• 한국근적외분광분석학회:학술대회논문집
• /
• 한국근적외분광분석학회 2001년도 NIR-2001
• /
• pp.4112-4112
• /
• 2001

The feasibility of NIR spectroscopy as a quick and nondestructive method for quality control of uniformity of coating thickness of pharmaceutical tablets was investigated. Near infrared spectra of a set of pharmaceutical tablets with varying coating thickness were measured with a diffuse reflectance fiber optic probe connected to a Broker IFS 28/N FT-NIR spectrometer. The challenging issues encountered in this study included: 1. The similarity of the formulation of the core and coating materials, 2. The lack of sufficient calibration samples and 3. The non-linear relationship between the NIR spectral intensity and coating: thickness. A peak at 7184 $cm^{-1}$ was identified that differed for the coating material and the core material when M spectra were collected at 2 $cm^{-1}$ resolution (0.4 nm at 7184 $cm^{-1}$). The study showed that the coating thickness can be analyzed by polynomial fitting of the peak area of the selected peak, while least squares calibration of the same data failed due to the lack of availability of sufficient calibration samples. Samples of coal powder and solid pieces of coal were analyzed by FT-NIR diffuse reflectance spectroscopy with the goal of predicting their ash content, percentage of volatile components, and energy content. The measurements were performed on a Broker Vector 22N spectrometer with a fiber optic probe. A partial least squares model was constructed for each of the parameters of interest for solid and powdered sample forms separately. Calibration models varied in size from 4 to 10 PLS ranks. Correlation coefficients for these models ranged from 86.6 to 95.0%, with root-mean-square errors of cross validation comparable to the corresponding reference measurement methods. The use of FT-NIR diffuse reflectance measurement techniques was found to be a significant improvement over existing measurement methodologies in terms of speed and ease of use, while maintaining the desired accuracy for all parameters and sample forms.(Figure Omitted).

• 한국수산과학회지
• /
• 제35권3호
• /
• pp.216-222
• /
• 2002

시계열자료가 가진 자기상관은 추정된 상관관계를 왜곡시키는 요인들 중의 하나로 작용한다. 회귀모형의 잔차항에 자기상관이 있는 지를 검정하기 위해 Durbin-Watson 통계량이 흔히 쓰인다. 잔차항에 자기상관을 가진 회귀모형의 효율성을 향상시키기 위해 yule-Walker 법, 비선형최소제곱법, 최우추정법 및 사전백색화법이 사용되어 왔다. 본 연구는 자기상관으로 인한 상관관계의 왜곡을 방지하기 위한 이들 방법들에 대해 고찰하였다. 사전백색화법을 제외한 앞의 3가지 방법을 20년간의 실제 시계열 자료에 적용하였으며 몬테카를로법을 이용하여 각 방법의 오차변이를 조사하였다. 각 방법의 평균잔차제곱분포의 경우, 최우추정법으로 추정된 평균잔차제곱이 가장 작았으며 분포 범위도 가장 작았으나 각 추정방법 사이에 유의한 차이가 발견되지는 않았다.

• Asian-Australasian Journal of Animal Sciences
• /
• 제19권8호
• /
• pp.1095-1099
• /
• 2006

Leptin and IGFBP-3 are two proteins that play an important role in growth and metabolism of the animals. They are also involved in the immune function of animals and, thus, are candidate genes for the study of association with immune functions. Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) of these two genes was done to screen 64 crossbred (Holstein Friesian${\times}$Hariana) female calves of one year of age. From each RFLPs (fragments) three genotypes were observed. In all the RFLPs the mutant homozygotes were very less in numbers and, hence, were excluded from the least squares analysis. The serum IgG level was estimated using SRID assay. The mean level of serum IgG was $28.83{\pm}2.73mg/ml$. The effect of these identified genotypes on serum IgG level of calves at one year of age was analysed using least squares analysis. The HaeIII RFLP-AB genotype had significantly (p<0.05) higher serum IgG level ($31.86{\pm}3.05$) than the HaeIII RFLP-AA ($25.62{\pm}2.96$) genotype. There was no significant effect of leptin genotypes on the IgG level. The present results indicated a role of the IGFBP-3 gene on serum IgG level of cattle calves.

