• 생물정신의학
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• 제12권2호
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• pp.173-180
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• 2005

Purpose:We investigated the effect of menopausal duration on cognitive function using adjunctive hormone replacement therapy(HRT) in postmenopausal women with depression. Method:Twelve postmenopausal women with depressive disorder were enrolled. Six patients having menopausal duration of less than 3 years was assigned to the short duration group and six patients of more than 3 years to the long duration group. Each patient was treated with conjugated equine estrogen(1.25mg) plus medroxyprogesterone(5mg) for 8 weeks. Cognitive performance was measured by the Verbal Memory Test, Visual Memory Test, Trail Making Test, Digit Symbol Test, and Attention Shift Test. The Beck Depression Inventory was used for evaluation of depressed mood. The reproductive hormone levels were also measured. Results:The long duration group showed the lower performance only in Trail Making Test B compared with the short duration group at baseline. After 8 weeks, the long duration group performed significantly better in the Trail Making Test B compared with the short duration group. The differences in change of depressive mood and gonadal hormone level between two groups were not significant. Conclusion:Menopausal duration before HRT may influence the effect of estrogen on cognition in some cognitive domains. This might be related with estrogen receptor hypersensitivity which induced by the longer estrogen deficiency.

• 한국의상디자인학회지
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• 제12권3호
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• pp.83-92
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• 2010

The current design paradigm shift which has been in progress around the world would be a good opportunity for Korea, which has led the age of information, to build design competence and gain international competitiveness. In addition, it would be a good idea for colleges as well as firms to develop a new educational system and create academia-industry-research synergy. This paper researches the market KU project promoted by Design Venture KU which has been established by the College of Artand Design of Konkuk University as a part of differentiation strategy. The methods to improve the competitiveness of Korean fashion design by uniting college creativity and market practicality are as follows: First, for convergence of creativity and practicality, it is necessary to come up with a systematic design-based educational system. In other words, the undergraduate program needs to gradually expand courses by focusing on creativity instead of functions while the graduate program should be able to develop design pattern, textile and marketing products and secure the market to gain competitiveness as a business incubator. Second, the working-level engineers as well as professors will be encouraged to participate in special lectures or seminars and take necessary lessons. In addition, academia-industry cooperation courses will be further strengthened. It is also important to actively participate in an official contest or exhibition and receive a prize. Third, to elicit creativity from students, it is necessary to help them think in a flexible and experimental way with voluntary and interesting programs. As mentioned above, it is expected that 'Market KU Project' would help students build expertise by offering them a chance to experience the real world and become the world's leading designers in Korean fashion design.

• 한국생활과학회지
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• 제10권1호
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• pp.113-126
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• 2001

The purpose of this study was to investigate clothing behavior and ornaments wear of university students. The subject of this study consists of 241 college students who were attended in Kongju National University. SPSSWIN Program was utilized to calculated frequency(N), mean value(M) and standard deviation(SD) for statistical analysis. Differences among the populations were examined through T-test, F-test, $x^2$-test. The results of this study were as follow : 1. Clothing behavior of university students had significant difference according to sex, grade. In general, female students showed higher score than did male students in clothing interest, clothing conformity, self-estimation about clothing, clothing dependence, clothing aesthetic, clothing modesty, A first-year students had high tendency in clothing interest. 2. The wear of ornaments had significant difference according to variables. Buying the ornaments, most of students sot information in show window and emphasized on design. Male students wanted to have the ornaments of shoes, watch, hat & necklet, but female students wanted to have the ornaments of shoes, earring, necklet & hairpin. 3. Clothing behavior has Influenced university students' ornaments wear. The university students who appeared to be interested in clothes were apparently influenced by peers when selecting ornaments. Ornaments were usually bought in the department store, while belts were among the most popular choices. Students who stressed color when purchasing ornaments showed a high level of interest in and dependence on clothes. On the basic of these results, we can conclude that university students' taste in clothing behavior and use of ornaments wear depend on several different factors. Therefore, it is possible to outline the shift in clothing attitudes during adolescence. In order to understand university students' behaviour concerning clothes, much guidance and various studies on the subject are much recommended.

