• 대한기계학회논문집B
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• 제35권5호
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• pp.547-550
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• 2011

레이저 기반의 무바늘 액체 약물전달장치는 계속해서 개발되어왔다. 레이저 빔이 고무 챔버 내부의 액체에 모이게 된다. 초점이 맞춰진 레이저 빔은 공기방울을 생성시키고 급격히 팽창하게 된다. 밀봉된 챔버 안쪽에서의 급격한 부피변화는 액체약물을 마이크로 노즐을 통해 빠르게 밀어내어 마이크로 약물젯을 생성한다. 노즐의 출구지름은 100 ${\mu}m$ 이하이며 본 연구팀은 생성된 마이크로 약물젯의 속도가 인체의 연조직으로 침투시키기에 충분함을 확인하였다. 이 실험에서는 사람의 혈전을 모사한 무게 비 5%의 젤라틴 수용액을 냉각시킨 샘플과 돼지 지방층을 사용하여 침투실험을 수행하였다.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2010년도 제34회 춘계학술대회논문집
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• pp.326-330
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• 2010

본 연구진은 레이저-물질 간의 상호작용을 응용하여 새로운 방식의 약물 전달 시스템을 개발하고 있다. 레이저 빔이 마이크로 단위 크기의 고무 챔버 속에 채워져 있는 액체 속에 집광되면 순간적인 고에너지 전달로 인해 기포가 생겨나고, 이로 인한 빠른 부피팽창으로 인해 마이크로 노즐 속의 약물 용액이 빠른 속도의 마이크로 젯의 형태로 분사되는 원리를 이용하는 것이다. 실험에서 노즐 출구의 지름은 125 ${\mu}m$, 측정된 마이크로 젯의 속도는 265 m/s였다. 이 장치의 주요한 특징은 시간에 따른 마이크로 젯의 제어가 가능하다는 것이다.

• Restorative Dentistry and Endodontics
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• 제43권1호
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• pp.2.1-2.10
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• 2018

Objectives: To determine the effect of size and insertion depth of irrigation needle on the amount of apical extruded debris and the amount of penetration depth of sealer using a confocal laser scanning microscope (CLSM). Materials and Methods: Twenty maxillary premolars were assigned to 2 groups (n = 10), according to the size of needle tip, 28 G or 30 G. Buccal roots of samples were irrigated with respective needle type inserted 1 mm short of the working length (WL), while palatal roots were irrigated with respective needle type inserted 3 mm short of the WL. Prepared teeth were removed from the pre-weighed Eppendorf tubes. Canals were filled with F3 gutta-percha cone and rhodamine B dye-labeled AH 26 sealer. Teeth were transversally sectioned at 1 and 3 mm levels from the apex and observed under a CLSM. Eppendorf tubes were incubated to evaporate the irrigant and were weighed again. The difference between pre- and post-weights was calculated, and statistical evaluation was performed. Results: Inserting needles closer to the apex and using needles with wider diameters were associated with significantly more debris extrusion (p < 0.05). The position of needles and level of sections had statistically significant effects on sealer penetration depth (p < 0.05 for both). Conclusions: Following preparation, inserting narrower needles compatible with the final apical diameter of the prepared root canal at 3 mm short of WL during final irrigation might prevent debris extrusion and improve sealer penetration in the apical third.

• Journal of Dental Anesthesia and Pain Medicine
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• 제24권3호
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• pp.145-159
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• 2024

Dental injections are routinely performed and can result in pain and anxiety in patients. This systematic review aimed to evaluate the efficacy of photobiomodulation therapy (PBMT) in dental injections for pain management in patients undergoing dental treatment. Indexed databases, including PubMed, EMBASE, Scopus, ISI Web of Knowledge, and Cochrane Library, were electronically searched without a time limit up to February 2024. A risk of bias evaluation was performed using the Cochrane tool. A preliminary investigation using electronic and manual methods yielded 4,920,881 manuscripts. Based on the eligibility requirements, 13 randomized control trials (RCTs) were included. Self-assessed pain was determined using the visual analog scale, Face, Legs, Activity, Cry, Controllability scale, or Wong-Baker face pain scale. Eight RCTs demonstrated a notable decrease in needle pain in patients undergoing dental needle injections using PBMT. Based on current evidence, PBMT may help reduce needle pain related to dental anesthesia. Further standardized studies are needed to assess the significance of PBMT for postoperative pain in patients undergoing dental injections.

• 한국분무공학회지
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• 제17권4호
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• pp.192-196
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• 2012

This paper reports on breakup characteristics of fuel droplet which includes metal nanoparticles. In order to develop a new injection system for nanoparticle-coated layers overcoming the conventional flame spray system, fundamental experiments were conducted to examine the interaction between a fuel droplet with nanoparticles and the external energy induced by the laser. In the experiments, this study used nickel nanoparticles whose size was under 100 nm to mix with kerosene as the fuel, and utilized a syringe pump and a metal needle to inject a fuel droplet. In particular, the Nd-YAG laser was adopted to give additional energy to the nanoparticles for evaporation of a fuel droplet containing nanoparticles. When the laser energy as 96 mJ was irradiated during the injection, it was observed that such an explosive evaporation occurred to break up a fuel droplet including nanoparticles, making the rapid increase in the ratio surface area to liquid volume. From this work, we suggest the possibility that the laser energy can be used for rapid evaporation of a fuel droplet.

