• The Journal of Internal Korean Medicine
• /
• v.29 no.4
• /
• pp.922-938
• /
• 2008

Objectives : Rhodiola rosea has been used in herbal medicine to treat various conditions, such as antimelancholia, antifatigue, improvement of work competence and prevention of altitude sickness. In this study, we investigated effects of Rhodiola rosea extract (KH101) on fatigue in forced swimming rats. Methods : Sprague-Dawley rats were induced with fatigue by forced swimming, then rats in each group were treated with KH101. We observed changes of glucose, LDH and cortisol in serum and LDH, glycogen, hexokinase, citrate synthase MDH, SDH and CK in muscle. Results : Obtained results were as follows: 1. Continuance times of exercise significantly increased in all groups at day 1, in the 50 mg/kg concentration group at day 2, in all groups at day 3 and in the 50 mg/kg conc. group at day 4. 2. In serum, glucose significantly decreased in all concentration groups. 3. In the soleus muscle, LDH significantly decreased in the 50 mg/kg concentration group. HK significantly decreased in the 100 mg/kg conc. group. SDH significantly increased in the 100 mg/kg conc. MDH were significantly decreased in all conc. groups. 4. In the gastrocnemius muscle, HK significantly decreased in all concentration groups, while MDH significantly increased all conc. groups. Conclusions : It is concluded that the KH101 has and anti-fatigue effect in rats. Additional studies are needed to find the mechanism of the association between each single herb.

• The Journal of Internal Korean Medicine
• /
• v.29 no.2
• /
• pp.334-347
• /
• 2008

Background and Objective : Haeyeol-tang, composed of Houttuyniae Herba, Lonicerae Flos, Taraxaci Herba, and Scrophulariae Radix, is widely used for alleviating the symptom of various kinds of inflammatory pulmonary disease, including asthma and COPD. We want to know whether Haeyeol-tang has an anti-inflammatory effect by analyzing expression of pro-inflammatory cytokines. Materials and Methods : We differentiated the THP-1 cells into macrophage-like cells by treatment with PMA. Inflammation was induced by treatment with LPS and PMA. We found the safe concentration of Haeyeol-tang by using MTS assay and used PD98059 as a negative control for comparison of anti-inflammatory effect of Haeyeol-tang. Results : The RT-PCR analysis results show that the cell survival rate is over 100% within 1 ng/mL to 1 ug/mL of Haeyeol-tang and begins to decrease under 100% at 10 ug/mL. The gene expression of $IL-1{\beta}$, IL-6, IL-8, IL-10, $TNF-{\alpha}$ and $TGF-{\beta}$ levels were down-regulated when Haeyeol-tang was treated at concentrations between 1 ng/mL an 1 ug/mL on monocyte-derived macrophages. Interestingly, 1 ug/mL Haeyeol-tang-treated samples showed that the transcriptional activities of IL-8, $TNF-{\alpha}$, IL-10 and $TGF-{\beta}$ were more down-regulated than those of PD098059 $(TNF-{\alpha}$ inhibitor). At protein level, the ELISA analysis results showed that there were more remarkable (p<0.001) decreases in expression of $IL-1{\beta}$, IL-6, IL-8 and $TNF-{\alpha}$ on both the 1 ug/mL Haeyeol-tang-treated group and the PD98059-treated group than the LPS-treated group. Conclusion : We conclude that Haeyeol-tang has an anti-inflammatory effect by inhibiting expression of pro-inflammatory cytokines and chemokines at mRNA and protein levels. These results may provide us a promising way to care for general inflammatory diseases as well as inflammatory pulmonary disease, including asthma and COPD, with further clinical study.

• Journal of Chest Surgery
• /
• v.36 no.7
• /
• pp.518-522
• /
• 2003

Left ventricular thrombosis is a frequent and potentially dangerous complication in acute myocardiac infarction, but its occurrence and adequate therapy has not been known in patients with Dor procedure for the ischemic cardiomyopathy. We report a patient, 45 year-old male, who had a new left ventricular thrombus developed after coronary arterial bypass graft, Dor procedure, and removal of the left ventricular thrombus for ischemic car-diomyopathy. Left ventricular thrombus was disappeared on the follow-up cardiac MRI following intravenous heparin injection and oral coumadin therapy. This case suggest that anticoagulation therapy may prevent patients with the severe left ventricular dysfunction and apical aneurysm and dyskinesia from developing the left ventricular thrombus, and that thrombi will resolve without clinical evidence of systemic embolism.

