• 대한교통학회지
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• 제26권2호
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• pp.81-88
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• 2008

장래교통수요에 대한 예측은 기본적으로 4단계 수요추정방법을 통해 이루어지지만, 각 단계마다의 변화가 최종수요예측 결과에 미치는 영향에 대해서는 고려되지 못하고 있다. 즉, 장래에 대한 예측이 많은 변동성을 내포하고 있음에도 수요예측분석과정은 점 추정치(point-estimation)의 값을 입력자료로 분석하여 최종결과물 또한 점추정값으로 제시하고 있어 교통수요의 가변성 및 탄력성을 반영하지 못하고 있다. 하지만 교통 상황이 급속히 변화는 우리나라의 현실을 볼 때 교통수요가 갖고 있는 가변성과 탄력성을 반영하여 결과를 분석할 수 있는 구간추정방식(Interval-estimation)의 방법론에 대한 연구가 필요하다. 본 연구에서는 장래교통수요 예측 과정의 가장 초기단계인 통행발생단계의 회귀분석모형 적용시 구간추정방식을 적용하여 상한값과 하한값을 함께 산출하였다. 상한값과 하한값에 의한 발생 도착량에 대해 4단계 교통모형을 적용하여 발생량-도착량에 대한 Balancing, 통행분포, 통행배정의 4단계과정을 적용하였고 수요분석 각 단계에서의 도출된 결과에 대해 비교하였다. 최종적으로, 통행배정 된 교통량의 변화비율을 링크특성과 함께 비교분석하였다. 본 연구를 통해 수요분석 시 입력 자료의 불확실성이 가져오는 영향을 파악하였으며 신뢰구간에 의한 결과를 비교분석함으로써 수요추정의 가변성이 미치는 영향을 평가하였다. 또한 수요분석의 가변성에 따른 링크교통량의 탄력성을 평가할 수 있는 방법을 제시함으로써 교통수요 추정시 분석방법의 가변성 및 탄력성을 고려할 수 있다고 판단된다.

• Journal of Microbiology and Biotechnology
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• 제14권6호
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• pp.1239-1248
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• 2004

The methylotrophic yeast Hansenula polymorpha has been extensively studied as a model organism for methanol metabolism and peroxisome biogenesis. Recently, this yeast has also attracted attention as a promising host organism for recombinant protein production. Here, we describe the fabrication and evaluation of a DNA chip spotted with 382 open reading frames (ORFs) of H. polymorpha. Each ORF was PCR-amplified using gene-specific primer sets, of which the forward primers had 5'-aminolink. The PCR products were printed in duplicate onto the aldehyde-coated slide glasses to link only the coding strands to the surface of the slide via covalent coupling between amine and aldehyde groups. With the partial genome DNA chip, we compared efficiency of direct and indirect cDNA target labeling methods, and found that the indirect method, using fluorescent-labeled dendrimers, generated a higher hybridization signal-to-noise ratio than the direct method, using cDNA targets labeled by incorporation of fluorescence-labeled nucIeotides during reverse transcription. In addition, to assess the quality of this DNA chip, we analyzed the expression profiles of H. polymorpha cells grown on different carbon sources, such as glucose and methanol, and also those of cells treated with the superoxide­generating drug, menadione. The profiles obtained showed a high-level induction of a set of ORFs involved in methanol metabolism and oxidative stress response in the presence of methanol and menadione, respectively. The results demonstrate the sensitivity and reliability of our arrays to analyze global gene expression changes of H. polymorpha under defined environmental conditions.

• 한국환경보건학회지
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• 제31권5호
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• pp.398-403
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• 2005

This study is undertaken to find the optimal method to make the decision on the degree of water pollution by comparison of K-WQI, KOE-WQI that is made for index with the water quality index and water quality environment standard of the Frame Act on Environment Policy as the result of survey for water quality reality on the major point of the Yeongsan river from 2002 to 2004. The water quality of major rivers has some differences depending on seasons. however, under the water quality standard by the $BOD_5$ density, most of rivers displayed the water quality level of $II{\sim}III$ grading, and on K-WQI that is classified by indexing for 10 categories of pH, DO, $BOD_5,\;COD,\;SS,\;T-N,\;NH_3-N,\;NO_{3^-}$ N, T-P, and E-Coli and classified into 5 groups from 100 points to 40 points, they displayed the score distribution of the first grade in water quality for $85{\sim}100$ points to the second grade in water quality for $70{\sim}84$ points. On KOE-WQI that is classified by indexing for 5 categories of pH, DO, $BOD_5$, COD and T-coli and classified into 5 groups from 90 points or above for outstanding and 29 points or below for very bad, and the water quality distribution is made ranged from the first grade in water quality for 90 points or more to the third grade in water quality for $69{\sim}50$ points. In addition, for the contribution of the water quality decline, the Environmental standard has significant dependency on the $BOD_5$ density, with K-WQI contributing in various water quality decline depending on the environment around the river area of $BOD_5,\;T-N,\;NH_3-N,\;NO_3-N,\;T-P$, and E-Coli, and KOE-WQI acting os the factor contributing to lower the water quality decline by $BOD_5$, COD, and T-coli. As such, the current water quality environment standard has high dependency on $BOD_5$ and KOE-WQI excludes some nitrogen and phosphorus that considers the river environment that the grade in water quality is set by some category, and K-WQI reflected well of the ecology environment of rivers with the diversity of the assessment factor as well as to have the low dependency of specific factor to be objective.

