• The Korean Journal of Physiology and Pharmacology
• /
• 제1권6호
• /
• pp.613-624
• /
• 1997

Dorsal root ganglion (DRG) is composed of neuronal cell bodies of primary afferents with diverse functions. Various types of ion channels present on DRG neurons may reflect those functions. In the present study, voltage-gated potassium currents in DRG neurons of neonatal rats were characterized by whole-cell voltage clamp method. Two types of delayed rectifier and three types of transient potassium currents were identified according to their electrophysiological properties. The delayed rectifier currents were named $I_{Ke}$ (early inactivating) and $I_{K1}$ (late inactivating). Steady state inactivation of $I_{Ke}$ began from -100 mV lasting until -20 mV. $I_{K1}$ could be distinguished from $I_{Ke}$ by its inactivation voltage range, from -70 mV to +10 mV. Three transient currents were named $I_{Af}$ (fast inactivation), $I_{Ai}$ (intermediate inactivation kinetics), and $I_{As}$ (slow inactivation). $I_{Af}$ showed fast inactivation with time constant of $10.6{\pm}2.0$ msec, $I_{Ai}$ of $36.9{\pm}13.9$ msec, and $I_{As}$ of $60.6{\pm}2.9$ msec at +30 mV, respectively. They also had distinct steady state inactivation range of each. Each cell expressed diverse combination of potassium currents. The cells most frequently observed were those which expressed both $I_{K1}$ and $I_{Af}$, and they had large diameters. The cells expressing $I_{Ke}$ and expressing $I_{Ke}$, $I_{Ai}$, and $I_{As}$ usually had small diameters. Judging from cell diameter, capsaicin sensitivity or action potential duration, candidates for nociceptor were the cells expressing $I_{Ke}$, expressing $I_{Ke}$ and $I_{Ai}$, and expressing $I_{Ke}$ and $I_{As}$. The types and distribution of potassium currents in neonatal rat DRG were similar to those of adult rat DRG (Gold et al, 1996b).

• 한국제4기학회지
• /
• 제18권2호통권23호
• /
• pp.103-104
• /
• 2004

This paper discuss some results of observed changes of meteorological elements as temperature, precipitation and some extreme indexes in Mongolia. Mongolia is one of the largest landlocked countries in the world. The climate is characterized by a long lasting cold winter, dry and hot summer, low precipitation, high temperature fluctuation and relatively high number of sunny days per year. During last 60 years the annual mean air temperature has risen $1.66^{\circ}C$. Intensive warming of > $2^{\circ}C$ was observed at higher altitudes of high mountains when warming of < $1^{\circ}C$ was observed the Domod steppe and the Gobi Desert. Heat Wave Duration have statistically significant risen trend with increaded number of days by 8-18 at significance level of 95-99.9% depending on geography and Cold Wave Duration have shortened by 13.3 days significance level of 95-99%. In general, by the amount of precipitation, Mongolia falls in semi-arid and arid region. It is 300-350 mm in the high mountain regions while it is only 50-150 mm in Gobi Desert regions. The changes of annual precipitation have very localized character i.e.decreasing at one site and increasing at a sit nearby. Annual precipitation decreased by 30-90 mm in the northern-central region and increased by 2-60 mm in the western and eastern region. The magnitude of alteration changes in precipitation regardless increasing or decreasing is 5-25%. A trends, significant at the level of 90%, found where changes are more than 40 mm or more than 15% of annual mean value. Moreover, the soil moisture resources was decreased in the last 40 years. Specially, moisture contents of the top soil have decreased 2 times(N. Natsagsuren, 2002). Months of June and July in Mongolia is the year that moisture is not inhibiting vegetation growth. Unfortunately, its also found that moisture in this time tends to decrease. Increased temperature, decreased precipitation and soil moisture are most likely resulted in occurences of more intense drought spells that have taken place during the recent years. Intimately, these changes have considerable impact on livestock in Mongolia.