• Imaging Science in Dentistry
• /
• v.32 no.3
• /
• pp.167-173
• /
• 2002

Purpose : To evaluate clinical and radiographic differential diagnosis between ameloblastoma and odontogenic keratocyst (OKC) using clinical data, plain radiographs, and CT. Materials and Methods: 25 cases of ameloblastoma and 44 cases of OKC diagnosed in biopsy, were selected from the files stored in Department of Oral and Maxillofacial Radiology, Seoul National University Dental Hospital from 1999 to 2001, and evaluated using following criteria: sex and age, location, shape, border to normal bone tissue, effect to adjacent tissues, homogeneity in the lumen of the lesion, response of the cortical bone, long-to-short length (LIS) ratio of the lesion, and expansion angle of the cortex. Results: Ameloblastoma and OKC were seen most frequently in third decades and no statistical significance was noted between both sexes. Ameloblastoma occurred most frequently in mandibular angle and ramus area (68%) and OKC at the maxillary molar (34.1 %), and mandibular angle and ramus area (43.2%). The root resorption of the adjacent teeth, mandibular canal displacement, and the impaction of teeth were seen more frequently in ameloblastoma than in OKC. The LIS ratio measured in CT was largest in maxillary OKC cases, followed by mandibular ameloblastoma, and mandibular OKC (1.2, 1.8 and 2.4 respectively). The expansion angle of the cortex shows a statistically significant difference between ameloblastoma (48.8°) and OKC (31.5°). Conclusion : The numeric morphology (LIS ratio) and expansion angle of the cortical bone of the lesion measured in computed tomography can be used to differentiate the ameloblastoma and odontogenic keratocyst.

• Imaging Science in Dentistry
• /
• v.36 no.1
• /
• pp.55-62
• /
• 2006

Purpose : To find the cause of root curvature by use of panoramic and lateral cephalometric radiograph. Materials and Methods : Twenty six 1st graders whose mandibular 1st molars .just emerged into the mouth were selected. Panoramic and lateral cephalometric radiograph were taken at grade 1 and 6, longitudinally. In cephalometric radio graph, mandibular plane angle, ramus-occlusal plane angle, gonial angle, and gonion-gnathion distance (Go-Gn distance) were measured. In panoramic radio graph, elongated root length and root angle were measured by means of digital subtraction radiography. Occlusal plane-tooth axis angle was measured, too. Pearson correlations were used to evaluate the relationships between root curvature and elongated length and longitudinal variations of all variables. Multiple regression equation using related variables was computed. Results : The Pearson correlation coefficient between curved angle and longitudinal variations of occlusal plane-tooth axis angle and ramus-occlusal plane angle was 0.350 and 0.401, respectively (p<0.05). There was no significant correlation between elongated root length and longitudinal variations of all variables. The resulting regression equation was $Y=10.209+0.208X_1+0.745X_2$ (Y: root angle, $X_1$: variation of occlusal plane-tooth axis angle, $X_2$: variation of ramus-occlusal plane angle). Conclusion : It was suspected that the reasons of root curvature were change of tooth axis caused by contact with 2nd deciduous tooth and amount of mesial and superior movement related to change of occlusal plane.

• Imaging Science in Dentistry
• /
• v.36 no.1
• /
• pp.25-32
• /
• 2006

Purpose : To investigate the validity of digital image processing on panoramic radiographs in estimating bone quality before endosseous dental implant installation by correlating bone quality in radiographic images with clinical bone quality classification. Materials and Methods : An experienced surgeon assessed and classified bone quality for implant sites with tactile sensation at the time of implant placement. Including fractal dimension eighteen morphologic features of trabecular pattern were examined In each anatomical sites on panoramic radiographs. Finally bone quality of 67 implant sites were evaluated in 42 patients. Results : Pearson correlation analysis showed that three morphologic parameters had weak linear negative correlation with clinical bone quality classification showing correlation coefficients of -0.276, -0.280, and - 0.289, respectively (p<0.05). And other three morphologic parameters had obvious linear negative correlation with clinical bone quality classification showing correlation coefficients of -0.346, -0.488, and -0.343 respectively (p<0.05). Fractal dimension also had a linear correlation with clinical bone quality classification with correlation coefficients -0.506 significantly (p<0.05). Conclusion : This study suggests that fractal and morphometric analysis using digital panoramic radiographs can be used to evaluate bone quality for implant recipient sites.

