• Structural Engineering and Mechanics
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• 제57권4호
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• pp.587-602
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• 2016

In structural reliability analysis, the response surface method is widely adopted because of its numerical efficiency. It should be understood that the response function must approximate the actual limit state function accurately in the main region influencing failure probability where it is evaluated. However, the size of main region influencing failure probability was not defined clearly in current response surface methods. In this study, the concept of sub-region of interest is constructed, and an improved response surface method is proposed based on the sub-region of interest. The sub-region of interest can clearly define the size of main region influencing failure probability, so that the accuracy of the evaluation of failure probability is increased. Some examples are introduced to demonstrate the efficiency and the accuracy of the proposed method for both numerical and implicit limit state functions.

• Journal of the Korean housing association
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• 제11권1호
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• pp.125-135
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• 2000

Recently, the space organization of Korean-Chinese houses is different from that of other territories. The vast land of China, coming from different hometown in Korean peninsula, and the different hometown in Korean peninsula, and the different procedure of settlement seem to make the different space organization of Chinese-Korean single family housing at the urban area in Liaoning Province.The characteristics of the Korean-Chinese space organization of single family housing at the urban area in Liaoning Province are as follows;i)Three types of space organization are central kitchen type, central corridors types, and central living room type. ii)The central kitchen type is mainly in old urban housing, after 1980's, the central corridor type appears in single family housing, and central living room type appears 1990's.iii) It seems that the main reason to change the space organization are fuel, system of heating, influence of Korea housing. Especially, Korean-Chinese like central living room type that is suitable for sit down living style. This central living room type supposes to be used as popular space organization in urban housing.

• Journal of the Speleological Society of Korea
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• 제65호
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• pp.39-51
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• 2004

To introduce the typical water caves of the northeastern district in China, the Shenyang Water Cave located in the Shenyang city and the Benxi Water Cave located in the Benxi city of the Liaoning province of the northeastern part of China are presented. The caves are very big and long, and the water flows in the cave to drive the motor boat for tourist watching the beautiful sight in the caves through the year. The geological information and the beautiful internal sight of views in the caves are introduced.

• Structural Engineering and Mechanics
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• 제62권2호
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• pp.125-138
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• 2017

Reliability-based design optimization (RBDO) is a powerful tool for design optimization when considering probabilistic characteristics of design variables. However, it is often computationally intensive because of the coupling of reliability analysis and cost minimization. In this study, the concept of reliability mapping function is defined based on the relationship between the reliability index obtained by using the mean value first order reliability method and the failure probability obtained by using an improved response surface method. Double-loop involved in the classical RBDO can be converted into single-loop by using the reliability mapping function. Since the computational effort of the mean value first order reliability method is minimal, RBDO by using reliability mapping functions should be highly efficient. Engineering examples are given to demonstrate the efficiency and accuracy of the proposed method. Numerical results indicated that the proposed method has the similar accuracy as Monte Carlo simulation, and it can obviously reduce the computational effort.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2883-2887
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• 2015

Background: The calcium-binding S100A4 protein is involved in epithelial to mesenchymal transition, oncogenic transformation, angiogenesis, cytoskeletal integrity, mobility and metastasis of cancer cells. This study aimed to clarify the roles of S100A4 in genesis and progression of glioma. Materials and Methods: S100A4 expression was examined by real-time RT-CPR and Western blot in glioma and paired normal brain tissue (n=69), and compared with clinicopathological parameters of tumors. In addition, glioma U251 cells transfected with an S100A4-expressing plasmid were examined for proliferation by MTT, apoptosis by Annexin V-FITC, and migration and invasion with Transwell chambers. Results: Increased S100A4 mRNA expression was found in gliomas, compared with paired non-tumor tissue (p<0.001). Gradual elevation of overexpression of S100A4 was observed with increasing glioma grade (p<0.001). Astrocytoma showed lower S100A4 mRNA expression than oligodendrogliomas, with glioblastomas having highest values (p<0.001). Similar results were obtained for S100A4 protein, a positive link being found between mRNA and protein expression in gliomas (p<0.001). There was higher growth, lower apoptosis, stronger migration and invasion of S100A4 transfectants than control and mock transfected cells (p<0.001). Conclusions: These findings indicate that up-regulated S100A4 expression is positively linked to pathogenesis, progression and histogenesis of glioma by modulating proliferation, apoptosis, migration and invasion.

