• Proceedings of the Korea Society of Design Studies Conference
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• 2005.05a
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• pp.90-91
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• 2005

• Proceedings of the KIEE Conference
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• 2007.07a
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• pp.768-769
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• 2007

국내의 풍력자원과 계통자원을 함께 고려해 강원도 풍력발전단지의 최적입지 타당성을 검증. 국내의 풍황 자료를 조사하고 우수한 지역 5곳을 선정한 후, WASP 프로그램을 이용해 최대 에너지 생산 가능한 지역에 풍력발전기의 배치를 결정하였다.

• Proceedings of the Korean Nuclear Society Conference
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• 2005.10a
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• pp.121-122
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• 2005

• Proceedings of the Korean Society of Sericultural Science Conference
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• 2002.10a
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• pp.105-105
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• 2002

No Abstract, See Full Text

• Proceedings of the Korean Society of Life Science Conference
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• 2000.09a
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• pp.50-51
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• 2000

• Proceedings of the Korean Society of Sericultural Science Conference
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• 2000.10a
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• pp.62-62
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• 2000

No Abstract.See Full-text

• Proceedings of the Korean Society of Sericultural Science Conference
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• 2004.04a
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• pp.44-44
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• 2004

• Proceedings of the Korean Environmental Sciences Society Conference
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• 2019.10a
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• pp.183-183
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• 2019

• Journal of Nutrition and Health
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• v.40 no.2
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• pp.130-137
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• 2007

Myelin basic protein (MBP), a major structural protein of the myelin, is thought to be important for the maintenance of myelin in the central nervous system (CNS). We investigated the effect of maternal folic acid nutritional status on the folate level and the synthesis of MBP in the offspring. In order to test this hypothesis, female Sprague-Dawley rats were fed either folic acid sufficient (8 mg/kg diet) or deficient (0 mg/kg diet) diet from 2 wks prior to the mating throughout the entire pregnancy, lactation and weaning period. We examined plasma folate level by the radioimmunoassay and homocysteine level by HPLC, respectively. The MBP expression was measured by the western blot analysis. The maternal folic acid deficiency decreased plasma folate level with a concomitant increase in plasma homocysteine level in their offspring. The maternal folic acid deficiency decreased hepatic levels of SAM and SAM/SAH ratio with a concomitant increase in hepatic levels of SAH and the MBP expression of spinal cord in their offspring at 7 wks of age. These results suggest that maternal folic acid nutritional status affect plasma folate and homocysteine level in their offspring. Moreover, the maternal folic acid deficiency mi호t inhibit the MBP expression of the spinal cord and disrupt many other vital CNS reactions in their offspring.

• Journal of Pharmaceutical Investigation
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• v.35 no.4
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• pp.279-285
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• 2005

Ground CS-891 (N-[1-(4-methoxyphenyl)-1-methylethyl]-3-oxo-4-aza-5a-androst-1-ene-$17{\beta}$-carboxamide) of poorly water soluble drug was obtained using a Heiko Seisakusho model TI-100 vibration mill, and samples with different crystallinity were prepared at mixture ratios of 10:0, 7:3, 5:5, 3:7 and 0:10 (intact;ground CS-891). Physicochemical characterizations were obtained using qualitative and quantitative X-ray diffractometry, different scanning calorimetry (DSC), scanning electron microscopy (SEM), Quantasorb surface area analyzer, and controlled atmosphere microbalance. With increase of amorphous CS-891 in mixture ratios, the intensities of X-ray diffraction peaks of crystalline CS-891 were decreased, whereas surface area, water absorption, and exothermic peaks in DSC were increased. The apparent solubility of ground CS-891 was $4.4\;{\mu}g/ml$ and the solubility of intact CS-891 was $3.1\;{\mu}g/ml$ at $37{\pm}1^{\circ}C$. The apparent precipitation rates of CS-891 in a supersaturated solution during the solubility test were increased with an increase of amorphous CS-891, and a crystalline form of CS-891 transformed from amorphous CS-891 after the solubility test was found by X-ray diffraction analysis, DSC and SEM. The dissolution profiles of CS-891 with different crystallinity at $37{\pm}1^{\circ}C$ by the USP paddle method were investigated, and the apparent dissolution rate constant of ground CS-891 was about 5.9-fold higher than that of intact CS-891. A linear relationships between the crystallinity of CS-891 and the apparent dissolution rate constant (r>0.96) were obtained.