• Biomolecules & Therapeutics
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• v.24 no.6
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• pp.604-609
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• 2016

5-fluorouracil (5-FU) is a chemotherapeutic agent commonly used for treatment of solid tumors, including colorectal cancer. However, chemoresistance against 5-fluorouracil (5-FU) often limits its success for chemotherapy and, therefore, finding out appropriate adjuvant(s) that might overcome chemoresistance against 5-FU bears a significant importance. In the present study, we have found that ${\alpha}$-mangostin can sensitize 5-FU-resistant SNUC5/5-FUR colon cancer cells to apoptosis. Exposure of ${\alpha}$-mangostin induced significant DNA damages and increased the intracellular 8-hydroxyguanosine (8-OH-G) and 4-hydroxynonenal (4-HNE) levels in SNUC5 and SNUC5/5-FUR cells. Western blot analysis illustrated that ${\alpha}$-mangostin-induced apoptosis was mediated by the activation of the extrinsic and intrinsic pathways in SNUC5/5-FUR cells. In particular, we observed that Fas receptor (FasR) level was lower in SNUC5/5-FUR cells, compared with SNUC5 cells and that silencing FasR attenuated ${\alpha}$-mangostin-mediated apoptosis in SNUC5/5-FUR cells. Together, our study illustrates that ${\alpha}$-mangostin might be an efficient apoptosis sensitizer that can overcome chemoresistance against 5-FU by activating apoptosis pathway.

• Journal of the Korean Society for Precision Engineering
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• v.18 no.9
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• pp.131-139
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• 2001

The use of fracture mechanics has traditionally concentrated on crack growth under an opening mechanism. However, many service failure occur from cracks subjected to mixed mode loadings. Hence, it is necessary to evaluate the fatigue behavior under mixed mode loading. Under mixed mode loading conditions, not only the fatigue crack propagation rate is of importance, but also the crack propagation direction. The mode I and II stress intensity factors of CTS specimen were calculated using elastic finite element method. The propagation behavior of the fatigue crack of the STS304 steeds under mixed mode loading condition was evacuated by using stress intensity factors $K_I$ and $K_II. The MTS criterion and effective stress intensity factor were applied to predict the crack propagation direction and the fatigue crack propagation rate.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.10
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• pp.1676-1685
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• 2003

Tensile and low cycle fatigue tests on prior cold worked 3l6L stainless steel were carried out at various temperatures ftom room temperature to 650$^{\circ}C$. Fatigue resistance was decreased with increasing temperature and decreasing strain rate. Cyclic plastic deformation, creep, oxidation and interactions with each other are thought to be responsible for the reduction in fatigue resistance. Currently favored life prediction models were examined and it was found that it is important to select a proper life prediction parameter since stress-strain relation strongly depends on temperature. A phenomenological life prediction model was proposed to account for the influence of temperature on fatigue life and assessed by comparing with experimental result. LCF failure mechanism was investigated by observing fracture surfaces of LCF failed specimens with SEM.

• Journal of the Korean Society for Precision Engineering
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• v.30 no.7
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• pp.687-693
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• 2013

The service conditions of railway cars have become more difficult in recent years due to increased speed. Faulty components in the railcars may result in service interruption, or in extreme cases, derailment. Thus, it is important to diagnose and monitor the main components of railcars. Temperature monitoring is one of the basic methods used to diagnose abnormal conditions in the main components of railway cars, such as in bearings, reduction gears, and traction motors. In this study, we developed a monitoring system for the main components, using an infrared thermography technique. This technique has the advantage of infrared thermal camera imaging of temperature contours in the components. Various hardware and software components of the monitoring system are used to acquire the sensor data, to identify potential problems in railcar operation.

• Journal of Power System Engineering
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• v.20 no.3
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• pp.5-10
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• 2016

The structure of the variable liquid column oscillator(VLCO) is analogous to that of the tuned liquid column damper used to suppress oscillatory motion in large structures like tall buildings and cargo ships. VLCO is using the technology which absorbs high potential energy made by process of accelerated motions effect of air spring by installation of inner air chamber. So, the application of VLCO can improve the efficiency of energy than that of wave energy converters made in Pelamis Company. In this research, experiments were performed for the models which have two different liquid column sizes. In order to find out the biggest motion response, two major conditions are taken into account. Two conditions are to open(or close) the valves and to differentiate the height of the liquid column.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2008.04a
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• pp.856-860
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• 2008

Wire-suspensions in the conventional actuators mechanically support the moving part and guarantee the accuracy of the actuator without tangential tilt actuation. However, such a suspension configuration has considerable stiffness in the tangential tilt direction with two additional wire beams for the tangential tilt. Thus, we performed a design sensitivity analysis for the wire-suspension stiffness of 4-axis actuator and controlled the main parameters such as distance among wire-suspensions and wire-suspension length to allow tangential tilt flexibility. The elasticity of frame PCB that supports the moving part by wire-suspensions was also exploited to improve the flexibility of wire-suspension in the tangential tilt direction. A novel suspension structure was devised by establishing eight wire-suspensions at both sides of the moving part for electrical connection to coils. The magnetic circuit according to the proposed 4-axis actuator using multi-polar magnet and coils was also suggested for the generation of electromagnetic forces in the focusing, tracking, radial and tangential tilt directions.

