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공황장애의 뇌영상 및 신경생물학적 식견 (Brain Imaging Provides Insight into the Neurobiology of Panic Disorder)

  • 박주언;강은호;이인수;유범희
    • 대한불안의학회지
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    • 제3권2호
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    • pp.91-96
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    • 2007
  • Panic disorder is a common psychiatric illness that causes considerable morbidity. However, the biological basis of panic disorder remains unclear. In this report, we present and summarize the current literature on functional neuroimaging studies related to the neurobiology of panic disorder. The findings were summarized and divided into six groups : (1) known brain structures related to anxiety, especially panic disorder ; (2) structural results ; (3) functional imaging studies at rest ; (4) functional imaging studies with challenge testing ; (5) neuroreceptor studies ; and (6) changes in the treatment of panic disorder. Based on the findings of these neuroimaging studies, it seems as though panic disorder involves the hippocampal and parahippocampal areas, including the amygdala, as well as some cortical regions, such as the temporal and prefrontal cortices. Panic disorder is known to be associated with an imbalance between the right and left hemispheres of the brain at rest or during panic attacks. During a panic attack, patients with panic disorder are likely to experience an increase in local activity in the cingulate, insula, midbrain, and so on. On the other hand, a widespread reduction in the cortical areas has also been reported in most provocation studies. Thus, panic disorder may be related to the excess activation of the fear networks in response to subtle environmental cues and insufficient inhibition from higher cortical control areas ; however ; further studies are recommended in order to fully understand the neurobiology of panic disorder.

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조선후기(朝鮮後期) 충청도(忠淸道) 전의현(全義縣) 관아건축(官衙建築)의 배치구성(配置構成)에 관한 연구(硏究) (Site Layout of ChungChong-Do Chonui-hyon Government Office in the Late Chosen Dynasty)

  • 김기덕;이재헌
    • 건축역사연구
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    • 제10권4호
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    • pp.7-21
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    • 2001
  • This study is to analyze site layout traditional government office building focused on Chonui-hyon(全義縣) in Chungchong province with Chungchong-do regional maps(忠淸道地方地圖) and Eupjis(邑誌, topography) being compiled in the late Chosun dynasty. The conclusion of analysis can be summarized as follows; 1. Chonui-hyon(全義縣) in Chosun dynasty is gone with a planning principle of the capital city(Han-Seong, 漢城) with disposing Sa-Ji-Dan(社稷壇) and Gaek-Sa(客舍), which are placed to the left and right of Eupchi(邑治), and it is followed in the wake of the spatial structure of Chosun dynasty palace with disposing Dong-Heon(東軒) in front, Nae-A(內衙) at the back of it, or from side to side, also by the Dong-Heon of the center, with organizing each facility around it. 2. Dong-Heon and Gaek-Sa of Chonui-hyon is passed through three step gate, Mun-Ru(門樓), Woi-Sammun(外三門), Nae-Sammun(內三門), from Hong-Salmon(紅門), and are shown hierarchy by haying been placed at the end of approach axis. 3. Dong-Heon can be disposed by Feng-Shui(風水) which have influence on the southeast direction with Jin-San(鎭山) and An-Dae(案對), on the other hand, Gaek-Sa can be disposed by symbolic of the authority of a king. 4. Site layout by function of provincial government office is provided into four ferrite, Dong-Heon, Gaek-Sa, Nae-A, practical business territory, and eve territory is organized by official institution on a social position to radiation, by the compositive axis to be made Woi-Sammun Nae-Sammun Dong-Heon Nae-A 5. Approach process of Chnui-hyon government office is three door system similar to Kam-Young(監營) in a different way two door system in most provincial government office, also approach axis is formed by bending.

