• Title/Summary/Keyword: Lee Min-Bong

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Volumetric change of the latissimus dorsi muscle after postoperative chemotherapy and radiotherapy in immediate breast reconstruction with an extended latissimus dorsi musculocutaneous flap: final results from serial studies

  • Song, Kyeong Ho;Oh, Won Seok;Lee, Jae Woo;Kim, Min Wook;Jeong, Dae Kyun;Bae, Seong Hwan;Kim, Hyun Yul;Jung, Youn Joo;Choo, Ki Seok;Nam, Kyung Jin;Joo, Ji Hyeon;Yun, Mi Sook;Nam, Su Bong
    • Archives of Plastic Surgery
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    • v.48 no.6
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    • pp.607-613
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    • 2021
  • Background Breast reconstruction using an extended latissimus dorsi (eLD) flap can supplement more volume than reconstruction using various local flaps after partial mastectomy, and it is a valuable surgical method since the reconstruction area is not limited. However, when performing reconstruction, the surgeon should consider latissimus dorsi (LD) volume reduction due to postoperative chemotherapy (POCTx) and postoperative radiotherapy (PORTx). To evaluate the effect of POCTx and PORTx on LD volume reduction, the effects of each therapy-both separately and jointly-need to be demonstrated. The present study quantified LD volume reduction in patients who underwent POCTx and PORTx after receiving breast-conserving surgery (BCS) with an eLD flap. Methods This study included 48 patients who received immediate breast reconstruction using an eLD flap from January 2013 to March 2017, had chest computed tomography (CT) 7-10 days after surgery and 10-14 months after radiotherapy completion, and were observed for more than 3 years postoperatively. One surgeon performed the breast reconstruction procedures, and measurements of breast volume were obtained from axial CT views, using a picture archiving and communication system. A P-value <0.05 was the threshold for statistical significance. Results The average volume reduction of LD at 10-14 months after completing POCTx and PORTx was 64.5% (range, 42.8%-81.4%) in comparison to the volume measured 7-10 days after surgery. This change was statistically significant (P<0.05). Conclusions Based on the findings of this study, when harvesting an eLD flap, surgeons should anticipate an average LD volume reduction of 64.5% if chemotherapy and radiotherapy are scheduled after BCS with an eLD flap.

Preparation of Dual-functionalized Polymeric Membrane Electrolyte and Ni, Co-based Nanowire/MOF Array on Carbon Cloth for High-performance Supercapacitor (이중 기능 고분자 전해질 막의 제조 및 탄소 섬유에 니켈, 코발트 기반의 나노와이어/MOF 배열을 통한 고성능 슈퍼커패시터 연구)

  • Hye Jeong Son;Bong Seok Kim;Ji Min Kwon;Yu Bin Kang;Chang Soo Lee
    • Membrane Journal
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    • v.33 no.4
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    • pp.211-221
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    • 2023
  • This study presents a comprehensive study on the synthesis and characterization of PVI-PGMA/LiTFSI polymeric membrane electrolytes and CxNy-C flexible electrodes for energy storage applications. The dual-functional PVI-PGMA copolymer exhibited excellent ionic conductivity, with the PVI-PGMA73/LiTFSI200 membrane electrolyte achieving the highest conductivity of 1.0 × 10-3 S cm-1. The electrochemical performance of the CxNy-C electrodes was systematically investigated, with C3N2-C demonstrating superior performance, achieving the highest specific capacitance of 958 F g-1 and lowest charge transfer resistance (Rct) due to its highly interconnected hybrid structure comprising nanowires and polyhedrons, along with binary Co/Ni oxides, which provided abundant redox-active sites and facilitated ion diffusion. The presence of a graphitic carbon shell further contributed to the enhanced electrochemical stability during charge-discharge cycles. These results highlight the potential of PVI-PGMA/LiTFSI polymeric membrane electrolytes and CxNy-C electrodes for advanced energy storage devices, such as supercapacitors and lithium-ion batteries, paving the way for further advancements in sustainable and high-performance energy storage technologies.

