• 대한수학회보
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• 제45권2호
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• pp.231-239
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• 2008

We obtain a necessary and sufficient condition for the existence of Mendelsohn triple systems excluding contiguous units with ${\lambda}$ = 1. Also, we obtain the spectrum for cyclic such systems.

• Communications for Statistical Applications and Methods
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• 제23권6호
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• pp.543-553
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• 2016

The validity of statistical inference depends on proper randomization methods. However, even with proper randomization, we can have imbalanced with respect to important characteristics. In this paper, we introduce a method based on ranked auxiliary variables for treatment allocation in crossover designs using Latin squares models. We evaluate the improvement of the efficiency in treatment comparisons using the proposed method. Our simulation study reveals that our proposed method provides a more powerful test compared to simple randomization with the same sample size. The proposed method is illustrated by conducting an experiment to compare two different concentrations of titanium dioxide nanofiber (TDNF) on rats for the purpose of comparing weight gain.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권2호
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• pp.335-352
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• 2023

When solving multi-objective optimization problems, the blindness of the evolution direction of the population gradually emerges with the increase in the number of objectives, and there are also problems of convergence and diversity that are difficult to balance. The many- objective optimization problem makes some classic multi-objective optimization algorithms face challenges due to the huge objective space. The sine cosine algorithm is a new type of natural simulation optimization algorithm, which uses the sine and cosine mathematical model to solve the optimization problem. In this paper, a knee-driven many-objective sine-cosine algorithm (MaSCA-KD) is proposed. First, the Latin hypercube population initialization strategy is used to generate the initial population, in order to ensure that the population is evenly distributed in the decision space. Secondly, special points in the population, such as nadir point and knee points, are adopted to increase selection pressure and guide population evolution. In the process of environmental selection, the diversity of the population is promoted through diversity criteria. Through the above strategies, the balance of population convergence and diversity is achieved. Experimental research on the WFG series of benchmark problems shows that the MaSCA-KD algorithm has a certain degree of competitiveness compared with the existing algorithms. The algorithm has good performance and can be used as an alternative tool for many-objective optimization problems.

• International Journal of Fluid Machinery and Systems
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• 제9권3호
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• pp.229-236
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• 2016

Exergetic analysis was introduced in optimization of a rotating equilateral triangular internal cooling channel with staggered square ribs to maximize the net exergy gain. The objective function was defined as the net exergy gain considering the exergy gain by heat transfer and exergy losses by friction and heat transfer process. The flow field and heat transfer in the channel were analysed using three-dimensional Reynolds-averaged Navier-Stokes equations under the uniform temperature condition. Shear stress transport turbulence model has been selected as a turbulence closure through the turbulence model test. Computational results for the area-averaged Nusselt number were validated compared to the experimental data. Three design variables, i.e., the angle of rib, the rib pitch-to-hydraulic diameter ratio and the rib width-to-hydraulic diameter ratio, were selected for the optimization. The optimization was performed at Reynolds number, 20,000. Twenty-two design points were selected by Latin hypercube sampling, and the values of the objective function were evaluated by the RANS analysis at these points. Through optimization, the objective function value was improved by 22.6% compared to that of the reference geometry. Effects of the Reynolds number, rotation number, and buoyancy parameter on the heat transfer performance of the optimum design were also discussed.

• 농업과학연구
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• 제43권3호
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• pp.379-386
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• 2016

Four ruminally cannulated Holstein steers (BW $482.9{\pm}8.10kg$), fed low protein TMR (CP 11.7%) as a basal diet, were used to investigate changes in rumen fermentation and blood metabolism according to protein fraction, cornell net carbohydrates and protein system (CNCPS), and enriched feeds. The steers, arranged in a $4{\times}4$ Latin square design, consumed TMR only (control), TMR supplemented with rapeseed meal (AB1), soybean meal (B2), and perilla meal (B3C), respectively. The protein feeds were substituted for 23.0% of CP in TMR. Ruminal pH, ammonia-N, and volatile fatty acids (VFA) in rumen digesta, sampled through ruminal cannula at 1 h-interval after the morning feeding, were analyzed. For plasma metabolites analysis, blood was sampled via the jugular vein after the rumen digesta sampling. Different N fraction-enriched protein feeds did not affect (p > 0.05) mean ruminal pH except AB1 being numerically lower 1 - 3 h post-feeding than the other groups. Mean ammonia-N was statistically (p < 0.05) higher for AB1 than for the other groups, but VFA did not differ among the groups. Blood urea nitrogen was statistically (p < 0.05) higher for B2 than for the other groups, which was rather unclear due to relatively low ruminal ammonia-N. This indicates that additional studies on relationships between dietary N fractions and ruminant metabolism according to different levels of CP in a basal diet should be required.