• 융합신호처리학회논문지
• /
• 제14권1호
• /
• pp.27-32
• /
• 2013

영상처리로 물체를 검출 하는 경우, 타원 형태를 검출 하는 것은 많은 응용 분야에서 중요한 역할을 한다. 실제 영상에서 타원은 영상에 포함된 노이즈나 다른 물체에 가려 보이지 않거나 교차되어 타원 검출이 용이 하지 않다. 이에 본 논문에서는 영상에서 타원을 검출 하기 위하여 경계(edge)를 추출하고, 이미지 정보량을 줄이기 위하여 그룹화 과정을 수행하여 타원 검출의 속도를 향상시켰다. 또한 타원 검출을 위해 5 개의 타원 변수를 랜덤으로 선택한 후 최적의 타원 파라미터 선택을 위해 선형 최소자승 근사법을 적용하였다. 검출된 타원들을 검증하기 위하여 RANSAC 알고리즘을 적용하였다. 본 연구에서 제안한 알고리듬을 구현하여 실제 영상에 적용한 결과 75%의 정확도를 나타내었고, 타 연구와 비교 결과 타원검출 속도 면에서 탁월함을 확인하였다. 이러한 결과는 본 연구에서 제안한 알고리듬이 영상 내 타원을 검출 하기 위한 유효한 방법임을 확인 할 수 있었다.

• 응용통계연구
• /
• 제21권6호
• /
• pp.901-910
• /
• 2008

국내 삼일열 말라리아는 1990년대 중반부터 급격히 증가하여 2000년대에는 연평균 1600여명이 발병하고 있다. 본 연구에서는 이미 알려진 잠복기 분포와 2001년부터 2006년까지의 발병자수 자료에 바탕하여 후향연산식을 활용하여 국내 삼일열 말라리아의 감염분포를 최소제곱법으로 추정하였다. 추정된 감염분포는 평균이 207일이고 표준편차가 30.7일인 정규분포를 이루었다. 이를 이용하여 연간 유병자수 분포를 산출한 결과, 말라리아의 하루 평균 유병자수는 628.8명 이었다.

• 농업과학연구
• /
• 제45권4호
• /
• pp.823-837
• /
• 2018

The objective of this study was to evaluate the firmness and the sweetness index (SI) of tomatoes with a hyperspectral imaging (HSI) technique within the wavelength range of 1000 - 1550 nm. The hyperspectral images of 95 tomatoes were acquired with a push-broom hyperspectral reflectance imaging system, from which the mean spectra of each tomato were extracted from the regions of interest. The reference firmness and sweetness index of the same sample was measured and calibrated with their corresponding spectral data by partial least squares (PLS) regression with different preprocessing methods. The calibration model developed by PLS regression based on the Savitzky-Golay second-derivative preprocessed spectra resulted in a better performance for both the firmness and the SI of the tomatoes compared to models developed by other preprocessing methods. The correlation coefficients ($R_{pred}$) were 0.82, and 0.74 with a standard error of prediction of 0.86 N, and 0.63, respectively. Then, the feature wavelengths were identified using a model-based variable selection method, i.e., variable importance in projection, from the PLS regression analyses. Finally, chemical images were derived by applying the respective regression coefficients on the spectral image in a pixel-wise manner. The resulting chemical images provided detailed information on the firmness and the SI of the tomatoes. The results show that the proposed HSI technique has potential for rapid and non-destructive evaluation of firmness and the sweetness index of tomatoes.