4-week dose range finding toxicity test of Magnoliae Flos extract in Sprague-Dawley rats (Sprague-Dawley 랫드를 이용한 신이 추출물의 4주 반복 용량 결정 독성시험)

  • Park, Ju-Hyoung;Ahn, Eun-Kyung;Park, Kitae;Hwang, Min Hee;Cho, Young-Rak;Lee, Dong-Ryung;Choi, Bong-Keun;Oh, Joa Sub
    • Journal of Applied Biological Chemistry
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    • v.65 no.1
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    • pp.43-48
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    • 2022
  • Medicinal herb demonstrated in many pharmacological effects and recognized to be safe has been used for a long time. However, side effects including safety of medicinal herb have not been identified yet. The aim of the study was to estimate safety evaluation of Magnoliae Flos used for the treatment of pain, rhinitis, and pneumonia in Korea, China and Japan through four-week dose range finding toxicity test in male and female Sprague-Dawley rats. Magnoliae Flos was orally administered to male and female SD rats once a day for 28 days at 1,500 and 3,000 mg/kg. The safety evaluation was determined to examine clinical signs, mortality, body weight, food intake, hematology, serum biochemistry and relative organ weights and there were no significant changes related toxicity. Consequently, these findings indicates that Magnoliae Flos did not show any side effects including toxicity in dose range finding toxicity test and the no observed adverse effect level for Magnoliae Flos was estimated as more than 3,000 mg/kg.

Comparison of Volatile Components in $\hat{O}yuk-jang$ and Commercial Sauce (어육장과 시판 소스의 휘발성 향기 성분 비교)

  • Lim, Chae-Lan;Lee, Jong-Mee;Kim, Ji-Won;You, Min-Jung;Kim, Young-Suk;Noh, Bong-Soo
    • Journal of the Korean Society of Food Culture
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    • v.22 no.4
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    • pp.462-467
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    • 2007
  • Volatile components of six commercial $sauces(A{\sim}F)$ and $\hat{O}yuk-jang$(G, H), a Korean traditional fermented sauce, were analyzed by electronic nose based on GC with surface acoustic wave(SAW) sensor. The obtained data were used for pattern recognition and a visual pattern called a $VaporPrint^{TM}$, derived from the frequency and chromatogram of the GC-SAW sensor. Volatile components of sauces and $\hat{O}yuk-jang$ were well discriminated with the direct use of $VaporPrint^{TM}$. Commercial sauces and $\hat{O}yuk-jang$ showed different volatile patterns, respectively, due to different major material, which meju, beef extract, pickled anchovies, and Katsuobushi were used. Volatile components of Oyuk-jang were decreased drastically during the fermentation time. After boiling $\hat{O}yuk-jang$, new several peaks were found. The responses by electronic nose were used for principal component analysis. The PCA plot showed that volatile components pattern were well discriminated by first principal component score(proportion: 96.8%), and first principal component score of $\hat{O}yuk-jang$ was between soy sauce of the liquid extracted from beef and sauce of pickled anchovies.

Analysis on Trends in Plogging Culture and Professional Sports Using BIG KINDS Analysis (빅카인즈 분석을 활용한 플로깅 문화와 프로스포츠 분야의 동향 분석)

  • Gyu-Min, Na;Kyung-A, Oh
    • Journal of the Korean Applied Science and Technology
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    • v.40 no.5
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    • pp.1072-1080
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    • 2023
  • The purpose of this study is to analyze major keywords and social phenomena related to 'plogging' in the sports field and to derive important information. In order to achieve this purpose, the news analysis system BIG Kinds provided by the Korea Press Promotion Foundation was used to analyze it. The analysis period is from 2018 to 2022, and 42 of the 5,148 news collected were finally used and analyzed. Frequency analysis, relationship map analysis, and related word analysis were performed as analysis methods, and the results are as follows. First, as a result of the frequency analysis related to 'Plogging' in the sports field, keywords such as 'Jeju', 'Players', 'World Marathon', 'SSG', and 'Lee Bong-ju' were identified. Second, as a result of the analysis of the relationship related to 'Plogging' in the sports field, keywords such as 'COVID-19', 'national representative', 'elite', 'masters', and 'COVID' were identified. Third, as a result of the analysis of words related to 'Plogging' in the sports field, keywords such as 'synthesized words', 'volunteer activities,' 'masters untact', 'Jeju', and 'athletes' were identified. In the domestic professional sports field, it has been shown that plogging is actively used for environmental activities and professional team promotion to practice carbon neutrality by international sports organizations.

Isolation and biochemical characterization of acid tolerance xylanase producing Bacteria, Bacillus sp. GJY from city park soil (도심공원으로부터 산내성 xylanase를 생산하는 박테리아 분리 및 효소학적 특성)