• 전자공학회논문지
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• 제49권10호
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• pp.202-208
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• 2012

태아심박의 모니터링은 태아의 안녕을 평가하기 위해 중요한 정보이다. 비관혈적인 태아심전도는 산모의 복부 신호로부터 추출될 수 있다. 따라서 산모 복부의 혼합 신호로부터 태아심전도를 추출하기 위해 많은 유망한 신호처리 방법들이 개발되어 왔다. 그러나 비관혈적인 태아심전도는 안정적인 신호 측정법이 부족하고 신호처리 방법의 어려움으로 여전히 임상에서 널리 적용되지 못하고 있다. 태아심전도를 추출하는 신호처리 결과는 가우시안 백색잡음에 의해 신호대잡음비가 낮아질 수 있다. 본 논문에서는 태아심전도에서 시간에 따라 변하는 백색잡음 신호를 제거하여 신호대잡음비를 높이기 위한 방법으로 시변 칼만 평활기를 제안하였고 그 가능성을 확인하였다. Wiener 과정을 시스템 모델로 설정하고 백색잡음 크기에 따라 공분산 행렬을 수정하였으며, 이를 통해 칼만 이득을 변화시켜 평활화 정도를 가변시킬 수 있도록 설계하였다. 5채널 태아심전도 모델을 이용하여 백색잡음의 크기에 따른 최적 공분산 행렬 값을 구하였고, 모의실험을 통해 제안된 방법의 가능성을 확인할 수 있었다.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회/대한산업공학회 1999년도 춘계공동학술대회:정보화시대의 지식경영
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• pp.426-426
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• 1999

;There are many sources of uncertainty in a typical production and inventory system. There is uncertainty as to how many items customers will demand during the next day, week, month, or year. There is uncertainty about delivery times of the product. Uncertainty exacts a toll from management in a variety of ways. A spurt in a demand or a delay in production may lead to stockouts, with the potential for lost revenue and customer dissatisfaction. Firms typically hold inventory to provide protection against uncertainty. A cushion of inventory on hand allows management to face unexpected demands or delays in delivery with a reduced chance of incurring a stockout. The proposed strategies are used for the design of a probabilistic inventory system. In the traditional approach to the design of an inventory system, the goal is to find the best setting of various inventory control policy parameters such as the re-order level, review period, order quantity, etc. which would minimize the total inventory cost. The goals of the analysis need to be defined, so that robustness becomes an important design criterion. Moreover, one has to conceptualize and identify appropriate noise variables. There are two main goals for the inventory policy design. One is to minimize the average inventory cost and the stockouts. The other is to the variability for the average inventory cost and the stockouts The total average inventory cost is the sum of three components: the ordering cost, the holding cost, and the shortage costs. The shortage costs include the cost of the lost sales, cost of loss of goodwill, cost of customer dissatisfaction, etc. The noise factors for this design problem are identified to be: the mean demand rate and the mean lead time. Both the demand and the lead time are assumed to be normal random variables. Thus robustness for this inventory system is interpreted as insensitivity of the average inventory cost and the stockout to uncontrollable fluctuations in the mean demand rate and mean lead time. To make this inventory system for robustness, the concept of utility theory will be used. Utility theory is an analytical method for making a decision concerning an action to take, given a set of multiple criteria upon which the decision is to be based. Utility theory is appropriate for design having different scale such as demand rate and lead time since utility theory represents different scale across decision making attributes with zero to one ranks, higher preference modeled with a higher rank. Using utility theory, three design strategies, such as distance strategy, response strategy, and priority-based strategy. for the robust inventory system will be developed.loped.

