• Title/Summary/Keyword: Levels of use

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Pharmacokinetics of a sustained-release bovine somatotropin in lactating cows

  • Han, Seong-kyu;Park, Jin-bong;Kim, Doo;Park, Sang-kyoon;Lee, Ho-sung;Kim, Seong-nam;Chang, Byoung-sun;Ryu, Pan-dong
    • Korean Journal of Veterinary Research
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    • v.39 no.2
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    • pp.267-275
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    • 1999
  • Bovine somatotropin is known to improve the growth rate and lactation in cattle. In this study, we examined the concentration-time profiles of a sustained-release formulation of bovine somatotropin (BST) and insulin-like growth factor-1 (IGF-1) in plasma and milk in cows. In addition, the possible effect of co-administrated vitamin ADE complex on the pharmacokinetic parameters of BST and IGF-1 was evaluated. 1. Plasma BST and IGF-1 levels reached the peak at 12~24 and 48 hours after the administration of BST, and plasma half-lives ranged 100 to 137 and 201 to 310 hours, respectively. To 8th day after administration, BST and IGF-1 levels in milk were not significantly different from the control levels. 2. Plasma BST levels showed cyclic pattern with high concentrations in early stage after each injection and following gradual declining during repeated administrations at 2 week intervals, while plasma IGF-1 levels in treated animals did not show such a cyclic pattern, but remained higher than the control levels. 3. Milk BST and IGF-1 levels during repeated treatments were not significantly different from the control levels. 4. Co-administration of vitamin ADE complex yielded slightly increased AUC of plasma BST for high dose group, but such effect was not evident in the IGF-1 levels. Co-administration of ADE complex tended to increase plasma BST levels and decrease the elimination half-life of IGF-1. 5. These results suggest that the BST formulation tested is one of the ideal sustained-release formulation for long term use in dairy industry. As for the co-administration of vitamin ADE complex, the benefit of co-administration with BST is needed to be further evaluated.

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Factors Affecting College Students' Intention to Use Mental Health Services for Mental Wellness (대학생들의 정신건강 서비스 이용의도에 영향을 미치는 요인에 관한 연구)

  • Sun, Hye-Jin
    • Journal of Korea Entertainment Industry Association
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    • v.15 no.3
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    • pp.251-261
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    • 2021
  • The purpose of this study is to find out how much psychosocial factors affecting the intention to use mental health services and the characteristics of respondents in college students. Specifically, the influence of the level of knowledge about mental health, subjective norms, attitudes for seeking help, and social psychological stress levels on the respondents'intention to seek help is examined. As a result of the study, it was found that the subjective norms, social and psychological stress levels, and mental health students'intention to use mental health services were influenced by factors. It was found that subjective norms, psychosocial stress level, and attitude toward using mental health service were factors that influence the intention to use mental health service. The influence of these factors on help seeking intention was in the order of psychosocial stress level, help seeking attitude, and subjective norm. The study provided implications that were helpful in message development when executing mental health promotion and awareness campaigns by identifying predictive factors of the intention to use mental health services of college students.

The Effect of BuOH Fraction of Polygonatum odoratum with Selenium on Blood Glucose Level and Lipid Peroxidation in Streptozotocin Induced Diabetic Rats (둥굴레 분획물과 Selenium이 Streptozotocin 유발 당뇨 흰쥐의 혈당수준과 지질과산화에 미치는 영향)

  • 임숙자
    • Journal of Nutrition and Health
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    • v.33 no.7
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    • pp.703-711
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    • 2000
  • The purpose of this study was to investigate the effect of butanol(BuOH) fraction of Polygonatum odoratum with selenium tr-eatment on blood glucose levels and lipid peroxidations in streptozotocin(STZ) induced diabetric rats. Male Sprague-Dawly rats weighing(180-200g) were divided into five groups : normal STZ-control and three expreimental groups(P, odoratum group P, odo-Se group and Se group) Diabetes mellitus was induced by injection STZ in the tail vein at the dose of 45mg/kg B.W The BuOH fraction of Polygonatum odoratum(500mg/kg. B,W) given orally administered for 14 days. The Se treated group were fed a AIN-76 recommendation diet mixed with Na2Seo3(2mg/kg diet). Diabetic rats showed the lower weight gain compared to the normal rats. the plasma glucose levels of the P. odo-Se group were significantly lower than the other experimental groups. The plasma cholesterol levels were higher in STZ-control and Se groups compared toP.odoratum and P. odo-Se groups and HDL-cholesterol levels were increased in the diabetic experimental groups fed on BuOH fraction of P. odoratum with Se supplementation. The liver and muscle glycogen levels were not significantly differ among all groups. The plasma free fatty acid levels were lower in diabetic experimental groups fed on BuOh fraction of P. odoratum or Se sup-plementation than STZ-control and Se groups. Diabetics rats showed the higher levels of triglyceride in plasma andlower levels in liver compared with the normal group. Supplementation with Se decreased significantly the liver triglyceride level. The MDA levels in liver and kidney were significantly reduced in all the experimental groups. In conclusion administration of BuOH fraction of Polygonatuum odoratum with selenium supplementation reduced blood glucose levels and peroxdative tissue damage in STZ induced diabetic rats showing the possibility of preventiave and therapeutic use of the wild edible plant to the diabetes mellitus.

