• Title/Summary/Keyword: Lee Sam

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Inhibitory Activity of Amentoflavone on Arachidonic Acid Releasing Enzyme, Phopholipase $A_2$ and Inhibition of Histamine Release from Mast Cells (Amentoflavone의 아라키돈산 유리효소인 phopholipase $A_2$에 대한 저해활성 및 비만세포에서 histamine 유리 억제효과)

  • Moon, Tae-Chul;Lee, Eun-Kyung;Lee, Sung-Ho;Son, Kun-Ho;Kim, Hyun-Pyo;Kang, Sam-Sik;Chang, Hyeun-Wook
    • Korean Journal of Pharmacognosy
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    • v.33 no.1 s.128
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    • pp.49-52
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    • 2002
  • Amentoflavone, naturally occurring biflavonoid, isolated from the leaves of Ginko biloba, selectively inhibited human seceretory phospholipase $A_2$. This compound potently and irreversibly inhibited human group IIA in a dose dependent manner with an $IC_50$ about $3\;{\mu}M$. Amentoflavone inhibited phospholipase $A_2$ by a noncompetitive manner with the apparent Ki value of $1{\times}10^{-5}M$. In addition, the inhibitory activity of amentoflavone is rather specific against group IIA phospholipase $A_2$ than group IB phospholipase $A_2$. Furthermore, this compound strong inhibit histamine release from $A_{23187}$ treated rat peritoneal mast cells. These results indicate naturally occurring biflavonoid represents a novel anti-inflammatory agent.

Isolation and Quantitative Analysis of Acetylshikonin from Lithospermi Radix (자근으로부터 acetylshikonin의 분리 및 함량분석)

  • Hwang, Suk-Yeon;Hwang, Bang-Yeon;Kang, Sam-Sik;Kim, Chang-Min;Park, Jeong-Hill;Bae, Ki-Hwan;Son, Kun-Ho;Lee, Seung-Ho;Chang, Seung-Yeup;Kang, Shin-Jung;Ro, Jai-Seup;Lee, Kyong-Soon
    • Korean Journal of Pharmacognosy
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    • v.31 no.3
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    • pp.295-299
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    • 2000
  • Lithospermi Radix has been used in traditional medicine for antimicrobial, antiinflammatory, immunostimulating, antitumor and wound-healing activities. For the quality control of this drug, acetylshikonin was isolated from the hexane extract of Lithospermum erythrorhizon(Boraginaceae) and identified by the spectroscopic evidences. A quantitative analysis of acetylshikonin using HPLC method showed that the average contents were $0.084{\pm}0.026%$ in 31 samples collected throughout the various regions of Korea.

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Determination of Eleutherosides B and E in Various Parts of Acanthopanax Species (오갈피나무의 부위별 Eleutheroside B와 Eleutheroside E의 정량)

  • Lee, Sang-Hyun;Kang, Sam-Sik;Cho, Seon-Haeng;Ryu, Su-Noh;Lee, Burm-Jong
    • Korean Journal of Pharmacognosy
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    • v.36 no.2 s.141
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    • pp.70-74
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    • 2005
  • High performance liquid chromatography(HPLC) was used for the determination of eleutherosides B and E in various parts of Acanthopanax species. Eleutheroside B was detected in the stem (1.45 mg/g) and the root (0.59 mg/g) of A. senticosus and the stem (0.31 mg/g) of A. senticosus grafted on A. sessiliflorus. But there is no detection of eleutheroside B in A. sessiliflorus and the root of A. senticosus grafted on A. sessiliflorus. Eleutheroside E was detected in the stem (0.92, 0.97 and 0.30 mg/g, respectively) and the root (0.65, 0.94, 0.34 mg/g, respectively) of A. senticosus, A. sessiliflorus and A. senticosus grafted on A. sessiliflorus.

A Study of Ways to Improve Periodical Indexing Services in Korea (정기간행물 기사색인 서비스 현황 및 발전방향에 대한 연구)

  • Lee, Eun-Chul;Lee, Sang-Bok;Oh, Sam-Gyun;Park, Ok-Nam
    • Journal of the Korean Society for Library and Information Science
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    • v.43 no.1
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    • pp.189-214
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    • 2009
  • The study acknowledges the values of periodical indexing as information resources. The study identified periodicals users' needs of article indexing services based on focus group interviews. The study also conducted a comparative study of periodicals indexing services of libraries and databases in Korea and the US. The study argues for the need of seamless services for users of periodical articles indexing services. The study also recommends the elements needed for improving the current service, which includes establishing a collaborative indexing system, adopting a metadata standard, implementing authority files, incorporating social web services, offering diverse ways of information discovery based on facet approach, and stabilizing identification systems.

