• International Journal of Industrial Entomology and Biomaterials
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• v.28 no.2
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• pp.66-70
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• 2014

In order to the feasibility of silk materials as protein delivery system, silk beads incorporated with bovine serum albumin (BSA) were prepared by dropping silk fibroin extract into dope solution composed of ethanol and dichloromethane. Structural and morphological characteristics of silk beads were examined using scanning electron microscopy (SEM), infrared spectrometry, and X-ray diffractometry. Swelling ratio of silk beads was also measured. Release behavior of prototypical protein, BSA, was studied by observing the electropheretic phenomenon and release profile. SEM showed that silk beads are spherical with porous interior structure. Infrared spectrometry and X-ray diffraction confirm that the silk beads have a ${\beta}$-sheet conformation. The swelling capability of silk beads increased with the incorporation of the protein. The protein was released from the beads with slow release following an initial burst release. Therefore, silk beads show promise as materials for encasing protein drugs to be delivered to targets in the human body.

• International Journal of Industrial Entomology and Biomaterials
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• v.27 no.2
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• pp.228-236
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• 2013

Breast cancer is one of the most common cancers among women worldwide. Recently anticancer agents have been developed using natural substances. To evaluate the anticancer effect of hydrolysates of silk fibroin (HSF), we investigated the effect of HSF on cell viability and apoptosis of a breast cancer cell line, MCF-7, induced through the mitochondrial pathway. The result showed that HSF decreased cell viability in MCF-7 cells in a dose- and time-dependent manner, resulting in an increase in the sub-G1 phase cell population. HSF increased the level of the pro-apoptotic Bax protein and decreased the levels of the anti-apoptotic Bcl-2 protein. In addition, HSF induced apoptosis in MCF-7 cells through a mitochondria-dependent pathway by increasing levels of cytochtome c, and cleavage of PARP. Taken together, these findings suggest that HSF inhibits the proliferation of MCF-7 breast cancer cells through a mitochondria and caspase dependent apoptotic pathway.

• Bulletin of the Korean Chemical Society
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• v.28 no.6
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• pp.941-946
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• 2007

Bacillus halodurans O-methyltransferase (BhOMT) is a S-adenosylmethionine (SAM or AdoMet) dependent methyltransferase. Three dimensional structure of the BhOMT bound to S-adenosyl-L-homocysteine (SAH or AdoHcy) has been determined by comparative homology modeling. BhOMT has 40% sequence identity with caffeoyl-CoA 3-O-methyltransferase (CCoAOMT) from alfalfa. Based on x-ray structure of CCoAOMT, three dimensional structure of BhOMT was determined using MODELLER. The substrate binding sites of these two proteins showed slight differences, but these differences were important to characterize the substrate of BhOMT. Automated docking study showed that four flavonoids, quercetin, fisetin, myricetin, and luteolin which have two hydroxyl groups simultaneously at 3'- and 4'-position in the B-ring and structural rigidity of Cring resulting from the double bond characters between C2 and C3, were well docked as ligands of BhOMT. These flavonoids form stable hydrogen bondings with K211, R170, and hydroxyl group at 3'-position in the Bring has stable electrostatic interaction with Ca2+ ion in BhOMT. This study will be helpful to understand the biochemical function of BhOMT as an O-methyltransferase for flavonoids.

• Publications of The Korean Astronomical Society
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• v.27 no.3
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• pp.61-69
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• 2012

The Ganui (簡儀, simplified armillary sphere) is a representative of astronomical instruments in Joseon Dynasty of Korea, as well as Yuan Dynasty and Ming Dynasty of China. In early 15th century, Joseon's scientists and engineers uniquely developed the Soganui (小簡儀, small simplified armillary sphere) and the Ilseongjeongsiui (日星定時儀, sun-and-star time determining instrument) from the structural characteristic of Ganui. These two astronomical instruments had a new design by the miniaturization and felt convinced a similar performance of Ganui in the harmony with Korean Astronomy and Astrology Cultures. Since mid-18th century after the enforcement of shixian-li (時憲曆), the Soganui and Ilseongjeongsiui handed over the Jeokdogyeongwiui (赤道經緯儀, equatorial armilla) by a change of the observational framework such as the time and angle measures. The Jeokdogyeongwiui made by Gwansanggam (觀象監, Bureau of Astronomy in Joseon Dynasty) adopted the new observational framework. We studied the structural characteristics and scientific values of these 3 astronomical instruments with theirs observation methods.

• Tuberculosis and Respiratory Diseases
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• v.38 no.2
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• pp.186-193
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• 1991

Three cases of double primary lung cancer occured synchronously are reported with brief review of literature. The incidence of multiple primary lung cancer relatively rare but may become increasingly prevalent as early detection techinque and cancer therapy has improved. The patients were a 67, 69, and 65-year-old men with doulbe primary lung cancer of different cell type or same cell type with other bronchus origin (squamous cell+small cell, squamous cell+squamous cell, squamous cell+bronchioloaveolar cell) were identified with flexible bronchofiberoscopic biopsies. More careful diagnostic evaluation and management are thought to be necessary.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.2
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• pp.93.1-93.1
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• 2012

