• Journal of Korean Neurosurgical Society
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• 제30권9호
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• pp.1103-1107
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• 2001

Objective : Atypical and malignant meningiomas(AM, MM) are known to be rare and show aggressive behavior. Limited data are available concerning the clinical features, effectiveness of surgical removal and role of radiation therapy with AM, MM. The authors report our experience of AM, MM, with respect to clinical features. Methods : Twenty-four cases of AM and 28 cases of MM, who were operated between 1988 and 1999 were retro-spectively studied review of medical records and radiological findings. These were compared with control group of 24 cases of menigiomas manifestating usual clinical course, which are selected arbitrarily among operative cases between Apr. 1999 and Dec. 1999. Mean follow-up periods were 26(1-91) months for AM and 23(1-62) for MM. Authors analyzed the prognostic factors for survival, and statistical analysis were accomplished by Kaplan-Meier method and log-rank test. Results : Differences of clinical features between control groups and these atypical and malignant meningioma group were not significant. However, the location of MM was frequent in non-basal area(p<0.01). In AM, there were 4 patients of recurrence, and 3 patients of mortality. Among mortality cases, only one patient died of tumor progression, the other patients died of other causes. The survival at 2 year and 5 year in this group were 88% and 74% respectively, and in MM, 11 patients died due to tumor progression and 2 had spinal metastasis. The survival at 2 year and 5 year were 72% and 20%, respectively. For extent of resection, total removal(Simpson grade 1 or 2) was less often achieved in MM compared with AM(50% vs. 83%). Extent of resection of tumor and postoperative radiation therapy did not affect survival in both AM, MM. Conclusions : Clinical behavior of AM showed more benign than that of MM. Prognostic factor for survival is not related extent of resection of tumor and postoperative radiation therapy. However, further investigation with long-term follow-up and additional cases is mandatory.

• 폴리머
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• 제30권1호
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• pp.85-89
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• 2006

이축압출기를 이용한 용융혼련으로 제조한 기상성장 탄소섬유(Vapor Grown Carbon Fiber, VGCF) 충전 폴리페닐렌설파이드(polyphenylene sulfide, PPS) 복합체외 VGCF 함량에 따른 전기적, 유변학적 특성을 살펴보았다. 복합체의 파단면 모폴로지 관찰결과, 본 방법은 PPS 매트릭스 내에 VGCF를 균일하게 분산시키는데 있어서 효과적임을 확인할 수 있었다. $5\;wt\%$, VGCF 혼입까지는 미충전 PPS와 거의 유사한 전기적 성질과 유변학적 거동을 보였으며 $10\;wt\%$로 VGCF의 혼입양을 증가시켰을 때 현저한 도전성 발현 및 점도 상승, 탄성률의 주파수 무의존성 등 유변학절 성질의 변동이 관찰되었다. 고충전 PPS계에서의 탄성률의 주파수 무의존성은 복합체 내에서의 VGCF의 네트워크 형성으로 인한 건으로 추정되며, 이는 전기적 성질뿐만 아니라 유변학적 성질의 측정결과로부터 복합체 내의 도전성 네트워크의 형성을 확인할 수 있음을 보여준다.

• 대한한의학회지
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• 제30권4호
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• pp.129-141
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• 2009

Objective: This study was to investigate the anti-tumor effect, safety, safety, mechanism and metabolizing enzyme of Agrimonia pilosa LEDEB (APL) in female C57B/L mouse tumor (in vivo). Method: First, to evaluate the antitumor activity of APL, we divided the mice into four groups: normal, control, APL50 (50mg/kg), and APL100 (100mg/kg). LLC-obtained American Type Culture Collection was used. LLC had been inoculated to induce tumors. To measure the anti-tumor effect of APL, we calibrated tumor size and weight. To analyze the mechanism of anti-tumor in APL, we used western blotting and to observe metabolizing enzyme in APL we used to real-time PCR. Result: APL50 and APL100 significantly inhibited tumor growth from 12 days after medicine injected. APL did not induce caspase-dependent apoptosis in LLC-bearing mouse tumor. In APL100, it decreased 41% and 71% in CYP2D22 and CYP3A11, respectively. Conclusion: These results suggest that APL has some anti-tumor effects in female C57B/L mouse tumor. APL should be used carefully with other drugs related with CYP2D22 and CYP3A11.