• Food Science and Preservation
• /
• v.16 no.6
• /
• pp.843-848
• /
• 2009

Green peppers were dried using maltodextrin and recycled dehydration liquid as dehydrating agents, and the quality of dried green pepper powders was compared with that of freeze-dried and hot air-dried samples in terms of moisture content, color, antioxidant activity, capsaicinoid level, and sensory acceptability. The moisture content of maltodextrin-treatedgreen pepper powder was higher than that of samples prepared using recycled dehydration liquid. The lightness (L) value rose with increasing concentrations of maltodextrin powder or liquid. The antioxidant activities of pepper powders prepared using the molecular press dehydration method were similar to that of alpha-tocopherol, and better than that offreeze-dried or hot air-dried samples. Capsaicinoid levels fell with increasing concentrations of maltodextrin powder and liquid. The sensory evaluation data on green pepper powders prepared using the molecular press dehydration method were better than those obtained when freeze-dried and hot air-dried samples were evaluated. These results indicate that drying of green pepper powders using maltodextrin and recycled dehydration liquid as dehydrating agents is very efficient.

• Journal of Animal Science and Technology
• /
• v.52 no.2
• /
• pp.97-102
• /
• 2010

The objective of this study was to examine the suitability of genetic evaluation models using the integrated racing records collected from Gwacheon and Busan Gyeongnam racetracks. Results obtained are summarized as follows: In the short-distance races of 1,400 meters and less the records of finishing time at Gwacheon racetrack was superior, whereas, in the races of 1,800 meters and more it was superior in the records from Busan Gyeongnam racetrack. The effects of contemporary groups accounted for 42.7~70.2% of the total variation, and the effects of the individual race considering racing classes was the biggest in all racing distances. Heritabilities and repeatabilities for the finishing time were estimated in the range of 0.153-0.238 and 0.401-0.498, respectively. Correlation coefficients between the breeding values estimated from the integrated records and the breeding values estimated from records of Gwacheon and Busan-Gyeongnam were 0.907 and 0.803, and coefficients of rank correlations were 0.891 and 0.846, respectively. The correlation coefficients between sire's annual earning of the integrated records and Gwacheon and Busan Gyeongnam racetracks records were 0.943 and 0.886, and coefficients of rank correlations were 0.938 and 0.853, respectively. Also, the correlation coefficient of sire's annual earning between Gwacheon and Busan Gyeongnam racetracks was 0.742. The results of this analysis indicate that the genetic evaluation using the integrated racing records are reliable when the racing records from Busan Gyeongnam racetracks are stabilized and more data are accumulated.

• Korean Journal of Ichthyology
• /
• v.22 no.2
• /
• pp.90-95
• /
• 2010

Blue devil (Pomacentrus caeruleus, also called Chrysiptera cyanea) is widespread in the Indo-Pacific Ocean and very popular all over the world as an aquarium fish because it is so easy to keep in a marine aquarium. However, tank-breeding techniques are not completely known. In this study, we reared blue devil and investigated its spawning ecology, as a necessary precursor for successful artificial-tank breeding. We investigated the spawning volume according to time with two types of calendars: solar and lunar. Rearing conditions were set at 30 ppt salinity, $27^{\circ}C$ water temperature, in two aquariums with water volumes of 80 and 125 L. We successfully bred P. caeruleus in this artificial-tank system. The aquarium fish formed a spawning harem with one male and more than two females. We harvested about 113,580 eggs in 44 spawning episodes by two spawning harems during the 11-month period from December to October. They showed a peak season of spawning volume and time in May and June. We confirmed the two peak points in spawning volumes and times, which coincided with the first quarter and last (third) quarter of the lunar phases of the moon.

• Journal of the Korean Society for Marine Environment & Energy
• /
• v.12 no.4
• /
• pp.255-263
• /
• 2009

This study assessed the facility volume distribution for artificial reefs (ARs) deployed at the sea bottom in fishing grounds in the Busan Sea region, and estimated the efficient use of volume in the initial AR group. Analysis of the volume of AR facilities in the Busan Sea region indicated that the quantity and surface areas of deployed facilities varied greatly between 1997 and 2004. However, a rapid decrease in AR facility volume after 2003 indicated an increased use of different kinds of ARs, such as steel or ceramic ARs. And the results revealed that a total of 2,777 AR facilities were deployed in the Gijang sea region with a founding ratio of 89%; corresponding numbers for the Heaundae and Namgu sea region were 7,691 and 84.9%, and 905 and 96% for the cubic type of AR in the Saha and Gangseo sea regions. The analysis indicated that ARs deployed in the Busan sea region maintained a good conservation ratio of more than 85%. The loss in AR volume (approximately 15%) was due to subsidence, breakaway, and incomplete deployment.