• Journal of Microbiology and Biotechnology
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• v.11 no.2
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• pp.287-293
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• 2001

A fast and easy PCR-SSCP method was developed and assessed for the early detection of rifampin-resistant Mycobacterium leprae in skin biopsy samples from Korean leprosy patients. The 190 bp of the rpoB gene, in which mutation is known to cause resistance to rifampin, was amplified by PCR and then analyzed by SSCP and DNA sequencing, All PCR products showing mobility shift on PCR-SSCP contained mutations, demonstrating that this method can be used for an early diagnositic method to detect a putative rifampin-resistant M. leprae strain. DNA sequence analysis revealed that 19 of 34 patient samples contained M. leprae strains with missense mutations in the rpoB gene: five were the same mutations previously reported to cause rifampin resistance and eight were the new type of mutatios that likely cause rifampin resistance. These newly identified dmutations, whose all five cytosine bases of four amino acids were substitued with thymine, were found at different sites from those reported in Mycobacterium tuberculosis or M. leprae. Therefore, they may provide additional clues to understand the molecular biological basis on the rifampin resistance of M. leprae.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.8
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• pp.105-116
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• 2018

The architecture reflects geographical characteristics such as geographical environments and climate, it has the characteristics and cultural characteristics of the region that has been constructed. Hansen Village constructed in Period of Japanese Occupation at 'Sorok-Island' in Go-heung, Jeollanam-do was also based on this point. The village, which is a ward of Sorok-Island Province, consists of a village in which patients are self-sufficient in economic and social activities, unlike the modern hospital systems where patients and treatments are concentrated in a single room. Additionally, the facilities for patient acceptance were gradually expanded, with limited interaction with external. Sorok-island shows the expansion of the village center where the new village is formed with the increase of the number of the early adopters in the 1910s and the accommodation facility is built, and it gradually increases the necessary space by opening and repairing the existing facilities by the 1990s Change. In addition, the spatial composition of the village can be divided into three types : decentralized, centralized and single-shift ; it has the same causal relationship as the village's formation. The purpose of this study is identifying the uniqueness of Sorok-Island by analyzing the correlation between the formation of a village to accommodate Hansen Patients in Sorok-Island and the spatial Component Factor.

• Journal of The Korea Institute of Healthcare Architecture
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• v.19 no.4
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• pp.7-18
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• 2013

Purpose: The aim of this paper is to reduce the stress and the disturbance occur in selective action of patient. This article will also help us to control spreading and reduce the order and bacteria produced by leprosy disease among the lepers. This will be achieved with the help of several variables and these variables help us on health benefits is 5S (Sort, Straighten, Shine, Standardize, Sustain) i.e. ratio of sectional morphology, lessor 90 degree angles, day light, universal design building and maximum ventilation. The replies from the questionnaire were collected based on varying levels of satisfaction and gloominess on the scale of 1-10. Methods: The multi-layer methodological framework for maximising the healing environment obtained from the observation of schemes and parameters of ANOVA: (Analysis Of Variance between five deciding factors) are. Firstly applied for the calculation of the patient's satisfaction for U.V light from sun on ECOTECT simulation, secondly the number of $90^{\circ}$ angle, along the corridors. Thirdly understanding the ways to represent people's perceptual structures and way finding with Space Syntax software. Fourthly the ratio of depth to height of the building typology and finally interviewing the subjects describing their special experiences based on scale value. The focus of this testing of human subjects was to receive data for the existence of image scheme in way-finding and to identify the mechanisms by which sun light impacts human (lepers) health. Results: AMPVA studies concluded that there is similarity between I and O plan as well as L and H plan whereas U plan was difference among the five selected architectural shapes. Implications: The purpose of this research is to show the effects of the I-type, L-type, C-type, U-type and O-type plan design, and to analyse the morphology for EBD (Evidence-Based Design) healing environment which is a universal design for Munghopir Karachi, in Pakistan.

• The Journal of the Korean Society for Microbiology
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• v.13 no.1
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• pp.49-54
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• 1978

Antibodies to Propionibacterium acnes in patients with tumor, leprosy, schizophrenia and normal human were measured by using a microtiter bacterial agglutination test. They were found in all sera examined, including normal human sera. It was comfirmed that a microtiter bacterial agglutination test on P. acnes is found to be an easy and satisfactory method for the measurement of antibody to P. acnes. The agglutinin titers of tumor patients, particularly hepatoma and gastric cancer patients, were significantly lower as compared with those of normal human sera. Antibody titers in leprosy patients were somewhat lower when compared with those in normal human sera. Antibody titers of lepromatous type of leprosy patient were lower than those of tuberculoid type. However, antibody levels were the same in schizophrenia patient and normal human. No correlation between antibody titers and age or sex of the patients and normal human was found.

• Journal of Korean Ophthalmic Optics Society
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• v.3 no.1
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• pp.137-143
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• 1998

The measurement of the inter outer canthal distance(IOCD), inter inner canthal distance(IICD), width palpebral fissure (WPF) and distribution of cataract, corneal abnormality and palpebral abnormality-were followed in III Korean in leprosy patient. The average dimension of IOCD was in male 89.9 mm and in female 88.4 mm, IICD were in male 36.9 mm and female 35.8 mm, and LPF was in male 52.9 mm, female 52.6 mm. The IOCD and LPF were decreased but IICD was not 29.7%, palpebral abnormality was 19.4% and corneal abnormality was 37.8%. These data were not changed by sex but increased by age. So the causes of visual impairment int the disease were corneal abnormalities that were the most common complications.

• Annals of Clinical Neurophysiology
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• v.4 no.1
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• pp.34-37
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• 2002

Background : The term "mononeuropathy multiplex" means simultaneous or sequential involvement of individual noncontiguous nerve trunks, evolving over days to years. The aim of this study was to delineate the causes, clinical features, and detailed electrophysiological findings in the patients with mononeuropathy multiplex. Methods : We analyzed the medical records of 22 patients with mononeuropathy multiplex confirmed on electrophysiological studies in Inje University Seoul Paik Hospital, Seoul Municipal Boramae Hospital, and Seoul National University Hospital between 1991 to 2000. Results : The number of male and female patients was equal. The mean age was 48 years with a peak incidence in the sixth decade. The etiology could be divided into vasculitis(11 patients) or non-vasculitis group. In vasculitis group, Churg-Strauss syndrome, polyarteritis nodosa, and rheumatoid arthritis were included. The non-vasculitis group included diabetes mellitus, leprosy, and Guillain-Barre syndrome. Ulnar and median nerves were most commonly involved(91%). In descending order of frequency, peroneal, posterior tibial, sural, and radial nerves were also involved. Bilateral involvement occurred most commonly in ulnar nerve. The symptoms and signs of mononeuropathy multiplex were the initial manifestations in 12 patients(55%), which was more frequent in vasculitis group(73%). Nerve conduction abnormalities could be divided into axonal, demyelinating, or mixed type. Most(91%) of the patients in vasculitis group revealed axonal type abnormalities. The location of the nerve lesion was frequently related to potential site of entrapment in demyelinating type. Conclusions : Mononeuropathy multiplex is the presenting features of the etiological disease frequently, especially in vasculitis group. Nerve conduction studies(NCS) reveals not only axonal type but also demyelinating type abnormalities. The etiological diseases were different in each type. Therefore, NCS is very helpful for the early etiological diagnosis and therapeutic implication in the patients with mononeuropathy multiplex.