  • Jang, Min-Young;Park, Hwa Rang;Lee, Chong Gyu;Choo, Gab-Chul;Cho, Hyun Seo;Park, Sam-Bong;Oh, Ki-Cheol;Kim, Bong-Gyu
    • Journal of Applied Biological Chemistry
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    • v.60 no.1
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    • pp.79-86
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    • 2017
  • Microbes in forest are very important due to not only to enhance soil fertility but also maintain a healthy ecosystem by supplying the energy available to living organisms by producing various kinds of enzymes related to degradation of lignocellulosic biomass. In order to isolate a lignocellulosic biomass degrading bacterial strain from the Jurassic park located in Gyeongnam National University of Science and Technology, We used the Luria-Bertani-Carboxymethyl cellulose (CMC) agar trypan blue method containing 0.4 % carboxymethyl cellulose and 0.01 % trypan blue. As a result, we isolated a bacterial strain showing both activity on the CMC and xylan. To identify the isolated strain, 16S rRNA sequencing and API kit analysis were used. The isolated strain turned out to belong to Bacillus species and then named Bacillus sp. GJY. In the CMC zymogram analysis, it showed that one active band of about 28kDa in size is present. Xylan zymogram analysis also showed to have one active band of about 25kDa in size. The optimal growth temperature of Bacillus sp. GJY was $37^{\circ}C$. The maximal activities of CMCase and xylanase were 12 hour after incubation. The optimal pH and temperature for CMCase were 5.0 and $40^{\circ}C$, respectively, whereas the optimal pH and temperature for xylanase was 4.0 and $40^{\circ}C$. Both activities for CMCase and xylanase showed to be thermally stable at 40and $50^{\circ}C$, while both activities rapidly decreased at over $60^{\circ}C$.

Distribution of Flora and Naturalized Plants in Gwangpo Bay, Sacheon (사천시 광포만의 식물상 및 외래식물 분포)

  • Lee, Min-Sook;Kim, Jung-Soo;Park, Sam-Bong;Cho, Gab-Ja;An, Jong-Bin;Song, Jin-Heon;Kwag, Chil-Sig;Kim, Bong-Gyu;Choo, Gab-Chul
    • Journal of Korean Society of Forest Science
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    • v.110 no.3
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    • pp.369-392
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    • 2021
  • This study aimed to provide basic data for efficient flora management of vascular plants, halophytes, and naturalized plants in the Gwangpo Bay area in Sacheon city, Gyeongsangnam-do. The flora found in this area incorporated 520 taxa, including 93 families, 299 genera, 466 species, 3 subspecies, 41 varieties, and 10 forma, and accounted for approximately 10.6% of total vascular plants (4,884 species) in Korea. According to the survey, 76 species of Gramineae showed the highest frequency (14.6%), followed by 67 species of Compositae (12.8%), 34 species of Leguminosae (6.5%), 27 species of Cyperaceae (5.2%), and 22 species of Rosaceae (4.2%). Rare plant species designated by the Korea Forest Service were categorized into six taxa, including three taxa in the LC grade, one taxon in the CR grade, one taxon in the VU grade, and one taxon in the EN grade. Korea endemic plants belonged to nine taxa consisting of seven families, seven genera, and nine species. The special floristic plants included 44 taxa, including one taxon (Prunus yedoensis) in the V grade, four taxa in the IV grade, ten taxa in the III grade, six taxa in the II grade, and 23 taxa in the I grade. Naturalized plants included 62 taxa consisting of 15 families, 47 genera, 59 species and 3 varieties. Halophytes consisted of 27 taxa, including 13 families, 24 genera, 24 species, 2 varieties, 1 forma, which consisted of Atriplex gmelinii, Suaeda glauca, Suaeda maritima, and Lathyrus japonicus. Invasive alien species in the Gwangpo Bay area included seven taxa. Since Ambrosia artemisiifolia, Sicyos angulatus, andPaspalum distichum var. indutummay have harmful effects on native plants, these plants must be artificially controlled.

Effects of Dietary Quercetin on the Feed Utilization, Blood Parameters, and Meat Quality in Korean Native Goats (Quercetin의 급여가 산양의 사료이용성, 혈액상 및 육질에 미치는 영향)

  • Cho, Sung-Kyung;Jo, Cheo-Run;Jung, Sa-Mu-El;Kim, Min-Kyu;Oh, Hyun-Min;Lee, Bong-Duk;Lee, Soo-Kee
    • Journal of Animal Science and Technology
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    • v.52 no.4
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    • pp.297-304
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    • 2010
  • This study was conducted to investigate the effects of dietary quercetin on feed utilization, blood parameters, and meat quality of Korean native goats. Totally sixteen Korean native goats, 15 kg of average BW aged at 7 months, were employed in the experiment with eight replicates per treatment. One group was fed quercetin at 200 mg/kg level and the other group was fed none as control for 15 days. Dietary inclusion of quercetin did not affect feed intake, water intake, and the amount of urine and feces. Digestibilities of crude fat, NDF, and ADF for 5 days were not affected, but digestibility of crude protein was increased by the dietary inclusion of qurecetin (P<0.05). Quercetin increased rumen total VFA, propionate, and butyrate significantly (P<0.05). Acetate/propionate ratio (A/P) in the quercetin treated group was significantly higher than control. 2,2-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) ($ABTS^+$) reducing activity of the loin from goat fed quercetin was higher than that of control. Sensory analysis conducted at 24 hr post mortem revealed that color, texture, and overall acceptability of the loin from goat fed quercetin were significantly preferred to that of control. Feeding quercetin did not influence pH, water holding capacity, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, TBARS value, and fatty acid composition of the loin significantly. In conclusion, the dietary inclusion of quercetin increased the digestibility of crude protein, rumen total VFA, propionate, butyrate, and A/P ratio. In addition the higher color and texture preference and ABTS+reducing activity of loin indicating some beneficial effect on enhancement of meat qualityin goats.

