• Title/Summary/Keyword: Lee In sung

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Enhanced in vitro/in vivo Characteristics of Glucagon-like Peptide-1 by PEGylation

  • Han, H.S.;Youn, Y.S.;Oh, S.H.;Hong, S.T.;Lee, J.E.;Lee, S.O.;Lee, K.C.
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.298.2-298.2
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    • 2003
  • The insulinotropic hormone, glucagons-like peptide-1 (GLP-1), which has been proposed as a new potential therapeutics for type-II diabetes, but this is metabolized extremely rapidly by the ubiquitous enzyme, dipeptidyl peptidase IV (DPP IV), forming a metabolite, which acts as an antagonist at the GLP-1 receptor. (omitted)

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Phytochemical Constituents from Saussurea nutans

  • Choi, Sang-Zin;Lee, Sung-Ok;Yang, Min-Cheol;Nam, Jung-Hwan;Lee, Kyu-Ha;Jang, Ki-Uk;Lee, Jong-Hwa;Lee, Kang-Ro
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.198.1-198.1
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    • 2003
  • As part of our systematic study for Korean Compositae plants, we have studied Saussurea nutans, collected at Gangwon Province on August 2001. Phytochemical studies on various species of genus Saussurea have resulted in the isolation sesquiterpene, triterpene and flavonoid$\^$1)/. S. nutans has been used for the treatment of rheumatic arthritis and dysmenorrhea in the Chinese folk medicine$\^$2)/. However, chemical constituents of this plant have not been reported until now. The MeOH extract of the aerial parts of this source was solvent fractionated into n-hexane, methylene chloride, ethyl acetate and BuOH soluble portions. (omitted)

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Terpene Constituents from Aster spathulifolius

  • Lee, Sung-Ok;Choi, Sang-Zin;Yang, Min-Cheol;Nam, Jung-Hwan;Lee, Kyu-Ha;Lee, Jong-Hwa;Jang, Ki-Uk;Lee, Kang-Ro
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.192.3-193
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    • 2003
  • Aster species has been used in traditional chinese medicine for treatment of a bruies and asthma. On reviewing the literatures of this species, monoterpene glycosides, diterpenoids, triterpene glycosides, cyclic pentapeptides, oligopeptides and flavonoids 1) were isolated and some pharmacological activites were investigated 2). In continuation of our search for bioative components from Korean medicinal plants, we have examined Aster spathulifolius, collected from Jeju island on August 2001. (omitted)

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Terpenoids from Artemisia rubripes Nakai

  • Lee, Kyu-Ha;Choi, Sang-Zin;Min, Yong-Deuk;Lee, Sung-Ok;Yang, Min-Cheol;Chung, Ae-Kyung;Nam, Jung-Hwan;Lee, Kang-Ro
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.373.1-373.1
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    • 2002
  • Twenty Artemisia species are distributed in South Korea and rich in terpenoids. Artemisia rubripes (Compositae) has been used as a Korean traditional medicine for stomachache. vomiting. diarrhea and hemostatic agent. The antimutagenic effect and essential oils of Artemisia rubripes were reported, but phytochemical study has not been fully investigated. As part of our systematic study on the terpene constituents of Artemisia species. we have investigated A. rubripes (1 kg) collected at Dae-Kwan ryung. Gangwon Province on Aug. 1997. (omitted)

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Phytochemical Constitutents of Siegesbeckia pubesence Makino.

  • Nam, Jung-Hwan;Choi, Sang-Zin;Lee, Sung-Ok;Yang, Min-Cheol;Chung, Ae-Kyung;Lee, Kyu-Ha;Shin, Dae-Hee;Lee, Kang-Ro
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.374.2-374.2
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    • 2002
  • Siegesbeckia pubesence (Cempesitae). a perenial herb, is widely distributed in our country and has been used for rheumaic arthritis, hypertension, malaria. neurasthnia and snake-bite in traditional Chinese medicine. On reviewing the literatures of this plant. diterpenoids and alkaloids were isolated and some pharmacological activities were investigated. As part of our systematic study fer Korean Compositae plants, we have investigated Siegesbeckia pubesence (7kg), cellected from Mt. Odae on Aug. 2001. (omitted)

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Diastereoselective Synthesis of Polysubstituted Pyrrolidinone as a Key Intermediate for the Anticancer Agents by Palladium(II)­Catalyzed Carboxylation

  • Choi Dong-Rack;Lee Kee-Young;Chung Yun-Sung;Joo Jae-Eun;Kim Yong-Hyun;Oh Chang-Young;Lee Yiu-Suk;Ham Won-Hun
    • Archives of Pharmacal Research
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    • v.28 no.2
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    • pp.151-158
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    • 2005
  • Palladium(II)-catalyzed carboxylation of chiral olefins 6a-d has been examined under various conditions. In the weak basic condition ($K_{2}CO_3$), 7a-d were obtained in good yields. Alternatively, in the strong basic condition, pyrrolidinones 8a-d were obtained resulting in excellent yields and with high diastereoselectivity.