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Effect of the Positions of Female Pro-Volleyball Players on the Stability of Shoulder Joints of the Dominant and Non-dominant Arms

  • Kim, Yong-Yeon;Shin, Hee-Joon;Kim, Bo-Kyung;Koo, Ja-Pung;Park, Joo-Hyun;Kim, Nyeon-Jun;Yun, Young-Dae;An, Ho-Jung
    • 국제물리치료학회지
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    • 제2권1호
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    • pp.229-236
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    • 2011
  • The purpose of this study was to comparatively analyze the active stability of shoulder joints according to the frequency of overhead motions, such as serving and spiking, engaged in by female professional volleyball athletes who play different positions, and to provide the results as the basic data for developing exercise programs to prevent shoulder joint injuries. The subjects of this study were 50 Korean female professional volleyball players and positions were as follows: left and right attackers, centers, setters, and liberos. The external rotation and internal rotation muscle strength and muscle strength ratios of the dominant and non-dominant arms of all subjects were measured using Biodex. The results of this study are as follows: Frist, no significant differences were found in the internal and external rotation muscle strength of the dominant and non-dominant arms between positions. Second, for the shoulder joint muscle strength ratio of the dominant arm, by position, the setter showed significantly greater stability compared to the other positions. Third, for the shoulder joint muscle strength ratio of the non-dominant arm, by position, no significant difference in stability between positions was found. Fourth, it was found that the dominant arm had significantly greater instability of the shoulder joint than the non-dominant arm for attackers and centers, but no significant difference was found for setters and liberos. This study comparatively analyzed the muscle strength ratios of the external/internal rotations and dominant/non-dominant arms, which can determine the stability of the shoulder joints between female professional volleyball playing positions that engage in jumps and spikes using only the dominant hand and positions that do not.

Narrator as Collective 'We': The Narrative Structure of "A Rose for Emily"

  • Kim, Ji-Won
    • 영어어문교육
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    • 제17권4호
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    • pp.141-156
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    • 2011
  • This study purposes to explore the narrative of fictional events complicated by a specific narrator, taking notice of his/her role as an internal focalizer as well as an external participant. In William Faulkner's "A Rose for Emily," the story of an eccentric spinster, Emily Grierson, is focalized and narrated by a townsperson, apparently an individual, but one who always speaks as 'we.' This tale-teller, as a first-hand witness of the events in the story, details the strange circumstances of Emily's life and her odd relationships with her father, her lover, the community, and even the horrible secret hidden to the climactic moment at the end. The narrative 'we' has surely watched Emily for many years with a considerable interest but also with a respectful distance. Being left unidentified on purpose, this narrative agent, in spite of his/her vagueness, definitely knows more than others do and acts undoubtedly as a pivotal role in this tale of grotesque love. Seamlessly juxtaposing the present and the past, the collective 'we' suggests an important subject that the distinction between the past and the present is blurred out for Emily, for whom the indiscernibleness of time flow proves to be her hamartia. The focalizer-narrator describes Miss Emily in the same manner as he/she describes the South whose old ways have passed on by time. Like the Old South, Emily is desperately trapped in the past, since she has not been able to adjust to the changes brought on by time. In the end, the tragic story of Emily Grierson which takes place in Jefferson plainly seems to serve as an introduction to mature Faulkner.

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MCT(medium-chain triglyceride) 및 LCT(long-chain triglyceride) 유제가 백서에서 허혈/재관류 심장기능손상 및 혈소판응집능에 미치는 영향 (Effect of MCT (medium-chain triglyceride) and LCT (long-chain triglyceride) on Myocardial Ischemia/Reperfusion Injury and Platelet Aggregation in Rat)

  • 이수환;정이숙;홍정;김민화;이희주;백은주;왕희정;김명욱;문창현
    • Biomolecules & Therapeutics
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    • 제6권4호
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    • pp.358-363
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    • 1998
  • Intravenous lipid emulsion is used extensively as a major component of parenteral nutrition for patients in the surgical intensive care unit. Abnormal cardiovascular function related to lipid infusion has been reported although conflicting results exist. In the present study, we investigated the effects of intravenous emulsions of long-chain triglyceride (LCT) and medium-chain triglyceride (MCT) on myocardial ischemia/ reperfusion injury and on platelet aggregation in rat. There was no difference between LCT and MCT considering the effects on left ventricular developed pressure (LVDP) and coronary flow rate (CFR) before and after ischemia/reperfusion in isolated rat heart. On the other hand, a difference was found between LCT and MCT with regard to their effects on heart rate (HR) and end diastolic pressure (EDP) after ischemia/reperfusion. After ischemia/reperfusion, HR was significantly (P<0.05) reduced and EDP significantly (P<0.05) inc.eased by LCT (18$\pm$2.0% and 42.8$\pm$8.9%, respectively), but not by MCT Ex vivo platelet aggregation induced by collagen was reduced by LCT infusion, but not by MCT These findings suggest that MCT may have slightly more favorable effect than LCT on the myocardial function after ischemia/reperfusion in rat.