• 한국산학기술학회논문지
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• 제21권3호
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• pp.269-275
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• 2020

무기체계를 지원하는 요소들 중에 있어서 RAM 업무는 개발 초기단계에 수행되며, 무기체계의 작전요구성능과 함께 설계 관점에서 무기체계가 달성해야 할 기준으로 제시된다. RAM 업무 중 운용가용도는 전투준비태세를 보장하고 전쟁에서 승리하기 위한 군의 핵심요소로서, 무기체계 개발 단계에서 개발기준으로 사용되고 있다. 이러한 운용가용도의 요소에는 평균 고장간 시간, 평균 수리시간, 행정 및 군수 지연시간(ALDT: Administrative and Logistic Delay Time, 이하 ALDT) 등이 있으며, ALDT는 무기체계의 노후화, 정비정책 및 지리적인 특수상항에 달라지는 요소로 군의 전투준비태세를 위해 유지해야 하는 운용가용도의 핵심요소라고 할 수 있다. 개발 간 군은 운용가용도의 요소 중 ALDT, 운용 및 대기 시간 등을 제공하며, 제공시 ALDT가 단순 가정으로 제시되어 개발단계에서 설정되어 산출되는 운용가용도는 실제 운용단계에서 분석한 운용가용도와 상이하다. 따라서, 본 논문에서는 초기 전력화 기간 동안 획득한 고장정비 데이터를 의사결정계보기법을 적용하여 ALDT를 산출하였으며, 본 연구를 통해 전력화 운용기간 동안 개발시 설정한 운용가용도를 달성하기 위한 최적의 ALDT 설정 방안을 제시한다.

• 유통과학연구
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• 제13권5호
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• pp.71-82
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• 2015

Purpose - The purpose of this study is to investigate risk price implied from the pricing kernel of Korean stock distribution market. Recently, it is considered that the quantitative easing programs of major developed countries are contributing to a reduction in global uncertainty caused by the 2007~2009 financial crisis. If true, the risk premium as compensation for global systemic risk or economic uncertainty should show a decrease. We examine whether the risk price in the Korean stock distribution market has declined in recent years, and attempt to provide practical implications for investors to manage their portfolios more efficiently, as well as academic implications. Research design, data and methodology - To estimate the risk price, we adopt a non-parametric method; the minimum norm pricing kernel method under the LOP (Law of One Price) constraint. For the estimation, we use 17 industry sorted portfolios provided by the KRX (Korea Exchange). Additionally, the monthly returns of the 17 industry sorted portfolios, from July 2000 to June 2014, are utilized as data samples. We set 120 months (10 years) as the estimation window, and estimate the risk prices from July 2010 to June 2014 by month. Moreover, we analyze correlation between any of the two industry portfolios within the 17 industry portfolios to suggest further economic implications of the risk price we estimate. Results - According to our results, the risk price in the Korean stock distribution market shows a decline over the period of July 2010 to June 2014 with statistical significance. During the period of the declining risk price, the average correlation level between any of the two industry portfolios also shows a decrease, whereas the standard deviation of the average correlation shows an increase. The results imply that the amount of systematic risk in the Korea stock distribution market has decreased, whereas the amount of industry-specific risk has increased. It is one of the well known empirical results that correlation and uncertainty are positively correlated, therefore, the declining correlation may be the result of decreased global economic uncertainty. Meanwhile, less asset correlation enables investors to build portfolios with less systematic risk, therefore the investors require lower risk premiums for the efficient portfolio, resulting in the declining risk price. Conclusions - Our results may provide evidence of reduction in global systemic risk or economic uncertainty in the Korean stock distribution market. However, to defend the argument, further analysis should be done. For instance, the change of global uncertainty could be measured with funding costs in the global money market; subsequently, the relation between global uncertainty and the price of risk might be directly observable. In addition, as time goes by, observations of the risk price could be extended, enabling us to confirm the relation between the global uncertainty and the effect of quantitative easing. These topics are beyond our scope here, therefore we reserve them for future research.

• Journal of the Korean Wood Science and Technology
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• 제43권4호
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• pp.456-462
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• 2015

KS F 3020-침엽수구조용재 기준에 따라 국산 소나무(Pinus densiflora) $38{\times}140{\times}3600mm$ 구조용 제재목 365개에 대하여 기계등급구분을 실시하고, 휨허용응력을 산출하여 현재 적용되는 KS기준허용응력과 비교 분석하였다. 휨허용응력 계산을 위하여 5% 휨강도 하한값을 75% 신뢰수준의 비모수적 방법, 2-parameter 그리고 3-parameter Weibull 분포를 가정한 모수적 방법, 휨강도-휨탄성계수 직선회귀 방법, 총 4가지 분석방법을 사용하여 결정하였다. 기계등급 E8, E9, E10 만이 비모수적 방법의 통계 처리가 가능한 자료 수를 얻었으며, 휨강도-휨탄성계수 직선회귀 방법은 이론적으로 모든 등급에 대한 5% 하한값 결정이 가능함을 보여주었다. 결정된 등급별 휨허용응력은 기준허용응력에 비하여 모두 낮은 값을 나타내었으며 이것은 과소설계의 위험성이 있는 것으로 현행 기계등급구분체계의 문제점으로 파악되었다. 이러한 문제는 구조설계 신뢰성과 관련하여 반드시 개선되어야 할 것으로, 휨강도-휨탄성계수 조합 등급 도입이 필요할 것으로 생각되었다.