Reactivities of $Li_2ZrO_3/$honeycomb for $H_2S$ Removal ($H_2S$ 제거를 위한 $Li_2ZrO_3$/honeycomb의 반응 특성)

  • Park, Joo-Won;Kang, Dong-Hwan;Lee, Bong-Han;Yoo, Kyung-Seun;Lee, Jae-Gu;Kim, Jae-Ho;Han, Choon
    • Journal of Korean Society of Environmental Engineers
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    • v.27 no.12
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    • pp.1347-1352
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    • 2005
  • [ $H_2S$ ] removal reaction using $Li_2ZrO_3/honeycomb$ has been carried out in a fixed bed reactor for the cleaning of syngas from the waste gasifier. $Li_2ZrO_3$ was synthesised using reagent-grade $Li_3CO_3$ and $ZrO_2$ with suitable amount of ethanol in a 1:1 ratio. And then $Li_2ZrO_3$ were calcined in air at $850{\sim}1000^{\circ}C$ for 14 h. The optimum condition of $H_2S$ removal reaction is around 20 wt% $Li_2ZrO_3$/honeycomb at 300 mL/min and $700^{\circ}C$. At this condition, removal amount of $H_2S$ was about 0.337 $g^{H_2S}/g^{sorbent}$. Addition of $K_2CO_3$, $Na_2CO_3$, NaCl and LiCl in the $Li_2ZrO_3$ remarkably improves the $H_2S$ removal capacity of modified $Li_2ZrO_3$/honeycomb up to 23%. Analyses of $Li_2ZrO_3/honeycomb$ sorbent by SEM and XRD showed that $Li_2ZrO_3$ was uniformly impregnated into honeycomb up to considerable amounts. Furthermore, the physicochemical properties of the sorbent did not vary much up to $1000^{\circ}C$.

Evaluation of Antidepressant Drug Effect in a Depressive Animal Model by Proton MR Spectroscopy (양성자 자기공명분광법을 이용한 우울증 동물모델에서의 항우울제 약물 효능 평가)

  • Kim, Sang-Young;Choi, Chi-Bong;Lee, Sung-Ho;Woo, Dong-Cheol;Yoon, Seong-Ik;Hong, Kwan-Soo;Lee, Hyun-Sung;Cheong, Chae-Joon;Jee, Bo-Keun;Hong, Sung-Tak;Kim, Hwi-Yool;Choe, Bo-Young
    • Progress in Medical Physics
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    • v.19 no.2
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    • pp.95-101
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    • 2008
  • In this study, we observed the alteration of choline signal intensity in hippocampus region of the depressive rat model induced by forced swimming test (FST). The purpose of this study was to evaluate the antidepressant efficacy in the depressive animal model using MR spectroscopy. Fourteen experimentally naive male Sprague-Dawley rats weighting $160{\sim}180\;g$ were used as subjects. Drug injection group was exposed to the FST except for control group. The drugs were administered subcutaneously (SC) in a volume equivalent to 2ml/kg. And three injections were administered 23, 5, and 1h before beginning the given test. 1H MR spectra were obtained with use of a point resolved spectroscopy (PRESS) localization sequence performed according to the following parameters: repetition time, 2500 ms; echo time, 144 ms; 512 average; 2048 complex data points; voxel dimensions, $1.5{\times}2.5{\times}2.5\;mm^3$ ; acquisition time, 25min. There were no differences in NAA/Cr and Cho/Cr ratio between the right and the left hippocampus both normal control rats and antidepressant-injected rats. Also, no differences were observed in NAA/Cr and Cho/Cr ratio between the normal control rats and the antidepressant-injected rats both the right and the left hippocampus. In this study, we found the recovery of choline signals in the depressive animal model similar to normal control groups as injecting desipramine-HCl which was antidepressant causing anti-immobility effects. Thus, we demonstrated that MR spectroscopy was able to aid in evaluating the antidepressant effect of desipramine-HCl.

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