• Title/Summary/Keyword: Lee Sam

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Herba Ephedrae and Rhizoma Amorphophalli modulates visceral obesity in micro-CT of high fat induced obese male mice (고지방식이 수컷 마우스 비만모델에서 micro-CT를 이용한 마황(麻黃)과 마우(魔芋)의 복부비만 조절효과)

  • Won, Chan-Uk;Jung, Yang-Sam;Yoon, Ki-Hyeon;Lee, Hee-Young;Yoon, Mi-Chung;Kim, Bo-Kyung;Park, Sun-Dong;Shin, Soon-Shik
    • Herbal Formula Science
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    • v.16 no.2
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    • pp.205-217
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    • 2008
  • Objectives : We investigated the effects of Herba Ephedrae and Rhizoma Amorphophalli on high fat diet induced obese male mice. Methods : 8 weeks old, high fat diet induced obese male mice were divided into 5 groups: C57BL/6 normal control, obese vehicle control, GGEx55 (Herba Ephedrae), GGEx61 (Rhizoma Amorphophalli), GGEx62 (Herba Ephedrae + Rhizoma Amorphophalli). After mice were treated with GGEx for 8 weeks, we measured body weight gain, food intake, feeding efficiency ratio, rectal temperature, fat weight, plasma leptin and lipid levels. We also took micro-computerized axial tomography (micro-CT) on the mice. Results : 1. GGEx55 and GGEx62 groups significantly decreased body weight gain and feeding efficiency ratio compared with vehicle control. But they significantly increased rectal temperature. 2. Plasma total cholesterol and LDL-cholesterol concentrations were significantly increased by GGEx55 groups, whereas were significantly decreased by GGEx62 groups compared with vehicle control. 3. GGEx55 and GGEx62 groups significantly decreased total, subcutaneous and visceral fat as well as fat areas in micro-CT analysis of abdomen compared with vehicle control. 4. Plasma GOT and GPT concentrations were significantly increased by GGEx55 groups compared with vehicle control. Conclusions : These results demonstrate that GGEx55 and GGEx62 effectively reduces body weight gain, feeding efficiency ratio in high fat diet induced obese mice, leading to the modulation of obesity. In addition, GGEx55 and GGEx62 decreases visceral adipose tissue mass and improves plasma lipids, suggesting that GGEx55 and GGEx62 may act as a therapeutic agent for obesity.

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Development of Yeongdong Heavy Snowfall Forecast Supporting System (영동대설 예보지원시스템 개발)

  • Kwon, Tae-Yong;Ham, Dong-Ju;Lee, Jeong-Soon;Kim, Sam-Hoi;Cho, Kuh-Hee;Kim, Ji-Eon;Jee, Joon-Bum;Kim, Deok-Rae;Choi, Man-Kyu;Kim, Nam-Won;Nam Gung, Ji Yoen
    • Atmosphere
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    • v.16 no.3
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    • pp.247-257
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    • 2006
  • The Yeong-dong heavy snowfall forecast supporting system has been developed during the last several years. In order to construct the conceptual model, we have examined the characteristics of heavy snowfalls in the Yeong-dong region classified into three precipitation patterns. This system is divided into two parts: forecast and observation. The main purpose of the forecast part is to produce value-added data and to display the geography based features reprocessing the numerical model results associated with a heavy snowfall. The forecast part consists of four submenus: synoptic fields, regional fields, precipitation and snowfall, and verification. Each offers guidance tips and data related with the prediction of heavy snowfalls, which helps weather forecasters understand better their meteorological conditions. The observation portion shows data of wind profiler and snow monitoring for application to nowcasting. The heavy snowfall forecast supporting system was applied and tested to the heavy snowfall event on 28 February 2006. In the beginning stage, this event showed the characteristics of warm precipitation pattern in the wind and surface pressure fields. However, we expected later on the weak warm precipitation pattern because the center of low pressure passing through the Straits of Korea was becoming weak. It was appeared that Gangwon Short Range Prediction System simulated a small amount of precipitation in the Yeong-dong region and this result generally agrees with the observations.

Manufacture of Dropwort Extract Using Brown Sugar, Fructose Syrup and Oligosaccharides (흑설탕, 과당, 올리고당을 이용한 미나리 추출물의 제품화)

  • Son, Min-Jung;Cha, Chun-Geun;Park, Jung-Hyun;Kim, Chan-Shick;Lee, Sam-Pin
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.34 no.9
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    • pp.1485-1489
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    • 2005
  • The dropwort was fermented by steeping with brown sugar, fructose syrup or oligosaccharide at room temperature for 2 month, and then stored at cold room for 6 months. The dropwort extracts prepared with three different sugars showed more than $50^{\circ}$Brix, below pH 4.0 and about $0.7\%$ titratable acidity. The dropwort extract with brown sugar showed $1.6{\times}10^6$ viable cell counts and $21.2\%$ reducing sugar. Formation of $CO_2$ gas was superior to the dropwort fermented with brown sugar or oligosaccharide. The dropwort extract with fructose syrup indicated $9.0{\times}10^3$ viable cell counts and $50.1\%$ reducing sugar. Microorganism present in fermented dropwort extract was effectively pasteurized by the addition of $3\%$ citric acid and heat-treatment at $85^{\circ}C$ for 15 min, resulting in the less production of $CO_2$ gas. The dropwort extracts prepared with brownsugar, fructose syrup or oligosaccharide was suitable for the standardization that required for plant extract in Korea Food Codex.

