• Journal of Microbiology and Biotechnology
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• 제11권2호
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• pp.287-293
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• 2001

A fast and easy PCR-SSCP method was developed and assessed for the early detection of rifampin-resistant Mycobacterium leprae in skin biopsy samples from Korean leprosy patients. The 190 bp of the rpoB gene, in which mutation is known to cause resistance to rifampin, was amplified by PCR and then analyzed by SSCP and DNA sequencing, All PCR products showing mobility shift on PCR-SSCP contained mutations, demonstrating that this method can be used for an early diagnositic method to detect a putative rifampin-resistant M. leprae strain. DNA sequence analysis revealed that 19 of 34 patient samples contained M. leprae strains with missense mutations in the rpoB gene: five were the same mutations previously reported to cause rifampin resistance and eight were the new type of mutatios that likely cause rifampin resistance. These newly identified dmutations, whose all five cytosine bases of four amino acids were substitued with thymine, were found at different sites from those reported in Mycobacterium tuberculosis or M. leprae. Therefore, they may provide additional clues to understand the molecular biological basis on the rifampin resistance of M. leprae.

• 대한건축학회논문집:계획계
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• 제34권8호
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• pp.105-116
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• 2018

The architecture reflects geographical characteristics such as geographical environments and climate, it has the characteristics and cultural characteristics of the region that has been constructed. Hansen Village constructed in Period of Japanese Occupation at 'Sorok-Island' in Go-heung, Jeollanam-do was also based on this point. The village, which is a ward of Sorok-Island Province, consists of a village in which patients are self-sufficient in economic and social activities, unlike the modern hospital systems where patients and treatments are concentrated in a single room. Additionally, the facilities for patient acceptance were gradually expanded, with limited interaction with external. Sorok-island shows the expansion of the village center where the new village is formed with the increase of the number of the early adopters in the 1910s and the accommodation facility is built, and it gradually increases the necessary space by opening and repairing the existing facilities by the 1990s Change. In addition, the spatial composition of the village can be divided into three types : decentralized, centralized and single-shift ; it has the same causal relationship as the village's formation. The purpose of this study is identifying the uniqueness of Sorok-Island by analyzing the correlation between the formation of a village to accommodate Hansen Patients in Sorok-Island and the spatial Component Factor.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제19권4호
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• pp.7-18
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• 2013

Purpose: The aim of this paper is to reduce the stress and the disturbance occur in selective action of patient. This article will also help us to control spreading and reduce the order and bacteria produced by leprosy disease among the lepers. This will be achieved with the help of several variables and these variables help us on health benefits is 5S (Sort, Straighten, Shine, Standardize, Sustain) i.e. ratio of sectional morphology, lessor 90 degree angles, day light, universal design building and maximum ventilation. The replies from the questionnaire were collected based on varying levels of satisfaction and gloominess on the scale of 1-10. Methods: The multi-layer methodological framework for maximising the healing environment obtained from the observation of schemes and parameters of ANOVA: (Analysis Of Variance between five deciding factors) are. Firstly applied for the calculation of the patient's satisfaction for U.V light from sun on ECOTECT simulation, secondly the number of $90^{\circ}$ angle, along the corridors. Thirdly understanding the ways to represent people's perceptual structures and way finding with Space Syntax software. Fourthly the ratio of depth to height of the building typology and finally interviewing the subjects describing their special experiences based on scale value. The focus of this testing of human subjects was to receive data for the existence of image scheme in way-finding and to identify the mechanisms by which sun light impacts human (lepers) health. Results: AMPVA studies concluded that there is similarity between I and O plan as well as L and H plan whereas U plan was difference among the five selected architectural shapes. Implications: The purpose of this research is to show the effects of the I-type, L-type, C-type, U-type and O-type plan design, and to analyse the morphology for EBD (Evidence-Based Design) healing environment which is a universal design for Munghopir Karachi, in Pakistan.