• 대한감각통합치료학회지
• /
• 제8권1호
• /
• pp.1-13
• /
• 2010

목적 : 본 연구는 주변 환경에 민감하고 감정기복이 심한 감각조절장애 아동에게 무게감 있는 조끼 착용을 통한 고유수용성 감각을 제공하여 아동의 문제행동에 미치는 영향을 알아보기 위하여 실시하였다. 연구 방법 : 연구 대상자는 일반초등학교 1학년에 재학 중인 만 7세 남아로 연구설계는 ABA'단일사례연구를 사용하였고, 14회기 실험을 실시하였다. 중재기간(B)동안 1.3kg의 무게를 첨부한 조끼를 착용하고 학습인지교육을 받았다. 결과 : 치료회기가 진행될수록 의자에서 엉덩이를 떼고 일어나거나 몸을 앞/뒤, 좌/우로 흔드는 경우 및 엄지손가락 을 입에 넣기, 손등 입으로 가져가기, 손장난하기 등 행동적 측면에서의 문제행동은 점차 감소되는 경향을 보였다. 결론 : 연구결과 무게감 있는 조끼를 착용한 후 아동의 문제행동이 회기가 지날수록 감소되는 양상을 보였다. 무게감 있는 조끼가 감각조절장애 아동의 문제행동에 대한 감각통합치료의 효과 유지에 미치는 영향을 설명하는데 본 연구설계 및 중재기간상 제한점이 있어서, 무게감 있는 조끼가 감각조절장애 아동의 문제행동에 영향을 주었다기 보다는 감각통합치료를 지속적으로 실시한 결과로 생각할 수 있다. 따라서 추후 연구에서는 연구설계의 변형이나 연구회기의 증가를 통해 무게감 있는 조끼가 감각통합치료의 효과를 지속하는지에 대해 명확히 알아보는 것이 필요하고, 감각조절장애 아동에게 무게감 있는 조끼를 착용시키는 것에 대한 적용방법, 무게, 적용시간에 대한 효율적인 프로토콜을 제시하는 연구가 필요할 것이다.

• Tuberculosis and Respiratory Diseases
• /
• 제80권1호
• /
• pp.45-51
• /
• 2017

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive diagnostic method for mediastinal and hilar lymphadenopathy. This study aimed to investigate the incidence of fever following EBUS-TBNA. Methods: A total of 684 patients who underwent EBUS-TBNA from May 2010 to July 2012 at Seoul National University Hospital were retrospectively reviewed. The patients were evaluated for fever by a physician every 6-8 hours during the first 24 hours following EBUS-TBNA. Fever was defined as an increase in axillary body temperature over $37.8^{\circ}C$. Results: Fever after EBUS-TBNA developed in 110 of 552 patients (20%). The median onset time and duration of fever was 7 hours (range, 0.5-32 hours) after EBUS-TBNA and 7 hours (range, 1-52 hours), respectively, and the median peak body temperature was $38.3^{\circ}C$ (range, $137.8-39.9^{\circ}C$). In most patients, fever subsided within 24 hours; however, six cases (1.1%) developed fever lasting longer than 24 hours. Infectious complications developed in three cases (0.54%) (pneumonia, 2; mediastinal abscess, 1), and all three patients had diabetes mellitus. The number or location of sampled lymph nodes and necrosis of lymph node were not associated with fever after EBUS-TBNA. Multiple logistic regression analysis did not reveal any risk factors for developing fever after EBUS-TBNA. Conclusion: Fever is relatively common after EBUS-TBNA, but is transient in most patients. However, clinicians should be aware of the possibility of infectious complications among patients with diabetes mellitus.