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Radiation Effects of Proton Particles in Memory Devices

  • Lho, Young-Hwan;Kim, Ki-Yup
    • ETRI Journal
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    • v.29 no.1
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    • pp.124-126
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    • 2007
  • In this letter, we study the impact of single event upsets (SEUs) in space or defense electronic systems which use memory devices such as EEPROM, and SRAM. We built a microcontroller test board to measure the effects of protons on electronic devices at various radiation levels. We tested radiation hardening at beam current, and energy levels, measured the phenomenon of SEUs, and addressed possible reasons for SEUs.

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Sensory and Physical Characteristics of Bam-dduk Prepared with Different Ratio of the Ingredients (재료배합비를 달리한 밤떡의 관능적 및 물리적 특성)

  • 김지영;차경희;이효지
    • Korean journal of food and cookery science
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    • v.13 no.4
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    • pp.427-433
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    • 1997
  • Various Bam-dduk were prepared by using two kinds of chestnut flour (dried chestnut, boiled chestnut), 2 types of sugar (sugar and honey), and 3 levels of sugar (10, 20, 30 g), and they were evaluated for sensory quality, texture, moisture, and color. The addition of 10∼15% of dried chestnut flour to glutinous rice flour increased the graininess, moistness, chewiness, and sweetness of Bam-dduk, and the addition of 30∼40% boiled chestnut flour increased the graininess, moistness, and sweetness, depending up on the types and levels of sugar. The use of 10% dried chestnut flour and 30 $m\ell$ of honey gave the highest value of springiness in Bam-dduk. Gumminess, hardness and chewiness were the highest with 15% dried chestnut flour and 20 g sugar. Cohesiveness was the strongest at 30% boiled chestnut flour and 10 $m\ell$ honey. Adhesiveness was most proper when 30 g sugar was added to 10% dried chestnut flour. The use of boiled chestnut flour gave higher moisture content in Bam-dduk (32.2∼41.3%) than the use of dried chestnut flour (29.6∼34.2%). The values of 'L' (67.43) and 'b' (18.07) were most intensive in Bam-ddfik prepared with 15% dried chestnut and 20 g sugar, and the replacement of 20 g sugar with 30 $m\ell$ of honey gave the highest 'a' value, 2.33.

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Clinical Effects of Salivary Peroxidase System Containing Gel on the Patients with Burning Mouth Syndrome (Salivary peroxidase system 함유 gel의 구강내 작열감 증후군 환자에 대한 치료효과)

  • Sung-Woo Lee;Jin-Woo Chung
    • Journal of Oral Medicine and Pain
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    • v.21 no.1
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    • pp.133-140
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    • 1996
  • Saliva have many important functions in the maintenance of oral health. Saliva contains protective components, antibacterial enzymes, and other rubricating glycoprotein elements. When the salivary flow decreases of the salivary composition changes, a normally healthy mouth can become susceptible to caries, periodontal disease, and mucositis, and other diseases. Salivary peroxidase system acts as an antimicrobial factor in the oral cavity, having a role in the prevention of dental plaque accumulation, dental caries and gingivitis. Recently, this enzyme system has been introduced by many researchers in the form of toothpaste, mouthwash or moisturizing gel for use in patients with various disease states . The author prescribed the peroxidase system containing gel (Oralbalance) to the 18 Burning Mouth Syndrome (BMS) patients for 1 week and investigated the changes of the subjective symptoms, $HOSCN/OSCN^-$ levels of unstimulated whole saliva, and the salivary flow rates. The obtained results were as follows : 1. The patients reported decrease in all symptoms of BMS after the use of peroxidase system containing gel, particulary, a significantly higher decreases of dry mouth and burning symptoms. 2. Decreased $HOSCN/OSCN^-$ levels of unstimulated whole saliva were detected in the patients with BMS after the use of perosidase system containing gel for 1 week. 3. There was no difference between the flow rates of unstimulated whole saliva before and after uses of peroxidase system containing gel for 1 week.

