• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제8권1호
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• pp.101-112
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• 1997

본 연구의 목적은 학습 장애를 진단하는데 있어 성취도 검사인 기초학습기능검사의 유용성을 살펴보는 것이다. 학습 장애 집단은 두 유형으로 나누어 언어적 학습 장애 집단(VLD：Verbal Learning Disorder) 34명, 비언어적 학습 장애 집단(NVLD：Nonverbal Learning Disorder) 14명으로 총 48명으로 구성되었으며, 비교 집단으로는 Dysthymia 집단 11명, 정상아 20명을 대상으로 지능 검사 및 기초학습 기능검사의 수행을 비교하였다. 지능 검사에서 VLD집단은 어휘력 및 언어를 통한 학습 과제, 언어-청각적인 주의과제에서 의미있는 저하를 나타내었고, NVLD 집단은 시-지각의 정확도, 정신-운동성 기능의 협응 속도, 시각-공각적인 조직력 등 동작성 기능 전반에 걸쳐 비효율성을 나타내었다. 기초학습기능검사에서는 VLD 집단은 음운 부호화과제, 셈하기 능력, 단어 재인 과제에서 의미있는 저하를 나타내었다. 또한 지능 검사의 소검사들에 기초학습기능검사의 소검사들을 포함하여 판별 분석을 한 결과, 기초학습기능검사를 포함시키지 않은 경우보다 판별율이 높아졌을 뿐 아니라, VLD집단을 유의미하게 판별해 주는 판별 함수를 도출하였다. 각 소검사들의 속성을 분석하기 위하여 요인 분석을 실시하였으며 이를 통하여 소검사들을 유목화하였으며 마지막으로 현 논문의 제한점 및 기초학습기능검사의 제한점을 논의하였다.

• Clinical and Experimental Pediatrics
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• 제51권9호
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• pp.922-934
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• 2008

Developmental language disorder is the most common developmental disability in childhood, occurring in 5-8% of preschool children. Children learn language in early childhood, and later they use language to learn. Children with language disorders are at increased risk for difficulties with reading and written language when they enter school. These problems often persist through adolescence or adulthood. Early intervention may prevent the more serious consequences of later academic problems, including learning disabilities. A child's performance in specific speech and language areas, such as phonological ability, vocabulary comprehension, and grammatical usage, is measured objectively using the most recently standardized, norm-referenced tests for a particular age group. Observation and qualitative analysis of a child's performance supplement objective test results are essential for making a diagnosis and devising a treatment plan. Emphasis on the team approach system in the evaluation of children with speech and language impairments has been increasing. Evidence-based therapeutic interventions with short-term, long-term, and functional outcome goals should be applied, because there are many examples of controversial practices that have not been validated in large, controlled trials. Following treatment intervention, periodic follow-up monitoring by a doctor is also important. In addition, a systematized national health policy for children with speech and language disorders should be provided.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제28권4호
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• pp.192-196
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• 2017

Social (pragmatic) communication disorder (SCD) is a new diagnosis included under communication disorders in the neurodevelopmental disorders section of Diagnostic and Statistical Manual of Mental Disorders-5. SCD is defined as a primary deficit in the social use of nonverbal and verbal communication. SCD has very much in common with pragmatic language impairment, which is characterized by difficulties in understanding and using language in context and following the social rules of language, despite relative strengths in word knowledge and grammar. SCD and Autism Spectrum Disorder (ASD) are similar in that they both involve deficits in social communication skills, however individuals with SCD do not demonstrate restricted interests, repetitive behaviors, insistence on sameness, or sensory abnormalities. It is essential to rule out a diagnosis of ASD by verifying the lack of these additional symptoms, current or past. The criteria for SCD are qualitatively different from those of ASD and are not equivalent to those of mild ASD. It is clinically important that SCD should be differentiated from high-functioning ASD (such as Asperger syndrome) and nonverbal learning disabilities. The ultimate goals are the refinement of the conceptualization, development and validation of assessment tools and interventions, and obtaining a comprehensive understanding of the shared and unique etiologic factors for SCD in relation to those of other neurodevelopmental disorders.