Formation of Brushite (CaHPO4 · 2H2O) in the Oyster Extracts (굴 엑기스에서 결정물질 Brushite(CaHPO4 · 2H2O)의 생성)

  • Lee, Jong-Soo;Yoon, So-Mi;Jang, Jun-Ho;Lim, Chi-Won;Choi, Kwang-Yeol
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.35 no.6
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    • pp.729-733
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    • 2006
  • Small yellowish brown crystals were found in some concentrated oyster extracts which prepared by heating with the drip and washed water of boiled oyster in oyster processing factories. We collected those crystals by filtering the oyster extracts and analysed X ray diffraction (XRD), scanning electron microscopy (SEM) and minerals by ICP. Those were composed of moisture (8.1%), organic materials (21.6%) and inorganic materials (70.2%). Those major inorganic materials were determined as Ca (53.8%) and P (43.8%), from the ICP and elucidated those crystal as brushite $(CaHPO_4{\cdot}2H_2O)$ by XRD and SEM. Organic materials contained crude protein (33.7%) consisting of 7 amino acids. It is presumed that brushite may be formed by the reaction of excess Ca with P in the oyster extracts during concentrating process under higher temperature.

Discussion on Optimal Shape for Wave Power Converter Using Oscillating Water Column (진동수주형 파력발전구조물의 최적형상에 대한 검토)

  • Lee, Kwang-Ho;Park, Jung-Hyun;Baek, Dong-Jin;Cho, Sung;Kim, Do-Sam
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.23 no.5
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    • pp.345-357
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    • 2011
  • Recently, as part of diversifying energy sources and earth environmental issues, technology development of new renewable energy using wave energy is actively promoted and commercialized around Europe and Japan etc. In particular, OWC(Oscillating Water Column) wave power generation system using air flow induced by vertical movement of the water surface by waves in an air-chamber within caisson is known as the most efficient wave energy absorption device and therefore, is one of the wave power generation apparatus the closest to commercialization. This study examines air flow velocity, which operates turbine(Wells turbine) directly in oscillating water column type wave power generation structure from two-and three-dimensional numerical experiments and discusses optimal shape of oscillating water column type wave power generation structure by estimating the maximum flow rate of air according to change in shape. The three-dimensional numerical wave flume was applied in interpretation for this study which is the model for the immiscible two-phase flow based on the Navier-Stokes Equation. From this, it turned out that size of optimal shape appears differently according to the incident wave period and air flow is maximized at the period where minimum reflection ratio occurs.

Numerical Simulation of Irregular Airflow within Wave Power Converter Using OWC by Action of 3-Dimensional Irregular Waves (3차원불규칙파동장하의 진동수주형 파력발전구조물에서 불규칙공기흐름의 수치시뮬레이션)

  • Lee, Kwang-Ho;Park, Jung-Hyun;Kim, Do-Sam
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.24 no.3
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    • pp.189-202
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    • 2012
  • An Oscillating Water Column (OWC) wave generation system uses the air flow induced by the vertical motion of water column in the air chamber as a driving force of turbine. It is well known that OWC is one of the most efficient devices to harness wave power. This study estimated the air flow velocity from the time variation of the water level fluctuation in the air chamber under regular wave conditions using 3-dimensional numerical irregular wave tank (3D-NIT) model that can simulate the 3-dimensional irregular wave field. The applicability of the 3D-NIT model was validated by comparing numerically predicted air flow velocities with hydraulic experimental results. In addition, the characteristics of air flow frequency spectrum variation due to the incident frequency spectrum change, and the variations of frequency spectrum and wave reflection due to the existence of converter inside the air chamber were discussed. It is found that the phase difference exists in between the air flow velocity and the water level fluctuation inside the air chamber, and the peak frequency of the spectrum in water level fluctuation is amplified by the resonance in the air chamber.

Numerical Analysis on Liquefaction Countermeasure of Seabed under Submerged Breakwater Using Concrete Mat Cover (for Irregular Waves) (콘크리트매트 피복을 이용한 잠제하 해저지반에서의 액상화 대책공법에 관한 수치해석 (불규칙파 조건))

  • Lee, Kwang-Ho;Ryu, Heung-Won;Kim, Dong-Wook;Kim, Do-Sam;Kim, Tae-Hyung
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.29 no.1
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    • pp.20-35
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    • 2017
  • In the case of the seabed around and under gravity structures such as submerged breakwater is exposed to a large wave action long period, the excess pore pressure will be significantly generated due to pore volume change associated with rearrangement soil grains. This effect will lead a seabed liquefaction around and under structures as a result of the decrease in the effective stress, and eventually the possibility of structure failure will be increased. The study of liquefaction potential for regular waves had already done, and this study considered for irregular waves with the same numerical analysis method used for regular waves. Under the condition of the irregular wave field, the time and spatial series of the deformation of submerged breakwater, the pore water pressure (oscillatory and residual components) and pore water pressure ratio in the seabed were estimated and their results were compared with those of the regular wave field to evaluate the liquefaction potential on the seabed quantitatively. Although present results are based on a limited number of numerical simulations, one of the study's most important findings is that a safer design can be obtained when analyzing case with a regular wave condition corresponding to a significant wave of the irregular wave.