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Comparison of Multilevel Inverters Employing DC Voltage Sources Scaled in the Power of Three

  • Hyun, Seok-Hwan;Kwon, Cheol-Soon;Kim, Kwang-Soo;Kang, Feel-Soon
    • Journal of international Conference on Electrical Machines and Systems
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    • v.1 no.4
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    • pp.457-463
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    • 2012
  • Cascaded H-bridge multilevel inverters shows a useful circuit configuration to increase the number of output voltage levels to obtain high quality output voltage. By applying the concept of the power of three to dc voltage sources, it can increase the number of output voltage levels effectively. To realize this concept, two approaches may be considered. One is to use independent dc voltage sources pre-scaled in the power of three, and the other is to use instantaneous dc voltage sources generated from a cascaded transformer, which has the secondary turn-ratios scaled in the power of three in sequence. A common feature in both approaches is to use the concept of the power of three for dc voltage sources, and a point of difference is whether it adopts a low frequency transformer or not, and where the transformer is located. According to the difference, application areas are limited and show different characteristics on THD of output voltages. We compare and analyze both approaches for their circuit configurations, voltage level generating method, THD characteristics of output voltage, efficiency, application areas, limitations, and other characteristics by experiments using 500 [W] prototypes when they generate a 27-level output voltage.

The effect of dentifrice containing garlic extract on dental plaque and gingivitis (마늘추출물 함유 치약이 치면세균막 감소 및 치은염 완화에 미치는 영향)

  • Jang, Jong-Hwa
    • Journal of Korean society of Dental Hygiene
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    • v.8 no.2
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    • pp.67-76
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    • 2008
  • The purpose of this study was to determine the effect of dentifrice containing 0.1% extracts of garlic on dental plaque and gingivitis in a double blind and crossover clinical studies in 33 healthy adults aged from 20 to 22 years who provided a consent for their participation. Oral examination was performed through clinical periods and on day of baseline, 6, 13, 19, 25 days plaque index and gingival index were scored by Turesky' modified index and L$\ddot{o}$e & Silness index. After 12, 19, 25 days use of their respective dentifrices, statistically decreases of plaque index, gingival index were shown in both the experimental and the control group, respectively, Experimental group exhibited significantly the lower plaque levels and the higher levels of gingival health by the use of the dentifrices contained extract of garlic from 12 days compare with control group(p<0.05). The degree of decrease was more significant on gingivitis level of the experimental group than the control group(p <0.05). This result indicate that the use of dentifrice containing extract of garlic has a positve effect in preventing plaque and gingivitis and treating periodontal diseases.

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A study on the stages of concern, level of use, innovation configurations and the analysis of their relationship to each other shown by elementary teachers regarding storytelling-based math education based on CBAM (CBAM(Concerns-Based Adoption Model)에 기초한 스토리텔링 수학교육에 대한 초등교사의 관심도, 실행 수준, 실행 형태 및 관계 연구)

  • Cha, Min Kyung;Kim, Min Kyeong
    • The Mathematical Education
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    • v.55 no.4
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    • pp.417-445
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    • 2016
  • The purpose of this research is to discover and analyze the stages of concern, level of use, innovation configurations and the analysis of their relationship to each other of storytelling-based math education among elementary teachers based on the concerns-based adoption model (CBAM). And then the researcher derives support strategies for the education by empirically examining at which levels and how actual elementary teachers perceive storytelling-based math education and also how they adopt it. In addition, the researcher lays the purpose of this study on seeking proper supporting strategies for helping elementary teachers implement storytelling-based math education and providing basic material for teaching activities by examining the correlation between stages of concern, levels of use and the innovation configuration, and grasping the relation between teachers concern and their educational practice regarding storytelling-based math education.

A Study on the Information Search, Information Use and Search Outcome of Adolescent Consumers -Focus on Clothing Purchase Behavior- (청소년 소비자의 정보탐색, 정보활용 및 탐색성과에 대한 인과분석 -의류 구매를 중심으로-)

  • Heo, Jin-Young;Kim, Young-Seen
    • Korean Journal of Human Ecology
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    • v.7 no.1
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    • pp.61-74
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    • 1998
  • The purpose of this study is to investigate the information search, information use and search outcomes. 420 students in Chungnam and Taejon area were surveyed. Questionnaire survey method and multiple regression and path analysis were used. Some major conclusions were as follows: 1) The levels of the information search, information use and search outcomes were relatively low. 2) The volumes of information search and the contents of information were mainly affected by psycho-behavioral variables. 3) The level of information use was affected by the content of information, desire to seek information, involvement, and previous knowledge. 4) The search outcome was affected positively by the information use, involvement, volume of information search, desire to seek information, and perceived risk. 5) The volume of information search and the information use were the parameter of the search outcomes.

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