "강역전도"와 10리 방안지도인 "동여도", 정상기의 "동국지도" 유형의 매우 훌륭한 팔도의 도별 지도인 "근구팔역 槿邱八幅", 해주신본 계열의 "좌해지도 左海地圖", 특히 함경도와 평안도의 병마절도사를 지낸 이삼(李森)의 서문이 기록된 북방 국경지역 지도인 "관북지도 關北地圖" 등은 조선의 지도 중 역사적 가치를 지니는 자료를 선별하는 안목을 지닌 수집가에 의해 소장된 자료임을 보여주는 대표적인 지도들로서, 한국의 지도학 발달사를 보충할 수 있는 중요한 자료들이다.

• 생명과학회지
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• 제15권6호
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• pp.851-856
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• 2005

Although valuable microbes have been isolated from the soil for the various productions of useful components, the microbes which can be cultivated in the laboratory are only $0.1-1\%$ of all microbes. To solve this problem, the study has recently been tried for making the valuable components from the environment by directly separating unculturable micrbial DNA in the soil. But it is known that humic acid originated from the soil interrupts various restriction enzymes and molecular biological process. Thus, in order to prevent these problems, this study modified the method separated soil DNA with phenol, CTAB and PEG. In order to compare the degree of purity for each DNA and the molecular biological application process, $A_{260}/A_{280}$ ratio, restriction enzymes, and PCR were performed. In case of DNA by the modified method, total yield of DNA was lower but $A_{260}/A_{280}$ ratio was higher than the previously reported methods. It was confirmed that the degree of purity is improved by the modified method. But it was not cut off by all kinds of tested restriction enzymes because of the operation of a very small amount of interrupting substances. When PCR was operated with each diluted DNA in different concentrations and GAPDH primer, the DNA by the modified method could be processed for PCR in the concentration of 100 times higher than by the previously reported separation method. Therefore, this experiment can find out the possibility of utilization for the unknown substances by effectively removing the harmful materials including humic acid and help establishing metagenomic DNA library from the soil DNA having the high degree of purity.

• 동양고전연구
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• 제72호
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• pp.127-156
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• 2018

김유신은 살아 있을 때는 물론이고 죽은 뒤에도 신라에서 높은 평가를 받았다. 살아 있을 때는 태종과 문무왕을 보필하여 '일통삼한'의 대업을 이룩한 최고의 신하로 평가받았다. 당나라는 물론이고 고구려와 일본에서도 김유신의 정치적 위상을 높이 평가했다. 김유신은 죽은 뒤에도 태종을 도와 대업을 이룬 '좋은 신하' 또는 '성스런 신하'라고 인식되었다. 또, 문무왕과 함께 '두 명의 성인'으로 추앙되었으며, 불교적으로 33천의 한 사람이 내려온 것이 김유신이라고 인식되었다. 신라 하대에는 '흥무대왕'으로 추봉되어 '무(武)를 일으킨 대왕'이라는 극찬을 받았다. 고려시기에는 신라에 이어서 진천현 태령산의 사당에서 국가제사로 받들어졌다. 김부식은 김유신과 태종무열왕 문무왕의 관계를 빗대어 자신의 처지를 보여주려 했는데, 김유신을 두 왕의 절대적인 신임을 받아 큰 공을 이룬 인물로 평가했다. 또 윤관은 김유신이 신령스러운 기적을 많이 일으킨 장군으로 인식했고, 이승휴는 김유신이 오묘한 병서를 얻어 무예에 뛰어났다고 말했다. 고려 말의 정추도 김유신이 기이한 능력을 가진 장수이고 큰 무공을 세웠다고 인식했다. 조선시기에서도 태종무열왕 문무왕과 신하 김유신의 절대적인 신임관계로 인해 김유신이 큰 공적을 세웠다는 평가가 지속되었다. 그리고 김유신은 신라의 무(武)를 대표하는 인물이거나 신라 왕조 전 역사에서 가장 뛰어난 인물이라고 보았다. 나아가 중국의 인물에 견줄만한 능력과 공훈이 있는 인물이라고 인식되었다. 조선에서도 김유신이 병법에 뛰어났고 쇠뇌와 같은 훌륭한 무기를 활용했다고 보았으며, 특히 임진왜란을 겪으면서 그들은 김유신이 왜적을 소탕해주기를 바랐다. 김유신은 우리나라 역사에서 무(武)를 대표하는 인물로 평가되었다. 그리고 성리학적 관점에서 이러한 김유신의 행적을 통해 그를 충신이라고 인식했다.

• Journal of Radiation Protection and Research
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• 제47권2호
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• pp.99-106
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• 2022

Background: The radionuclide inventory calculation codes such as ORIGEN and FISPACT collapse neutron reaction libraries with energy spectra and generate an effective one-group cross-section. Since the nuclear cross-section data, energy group (g) structure, and other input details used by the two codes are different, there may be differences in each code's activation inventory calculation results. In this study, the calculation results of neutron-induced activation inventory using ORIGEN and FISPACT were compared and analyzed regarding radioactive waste classification and worker exposure during nuclear decommissioning. Materials and Methods: Two neutron spectra were used to obtain the comparison results: Watt fission spectrum and thermalized energy spectrum. The effective one-group cross-sections were generated for each type of energy group structure provided in ORIGEN and FISPACT. Then, the effective one-group cross-sections were analyzed by focusing on ⁵⁹Ni, ⁶³Ni, ⁹⁴Nb, ⁶⁰Co, ¹⁵²Eu, and ¹⁵⁴Eu, which are the main radionuclides of stainless steel, carbon steel, zircalloy, and concrete for decommissioning nuclear power plant (NPP). Results and Discussion: As a result of the analysis, ¹⁵⁴Eu and ⁵⁹Ni may be overestimated or underestimated depending on the code selection by up to 30%, because the cross-section library used for each code is different. When ORIGEN-44g, -49g, and -238g structures are selected, the differences of the calculation results of effective one-group cross-section according to group structure selection were less than 1% for the six nuclides applied in this study, and when FISPACT-69g, -172g, and -315g were applied, the difference was less than 1%, too. Conclusion: ORIGEN and FISPACT codes can be applied to activation calculations with their own built-in energy group structures for decommissioning NPP. Since the differences in calculation results may occur depending on the selection of codes and energy group structures, it is appropriate to properly select the energy group structure according to the accuracy required in the calculation and the characteristics of the problem.

• 생약학회지
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• 제53권4호
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• pp.226-233
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• 2022

Ephedra herbs are defined as stem of Ephedra sinica , Ephedra intermedia and Ephedra equisetina in the Korean Pharmacopoeia. It is important to use pure herbs to derive the safety and efficacy of herbal medicine. However, the identification of these herbs by conventional taxonomic methods is difficult. Recently, many studies have applied these DNA barcoding for the identification of herbal medicinal species using standard DNA markers. In this study, we report a case study in which the identification of Ephedra species was done by DNA barcoding. For identification of Ephedra species, 17 samples were collected, and a reference DNA barcode library was developed using 6 markers (rbcL, matK, ITS2, ycf1, ycf3, and rpoC2). To develop KASP-SNP markers, we selected 4 markers (ycf1, ycf3, rpl2, and rbcL), which were able to distinguish three Ephedra species. In the result, the specific markers for each of the three Ephedra were clustered into FAM-positive section, whereas non-targeted plants were clustered either HEX-positive or negative section. Therefore, we have developed KASP assay that allow rapid and easy Ephedra species identification using three KASP markers.