• 한국정보통신학회논문지
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• 제19권6호
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• pp.1411-1418
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• 2015

공간정보 정책과 관련하여, 아직까지 그 개념이나 구성 및 체계에 관한 선행연구가 미미한 수준이며, 그 연구들마저도 정책이론 관점에서 공간정보 정책의 기본 구조체계를 제시하는 정도로, 공간정보 정책을 정립하기 위한 목적에서 기본 개념을 모색하려는 시도에 불과한 실정이다. 이에 본 논문에서는 2000년대 중반부터 시작된 기존의 PC기반에서 스마트폰 등 모바일 기반으로의 새로운 패러다임 변화라는 현재의 스마트사회에 있어, 한국의 미래국가경쟁력을 좌우할 공간정보기술 정책의 바람직한 미래전략 설정을 위한 전략방향을 고찰하고 대안을 모색해 보고자 한다. 이러한 연구를 통해 글로벌 차원에서 지리공간정보와 관련된 다양한 이슈와 기술 변화를 과학적으로 분석하고 국내지리공간정보에 대한 정책 및 연구 개발 로드맵 수립을 지원하는데 활용될 수 있을 것으로 판단된다.

• BMB Reports
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• 제30권6호
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• pp.431-437
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• 1997

Since the role of CD40 on the interleukin-4(IL-4) -induced B cell activation has been strongly implicated in the agumentation of IgE production and response, we have investigated the intracelluar signaling pathways utilized by IL-4 and CD40 for type II IgE receptor (CD23) expression. IL-4 and anti-CD40 antibody treatment of human B cells, independently caused a rapid induction of CD23 gene activation within 2 h. There was a noticeable synergism between the action of the two agents inducing CD23 expression: the addition of anti-CD40 to the IL-4-treated culture significantly agumented the IL-4-induced CD23 on both mRNA and surface protein levels, and the inclusion of IL-4 in the anti-CD40-treated cells caused a further increase of CD23 expression far above the maximal level induced by anti-CD40. Protein tyrosine kinase (PTK) inhibitors effectively suppressed the both IL-4- and anti -CD40-induced CD23 expression. whereas protein kinase C (PKC) inhibitors had no effects. Electrophoretic mobility shift assays (EMSA) have shown that IL-4 and anti-CD40 induce the activation of NF-IL-4 and $NF-_{K}B$, respectively, binding to the CD23 promoter, both in a PKC-independent and PTK-dependent manner. These data suggest that the synergistic activation of CD23 gene expression by IL-4 and anti-CD40 is mediated by co-operative action of distinct nuclear factors. each of which is rapidly activated via PKC-independent and PTK-dependent process.

• Journal of Applied Biological Chemistry
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• 제59권1호
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• pp.37-43
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• 2016

Bioactive components of ultra-fine ground Saururus, the extraction yield increases when the leaves are ultra-fine ground. Comparison of normal-ground and ultra-fine ground Saururus chinensis leaves showed that the solid content and antiinflammatory activity of ultra-fine ground extracts was higher than that of normal-ground extracts. Lipopolysaccharide (LPS)-stimulated Raw 264.7 cells were treated with different concentrations of Saururus chinensis extract and the amount of nitric oxide (NO) was determined; LPS-treated cells produced 2 times more NO than cells that were not treated with LPS. Moreover, the NO production in cells treated with Saururus chinensis extract was inhibited in a concentration-dependent manner. Because the stimulant-induced NO production is regulated by the inducible nitric oxide synthase (iNOS), we measured the iNOS protein level to elucidate the mechanism by which the NO production was inhibited. We found that the amount of iNOS decreased dose-dependently. It was reduced by 53% at a Saururus chinensis extract concentration of $100{\mu}g/mL$. The protein expression of cyclooxygenase-2 (COX-2) in LPS-treated Raw 264.7 cells was inhibited by 31% at $100{\mu}g/mL$ of Saururus chinensis extract. Gel shift of the nuclear factor kappa B-DNA complex occurred in LPS-treated cells and the intensity of the band decreased gradually in a concentration-dependent manner. Ultra-fine ground Saururus chinensis extract had a concentration-dependent inhibitory effect on the production of prostaglandin $E_2$, tumor necrosis factor ${\alpha}$, interleukin $1{\beta}$ (IL-$1{\beta}$), IL-6, and IL-8 in LPS-treated Raw 264.7 cells, i.e., at $50{\mu}g/mL$ of Saururus chinensis extract, their levels were decreased by 53, 67, 52, 37, and 21% respectively.

• 한국콘텐츠학회논문지
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• 제18권9호
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• pp.217-230
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• 2018