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CO2 Laser와 Scalpel을 이용한 절개 시 돼지 방광에서의 창상치유 평가 (Comparative study of wound healing in porcine urinary bladder with CO2 laser and scalpel incisions)

  • 이재연;정성목;조성환;박창식;김명철
    • 대한수의학회지
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    • 제50권3호
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    • pp.247-251
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    • 2010
  • This study compared the instrument performance and tissue healing of a steel scalpel with a $CO_2$ laser in an animal urinary bladder surgery model. Landrace and Yorkshire mixed breed pigs were used. Two symmetrical incisions were made in urinary bladder of each pig. One incision was made on the left side of ventral aspect on urinary bladder using a steel scalpel, while the other incision was performed on the right side using a $CO_2$ laser with an 8W output power. Each instrument was evaluated clinically for speed, ease of incision, and extent of bleeding. At 7 and 21 days after initial wounding, each wound was taken for histological observations. The scalpel was an easier instrument to use in the confines of the urinary bladder tissue, compared with the laser. However, there was no significant difference between the two groups. The amount of bleeding was less in the laser group but the time of the incisions was shorter with the scalpel. Scalpel incisions showed complete restoration of the epithelium and muscularis. On the other hand, the laser incisions showed incomplete restoration of the epithelium and muscularis. However, most of wound healing in the laser incisions was accomplished according to the time lapse. Although the scalpel produced less damage to the urinary bladder tissue and was easier to handle than the $CO_2$ laser, it did not provide hemostasis that was helpful for use on highly vascular tissue. The $CO_2$ laser provided good hemostasis, but delayed wound healing. In conclusion, the $CO_2$ laser provided better hemostasis and better surgical field than the scalpel. The $CO_2$ laser was used effectively in urinary bladder incision.

An overlap syndrome of Churg-Strauss syndrome and rheumatoid arthritis

  • Bae, Seung Il;Jang, Jong Geol;Kim, Hun Tae;Ahn, Hee Yun;Kim, Min Jung;Kim, Hyun Je;Lee, Choong Ki;Hong, Young Hoon
    • Journal of Yeungnam Medical Science
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    • 제32권2호
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    • pp.127-131
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    • 2015
  • Churg-Strauss syndrome (CSS) is a necrotizing vasculitis with extra-, peri-vascular eosinophilic infiltration. Chronic symmetric polyarthritis with the presence of rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody are the mainstay of rheumatoid arthritis (RA) diagnosis. Mononeuritis multiplex is a peripheral neuropathy involving more than 2 separate nerve areas. A 62-year-old male patient was referred for left foot drop and polyarthritis of both hands and feet for 4 months. During evaluation, mononeuritis multiplex was detected on nerve conduction study and electromyography tests: vasculitis with neutrophil, eosinophil, and lymphocyte infiltration on peroneal nerve biopsy. A positive response to methacholin and bronchodilator was observed on the pulmonary function test. Radiologic tests showed peri-articular soft tissue swelling and osteopenia on both hand and foot. Marked peripheral eosinophilia, high RF, and positive perinuclear anti-neutrophil cytoplasmic antibody were detected on blood tests. Here, we report on a patient with overlap syndrome of CSS and RA with review of the relevant literature, from which a few references to overlap syndrome of CSS and RA were available.