• 척추신경추나의학회지
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• 제6권2호
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• pp.155-164
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• 2011

Objectives : The purpose of this study is to compare the effects of Pharmacopuncture Treatment with Chuna Treatments for Low Back Pain caused by Traffic accidents. Methods : This study was carried out on 81 patients with low back pain caused by Traffic accidents. The patients were divided into 2 group ; The pharmacopuncture(A) group was treated by pharmacopuncture treatment. The chuna(B) group was treated by chuna treatment. We measured Oswestry Disability Index(ODI) and Visual Analog Scale(VAS) on the patients before the treatment and on the 2nd, and 4th weeks after the treatments. Results : After being treated by our methods, the ODI and VAS score's were improved after the 4th weeks treatment in both groups. There is no significant difference on ODI and VAS score after the 4th weeks treatment in both groups. In the early stages(from pre to 2 weeks worth of treatment), Group A showed a decreasing VAS score compared to Group B. In the final stages(from 2 weeks to 4 weeks worth of treatment), Group B showed a higher decreasing amount compared to Group A in VAS score. Conclusions : The results suggest that both pharmacopuncture treatment and chuna treatment is considered to be effective and useful on low back pain caused by traffic accidents. There is no significant difference between pharmacopuncture treatment and chuna treatment for low back pain caused by traffic accidents, however the early stages of treatments(from pre to 2 weeks treatement) show that pharmocopouncture treatment is more effective than chuna treatment for low back pain by traffic accidents. In the final stages(from 2 weeks to 4 weeks treatment), chuna treatment is more effective than pharmacopuncture treatment for low back pain by traffic accident.

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 2003년도 추계국제학술대회
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• pp.57-69
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• 2003

It is well known that many pesticides possess hormonal activity, and affect the developments of wildlife and mammals including human. Currently, pyrethroid insecticides are in worldwide use to control in and outdoor pests, providing potential far environmental exposure. Hormonal activities of these pyrethroid insecticides, however, have been little studied, and the developmental effects of them were no reported. Therefore, we firstly examined the potential estrogenic activities of some pyrethroid insecticides (permethrin, cypermethrin, tetramethrin, deltamethrin, sumithrin, fenvalerate and bioallethrin) by immature rat uterotrophic assay, luciferase reporter gene assay and Calbindin-D$\sub$9k/ (CaBP-9k) gene expression assay. Uterine wet weights were increased by permethrin and the permethrin-induced weights were inhibited by ICI 182780 in the uterolrophic assay. On the other hand tetramethrin significantly reduced uterine and vaginal wet weights, and also inhibited the E2-induced weight increases at all doses tested. Cypermethrin and sumithrin had a tendency to increase uterine weights, although not statistically significant. Permethrin and cypermethrin dose-dependently increased the luciferase activity in reporter gene assay. Northern blot analysis showed that permethrin induced CaBP-9k mRNA expression whereas tetramethrin inhibted. Subsequent studies were conducted to investigate the possible developmental effects of four pyrethroid insecricides (permethrin, cypermethrin, sumithrin and teramethrin). Either diethlbestrol (DES) or 17${\beta}$ -estradiol (E2) was used as a reference control in this study. Pyrethroid insecticides were administered to Sprague Dawley rats via subcutaneous injection at 6 to 18 days of gestation or 1 to 5 days after birth. In utero treatment of permethrin (10mg/kg/day) in female rat resulted in significant increases in uterine and ovarian weights while significant decreases in serum E2 concentration, uterine and ovarian ER${\alpha}$ mRNA levels. Sumithrin and permethrin led to acceleration in vaginal opening of female rat, while delay in preputial separation of male after neonatal treatment. Anogenital distances of PND 18 were significantly reduced in sumthrin-treated, and permerhrin-treated male rats after neonatal treatment. All the pyrethroid insecticides tested caused significant increases in uterine weights on PND 18, while significant reductions in the first diestrus phase when neonataly treated. In addition, exposure to pyrethroids in neonatal period led to significant reduction in relative brain weight in female rat on PND 18, but its weight was recovered in diestrus phase. In summary, Our experimental data demonstrate the possibilities of developmental effects of pyrethroid insecticides via estrogenic or antiestrogenic activity.

• 한국유기농업학회지
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• 제23권1호
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• pp.43-58
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• 2015

본 시험은 유기재배에 적합한 양파 품종 선발을 통해 유기재배 시 발생할 수 있는 문제점을 보완하기 위해 수행되었다. 농가 선호도, 육성계통, 육종회사, 고정종, 교배종, 국내종, 외국종 등을 고려하여 15개 품종을 선발하여 시험을 수행하였다. 각 품종들은 저온생장성, 동해 저항성, 추대, 분구 등 생리장해에 대한 저항성, 수확기 도복률 및 상품 수량 등 5개 영역에서 평가되었다. 교배종에서는 e-조은, 카타마루, 팝, 아트, 신기한 등이, 교배종에서는 창녕대고, 서울대고, 천주중고 등이 유기재배에 적합한 품종으로 선발되었다. 비록 적합한 품종으로 선발되지는 못했지만, 선파워는 구 특성에서 좋은 결과를 보였다. 고정종, 교배종간에는 저온생장성(엽초경), 수확기 도복률(5월 24일)을 제외한 전 영역에서, 국내종, 외국종 간에는 월동 후 결주율을 제외한 전 영역에서 유의한 차이가 발견되지 않았다.