• 대한미생물학회지
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• 제13권1호
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• pp.49-54
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• 1978

응집반응(凝集反應)을 이용(利用)하여 각종(各種) 종양환자(腫瘍患者), 정신분열증환자(精神分裂症患者) 및 정상인(正常人)의 Propionibacterium acres(동의어(同義語) Corynebacterium parvum))에 대(對)한 항체가(抗體價)를 측정(測定)하였든바 각종환자(各種患者) 및 정상인(正常人)에게 P. acnes에 대(對)한 항체(抗體)가 검색(檢索)되었다. 종양환자(腫瘍患者)의 항체가(抗體價)는 정상인에 비(比)해 유의(有意)하게 저하(低下)되어 있었다. 나환자(癩患者)의 항체가(抗體價)는 다소(多少) 낮았으며, 나종형환자(癩腫型患者)의 항체가(抗體價)는 유결핵형환자(類結核型患者)에 비(比)해 다소(多少) 낮은 경향(傾向)이었다. 그러나 정신분류증환자(精神分類症患者)의 항체가(抗體價)는 정상인(正常人)의 그것과 비슷하였다. 대체적(大體的)으로 각종환자(各種患者) 및 정상인(正常人)에게 연령(年齡) 및 성별(性別)에 따른 항체(抗體) 가(價)로 차이(差異)가 없었다.

• 한국안광학회지
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• 제3권1호
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• pp.137-143
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• 1998

나환자 111명을 대상으로 외안각 간격(IOCD), 내안각 간격(IICD), 눈꺼풀틈새 폭 (WPF) 그리고 백내장, 각각, 눈꺼풀 이상을 조사한 결론은 다음과 같다. 외안각 간격의 평균치는 낭자 89.8 mm, 여자 88.4 mm이었고, 내안각 간격은 남자 36.9 mm, 여자 35.8 mm이었으며, 눈꺼풀틈새 폭은 남자 52.9 mm, 여자 52.6 mm이었다. 연령에 따른 연화는 외안각 간격과 눈꺼풀틈새 폭이 좁아졌지만, 내안각 간격은 차이가 없었다. 나병의 눈합병증은 각막이상 37.8%, 눈꺼풀 이상 19.4% 그리고 백내장 29.7%으로 각막 병변이 주증상 이었다. 이들 중상은 남, 여 차이는 없지만 나이가 많아짐에 따라 발병빈도가 높아져 실명과 저시력 환자가 증가하였다.

• Annals of Clinical Neurophysiology
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• 제4권1호
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• pp.34-37
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• 2002

Background : The term "mononeuropathy multiplex" means simultaneous or sequential involvement of individual noncontiguous nerve trunks, evolving over days to years. The aim of this study was to delineate the causes, clinical features, and detailed electrophysiological findings in the patients with mononeuropathy multiplex. Methods : We analyzed the medical records of 22 patients with mononeuropathy multiplex confirmed on electrophysiological studies in Inje University Seoul Paik Hospital, Seoul Municipal Boramae Hospital, and Seoul National University Hospital between 1991 to 2000. Results : The number of male and female patients was equal. The mean age was 48 years with a peak incidence in the sixth decade. The etiology could be divided into vasculitis(11 patients) or non-vasculitis group. In vasculitis group, Churg-Strauss syndrome, polyarteritis nodosa, and rheumatoid arthritis were included. The non-vasculitis group included diabetes mellitus, leprosy, and Guillain-Barre syndrome. Ulnar and median nerves were most commonly involved(91%). In descending order of frequency, peroneal, posterior tibial, sural, and radial nerves were also involved. Bilateral involvement occurred most commonly in ulnar nerve. The symptoms and signs of mononeuropathy multiplex were the initial manifestations in 12 patients(55%), which was more frequent in vasculitis group(73%). Nerve conduction abnormalities could be divided into axonal, demyelinating, or mixed type. Most(91%) of the patients in vasculitis group revealed axonal type abnormalities. The location of the nerve lesion was frequently related to potential site of entrapment in demyelinating type. Conclusions : Mononeuropathy multiplex is the presenting features of the etiological disease frequently, especially in vasculitis group. Nerve conduction studies(NCS) reveals not only axonal type but also demyelinating type abnormalities. The etiological diseases were different in each type. Therefore, NCS is very helpful for the early etiological diagnosis and therapeutic implication in the patients with mononeuropathy multiplex.