• Title/Summary/Keyword: Lee Sam

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Prenylated Flavonoids as Tyrosinase Inhibitors

  • Lee, Nan-Kyoung;Son, Kun-Ho;Chang, Hyeun-Wook;Kang, Sam-Sik;Park, Hae-Il;Heo, Moon-Young;Kim, Hyun-Pyo
    • Archives of Pharmacal Research
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    • v.27 no.11
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    • pp.1132-1135
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    • 2004
  • In order to find new tyrosinase inhibitors and the effects of prenyl residue on flavonoid molecules, eight prenylated and three synthetic vinylated flavonoids were examined on their inhibitory effect against tyrosinase activity. From the results, kuwanon C, papyriflavonol A, sanggenon D and sophoflavescenol were found to possess the considerable inhibitory activity. Especially, sanggenon D is revealed as a potent inhibitor ($IC_{50}$ =7.3$\mu$ M), compared to the reference compound, kojic acid ($IC_{50}$ =24.8 $\mu$M). However, the prenylation with isoprenyl group or the vinylation to flavonoid molecules did not enhance tyrosinase inhibitory activity.

Synthesis and Immunosuppressive Activity of Novel Succinylacetone Analogues

  • Kim, Taek-Hyeon;Oh, Dong-Ryun;Na, Hee-Sam;Lee, Hyun-Chul
    • Archives of Pharmacal Research
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    • v.26 no.3
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    • pp.192-196
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    • 2003
  • This study describes the synthesis of novel enol esters (3) and triketones (4) as analogues of succinylacetone (SA) (Ed- this abbreviation is introduced here based on your use of it in the body of the paper) and the evaluation on the mouse allogeneic mixed lymphocyte reaction (MLR) and the murine model of antigen-induced paw edema formation for immunosuppressive activity. Enol esters (3a-f) were about 2-4 fold more potent than SA in in vitro activity.

The cause examination of the crack of the end beam for welding structure type bogie (용접구조형 대차 엔드빔의 균열원인 규명)

  • Hong Jai-Sung;Ham Young-Sam;Lee Dong-Hyong;Sea Jung-Won
    • Proceedings of the KSR Conference
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    • 2004.06a
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    • pp.726-731
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    • 2004
  • Bogie is the connection device between carbody and wheel in railway vehicles. It is the core part that exert a important effect on the passenger safety and running safety. Bogie largely consists of bogie frame, suspension, brake, wheel set. Static and Dynamic load have acted on it complexly. When the bogie is designed, finite element method, static load test, fatigue test, running test should be considered. Some bogie frame of high speed railway freight car have the problem. It's end beam was cracked. The crack of the end beam have a bad effect on brake system. In that case, the cars would be in danger of derailment.

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Measurement of contact position between wheel and rail for clarification of derailment mechanism (탈선 매커니즘 해명을 위한 차륜/레일 접촉위치 측정)

  • Ham Young-Sam;Hong Jai-Sung;Lee Kwan-Sup;Seo Byung-Wook
    • Proceedings of the KSR Conference
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    • 2004.06a
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    • pp.608-612
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    • 2004
  • Safety from derailment has been evaluated according to the magnitude of the derailment coefficient, which does not always ensure sufficient safety evaluation, and is not necessarily helpful in clarifying the mechanism of derailment. When wheel rolls, point of contact between wheel and rail was change continuously and flange touches with rail. Established gauge so that can measure location of contact point between wheel and rail by strain gauge. Also, wish to describe result that compose bridge circuit and execute load test.

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Analysis of Land Subsidence and Microwave Penetration on Drying Mudflat by using a Polarimetric Scatterometer Experiment (다편광 산란계 실험을 통한 개펄 건조시의 지반 침하와 마이크로파 침투 분석)

  • Lee Hoon-Yol;Chae Hee-Sam;Cho Seong-Jun
    • Proceedings of the KSRS Conference
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    • 2006.03a
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    • pp.145-148
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    • 2006
  • 새로 조성된 간척지 갯벌이 건조 수축하면 지반 침하와 더불어 토양 내로의 마이크로파의 침투 깊이가 증가한다 따라서 인공위성 DInSAR를 이용하여 지반 침하량을 구하고자 할 때, 건조 시 동시에 발생하는 마이크로파의 개펄 침투 현상을 규명하여 보정해 주어야 한다. 이를 위하여 다편광 산란계(Polarimetric Scatterometer)를 구성하여 건조 개펄에 대한 실내실험을 실시하였다. PolScat의 구성은 5.0-5.6GHz 대역의 dual-polarization square horn antenna를 사용하였으며 Agilent 8753ES 벡터 네트워크 분석기를 사용하였다. 길이 2m, 폭 2m, 높이 20cm의 개펄 샘플을 약 6주 동안 실내에서 건조시켜 위상을 측정한 결과 지반 침하와 함께 약 4mm의 마이크로파 투과현상이 발견되었다. 따라서 인공위성 DInSAR 지반침하량 계산에 있어서 반드시 토양 수분에 따른 마이크로파의 토양 침투 깊이를 보정해 주어야 함이 밝혀졌다.