• Clinical Psychopharmacology and Neuroscience
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• 제16권4호
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• pp.449-460
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• 2018

Objective: Prior functional magnetic resonance imaging (fMRI) work has revealed that children/adolescents with disruptive behavior disorders (DBDs) show dysfunctional reward/non-reward processing of non-social reinforcements in the context of instrumental learning tasks. Neural responsiveness to social reinforcements during instrumental learning, despite the importance of this for socialization, has not yet been previously investigated. Methods: Twenty-nine healthy children/adolescents and 19 children/adolescents with DBDs performed the fMRI social/non-social reinforcement learning task. Participants responded to random fractal image stimuli and received social and non-social rewards/non-rewards according to their accuracy. Results: Children/adolescents with DBDs showed significantly reduced responses within the caudate and posterior cingulate cortex (PCC) to non-social (financial) rewards and social non-rewards (the distress of others). Connectivity analyses revealed that children/adolescents with DBDs have decreased positive functional connectivity between the ventral striatum (VST) and the ventromedial prefrontal cortex (vmPFC) seeds and the lateral frontal cortex in response to reward relative to non-reward, irrespective of its sociality. In addition, they showed decreased positive connectivity between the vmPFC seed and the amygdala in response to non-reward relative to reward. Conclusion: These data indicate compromised reinforcement processing of both non-social rewards and social non-rewards in children/adolescents with DBDs within core regions for instrumental learning and reinforcement-based decision-making (caudate and PCC). In addition, children/adolescents with DBDs show dysfunctional interactions between the VST, vmPFC, and lateral frontal cortex in response to rewarded instrumental actions potentially reflecting disruptions in attention to rewarded stimuli.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제31권3호
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• pp.97-104
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• 2020

Deep learning (DL) is a kind of machine learning technique that uses artificial intelligence to identify the characteristics of given data and efficiently analyze large amounts of information to perform tasks such as classification and prediction. In the field of neuroimaging of neurodevelopmental disorders, various biomarkers for diagnosis, classification, prognosis prediction, and treatment response prediction have been examined; however, they have not been efficiently combined to produce meaningful results. DL can be applied to overcome these limitations and produce clinically helpful results. Here, we review studies that combine neurodevelopmental disorder neuroimaging and DL techniques to explore the strengths, limitations, and future directions of this research area.

• Molecules and Cells
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• 제23권3호
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• pp.259-271
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• 2007

Investigation of molecular and cellular mechanisms of synaptic plasticity is the major focus of many neuroscientists. There are two major reasons for searching new genes and molecules contributing to central plasticity: first, it provides basic neural mechanism for learning and memory, a key function of the brain; second, it provides new targets for treating brain-related disease. Long-term potentiation (LTP), mostly intensely studies in the hippocampus and amygdala, is proposed to be a cellular model for learning and memory. Although it remains difficult to understand the roles of LTP in hippocampus-related memory, a role of LTP in fear, a simplified form of memory, has been established. Here, I will review recent cellular studies of LTP in the anterior cingulate cortex (ACC) and then compare studies in vivo and in vitro LTP by genetic/pharmacological approaches. I propose that ACC LTP may serve as a cellular model for studying central sensitization that related to chronic pain, as well as pain-related cognitive emotional disorders. Understanding signaling pathways related to ACC LTP may help us to identify novel drug target for various mental disorders.

• 재활복지
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• 제15권4호
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• pp.27-47
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• 2011

본 논문은 발달장애인의 역량강화를 통해 지역사회로의 자연스러운 전환을 목표로 한 전환과정과 프로그램을 개발하기 위한 연구이다. 연구목적을 달성하기 위하여 문헌연구, 관련 프로그램 사례조사, 전문가 심층면접 방법을 활용하였으며 연구의 결과는 다음과 같다. 첫째, 현재 발달장애인들을 고려한 전환과정은 지나치게 제한되어 있고 이들의 특성을 고려하지 못하고 있다. 둘째, 발달장애인을 위한 새로운 고등교육프로그램이 새로운 전환과정으로 시작되고 있으나 중등학교와 연계가 부족하다. 셋째, 중등학교 이후 발달장애인을 위한 대학프로그램에서 중요하게 고려되어야 하는 요인은 자기인지와 자기이해이다. 이 결과를 중심으로 한국에서 발달장애인을 위한 대학 내 전환과정과 프로그램을 제안하면 첫째, 발달장애인을 위한 중등학교 이후 전환과정은 최소한 발달장애인의 특성과 자기이해와 자기인지가 이루어질 수 있도록 주류화교육이 이루어져야 하며, 이를 고려할 때 대학 내에서의 전환과정 구성은 하나의 대안이 될수 있다. 둘째, 대학 내 구성되는 고등교육프로그램은 다음과 같은 측면이 고려되어 구성될 필요가 있다. ① 대학 내의 많은 고등교육 관련 프로그램의 지원을 받을 수 있도록 연계되거나 지원망이 구축될 필요가 있다. ② 대학 내의 모든 프로그램에 발달장애학생들이 참여할 수 있도록 문호가 개방되어야 한다. ③ 대학 내의 전문 인력들이 필요에 따라 참여할 수 있도록 인적구성이 체계화되고 연계될 수 있어야 한다. ④ 대학 내의 비장애학생들이 발달장애학생들의 프로그램에 참여할 수 있도록 통합학습이나 활동이 자연스럽게 이루어질 수 있도록 해야 한다.