• Korean Journal of Adult Nursing
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• v.19 no.1
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• pp.109-120
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• 2007

Purpose: This study was conducted to investigate factors related to middle-aged women's health beliefs and their intention to practice health behaviors for preventing and improving hypertension. Methods: The participants were 319 middle-aged(40-59 years) women who lived G city. Data was collected from January to February, 2005. Personal interviews were performed. The data was analyzed using t-test, ANOVA, Scheffe's multiple comparison test and hierarchial multiple regression analysis. Results: Perceived susceptibility of health belief was high in those who had higher educational level, disease history and health education experience, significantly(p<0.05). Perceived seriousness was high in those who had higher educational level, middle economic status and health education experience, significantly(p<0.05). Perceived benefits was high in those who had higher educational level and perceived barriers was low in those who had disease history and hypertension, significantly(p<0.05). The subject's intention to practice health behaviors was significantly high in those who were younger, who had higher educational level and menopausal status(p<0.05). In hierarchial multiple regression analysis, the subject's intention was related to perceived seriousness, perceived benefit and educational level, significantly(p<0.05). Conclusion: It is necessary to develope the education programs which can increase the subject's health belief and intention to practice health behaviors towards hypertension in middle-aged women.

• Journal of agricultural medicine and community health
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• v.9 no.1
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• pp.109-116
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• 1984

The epidemiological information on 156 cases of acute drug intoxication treated at emergency room of Sin An Dai-Woo Hospital in Bi-Gum island during the year of 1981-1982 were reviewed and analyzed. And the findings obtained was as follows : 1) Annual incidence rate of acute drug intoxication was 3.3 per 1,000 in habitants (male 3.5, female 3.1). 2) In both sexes the highest incidence was obsesved in the age group of 20~49 years with 7.6 in male and 6.2 in female per 1,000 inhabitants. 3) In both sexes the highest ease distribution was observed during summer season of July and August (male 33.2%, female 26.4%). 4) Eating pesticides was the most frequently used for suicide purpose in both sexes (male 89. 3%, female 82.2%). 5) In terms of foundation for conclusion to eating poison, "by guardion's explanation" was the highest rate in both groups of eating pesticides (97.8%) and eating rodentcides(77.8%). 6) The case fatality rate due to eating poison was 4.5% (male 5.9%, female 2.8%). 7) In haspitalization days, the most cases was observed at less than 3 days (male 73.8%, female 79.2%).

• Honam Mathematical Journal
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• v.26 no.4
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• pp.411-421
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• 2004

A digital $(k_0,\;k_1)$-homotopy is induced from digital $(k_0,\;k_1)$-continuity with the n kinds of $k_i$-adjacency relations in ${\mathbb{Z}}^n$, $i{\in}\{0,\;1\}$. The k-fundamental group, ${\pi}^k_1(X,\;x_0)$, is derived from the pointed digital k-homotopy, $k{\in}\{3^n-1(n{\geq}2),\;3^n-{\sum}^{r-2}_{k=0}C^n_k2^{n-k}-1(2{\leq}r{\leq}n-1(n{\geq}3)),\;2n(n{\geq}1)\}$. In this paper two kinds of digital 8-pseudotori stemmed from the minimal simple closed 4-curve and the minimal simple closed 8-curve with 8-contractibility or without 8-contractibility, e.g., $DT_8$ and $DT^{\prime}_8$, are introduced and their digital topological properties are studied by the calculation of the k-fundamental groups, $k{\in}\{8,\;32,\;64,\;80\}$.

• 제어로봇시스템학회:학술대회논문집
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• 1995.10a
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• pp.464-467
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• 1995

Autonomous Mobile Robot(AMR) is a field of study which is under active research along with rapid development of the engineering technology. The main reasons for the high interest in AMR are because of its ability to change work space freely and its capability to replace human being for difficult and dangerous jobs. Also the fact that AMR provides a variety of research fields, such as path planning, navigation algorithm, sensor fusion, image processing, and controller design is part of the reason for its popularity. But relatively few researches are concerned with controller. So in this paper, a control strategy of mobile robot with nonholonomic constraint for tracking ordered discontinuous motion is proposed. The proposed control strategy has been designed as a state feedback shape to allow the AMR to obtain continuous velocity and track the path which is composed of discontinuous motions. In order to design such controller, 3 states have been reduced to 2 states through coordinate projection. These ideas are tested for validity through simulation and simulation result is compared with experiments result.