• 대한치과보철학회지
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• 제44권4호
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• pp.394-404
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• 2006

Statement of problem: A conventional 3-unit fixed partial denture design with a pontic between two retainers is the most commonly used. However in cases where the mental nerve is in close proximity to the second premolar, a cantilever design can be considered. As such, logical and scientific evidence is lacking for the number and position of implants to be placed for partially edentulous patients, and no clear-cut set of treatment principles currently exist. Purpose : The purpose of this study was to evaluate prognosis of implant-supported fixed partial dentures and to compare changes in bone level which may rise due to the different factors. Material and method : The present study examined radiographical marginal bone loss in patients treated with implant-supported fixed partial dentures (87 prostheses supported by 227 implants) and evaluated the influence of the span of the pontic, type of the opposing dentition. Clinical complications were studied using a retrospective method. Within the limitation of this study. the following result were drawn Result, 1. Seven of a total of 227 implants restored with fixed prostheses failed, resulting in a 96.9% success rate. 2. Complications encountered during recall appointments included dissolution of temporary luting agent (17 cases), porcelain fracture (8 cases), loosened screws (5 cases), gingival recession (4 cases), and gingival enlargement (1 case). 3. Marginal bone loss, 1 year after prosthesis placement, was significant(P<0.05) in the group that underwent bone grafting, however no difference in annual resorption rate was observed afterwards. 4. Marginal bono loss, 1 year post-placement, was greater in cantilever-type prostheses than in centric pontic protheses (P<0.05). 5. Marginal bone loss was more pronounced in posterior regions compared to anterior regions (P<0.05). 6. The degree of marginal bone loss was proportional to the length of the pontic (P<0.05). Conclusion: The success rate of implant-supported fixed partial dentures, including marginal bone loss, was satisfactory in the present study. Factors influencing marginal bone loss included whether bone graft was performed, location of the pontic (s), location of the surgical area in the arch pontic span. Long-term evaluation is necessary for implant-supported fixed partial dentures, as are further studies on the relationship between functional load and the number of implants to be placed.

• 대한디지털의료영상학회논문지
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• 제5권1호
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• pp.32-44
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• 2002

The role of radiology department has been greatly increased in the past few years as the technology in the medical imaging devices improved and the introduction of PACS (Picture Archiving and Communications System) to the conventional film-based diagnostic structure is a truly remarkable factor to the medical history. In addition, the value of using digital information in medical imaging is highly expected to grow as the technology over the computer and the network improves. However, the current medical practice, using PACS is somewhat limited compared to the film-based conventional one due to a poor image quality. The image quality is the most important and inevitable factor in the PACS environment and it is one of the most necessary steps to more wide practice of digital imaging. The existing image quality control tools are limited in controlling images produced from the medical modalities, because they cannot display the real image changing status. Thus, the image quality is distorted and the ability to diagnosis becomes hindered compared to the one of the film-based practice. In addition, the workflow of the radiologist greatly increases; as every doctor has to perform his or her own image quality control every time they view images produced from the medical modalities. To resolve these kinds of problems and enhance current medical practice under the PACS environment, we have developed a program to display a better image quality by using the ROI optical density of the existing gray level values. When the LUT is used properly, small detailed regions, which cannot be seen by using the existing image quality controls are easily displayed and thus, greatly improves digital medical practice. The purpose of this study is to provide an easier medical practice to physicians, by applying the technology of converting the H-D curves of the analog film screen to the digital imaging technology and to preset image quality control values to each exposed body part, modality and group of physicians for a better and easier medical practice. We have asked to 5 well known professional physicians to compare image quality of the same set of exam by using the two different methods: existing image quality control and the LUT technology. As the result, the LUT technology was enormously favored over the existing image quality control method. All the physicians have pointed out the far more superiority of the LUT over the existing image quality control method and highly praised its ability to display small detailed regions, which cannot be displayed by existing image quality control tools. Two physicians expressed the necessity of presetting the LUT values for each exposed body part. Overall, the LUT technology yielded a great interest among the physicians and highly praised for its ability to overcome currently embedded problems of PACS. We strongly believe that the LUT technology can enhance the current medical practice and open a new beginning in the future medical imaging.