• 전기전자학회논문지
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• 제28권1호
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• pp.97-103
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• 2024

일부 약물은 피부의 표피층 이하로 주입될 때 훨씬 더 효과적인 의료 효과를 제공할 수 있다. 그러나 전통적인 비침습 주입 장치는 피부의 한 부분에 상대적으로 많은 양의 약물을 전달하며, 이는 조직층 구조를 분리하여 멍과 출혈을 유발할 수 있다. 피부의 큰 표면적에 빠른 반복율로 소량을 주입함으로써 환자의 부상과 통증을 감소시킬 수 있다. 이를 위해서 약액을 분사하는 압력은 빠른 속도로 침투 가능 압력까지 상승되고 빠르게 하강하여 주입되지 않는 되튀김량을 줄이고, 주입량을 최소화해야한다. 이러한 형태의 비침습 주사 장치가 개발되었지만 그 장치들의 의학적 효능은 분석된 바가 거의 없다. 따라서 이 연구에서는 속도가 ~310m/s인 마이크로젯을 분사하는 레이저 유도 마이크로젯 장치를 개발했다. 펄스 시간은 400~800 ㎲이며 각 분사가 초당 10번 반복되는 속도로 약물을 약 1 µL 분사할 수 있습니다. 이러한 원리를 사용하여 우리는 마우스 모델에 대한 약물 주사의 효과를 평가했다. 마우스 모델에 인슐린 용액을 주입한 후 혈중 인슐린 농도를 측정하였으며, 일반 바늘 주사 주법과 동일한 값을 얻었다.

• 한국임상수의학회지
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• 제11권1호
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• pp.393-399
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• 1994

This study was carried out to investigate the analgesic and antipyretic effects of acupuncture in goat suffered from pain and fever induced experimentally : electroacupuncture and laser acupuncture for the relief of pain and traditional needing for the of fever. Pain was induced by intraperitoneal injection of 0.7% acetic acid solution and it's extent was estimated with the number of writhing syndrom as indicator of pain. When lipopolysaccharide was given into the vein in goat, fever with biphasic type was produced. In the goats with pain the superior analgesic effects of electroacupuncture to aminopyrine and sulpyrine were found, but the effects of laser acupuncture were not satisfactory. The high body temperature of goats was gradually decreased with the lapse of time following traditional needling(venesection by needle) and showed a tendency to return to normal body temperature. Serum GOT, GPT:, BUN, creatinine values and acetylcholinesterase activity following electroacupuncture were not altered. It is considered that electroacupuncture combined with medicament can sucure exellent analgesic and antipyretic effects in animal practice.

• 한국재료학회지
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• 제27권10호
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• pp.563-568
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• 2017

In this study, the coating of an Al-Cr layer on the surface of a Zircaloy-4 alloy was carried out through plasma pretreatment coating and a laser surface melting process. Two different conditions for laser treatment, severe or minimal surface melting of the Zr alloy substrate, were applied to form the final coating. When there was significant surface melting of the Zr alloy, the solidification microstructure of the newly formed coating layer was mainly composed of needle-shaped $Al_3Zr$, Al(Cr) and $Al_7Cr$ phases. On the other hand, the solidification microstructure of the coating layer was mainly composed of Al(Cr) and $Al_7Cr$ phases when there was minimal surface melting of Zr base in the laser process. However, when the coating was maintained at $1100^{\circ}C$ for 2 hours, significant inter-diffusion occurred between the phases in the coating. As a result, the upper part of the coating layer was observed to mainly consist of $Al_3Zr$ and $Al_8Cr_5$ phases, regardless of the laser treatment conditions.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2002년도 춘계합동학술대회 논문집
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• pp.172-175
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• 2002

The technique of induced discharge by a pulsed CO2 laser is being applied to control electrical discharge path, material processing, triggered lightning for protecting the power equipments. In this paper, we have investigated about the characteristics of the induced discharge at atmospheric conditions by using a plasma channel, which is produced when a pulsed CO2 laser radiation is focused by a focusing mirror as a trigger source. A plasma channel produced by laser radiation has an effect on decreasing the threshold voltage and inducing the discharge in both needle electrodes. We have confirmed a delay time between a produced plasma channel and an electrical discharge after laser radiation. We provided the decreased voltage lower than the natural discharge voltage between electrode type of needles and was induced the discharge by forming a plasma channel between them. In this research we could understand the time delay of induced discharge by laser radiation, and the characteristics of the discharge cause by the decrease in the threshold voltage, and the polarity effect by changes of plasma channel positions between two electrodes.

• Journal of the Optical Society of Korea
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• 제19권2호
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• pp.169-174
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• 2015

Muscle vibration measurement has long been an unique scientific study, in general, and the direct reaction of animals to feel pain (algesia), either from vascular or muscle contraction, is a complex perceptual experience. Thus this paper proposes a way to measure animal algesia quantitatively, by measuring the changes in muscle vibration due to a pinprick on the surface of the skin of a Spodoptera litura larva. Using the laser optical triangulation measurement principle, along with a CMOS image sensor, linear laser, software analysis, and other tools, we quantify the subtle object point displacement, with a precision of up to $10{\mu}m$, for our chosen Spodoptera litura larva animal model, in which it is not easy to identify the tiny changes in muscle contraction dynamics with the naked eye. We inject different concentrations of formalin reagent (empty needle, 12% formalin, and 37% formalin) to obtain a variety of different muscle vibration frequencies as the experimental results. Because of the high concentrations of reagent applied, we see a high frequency shift of muscle vibration, which can be presented as pain indices, so that the algesia can be quantified.