• 전자공학회논문지
• /
• 제50권7호
• /
• pp.76-84
• /
• 2013

순시(instantaneous) TDOA (time difference of arrival)와 FDOA (frequency difference of arrival)를 이용한 위치추정 방법은 추가적인 측정값 획득을 통해 정확도 향상을 도모할 수 있으며, 이를 위해서는 동시에 운용되는 수신단의 수를 증가하여야 한다. 하지만 전자전 환경에서 수신단 수의 증가는 아군의 피탐확률(probability of intercept) 상승으로 인한 전력 손실을 야기할 수 있고, 수신단 간의 데이터 링크 및 시각동기화와 같은 과정에 대한 추가적인 고려가 필요하다. 따라서 본 논문에서는 이격된 2개의 이동 수신단만을 운용하여 연속적으로 다수의 TDOA와 FDOA 정보를 측정하고, 이를 이용하여 고정 신호원의 위치를 추정하는 방법을 제안한다. 이 경우 매 측정 순간마다 독립된 수신단 쌍(pair)이 추가되므로 각 수신단 조합은 서로 다른 기준 수신단을 가지게 된다. 그러므로 모든 수신단 쌍이 동일한 기준 수신단을 공유해야하는 QCLS (quadratic correction least squares) 방법을 적용할 수 없다. 이러한 이유로 본 논문에서는 비선형 LS 최적해를 반복계산을 통해 얻어내는 Gauss-Newton 기법을 적용한다. 또한 모의실험을 통해 획득된 TDOA와 FDOA의 수가 증가함에 따른 위치추정 결과의 RMSE (root mean square error)값과 CRLB (Cramer-Rao lower bound)를 비교하고, CEP (circular error probable) 평면을 도시하여 2차원 공간상에서의 기대 추정 성능을 분석한다.

• 한국임상약학회지
• /
• 제6권2호
• /
• pp.1-6
• /
• 1996

Carcadian rhythm dependence of vancomycin pharmacokinetics was evaluated in 5 normal volunteers receiving a single intravenous 1.0 g dose of vancomycin at 8 o'clock in the morning and another occasion at 8 o'clock in the evening in a crossover manner. The serum data were subjected to simultaneous computer nonlinear least squares regression analysis using a two-compartment pbarmacokinetic model. The mean half-life of vancomycin was $4.78\pm0.81$ hr in the morning and $4.25\pm0.51$ hr in the evening. The mean total body clearance of vancomycin was $1.29\pm0.58$ hr in the morning and $5.58\pm0.48$ hr in the evening. No circadian rhythm was found to be apparent in normal volunteers. The mean in intrasubject difference in the half-life between 8 A.M. and 8 P.M. was $15.4\%$ with fluctuations ranging from $10.4\sim33.8\%$, It is reasonable to consider individual circadian rhythm for effective dosage regimen of vancomycin in clinical chronotherapeutics.

• 한국자동차공학회논문집
• /
• 제21권6호
• /
• pp.175-182
• /
• 2013

Lately, customers think highly of the emotional satisfaction and as a result, issues on odor are matters of concern. The cases are odor of interior material and air-conditioner of vehicles. In particualar, with respect to the odor of air-conditioner, customers strongly claimed defects with provocative comments : "It smells like something rotten," "It smells like a foot odor," "It stinks like a rag." Generally, it is known that mold of evaporator core in the air-conditioning system decays and this produce VOCs which causes the odor to occur. In this study, partial least squares regression model is applied to predict the strength of the odor and select of important VOCs which affect car air conditioning smell. The PLS method is basically a particular multilinear regression algorithm which can handle correlated inputs and limited data. The number of latent variable is determined by the point which is stabilized mean absolute deviations of VOCs data. Also multiple linear regression is carried out to confirm the validity of PLS method.

• Journal of Forest and Environmental Science
• /
• 제34권2호
• /
• pp.119-125
• /
• 2018

The tropical forests in developing countries are faced with the problem of illegal exploitation of trees. However, dearth of empirical means of expressing the dimensions, structure, quality and quantity of a removed tree has imped conviction of offenders. This study aimed at developing a model that can effectively estimate individual tree basal area (BA) from stump diameter (Ds) for Tectona grandis stands in Omo Forest Reserve, Nigeria, for timber valuation in case of illegal felling. Thirty-six $25m{\times}25m$ temporary sample plots (TSPs) were laid randomly in six age strata; 26, 23, 22, 16, 14, and 12 years specifically. BA, Ds and diameter at breast height were measured in all living T. grandis trees within the 36 TSPs. Least square method was used to convert the counted stumps into harvested stem cross-sectional areas. Six basal area models were fitted and evaluated. The BA-Ds relationship was best described by power model which gave least values of Root mean square error (0.0048), prediction error sum of squares (0.0325) and Akaike information criterion (-15391) with a high adjusted coefficient of determination (0.921). This study revealed that basal area estimation was realistic even when the only information available was stump diameter. The power model was validated using independent data obtained from additional plots and was found to be appropriate for estimating the basal area of Tectona grandis stands in Omo Forest Reserve, Nigeria.