• Biomolecules & Therapeutics
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• 제6권3호
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• pp.296-302
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• 1998

The bioequivalence of two cyclosporin A products was evaluated in 26 normal male volunteers (age 25 ~33 yr, body weight 56~84 kg) following single oral administration. Test product was a hard capsule containing the granule of cyclosporin A (Chong Kun Dang Corp., Korea) and reference product, Sandimmun", was a soft capsule containing surfactant, oil, alcohol and cyclosporin A (Sandoz, Swiss). Both products contain 100 mg of cyclosporin A. Four capsules of the test and the reference product were administered to the volunteers, respectively, by randomized two period cross-over study (2$\times$2 Latin square method). Average drug concentrations at each sampling time and pharmacokinetic parameters were not significantly different between two products (p>0.05); the area under the concentration-time curve to last sampling time (24 hr) (AU $Co_{24}$) (5034.8$\pm$ 1760.6 vs 4635.4$\pm$ 1158.9 ng . h/ml), maximum plasma concentration ( $C_{max}$) (1002.7$\pm$353.1 vs 980. 4$\pm$ 171.7 ng/71), and mean residence time (MRT) (6.16$\pm$0.81 vs 5.64$\pm$0.50 h). The differences of mean AUC 7-,4,7~, T_ and MRT between the two products (7.93,2.22,16 and 8.39%, respectively) were less than 20% given as a guideline. The power (1-$\beta$) and treatment difference ($\Delta$) for AU $Co_{24}$, $C_{max}$ and MRT were more than 0.8 and less than 0.2, respectively. Although $T_{max}$ of the two products was significantly different each other (p<0.05), $T_{max}$ might be an insignificant parameter because cyclosporin A generally requires long-term administration. From these results, the two products are bioequivalent.alent.t.

• Nuclear Engineering and Technology
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• 제21권1호
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• pp.18-31
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• 1989

대기오염의 제어가 발전 단가에 미치는 영향을 분석하기 위하여 전산 모델이 개발 되었다. POGEN은 석탄 화력 발전소에 대해 대기오염 제어 비용을 가산한 균등화 발전 단가를 계산한다. 부 프로그램 Pollution은 대기 오염 제어 비용을 가산한 지배 방정식을 사용하여 총 자본 비용과 변동비용을 계산한다. 이 비용은 균등화 발전 단가를 계산하는 부 프로그램 GENeration의 추가 입력으로 사용된다. 탈황설비의 직접 비용에 대한 Pollution을 이용한 결과는 경험이 풍부한 선진국에서 발간된 비용 자료로써 검증하였다. 2001년의 전력 생산비용은 석탄화력발전소에 적용된 세 가지의 규제 시나리오에 의해 추정되었다. 입력 변수의 중요도와 미래 발전소에 대한 입력 변수에 포함된 불확실성 때문에 생기는 불확실도의 전파를 검토하기 위해 Latin Hypercube Sampling과 Multiple Least Squares 방법을 사용하여 민감도 분석과 불확실도 분석을 수행하였다. 가장 민감한 입력 변수는 원자력, 화력 공히 할인률이다. 배출가스제어 비용으로서 9-11 mills/kWh 정도가 추가되어야 한다. 이 비용은 전력 생산비용의 거의 20 퍼센트가 되고, 이에 해당하는 투자비는 1GW 용량의 석탄 화력발전소 초기 투자비용의 40%가 될 것이다. 원자력 발전에 대한 단가는 90퍼센트의 신뢰도로써 32.6-65.9, 석탄 화력에 대해서는 45.5-60.5 mills/kWh가 되며, 엄격한 규제 분위기 하에서는 원자력이 95%의 신뢰도로써 유리할 것이 전망된다.