Phytochemical Studies on Rehmanniae Radix (지황 (地黃)의 성분연구)

  • Lee, So-Young;Yean, Min-Hye;Kim, Ju-Sun;Lee, Je-Hyun;Kang, Sam-Sik
    • Korean Journal of Pharmacognosy
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    • v.42 no.2
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    • pp.127-137
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    • 2011
  • Twenty-four compounds were isolated from the 70% ethanolic extract of Rehmanniae Radix (Scrophulariaceae) cultivated in Ubo-myeon, Gunwi-gun, Gyeongbuk province, Korea and their structures were identified as four iridoids [6-O-(4''-O-${\alpha}$-L-rhamnopyranosyl) vanilloyl ajugol (17), ajugol (18), aucubin (19), and catalpol (20)], three phenethyl alcohol glycosides [decaffeoyl acteoside (15), isoacteoside (16), and acteoside (21)], five sugar derivatives [ethyl ${\beta}$-D-fructofuranoside (7), eleutheroside C (14), mannitol (22), raffinose (23), and stachyose (24)], two terpenoids [remophilanetriol (4) and glutinolic acid (11)], a lignan, paulownin (2), and eight others [${\beta}$-sitosterol (1), daucosterol (6), monopalmitin (3), pinellic acid (9), uracil (5), adenosine (12), jio-cerebroside (10), aeginetic acid 5-O-${\beta}$-D-quinovoside (8), aeginetoyl ajugol 5''-O-${\beta}$-D-quinovoside (13)]. The chemical structures of these compounds were identified on the basis of spectroscopic methods and comparison with literature values. Among these compounds, paulownin (2), monopalmitin (3), uracil (5), daucosterol (6), ethyl ${\beta}$-D-fructo-furanoside (7), and eleutheroside C (14) were isolated from this plant for the first time.

Breeding of Hansaengjam a Parental Sex-limited Larval Marking Strain Suitable for Spring Rearing Season

  • Kang, Pil-Don;Sung, Gyoo-Byung;Kim, Kee-Young;Lee, Hee-Sam;Kim, Mi-Ja;Ji, Sang-Duk;Hong, In-Pyo;Kweon, Hae-Yong;Park, Kwang-Young;Lee, Kwang-Gil;Sohn, Bong-Hee
    • International Journal of Industrial Entomology and Biomaterials
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    • v.23 no.1
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    • pp.179-182
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    • 2011
  • Normally the first generation of hybrid is supplied for farm rearing, precise and labor saving sex discrimination is needed. The new strain "Hansaengjam" is sex-limited (female:larval markings, male:no-markings) strain which was bred from both sex-limited strain Japanese originated Jam 153 and Chinese originated strain Jam 154. Productivity test of Hansaengjam during 2007 and 2009 showed high healthiness and cocoon yield. The Hansaengjam is evaluated as an excellent strain from healthiness, cocoon yield and other test results.

Breeding of New Silkworm Strain Yeonnokjam

  • Kang, Pil-Don;Sung, Gyoo-Byung;Kim, Kee-Young;Lee, Hee-Sam;Kim, Mi-Ja;Ji, Sang-Duk;Hong, In-Pyo;Kweon, Hae-Yong;Park, Kwang-Young;Lee, Kwang-Gil;Sohn, Bong-Hee
    • International Journal of Industrial Entomology and Biomaterials
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    • v.23 no.1
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    • pp.175-178
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    • 2011
  • Yeonnokjam is a newly bred high yield special silkworm strain for spring rearing, bred from Japanese originated green cocoon spinning strain Jam 315 and Chinese originated white cocoon spinning strain Jam 316. This strain showed high hatching ratio of 96% and high healthiness of 96.7% of pupatin ratio. And its spins heavier cocoon with somewhat shorter fiber length but thicker fineness. The merits of these_strains are short larval period and labor saving, and its breeding goals are producing polish green silk and use for education.