• 한국전문물리치료학회지
• /
• 제10권3호
• /
• pp.17-27
• /
• 2003

Repetitive transcranial magnetic stimulation (rTMS) modulates cortical excitability beyond the duration of the rTMS trains themselves. Depending on rTMS parameters, a lasting inhibition or facilitation of cortical excitability can be induced. Therefore, rTMS of high or low frequency over motor cortex may change certain aspects of motor learning performance and cortical activation. This study investigated the effect of high and low frequency subthreshold rTMS applied to the motor cortex on motor learning of sequential finger movements and brain activation using functional MRI (fMRI). Three healthy right-handed subjects (mean age 23.3) were enrolled. All subjects were trained with sequences of seven-digit rapid sequential finger movements, 30 minutes per day for 5 consecutive days using their left hand. 10 Hz (high frequency) and 1 Hz (low frequency) trains of rTMS with 80% of resting motor threshold and sham stimulation were applied for each subject during the period of motor learning. rTMS was delivered on the scalp over the right primary motor cortex using a figure-eight shaped coil and a Rapid(R) stimulator with two Booster Modules (Magstim Co. Ltd, UK). Functional MRI (fMRI) was performed on a 3T ISOL Forte scanner before and after training in all subjects (35 slices per one brain volume TR/TE = 3000/30 ms, Flip angle $60^{\circ}$, FOV 220 mm, $64{\times}64$ matrix, slice thickness 4 mm). Response time (RT) and target scores (TS) of sequential finger movements were monitored during the training period and fMRl scanning. All subjects showed decreased RT and increased TS which reflecting learning effects over the training session. The subject who received high frequency rTMS showed better performance in TS and RT than those of the subjects with low frequency or sham stimulation of rTMS. In fMRI, the subject who received high frequency rTMS showed increased activation of primary motor cortex, premotor, and medial cerebellar areas after the motor sequence learning after the training, but the subject with low frequency rTMS showed decreased activation in above areas. High frequency subthreshold rTMS on the motor cortex may facilitate the excitability of motor cortex and improve the performance of motor sequence learning in normal subject.

• 한국식품과학회지
• /
• 제5권1호
• /
• pp.42-48
• /
• 1973

일부(一部) 식품항산화제(食品抗酸化劑)를 주로하는 항산화제(抗酸化劑)들, 즉 BHA, BHT, PG, ${\alpha}-tocopherol$, ascorbic acid (As.A), pyrogallol, 및 antage 3C를 식용대두유(食用大豆油)에 각각(各各) 0.05%의 농도(濃度) 첨가(添加)하여, 일사광선조사(日射光線照射) 조건하(條件下) 및 암소저장(暗所貯藏) 조건하(條件下) $(45.0{\pm}0.5^{\circ}C)$에서의 이들 항산화제(抗酸化劑)의 식용대두유(食用大豆油)에 대한 과산화물형성(過酸化物形成) 억제효과와 유리지방산형성(遊離脂肪酸形成) 억제효과를 비교(比較) 검토(檢討)하였다. 암소저장(暗所貯藏) 조건하(條件下)에서 저장(貯藏)할 때는 ${\alpha}-tocopherol$ 을 제외(除外)한 다른 항산화제(抗酸化劑)들은 비교적 강(强)한 과산화물형성(過酸化物形成) 억제효과를 보였으며, 특히 PG, BHT, antage 3C, As.A 등의 억제효과는 매우 강(强)하였다. 일사광선조사(日射光線照射) 조건하(條件下)에서도 BHT, PG 등은 강(强)하고 지속적(持續的)인 효과를 나타냈었다. 한편 동일조건하(同一條件下)에서의 pyrogallol, antage 3C의 억제효과는 BHA, BHT, PG 등의 식품항산화제(食品抗酸化劑)의 효과를 훨씬 능가하였었다. ${\alpha}-Tocopherol$의 억제효과는 상기의 두 조건하(條件下)에서 다 같이 저장일수(貯藏日數)가 경과(經過)함에 따라 급속(急速)히 상실(喪失)되었다. 일반적(一般的)으로 암소저장조건하(暗所貯藏條件下)에서의 각(各) 항산화제(抗酸化劑)의 과산화물형성(過酸化物形成) 억제효과는 일사광선조사(日射光線照射) 조건하(條件下)에서보다 훨씬 더 효과적인 듯하였다. 각(各) 항산화제(抗酸化劑)의 유리지방산형성(遊離脂肪酸形成) 억제효과는 암소저장(暗所貯藏) 조건하(條件下)에서 더 강력(强力)하고 효과적인 듯하였다. 특히 pyrogallol 은 상기의 두 조건하(條件下)에서 다 같이 강력(强力)한 억제효과를 보여주었다. 또한 모든 항산화제(抗酸化劑)의 일사광선조사(日射光線照射) 조건하(條件下)에서의 유리지방산형성(遊離脂肪酸形成) 억제효과는 동일조건하(同一條件下)에서의 과산화물형성(過酸化物形成) 억제효과와 비교할 때 매우 현저하였다.