• 한국축산시설환경학회지
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• 제19권2호
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• pp.81-88
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• 2013

We planned to study how the chemical disposal designed by SOP can affect on physicochemical compositions of the livestock excrement. According to Livestock Manure Management Scheme, we experimented in two steps; the first step, NaOH treatment-Citric acid neutralization, and then the second procedure, Thermophilic Aerobic Oxidation (TAO) system. Physicochemical compositions of the 3-days-old samples after NaOH treatment were pH 10.31, EC 24.54 mS/cm, SCOD 3,022 mg/L, T-N 4,315 mg/L, $NH{_4}^+-N$ 1,960 mg/L, and not detected E. coli.. And those of one-day-old samples after citric acid neutralization were pH 7.36, EC 32.89 mS/cm, $SCOD_{Mn}$ 12,733 mg/L, T-N 4,787 mg/L, $NH{_4}^+-N$ 2,450 mg/L, and E. coli. not detected. In contrast, the physicochemical compositions of the treatment plots after the second treatment with TAO system (72hr) were pH 9.42 EC 24.21 mS/cm, $SCOD_{Mn}$ 3,660 mg/L, T-N 3,616 mg/L, $NH{_4}^+-N$ 1,190 mg/L, and no detection of E. coli.

• 한국농림기상학회지
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• 제20권2호
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• pp.159-165
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• 2018

본 연구는 급격하게 진행되고 있는 기후변화에 따른 콩의 생육과 종실 수량 반응을 온도구배챔버에서 수행하였다. 생식상 장기간의 고온 발생은 농업 생산성을 저해시키며, 인류의 식품안정성에도 영향을 줄 수 있다. 모든 품종이 $Ta+4^{\circ}C$에서 개화기간이 지연되는 현상을 보여 영양생장기보다 생식생장기의 고온에 대해 민감하게 반응을 하였다. 온도 변화에 대한 종실 수량 구성 반응을 보면 대원콩은 온도가 상승 할수록 협수, 종실 무게가 높아져 수량이 증가하였다. 반면 풍산나물콩과 대풍콩은 각각 $Ta+3^{\circ}C$와 $Ta+4^{\circ}C$사이에서 각각 일정 온도를 벗어나게 되면 온도에 민감하게 반응하여 착협수와 100립중이 감소를 하여 수량 감소로 이어졌다. 종자 크기로 보았을 때 대립 품종인 대원콩은 일정 온도 범위까지는 수량이 증가 할 것으로 판단된다. 반면 중립과 소립품종인 대풍콩과 풍산 나물콩은 일정 온도를 벗어나게 되면 수량이 감소 할 것으로 판단된다.

• 한국균학회지
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• 제40권4호
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• pp.282-287
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• 2012

Sclerotium cepivrum은 마늘과 같은 파속작물에 발생하는 흑색썩음균핵병의 병원균이다. 기생진균 Paraconiothyrium minitans S134 균주는 마늘 흑색썩음균핵병의 생물적 방제를 위하여 선발되었다. 포장실험은 태안에서 2011년 10월부터 2012년 6월까지 실시하였다. P. minitans S134 균주의 포자현탁액($5{\times}10^6m{\ell}$)을 마늘 종구를 파종직후와 다음해 2월 하순에 주당 $100m{\ell}$씩 각각 관주처리하여 6월 5일에 흑색썩음균핵병 발생 억제효과를 조사하였다. P. minitans S134 균주를 2회 관주처리구가 6.8%, 플루퀀코나졸수화제 분의처리구가 0.4%, 무처리구가 19.5%의 흑색썩음균핵병이 발생하였다. 그러므로 P. minitans S134 균주는 마늘 흑색썩음균핵병에 대한 유망한 미생물농약으로서 가능성을 나타내었다.

• 한국균학회지
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• 제40권4호
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• pp.271-276
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• 2012

S. sclerotiorum에 의한 상추 균핵병의 생물적 방제를 위하여 기생진균 P. minitans CM2을 선발하였다. 경기도 양평군의 상추 시설재배포장에서 실험이 3월부터 4월에 수행되었다 상추균핵병 발생초기에 기생진균의 포자현탁액의 농도별로 7일 간격 1회 부터 3회까지 상추의 지제부에 관주처리하였다. P. minitans CM2($1{\times}10^7/m{\ell}$)의 1회 처리구가 11.0%, 베노밀수화제가 2.7%, 무처리가 31.0% 각각 균핵병이 발생하였고, 2회 관주처리가 7.9%, 3회 관주처리가 12.8% 균핵병이 각각 발생하였다. P. minitans CM2 균주의 처리시기에 대한 시험을 양평과 수원에서 실시하였다. P. minitans CM2 균주의 포자현탁액($5{\times}10^6/m{\ell}$)을 상추 정식직후에 관주 처리가 75.3~84.7%, 정식전 육묘 200공 연결포트에 관주처리한 후 균핵병 발생초기에 관주처리는 58.0~63.8% 방제효과를 나타내었다. 이와 같은 결과에서 P. minitans CM2 균주는 상추균핵병에 생물적 방제를 위한 유망한 미생물농약개발이 가능하다고 생각된다.