세종대 간의대(簡儀臺)는 우리나라 역사상 가장 대규모로 수행된 천문 관련 국책사업의 일환으로 축조된 조선시대의 국립천문대이다. 지금까지 세종대 간의대에 대한 선행 연구는 주로 궁내 위치 및 변화, 개보수 상황 및 중수 여부, 규모와 관련한 주척(周尺) 또는 영조척(營造尺)에 대한 논의 등에 천착하고 있으나 간의대의 외형, 구조, 기능, 역할 등에 대한 연구는 미진한 편이다. 이 중 간의대의 외형에 대한 선행 연구들에서는 원대(元代) 북경 사천대(北京 司天臺, 1279년 전후 축조) 또는 명대(明代) 북경 관성대(北京 觀星臺, 1442년 축조, 現 古觀象臺) 등을 간의대의 원형으로 추정하고 있다. 이 연구에서는 간의대 복원을 위하여 외형에 대한 재해석을 시도하였으며, 이를 위하여 1997년 소더비(Sotheby) 경매 출품본 "경복궁도(景福宮圖)"를 비롯한 각종 경복궁 궁궐도(宮闕圖)를 분석하였다. 또한 구조와 축조 방식의 규명을 위하여 제단(祭壇) 등의 각종 석축물(石築物)을 분석하였으며, 이와 함께 "조선왕조실록"을 비롯한 각종 사료(史料)에 대한 조사를 병행하였다. 이와 같은 연구를 통하여 원대 북경 사천대 또는 명대 북경 관성대와는 다른 세종대 간의대의 독자적인 모델을 제시하였다.

• Proceedings of the Korea Concrete Institute Conference
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• 2004.11a
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• pp.553-556
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• 2004

This paper is to investigate the spalling and fire endurance of high performance RC column member with PP fiber and lateral confinement of metal lath and non fire resistance removal type form. According to test results, combination of PP fiber and metal lath as well as use fire resistance non removal type form had favorable fire resistance by discharging internal vapour pressure and lateral confining. After fire endurance test, compressive strength decreased markedly caused by internal expansion pressure and crack. Residual strength of plain concrete was decreased to $22\%$. The use of PP fiber and lateral confinement of metal lath and non removal type form enhanced the residual strength above $40\%$. Especially, the combination of $0.1\%$ of PP fiber and lateral confinement with the level of 2.3T exhibited more than $51\%$ of residual strength. Therefore, to improve fire endurance and spalling resistance, the combination of $0.1\%$ of PP fiber and metal lath with 2.3T can be the proper measure.

• Archives of Craniofacial Surgery
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• v.18 no.4
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• pp.273-276
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• 2017

Osteomas are benign, slow-growing tumors that most frequently occur in the craniomaxillofacial region. These tumors are mostly asymptomatic and are generally found incidentally. A giant osteoma is generally considered to be greater than 30 mm in diameter or 110 g in weight. A 35-year-old female presented to us with complaints of a firm mass that showed continuous growth on the forehead following trauma. A hairline incision was made to expose the osteoma. Biopsy of the tumor confirmed a osteoma. There were no complications after surgery. Postoperative computed tomography revealed that the tumor was completely removed. Because a peripheral giant osteoma of the frontal bone with a history of trauma is a rare finding, thorough history-taking, physical examination, and preoperative imaging tests are needed for patients with a history of trauma to rule out a giant osteoma.

• Proceedings of the KIEE Conference
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• 2005.07c
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• pp.2040-2042
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• 2005

ITO/N,N'-diphenyl-N,N'-di(m-tolyl)-benzidine(TPD)/Tris(8-hydroxyquinolinato Aluminum $(Alq_3)/Al$ 구조에서 정공 수송층 TPD와 발광충 $Alq_3$를 각각 두께 변화에 따라 Agilent 4294A, Precision Impedance Analyzer를 이용하여 주파수에 의존하는 저항성 특성과 용량성 특성을 연구하였다. 측정 결과 주파수가 증가할수록 저항성 특성은 감소함을 보였고 용량성 특성은 감소하다가 다시 증가하는 특성을 보였다. TPD와 $Alq_3$의 두께가 각각 70[nm], 30[nm]일 때 저주파 영역에서는 가장 낮은 저항성 특성이 보이다가 고주파 영역에서는 가장 높은 특성을 확인하였다. 또한 용량성 특성은 저주파 영역에서는 가장 높은 특성이 보이다가 고주파영역에서 두께 변화에 상관없이 거의 일치함을 확인하였다.

• Proceedings of the KIEE Conference
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• 2003.07d
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• pp.2594-2596
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• 2003

유한요소법(FEM)은 많은 공학문제를 해결하는 가장 중요한 방법 중 하나로 인식되고 있다. 본 논문에서는 자동제어 및 신호처리 문제해결에 효율적이며 강력한 수치해석 패키지인 CEMTool환경에서 유한요소법을 이용하여 일반적인 편미분방정식 Solver 구현에 관한사항을 논의하고자 한다. 기본적으로 영역정보 및 노드수 등의 정보를 입력받아 각 노드의 정보를 출력하는 Mesh함수를 구현하며, 생성된 요소방정식들을 조립하는 Assemble함수를 작성한 뒤, Boundary함수를 통해 경계조건을 적용시킨 후 선형행렬 방정식을 풀어 전체노드의 값을 찾아내는 Solve함수를 구현하는 과정을 알아본다. 구현된 FEM Solver의 전체적인 구조를 통해 구현시 고려해야 할 사항을 논의하며 기본적인 편미분방정식의 예제를 통해 FEM PDE Solver의 동작과정을 검증할 것이다.