줄리오 로마노의 만토바 저택: 메르쿠리우스로 표현된 화가의식 (The Facade Decoration of Julio Romano's House in Mantua: Ideas on Painting Expressed through Mercury)

  • 이한순
    • 미술이론과 현장
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    • 제14호
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    • pp.159-186
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    • 2012
  • Julio Romano decorated the facade of his house in Mantua with a statue of Mercury to give expressions to his ideas on painting. Hereby the painter from Rome could show his home to the world as that of a painter. To be concrete, Mercury was the planet god to which visual artists belonged, and so was basically related to visual arts. In his role to deliver diverse features of art works Mercury could also convey concepts and emotions expressed in a picture to the viewer. The power of a painting to arouse certain emotions or move the mind of the viewer was further connected to the role of Mercury as the guide of the human soul. This function again related the Roman god to the characteristic of a portrait to present absent persons to the viewer. Above the statue of Mercury, a Lucian head of the god is seen, so that they together form the central axis of the facade. This seems to emphasize that the theme of the facade decoration was the powerful persuasive forces of eloquence. The two masks on the left could then refer to sources of eloquence, I.e. various beautiful expressions of a language and its generative process. On the other hand, the masks on the right could represent consequences of eloquence, for instance, prudence, evil effects which come about to imprudent listeners, and other influences on listeners. Finally, it would be useful to remind us of a line from On Architecture by Leon Battista Alberti. According to the humanist architect parts of a building which are seen from the outside, like a facade, should be appropriately designed, since the decoration of a house could play a significant role to enhance the fame and honor of the family and its fatherland. This theory of Alberti could have provided the foundation to the facade decoration of the Casa Pippi which proudly presented the profession of painting to the public in visual form.

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Variance-Considered Machine에 기반한 Brain-Computer Interface 시스템의 성능 향상 (Performance Improvements of Brain-Computer Interface Systems based on Variance-Considered Machines)

  • 염홍기;심귀보
    • 한국지능시스템학회논문지
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    • 제20권1호
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    • pp.153-158
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    • 2010
  • 본 논문에서는 선행 연구를 통해 제안하였던 새로운 분류 알고리즘인 Variance Considered Machines (VCM)을 통해 EEG 신호의 분류 에러율을 감소시킴으로 Brain-Computer Interface (BCI)의 성능향상 가능성을 보였다. BCI란 뇌파를 통해 컴퓨터와 같은 시스템을 제어하는 것으로 BCI의 인식률에 영향을 미치는 것에는 많은 요소가 있지만 본 논문에서는 그 중에서도 가장 중요한 분류 알고리즘을 제안된 알고리즘을 통해 인식률을 향상하는 것을 보였다. 이를 위해 피험자가 가상으로 왼쪽 손과 다리를 움직이는 상상을 한 데이터를 기존에 가장 많이 사용되고 있는 분류 알고리즘인 SVM과 제안된 VCM으로 분류하여 인식률을 비교하였다. 기존 연구를 통해 VCM의 우수성을 이론적 결과와 시뮬레이션 결과로 보였다면 본 논문에서는 실제 데이터를 통한 실험을 통해 인식률 향상을 보였다.

상지동맥 혈관계의 모델링과 혈유동의 전산수치해석 (Modeling of the Artery Tree in the Human Upper Extremity and Numerical Simulation of Blood Flow in the Artery Tree)

  • 김기원;김재욱;백현만;김성균
    • 대한기계학회논문집B
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    • 제40권4호
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    • pp.221-226
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    • 2016
  • 하지혈관에 비해 상지혈관질환은 드물기 때문에 상지혈관계에 대한 실험적, 수치해석적 연구는 매우 드물다. 본 논문에서는 최초로 MRA 영상데이터로부터 한국 성인 왼팔의 혈관계, 상완동맥에서 1 mm 이상의 손가락동맥들에 이르는, 3차원 컴퓨터 모델을 제작하였다. 이 모델에 대해 수치해석을 수행하여 정상, 주기유동에 대한 속도장, 압력장을 계산하였고 주요 분지관에서의 유량분배와 벽전단응력 분포에 대해 분석하였다.