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M-shaped Change of Radar Backscattering Coefficient on a Drying Tidal Mudflat Observed by Radarsat-1 SAR Images and a Laboratory Scatterometer Experiment (Radarsat-1 SAR 영상과 산란계 실내 실험을 통해 관찰된 조간대 갯벌 건조시 레이더 후방산란계수의 M형 변화)

  • Chae Hee-Sam;Lee Hoon-Yol;Cho Seong-Jun;Park No-Wook
    • Proceedings of the KSRS Conference
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    • 2006.03a
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    • pp.75-78
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    • 2006
  • 이 연구에서는 Radarsat-1 SAR 영상과 조위자료, 증발자료 및 다편광 산란계를 이용한 개펄 건조 실내실험 등을 통하여 해수면 위로 노출된 자연갯벌이 증발과 구조적 변화를 일으킬 때 레이더 후방산란계수의 변화를 분석하였다. 개펄 건조 실내실험 결과, 후방산란계수가 증발시간에 따라 단순한 증가나 감소를 보이지 않았으며 갯벌의 구조와 배수, 증발, 건조 등에 의해 보다 복잡한 M자 형태(증가-감소-증가-감소)의 변화를 나타내었다. 이러한 M형의 변화는 증발시간에 따른 Radarsat-1 SAR 15개 영상의 후방산란계수 변화 양상에서도 나타나는 것으로 확인되었다.

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In-Situ Cross-linked Polymer Electrolyte Membranes from Thermally Reactive Oligomers for Direct Methanol Fuel Cells

  • Kim, Hae-Kyoung;Lee, Won-Mok;Park, Sam-Dae;Chang, Yoon-Ju;Jung, Jin-Chul;Chang, H.
    • Proceedings of the Polymer Society of Korea Conference
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    • 2006.10a
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    • pp.271-271
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    • 2006
  • The present article describes a novel method of preparing the sulfonated polysulfone-based PEMs for DMFC, which are excellent in film quality, proton conductivity, methanol impermeability and mechanical properties. No depression in film quality or difficulty in film preparation is observed, even though sulfonated group of the PEMs are kept as high as 70 mol %. Allyl-terminated cooligo-PESs containing the organic sulfonate groups were solvent-cast into films and then thermally treated for cross-linking. Cross-linked sulfonated polysulfone-based PEMs gave unprecedented reduction of methanol cross-over and high ionic conductivity through in-situ thermal polymerization and cross-linking of telechelic sulfonated sulfone oligomers during a membrane preparation.

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A study on the relationship of discharge and sediment at the Seok-hwa Station in the Mi-ho River (미호천 석화지점의 유량 및 유사량 분석)

  • Yeon, Gyu-Bang;Lee, Sam-Hee;Cho, Yong-Soo;Hwang, Seung-Yong
    • Proceedings of the Korea Water Resources Association Conference
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    • 2008.05a
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    • pp.972-976
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    • 2008
  • 본 연구는 유량과 하천유사를 현장에서 직접 관측하여 분석한 연구로서 그 동안 하천에서 유사량을 산정할 때 부유사만을 측정하던 방법과 달리 미호천 석화수위표는 유역특성상 소류사량의 이송이 상당할 것으로 판단되어 미호천유역의 소류사를 부유사와 동시에 관측하는 연구를 수행하였다. 유량의 측정 방법은 간략법인 삼선법을 이용하였고 부유사 관측에는 수심적분 채취법을 적용, 채취기의 이동속도를 모든 채취선에서 일정하게 유지하는 등이동속도법을 이용하고 소류사 관측은 부유사 관측과 동일한 채취선에서 이루어졌다. 각각 부유사량과 소류사량을 15회 측정하여 더한 값을 유사량으로 산출하였고 이를 그 동안 많은 연구에 이용되었던 수정아인슈타인 방법으로 추정한 값과 실측된 유사량의 값을 비교하였다. 본 연구는 소류사량과 부유사량의 관계를 비교할 수 있는 연구로서 연구결과는 다음과 같다.

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Design and Implementation of the Ensemble Remultiplexer for DMB Service Based on Eureka-147

  • Bae, Byung-Jun;Yun, Joung-Il;Cho, Sam-Mo;Hahm, Young-Kwon;Lee, Soo-In;Sohng, Kyu-Ik
    • ETRI Journal
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    • v.26 no.4
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    • pp.367-370
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    • 2004
  • A new transmission system is necessary for the Digital Multimedia Broadcasting (DMB) service in Korea. Therefore, in this paper, we propose a new architecture for the implementation of a DMB transmission system based on Eureka-147. We describe the design and implementation of the Ensemble remultiplexer, which is essential to the proposed system for remultiplexing ETI frames and MPEG-2 transport streams. The proposed system provides a solution with high flexibility and low cost for multimedia broadcasting service. The functions of this transmission system have been verified by using our DMB receiver and other related systems.

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Control of a Balance-Beam with Unknown Loads Using the Restoration Angle of a Gimbal

  • Yi Keon-Young;Kim Yong-Jun;Chung Sam-Yong;Han Song-Soo;Lee Sang-Heon
    • International Journal of Control, Automation, and Systems
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    • v.4 no.4
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    • pp.524-528
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    • 2006
  • A controller built with the gyro effect for a balance-beam can freely control the attitude of an unstructured object by changing the position of an inner gimbal. In this paper, we propose a new balance-beam controller that can detect the inertia of the load to limit the velocity of the load commanded by a user. We found that when there was smaller load inertia, a larger restoration displacement occurred. Therefore, the load can be identified by issuing a predefined command to measure the restoration displacement, which enables us to construct a controller that can limit the angular velocity of the load by planning the motion. Experimental results show the performance of the controller with different loads.