• 대한기계학회논문집A
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• 제36권9호
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• pp.1065-1071
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• 2012

풍력발전기의 안정적인 전력생산은 정격풍속 이상에서 피치제어와 스톨제어와 같은 일정속도제어로 이루어지고 있다. 최근, 효율적인 전력생산을 위하여 정격풍속 이하의 변동풍속 조건에서 최대 출력을 얻기 위한 가변 속도제어가 적용되고 있는 추세이다. 기존의 피치제어기에서는 지글러-니콜스 계단응답법에 의한 제어기 최적화가 이루어지고 있으나, 가변 속도제어의 요구로 보다 정확한 최적화가 필요하게 되었다. 본 연구에서는 기존의 지글러-니콜스 계단응답법을 개선하기 위하여 라틴 하이퍼큐브 샘플링을 통한 신경망모델을 구축하고, 구축된 PID 제어 계수 신경망모델에 유전자 알고리즘을 적용하여 피치제어기를 최적화하였다. 유전자 알고리즘으로 구한 최적해가 지글러-니콜스 계단응답법의 초기해 보다 평균제곱근 오차가 13.4% 향상되었고, 응답특성을 나타내는 상승속도와 정착시간은 각각 15.8% 및 15.3%으로 개선되었다.

• Asian-Australasian Journal of Animal Sciences
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• 제17권7호
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• pp.960-966
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• 2004

The purpose of this study was to evaluate the effects of protein supplementation of green tea waste (GTW) on the performance of lactating cows. Another aim was to increase resource utilization and to eliminate any environmental negative impact from the tea waste. GTW from a beverage company was ensiled at a low pH (<4.0) and high acetic acid and lactic acid concentration, and it contained high crude protein (CP, 34.8%), total extractable tannins (TET, 9.2%) and condensed tannin (CT, 1.7%). Two experiments were conducted to investigate the palatability and performance in lactating cows fed GTW. In the palatability trial, three lactating cows were allocated to three dietary treatments in a 3$\times$3 Latin square design. The animals were offered a total mixed ration (TMR) including GTW at rates of 0, 2.5 and 5.0% on a dry matter (DM) basis. Total DM intake was not different among the treatments. In the performance trial, four lactating cows were used in a 2$\times$2 Latin square design with a 3 week sampling period. GTW was incorporated into TMR at a rate of 5.0% on a DM and 10.0% on a CP basis. Thus GTW replaced alfalfa hay and soybean meal at a level of 25.0% on a DM. DM and CP intake were not affected by the inclusion of GTW, whereas TET and CT intake were significantly increased (p<0.001). Milk production, milk composition and the efficiency of milk production were not altered by the GTW inclusion. Although ruminal pH and VFA, and blood urea nitrogen were not changed, ruminal $NH_{3}-N$ and plasma total cholesterol were relatively low in the GTW group, but not significantly different. The excretion of urinary purine derivatives and estimated MN supply were also not significantly affected by GTW treatment. It is therefore concluded that GTW can be used as a protein source without any detrimental effects on the performance of lactating cows.

• Asian-Australasian Journal of Animal Sciences
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• 제18권12호
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• pp.1746-1751
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• 2005

The objective of this study was to evaluate the effects of sarsaponin on methane production, ruminal fermentation, nutrient digestion and blood metabolites using three Holstein steers in a 3${\times}$3 Latin Square design. The steers were fed Sudangrass hay plus concentrate mixture at a ratio 1.5:1 twice daily, and sarsaponin (0, 0.5 and 1% of DM), which was given at 09:00 and 17:00 h daily by mixing with concentrate. Rumen samples were collected 0, 2, and 5 h after morning dosing. Ruminal pH was numerically decreased and numbers of protozoa were decreased linearly (p<0.01) by treatment. Ruminal ammonia-N was reduced (linear; p<0.05) and total VFA was increased (quadratic; p<0.05) at 2 and 5 h after sarsaponin dosing. The molar proportion of acetate was decreased (quadratic; p<0.05) and propionate was increased (linear; p<0.01) at all sampling times. Blood plasma glucose was increased and urea-N was decreased (linear; p<0.05) at 2 and 5 h after dosing. Methane was decreased by approximately 12.7% (linear; p<0.05). The apparent digestibility of DM and NDF were decreased (quadratic; p<0.05) and that of CP remained unchanged due to the sarsaponin. The numbers of cellulolytic bacteria were decreased (quadratic; p<0.05), while numbers of total viable bacteria remained unchanged due to the sarsaponin. These results show that sarsaponin can partially inhibit rumen methanogenesis in vivo and improve ruminal fermentation, which supports our previous in vitro results.