• 대한조현병학회지
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• 제21권2호
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• pp.74-80
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• 2018

Objectives : This study investigated whether long-acting injectable (LAI) paliperidone is different from its oral form in terms of the effect on cognitive function in schizophrenia spectrum and other psychotic disorders. Methods : We reviewed the medical records of patients in Seoul National University Bundang Hospital who were diagnosed as having schizophrenia and/or other psychotic disorders based on DSM-5 from 2016 to 2017. Seven patients were treated with oral paliperidone and 11 were treated with paliperidone palmitate. All patients underwent clinical and neuropsychological assessment, including the Korean version of the MATRICS Consensus Cognitive Battery (MCCB) at their first visit or within one month of their initial treatment. MCCB was repeated within three to 12 months after the initial assessment. Results : There was no significant difference between the two groups in most cognitive domains including speed of processing, attention and vigilance, working memory, verbal learning, visual learning and reasoning and problem solving domain. However, patients treated with paliperidone palmitate showed better improvement in social cognition domain than those taking oral paliperidone. The standardized values of social cognition domain scores had significantly improved over time in patients under paliperidone palmitate, demonstrating a significant time-by-group interaction. Conclusion : Our results show that long-acting injectable paliperidone could be helpful in some aspects of improving cognitive function in schizophrenia spectrum and other psychotic disorders. Further studies with other antipsychotics are necessary to generalize the results.

• 대한장애인치과학회지
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• 제9권1호
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• pp.46-50
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• 2013

저자는 본 증례를 통하여 발달장애 환자의 치과치료 시 다음과 같은 지견을 얻었다. 1. 발달장애 환자의 경우 불량한 구강위생 등으로 인하여 치과적 치료가 필요한 경우가 많다. 2. 발달장애 환자의 경우 비약물적 행동조절만으로 치과적 치료를 위한 충분한 협조도를 얻기가 어렵다. 3. 발달장애 환자에 있어서 midazolam 구강 전투약을 이용한 전신마취 하 치과치료가 매우 유용하게 적용될 수 있다. 4. 숙련된 의료진의 철저한 감시하에 정맥주사용 midazolam 제재를 설탕시럽에 혼합하여 투약한다면 전투약을 통해 기대하는 효과를 얻을 수 있다.

• 셀메드
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• 제11권1호
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• pp.2.1-2.8
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• 2021

The clinical condition Amnesia causes difficulty in learning new information and the inability to recall past events. It is primarily concerned with recent memory loss. Majoon-e-Nisyan (MJN) is a polyherbal Unani formulation, present in a semi-solid form. It is widely used potent drug of the Unani System of Medicine (USM) for treating Nisyan (amnesia). In the present study polyherbal Unani formulation, MJN has been studied for its quality control and acute toxicity. Standardization (quality control) of drugs deals with drug identity, drug quality and purity determination. Standardization of MJN had been done as per the Unani pharmacopoeial parameters approved by World Health Organization (WHO) - Pharmacognostical parameters, Physico-chemical parameters, high-performance thin-layer chromatography (HPTLC), microbial load, aflatoxin, and heavy metals. Solvents and chemicals used in the study were of analytical grade and used instrument were calibrated. By conducting an acute oral toxicity study in rats, the safety of MJN was assessed. The limit test method of OECD guideline 425 was followed in the study. Results of standardization and standard operating procedures (SOPs) for preparation of MJN may serve as the standard reference in the future. The data generated in the study for the quality control of MJN proved the quality of formulation and shows that MJN is not toxic in rats following acute dosing up to 2000 mg/kg bw. The data obtained in the paper for MJN may be used as a standard guideline for preparation of the formulation which can save time, cost, and resources for future research endeavours.