제조업의 기술고도화에 따라 생산직 근무자들에게 요구되는 직무역량은 과거의 숙련도 중심에서 전문기술과 지식으로까지 확대되고 있어 인력과 역량 관리에 대한 패러다임이 변해야 경쟁력 유지와 안정적인 조직 운용이 가능한 상황이다. 다양한 분야에서 직무역량이 직무만족에 긍정적인 영향을 미친다는 연구 결과가 존재하지만 제조업 생산직 근무자들의 직무역량에 대한 연구자들의 시각은 숙련도에 국한되어 왔으며 이에 따라 생산직 근무자들의 확장된 직무역량에 대한 연구가 필요한 상황이다. 이에 본 연구에서는 제조 환경의 변화가 빠른 S기업의 가전제품 조립 공장의 생산직 근무자들을 대상으로 직무지식과 숙련도가 이직 의도에 미치는 영향과 직무만족의 매개효과를 실증 분석하였다. 분석 결과 생산직 근무자들의 직무지식, 숙련도는 직무만족에 긍정적인 영향을 주고 직무만족은 이직의도에 영향을 주는 것으로 확인되었다. 이는 최근 변화된 제조업 생산 조직의 역할을 배경으로 그 구성원들의 직무지식과 이직의도와의 관계를 측정함으로써 제조 근무자들의 직무역량 관리에 대한 기초 자료를 제공하는데 의의가 있다.

• 한국산학기술학회논문지
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• 제15권11호
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• pp.6782-6792
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• 2014

본 연구는 일개 대학병원 근무자 679명을 대상으로 신체 부담과 근골격계 증상이 직무 스트레스에 미치는 영향을 파악하였다. 분석 결과 직무스트레스에 영향을 미치는 관련 요인으로는 여성, 저연령층, 미혼, 교대근무자, 8시간 이상 근무자, 근무 경력이 낮은 군이 유의한 변수로 선정되었다. 직무 스트레스 수준은 비흡연(p=0.000), 운동을 하지 않는다(p=0.022) 및 비음주(p=0.038)에서 높았고 통계적으로도 유의한 차이를 보였다. 또한 직무스트레스에 영향을 미치는 관련 변수로 정신적 피로, 근골격계 증상, 피로수준 및 결혼상태가 직무스트레스 위험을 증가시킬 수 있다. 결론적으로 육체적 작업부담과 직무스트레스간의 쌍방향성 상승효과가 있음을 확인하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제21권2호
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• pp.181-189
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• 2008

The aim of this study was to evaluate the effects of $Ca^{2+}$, $HCO_3{^-}$ and BSA on the in vitro capacitation-associated protein tyrosine phosphorylation, hyperactivation and acrosome reaction in guinea pig sperm. Caudal epididymal sperm were incubated in four different groups: modified TALP (Tyrode's albumin lactate pyruvate) or TALP without one of the medium constituents ($Ca^{2+}$, $HCO_3{^-}$ and BSA). After incubation for the required time (0 h, 0.5 h, 1 h, 3 h, 5 h, and 7 h), sperm were removed for further experiment. The capacitation effect was assessed by CTC (Chlortetracycline) staining. Western blotting and indirect immunofluorescence were used to analyze the level and localization of tyrosine phosphorylation. The results showed that guinea pig sperm underwent a time-dependent increase in protein tyrosine phosphorylation during the in vitro capacitation and the percentage of protein tyrosine phosphorylated sperm increased from 36% to 92% from the beginning of incubation to 7 h incubation. Also, there was a shift in the site of phosphotyrosine-specific fluorescence from the head of sperm to both the head and the flagellum. Moreover, an absence of $Ca^{2+}$ or $HCO_3{^-}$ inhibited in vitro hyperactivation and acrosome reaction and decreased the phosphorylation of the proteins throughout the period of in vitro capacitation. However, an absence of BSA could not influence these processes if substituted by polyvinyl alcohol (PVA) in the medium.

• Ocean and Polar Research
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• 제37권3호
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• pp.211-223
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• 2015

Korean society has been recently promoting the restoration of coastal wetlands. These efforts might become the basis of a policy framework that compensates for the limitations of a regulation-oriented policy such as the designation of Marine Protected Areas (MPAs). The shift in government policy could contribute to strengthening the socioeconomic infrastructure of coastal development through the accumulation of ecological capital. Although our scientific efforts and social demands in regard to the ecological restoration of the coastal wetlands have increased during the past years, the bases for restoration in Korea requires that scientific, technological, financial, social and legal aspects be enhanced. The present study re-examined the concept and attitudes behind coastal wetland restoration in the light of changing circumstances in Korea. Herein, we first defined coastal wetland restoration as "An act of recovering the functions of the ecosystem of coastal wetlands to a state that resembles conditions prior to being damaged." Next, this study discussed the limitations and future directions of such restoration efforts based on the descriptive analyses of recent restoration practices from social, economic, and technological aspects. Finally, we suggest future policy directions regarding coastal wetland restoration on the basis of a PFST (Policy, Financial, Social, and Technological) analysis; 1) re-arranging legal mechanisms, 2) setting multi-dimensional restoration goals, 3) establishing a multi-discipline- and convergence based R&D system, 4) linking spatial management and local development to the restoration, 5) building restoration governance at the local level, 6) implementing an ecosystem service payment system, and 7) applying test-bed projects in accordance with proper directions.