• 한국조경학회지
• /
• 제46권3호
• /
• pp.92-102
• /
• 2018

본 연구는 생활권 도시림의 방문이 시민들의 주관적 웰빙의 향상에 기여하는지를 검토하였다. 도시림 방문은 강한 경험이 아니기 때문에 강도 대신 빈도에 해당하는 방문회수와 체류시간을 독립변수로 사용하였으며, 종속변수는 긍정적 감정, 부정적 감정 및 삶의 만족도이었다. 서울시민을 대상으로 여론조사기관이 온라인 설문으로 수집한 600매의 자료를 분산분석한 결과, (a) 도시림의 방문회수와 체류시간 간에는 상호작용 효과가 없었으며, (b) 방문회수와 상관없이 최근 2주간 도시림을 방문한 사람들은 방문하지 않는 사람들보다 긍정적 감정이 높았으며 부정적 감정은 낮았고, 평소에 한 달에 1번 이상 도시림을 방문한 사람들은 미방문자들보다 삶의 만족도가 높았지만, (C) 방문자들의 체류시간은 긍정적 감정, 부정적 감정 및 삶의 만족도 모두에 영향을 주지 못하였다. 결과적으로, 도시림 방문이란 의도적 활동이 유전적으로 결정된 주관적 웰빙 수준을 변화시킨다는 기존 이론을 확인함으로써, 도시림의 확대와 유지관리는 시민들의 복지향상을 위한 정부의 의미 있는 투자라는 것이 밝혀졌다. 보다 신뢰성 높은 추후연구를 위해 응답자 집단의 선정과 영향변수들의 중요성을 고찰하였다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권11호
• /
• pp.4999-5003
• /
• 2016

The testicular cancer (TCa) incidence is increasing in many countries, with age-standardized incidence rates up to 7.8/100,000 men in the Western world, although reductions in mortality and increasingly high cure rates are being witnessed at the same time. In Africa, where rates are lower, presentation is often late and morbidity and mortality high. Given this scenario, awareness of testicular cancer and practice of testicular self-examination among future first response doctors is very important. This study was conducted to determine knowledge and attitude to testicular cancer, and practice of testicular self-examination (TSE) among final (6th) year medical students. In addition, the effect of an intervention in the form of a single PowerPoint(R) lecture, lasting 40 minutes with image content on testicular cancer and testicular self examination was assessed. Pre and post intervention administration of a self-administered structured pre tested questionnaire was performed on 151 medical students, 101 of whom returned answers (response rate of 66.8%). In the TC domain, there was a high level of awareness of testicular cancer, but poor knowledge of the age group most affected, with significant improvement post intervention (p<0.001). Notable also was the poor awareness of the potential curability of TC, this also being improved following the intervention (p<0.001). A poor level of awareness and practice of testicular self-examination pre-intervention was found considering the nature of the study group..Respondents had surprisingly weak/poor responses to the question "How important to men's health is regular testicular self-examination?" Answers to the questions "Do you think it is worthwhile to examine your testis regularly?" and "Would you be interested in more information on testicular cancer and testicular self-examination?" were also suboptimal, but improved post intervention p<0.001, p<0.001 and p=0.037. Age, gender and marital status were without specific influence. In conclusion, this study showed poor levels of knowledge regarding epidemiology of TCa and its potential curability when detected early. There was also a poor awareness of, practice of, and poor attitudes to TSE. The significant improvement in these parameters post intervention indicates value in educational intervention. We recommend inclusion of TCa coverage and TSE teaching in the secondary school curriculum (targeting adolescents). Greater emphasis should also be given to testicular cancer in the curricula of medical schools and other training institutions for health care personnel.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제38권6호
• /
• pp.343-353
• /
• 2012