• Parasites, Hosts and Diseases
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• 제55권6호
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• pp.673-677
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• 2017

The present study was performed to investigate the seroprevalence and risk factors for Dirofilaria immitis infection in cats from Liaoning province, northeastern China. From October 2014 to September 2016, sera of 651 cats, including 364 domestic cats and 287 feral cats (332 females and 319 males) were assessed. They were tested for the presence of D. immitis antigen using SNAP Heartworm RT test kit. In this population, the average prevalence was 4.5%. Age and rearing conditions (feral or domestic) were found to be associated with the prevalence of D. immitis. The prevalence was significantly higher in feral cats compared with domestic cats (8.4% vs 1.4%, P<0.01). There was no significant difference between males and females (4.7% vs 4.2%, P>0.05), but older cats (${\geq}3$ years old) showed a statistically higher prevalence compared with younger cats (<3 years old) in feral populations (16.8 vs 2.4%, P<0.01), while the difference between the age groups was not statistically significant in domestic cats (2.4% vs 0.51%, P>0.05), all these results suggest that outdoor exposure time may be one of the most important factors for D. immitis prevalence in cats. Results reveal that D. immitis are prevalence in domestic and feral cats in northeastern China, which indicates that appropriate preventive measures should be taken to decrease the incidence of feline heartworm disease in Liaoning province, northeastern China.

• Magazine of the Korean Society of Agricultural Engineers
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• 제52권3호
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• pp.70-75
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• 2010

• Parasites, Hosts and Diseases
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• 제39권4호
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• pp.285-292
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• 2001

The present study aimed to evaluate control efficacy of clonorchiasis by two schemes of repeated treatment with praziquantel at two endemic villages in China. Residents of one village at Guangxi Autonomous Region were treated and examined 6-monthly and of another at Liaoning Province 12-monthly, In residents that took 25 mg/kg x3 (total 75 mg/kg) of Praziquantel every 6 months for one Year the e99 Positive rate showed a significant drop from 69.0% to 17.1%. In contrast, a group of same praziquantel medication once showed a slight marginal decrease in the egg rate from 18.9% to 12.2% after one year Of 39 subjects examined 3 times, 56.4% were cured, 7.7% persistently positive, one (2.6%) reinfected after cure or newly infected, but 25.6% were persistently negative. The present finding suggests that 6-monthly medication with 75 mg/kg of praziquantel should effectively lower the prevalence but incomplete for control of clonorchiasis in heavy endemic areas.

• Structural Engineering and Mechanics
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• 제57권3호
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• pp.457-471
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• 2016

To analyze laminated composite and sandwich beams under temperature loads, a $C^0$-type Reddy's beam theory considering transverse normal strain is proposed in this paper. Although transverse normal strain is taken into account, the number of unknowns is not increased. Moreover, the first derivatives of transverse displacement have been taken out from the in-plane displacement fields, so that the $C^0$ interpolation functions are only required for the finite element implementation. Based on the proposed model, a three-node beam element is presented for analysis of thermal responses. Numerical results show that the proposed model can accurately and efficiently analyze the thermoelastic problems of laminated composites.

• Journal of Ginseng Research
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• 제47권1호
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• pp.144-154
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• 2023

Background: As the major pathophysiological feature of obstructive sleep apnea (OSA), chronic intermittent hypoxia (CIH) is vital for the occurrence of cardiovascular complications. The activation of calpain-1 mediates the production of endothelial reactive oxygen species (ROS) and impairs nitric oxide (NO) bioavailability, resulting in vascular endothelial dysfunction (VED). Ginsenoside Rg1 is thought to against endothelial cell dysfunction, but the potential mechanism of CIH-induced VED remains unclear. Methods: C57BL/6 mice and human coronary artery endothelial cells (HCAECs) were exposed to CIH following knockout or overexpression of calpain-1. The effect of ginsenoside Rg1 on VED, oxidative stress, mitochondrial dysfunction, and the expression levels of calpain-1, PP2A and p-eNOS were detected both in vivo and in vitro. Results: CIH promoted VED, oxidative stress and mitochondrial dysfunction accompanied by enhanced levels of calpain-1 and PP2A and reduced levels of p-eNOS in mice and cellular levels. Ginsenoside Rg1, calpain-1 knockout, OKA, NAC and TEMPOL treatment protected against CIH-induced VED, oxidative stress and mitochondrial dysfunction, which is likely concomitant with the downregulated protein expression of calpain-1 and PP2A and the upregulation of p-eNOS in mice and cellular levels. Calpain-1 overexpression increased the expression of PP2A, reduced the level of p-eNOS, and accelerated the occurrence and development of VED, oxidative stress and mitochondrial dysfunction in HCAECs exposed to CIH. Moreover, scavengers of O₂^·-, H₂O₂, complex I or mitoKATP abolished CIH-induced impairment in endothelial-dependent relaxation. Conclusion: Ginsenoside Rg1 may alleviate CIH-induced vascular endothelial dysfunction by suppressing the formation of mitochondrial reactive oxygen species through the calpain-1 pathway.