A Study on the Prediction of Bed Changes on Hahoi Region in the Nakdong River by Using the KU-RLMS Model (KU-RLMS 모형을 이용한 낙동강 하회지구 지형변화 예측에 관한 연구)

  • Lee, Nam-Joo;Hwang, Seung-Yong;Lee, Sam-Hee
    • Proceedings of the Korea Water Resources Association Conference
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    • 2007.05a
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    • pp.1402-1406
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    • 2007
  • 낙동강에 위치한 안동의 하회마을, 내성천에 위치한 예천의 회룡포와 영주의 무섬마을 등은 마을 앞에 위치한 깨끗한 백사장으로 널리 알려진 관광명소이다. 하회마을의 점사주의 경우 낙동강 상류에 안동 및 임하 다목적댐이 건설되면서, 수량이 조절됨에 따라 토사수리학적 특성이 상당히 변화되었으며, 식생이 발생하는 등 옛 모습을 상실해 가고 있는 지역이다. 이 연구는 낙동강의 중상류에 위치한 하회지구에 평면 이차원 하상변동 및 수질예측 수치모형인 KU-RLMS 모형을 적용하여 하회마을 앞의 점사주에 영향을 미치는 토사수리학적 특성 변화를 규명할 목적으로 수행하였다. 수치모형 적용을 위한 현황분석으로 하상토 특성 자료를 수집 분석하였다. 지형자료에 대한 분석 결과, 다목적댐 건설 이후 하회구간의 하천 지형 변화의 특징으로 저수로 쪽의 하상저하가 두드러지게 나타남을 발견할 수 있었다. 이동상 수리모형 실험결과를 사용하여 유사이동모형에서 사용할 유사량 공식을 선정하였다. 안동다목적댐과 임하다목적댐의 방류량, 수공구조물 설치 여부 등을 고려하여 수치모의조건을 결정하였으며, 각 조건에 대한 지형변화 변화 특성을 분석하였다.

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The effect of Palmitoylcarnitine and Ginseng Saponin on the nutrient uptake in Escherichia coli B. (대장균에 있어서 영양물 흡수에 미치는 Palmitoylcarnitine과 인삼 Saponin의 영향)

  • Kim, Soon-Ok;Lee, Ho-Yong;Lee, Chong-Sam;Choi, Yong-Keel;Cho, Key-Seung
    • Korean Journal of Microbiology
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    • v.22 no.3
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    • pp.151-156
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    • 1984
  • When enterobacterium, Escherichia coli B was cultivated with normal media in the presence of $0.2{\sim}0.6%$ Palmitoylcarnitine and $0.05{\sim}0.2%$ Ginseng Saponin, maximum population growth of the bacteria was presented 71% and 31%, respectively. Such a result, in vitro test, was concluded from the result that both detergents stimulated $C^{14}$-glucose, $C^{14}$-alanine and $C^{14}$-phosphatidylethanolamine uptake into the membrane of cells. The pre-treatment of cells with different amounts of Palmitoylcarnitine from $0.005{\sim}0.05{\mu}$ moles represented a significant increase of uptake, 33% of $C^{14}$-glucose, 129% of $C^{14}$-alanine and 158% of phosphatidylethanolamine at the concentration of $0.05{\mu}$ moles of Palmitoylcarnitine. On the other hand, the result of $C^{-2}%$ Saponin treatment showed the maximum value of uptake, 17% of $C^{14}$-glucose and 112% of $C^{14}$-alanine. In case of $C^{14}$-phosphatidylethanolamine, the maximum uptake showed 25% of increase at the concentration of $C^{14}$% Saponin.

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Studies on Synthesis of Diphenyl Butylamidophosphate and Flame Retardancy Effects of DPBAP on PET Fabric (I) (Diphenylbutyamidophoshate의 합성과 PET 섬유에 대한 방염성에 관한 연구)

  • Lee, Kwang-Woo;Heo, Man-Woo;Kang, Byung-Woo;Yoon, Jong-Ho;Lee, Chang-Sub;Cho, Yong-Seok;Kim, Sam-Soo;Cho, Hwan
    • Textile Coloration and Finishing
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    • v.6 no.3
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    • pp.8-14
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    • 1994
  • A new flame retardant diphenyl butylamidophosphate (DPBAP) for PET fabric was synthesized and its flame retardancy was examined. The results have shown that PET fabrics treated by DPBAP(with DPBAP and on 4-10 %) show excellent flame retardancy. Since the DPBAP treated PET fabric show essentially no change in the drape stiffness and the tensile strength, it is believed that DPBAP is chemically stable in PET fabric. In addition to this, the washing fastness of DPBAP on PET fabric tested by the 5 times of water washing method also appeared to be excellent. Judging from the fact that DPBAP was synthesized from relatively cheap material as well as the above cited DPBAP properties as a good flame retardant, the potential of DPBAP to be developed as a commercial flame retardant for PET fabric seems to be high.

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