Objectives: This aim of this study was to effectively isolate mesenchymal stem cells (hSMSCs) from human submandibular skin tissues (termed hSMSCs) and evaluate their characteristics. These hSMSCs were then chemically induced to the neuronal lineage and analyzed for their neurogenic characteristics in vitro. Materials and Methods: Submandibular skin tissues were harvested from four adult patients and cultured in stem cell media. Isolated hSMSCs were evaluated for their multipotency and other stem cell characteristics. These cells were differentiated into neuronal cells with a chemical induction protocol. During the neuronal induction of hSMSCs, morphological changes and the expression of neuron-specific proteins (by fluorescence-activated cell sorting [FACS]) were evaluated. Results: The hSMSCs showed plate-adherence, fibroblast-like growth, expression of the stem-cell transcription factors Oct 4 and Nanog, and positive staining for mesenchymal stem cell (MSC) marker proteins (CD29, CD44, CD90, CD105, and vimentin) and a neural precursor marker (nestin). Moreover, the hSMSCs in this study were successfully differentiated into multiple mesenchymal lineages, including osteocytes, adipocytes, and chondrocytes. Neuron-like cell morphology and various neural markers were highly visible six hours after the neuronal induction of hSMSCs, but their neuron-like characteristics disappeared over time (24-48 hrs). Interestingly, when the chemical induction medium was changed to Dulbecco's Modified Eagle Medium (DMEM) supplemented with fetal bovine serum (FBS), the differentiated cells returned to their hSMSC morphology, and their cell number increased. These results indicate that chemically induced neuron-like cells should not be considered true nerve cells. Conclusion: Isolated hSMSCs have MSC characteristics and express a neural precursor marker, suggesting that human skin is a source of stem cells. However, the in vitro chemical neuronal induction of hSMSC does not produce long-lasting nerve cells and more studies are required before their use in nerve-tissue transplants.

• 대한심미치과학회지
• /
• 제25권2호
• /
• pp.98-108
• /
• 2016

전통적인 Metal-ceramic 보철 제작 방식으로부터 All-ceramic 보철에 이르기까지 최근 신소재 개발에 영향을 주는 가장 큰 요인은 심미적인 욕구일 것이다. 우리가 사용하는 각각의 치과용 수복 재료는 재료 별로 강도, 인성, 기계 가공의 효율성 및 사용에 필요한 다양한 과정을 기반으로 임상에서 다양하게 사용되고 있다. 예를 들어 Glass ceramic과 같은 단일 소재의 경우 약한 물성을 고려하여 주로 싱글 크라운과 같은 간단한 보철에 사용하고 있으며 상대적으로 높은 파괴 인성을 가진 지르코니아 재료의 경우 싱글 크라운은 물론 브릿지의 제작에도 널리 사용하고 있다. 하지만 지르코니아 재료는 제작 과정에서 긴 Sintering 시간을 필요로 하므로 Chair side에서 빠른 보철물 제작에 쉽지 않은 부분이 있으며 주로 Lab. side에서 사용하고 있다. CAD / CAM 시스템을 이용하여 보철물을 제작하는 용도로 개발 된 Hybrid ceramic 소재는 Resin Nano Hybrid Ceramic이라고도 하며, 개선 된 물성을 포함한 나노 세라믹 요소를 기반으로 하고 있다. 이러한 특징들은 심미적이며 기능적인 보철물의 제작이 용이한 과정과 결과를 보이고 있으며 동시에 향상된 내구성을 바탕으로 보철물의 제작 과정에 유리한 조건들을 가지고 있다. 새로운 Nano Hybrid Ceramic 재료는 Composite Resin과 Glass ceramic과 같은 단일 소재들이 가진 장점들을 이용하여 술자들의 요구사항을 바탕으로 오랜 연구를 통해 개발된 치과 수복 아이템이며 Nano ceramic filler가 혼합된 구조로 되어있어 치과 수복용 복합소재로서 널리 사용하고 있다. 또한 Nano Hybrid Ceramic소재는 Composite resin의 가공 과정에서 쉽게 파절되지 않는 개선된 물성과 Glass ceramic이 가진 심미성 동시에 포함하고 있는 것이 특징이다. 따라서 Chair side와 Lab. side에서 CAD/CAM 시스템을 이용하여 보철물을 제작할 때 임상적용이 쉽고 유용한 장점을 가지고 있어 추가적인 연구가 필요하다.