Studies on the Complexes of Lanthanide ion with Multidentate Ligand (I). Determination of Thermodynamic Parameters with Solution Calorimetric Method in Nonaqueous Solvents (란탄족 원소의 여러자리 리간드 착물에 관한 연구 (제 1 보) 물아닌 용액에서 용액열량계에 의한 열역학적 함수결정)

  • Sam-Woo Kang;Won-Hae Koo;Soo-Min Lee;Chang Choo-Hwan;Moo-Yol Seo
    • Journal of the Korean Chemical Society
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    • v.33 no.6
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    • pp.588-595
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    • 1989
  • Log K, ${\Delta}$H and ${\Delta}$S for the complexation of $La^{3+},\;Ce^{3+}$ and $Eu^{3+}$with various multidentate ligand containing crown ether, diaza crown ether and diamine ether have been determined in methanol and acetonitril solutions at $25^{\circ}C$ by solution calorimetric titration method. The greater stability constant of $La^{3+}$-15C5 than those of 18C6 diaza [2.2] in methanol are discussed in terms of the size of metal ion and the ligand cavity and of metal ion solvation. The stabilities of $Ce^{3+}$ and $La^{3+}$ ion complexes with a various multidentate ligand in acetonitril are in the order of (diamine ether)<18C6<15C5$Ce^{3+}$, $La^{3+}$ and $Eu^{3+}$-diaza [2.2] complexes in acetonitril are increased with the following order: $Eu^{3+}$ < $La^{3+}$ < $Ce^{3+}$, that is increasing order of the optimum size and of the charge density of metal ion.

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Adsorption Characteristics of Toluene Vapor According to Pore Structures of Zeolite 5A Modified with Hydrochloric Acid (산으로 개질한 Zeolite 5A의 세공구조에 따른 Toluene Vapor의 흡착특성)

  • Lee, Song-Woo;Bae, Sang-Kyu;Kwon, Jun-Ho;Na, Young-Soo;An, Chang-Doeuk;Yoon, Young-Sam;Song, Seung-Koo
    • Journal of Korean Society of Environmental Engineers
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    • v.27 no.8
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    • pp.807-812
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    • 2005
  • This study is to investigate the correlation of pore structures of Zeolite 5As modified with acid and their adsorption capacity of toluene vapor using the dynamic adsorption method. The experimental results showed that the modification with acid allowed more micropores and enlarged the existing pores. Toluene vapor was mainly adsorbed on the surface of pores over $15\;{\AA}$ in diameter. The equilibrium adsorption capacity of toluene vapor of the modified Zeolite 5As was in the range of $15{\sim}70\;mg/g$ and the equilibrium adsorption capacity was increased to f times than that of the Zeolite 5A. The correlation between the total cumulative surface area and the equilibrium adsorption capacity was hard to say linear. The correlation in diameter between the cumulative surface area in the range of over $15\;{\AA}$ and the equilibrium adsorption capacity gate the highest correlation factor of 0.997.

Investigation of Dynamic Elemental Distribution in Six Human Tissues by Neutron Activation Analysis (중성자방사화분석에 의한 인체 6개 조직 내 기능성원소 함량 분포 조사)

  • Kang, Sang-Hoon;Moon, Jong-Hwa;Chung, Yong-Sam;Cho, Seung-Yeon;Lee, Han-Young
    • Analytical Science and Technology
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    • v.15 no.4
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    • pp.365-372
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    • 2002
  • In this study, inorganic elemental distribution in Korean adult human tissue of liver, lung, muscle, kidney, rib and thyroid has been investigated. These tissues were collected from human's body within 48 hours after their death according to IAEA's recommended method, dried by freeze drying method and then pulverized. Neutron activation analysis was applied to these samples to determine the concentrations of 5 major elements of Ca, Mg, Na, K, and Cl and 12 trace elements of Mn, I, Sr, As, Br, Co, Cr, Cs, Fe, Rb, Se, and Zn. To confirm accuracy of analytical result was performed using three kinds of standard reference materials and resulted that the relative error is within 10% for the most of elements and the Z-score indicating a performance of analysis is within 2. The elemental distribution shows that the major elements are distributed homogeneously with a specific concentration and that the trace elements shows a distribution of different concentration with kinds of tissue and their age. Particularly, iodine shows higher concentration with 1000 ${\mu}g/g$ in thyroid, and calcium and strontium show the concentration with 15.9% and 84.4 ${\mu}g/g$ in rib, respectively.