• International Journal of Precision Engineering and Manufacturing
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• 제9권3호
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• pp.68-71
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• 2008

Transdermal and topical drug delivery with minimal tissue damage has been an area of vigorous research for a number of years. Our research team has initiated the development of an effective method for delivering drug particles across the skin (transdermal) for systemic circulation, and to localized (topical) areas. The device consists of a micro particle acceleration system based on laser ablation that can be integrated with endoscopic surgical techniques. A layer of micro particles is deposited on the surface of a thin metal foil. The rear side of the foil is irradiated with a laser beam, which generates a shockwave that travels through the foil. When the shockwave reaches the end of the foil, it is reflected as an expansion wave and causes instantaneous deformation of the foil in the opposite direction. Due to this sudden deformation, the microparticles are ejected from the foil at very high speeds, and therefore have sufficient momentum to penetrate soft body tissues. We have demonstrated this by successfully delivering cobalt particles $3\;{\mu}m$ in diameter into gelatin models that represent soft tissue with remarkable penetration depth.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 1998년도 추계학술대회 논문집
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• pp.204-209
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• 1998

The acceleration of the performance of machine tools influences the development of the semi-conductor and optical technology as the development of NC and measurement technology. We can mention that a traction role of the acceleration for the development like that depends on the development of the measurement technics Stylus instrument method, STM, SEM, Laser interferometer method which are used for measuring the quasi-static error of machine tools. Because the measurement has been done to unload condition without considering of mechanical stiffness in the case of machining center as we measure the quasi-static error of machine tools on general studies, people who works on the spot has many problems on the data value. Therefor we will help working more accurately on the spot by measuring, analyzing, displaying the deflection of the table and support shaft when we load on the table and the support shaft of machining center using laser interferometer. Also we try to settle new conception of the measurement method and more accurate grasp of the deflection tendency by verifing the tendency of the error measured through the comparison of the simulated error using ANSYS, a common finite element analysis program, which is able to measure heat deformation, material deformation, and error resulted form this study.

• Journal of the Optical Society of Korea
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• 제13권1호
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• pp.48-52
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• 2009

Micro-hole targets are studied to generate energetic protons from laser-thin foil targets by using 2-dimensional particle-in-cell simulations. By using a small hole, the maximum energy of the accelerated proton is increased to 4 times higher than that from a simple planar target. The main proton acceleration mechanism of the hole-targets is the electrostatic field created between the fast electrons accelerated by the laser pulse ponderomotive force combined with the vacuum heating and the target rear surface. But in this case, the proton angular distribution shows double-peak shape, which means poor collimation and low current density. By using a small cone-shaped hole, the maximum proton energy is increased 3 times higher than that from a simple planar target. Furthermore, the angular distribution of the accelerated protons shows good collimation.

• Journal of the Optical Society of Korea
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• 제13권1호
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• pp.2-7
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• 2009

This paper reviews evolution of the research networks on intense laser science under international and Asian frameworks during 2000 to 2008. The OECD Global Science Forum Steering Committee on Compact, High-Intensity Short-Pulse Lasers led to the establishment of the International Union of Pure and Applied Physics (IUPAP) Working Group: International Committee on Ultrahigh Intensity Lasers (ICUIL) and the Asian Intense Laser Network (AILN) in 2004. Through various activities under AILN such as the Asian Symposium on Intense Laser Science (ASILS), the Asian Summer School on Laser Plasma Acceleration and Radiation, and the High-Order Harmonics Workshops, closer relations are being formed among the scientists and also among the young generations working in intense laser science in the Asian regions.

• 한국광학회:학술대회논문집
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• 한국광학회 2002년도 하계학술발표회
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• pp.240-241
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• 2002

Propagation of an intense laser pulse through fully ionized plasma has been an interesting topic in many fields. It includes laser-driven electron accelerators,(1) generation of high harmonics,(2) soft x-ray laser development(3) and so on. Specifically, in the application of laser-driven electron accelerators a large laser-plasma interaction length is required to get sufficient acceleration energy of electron. (omitted)

• 한국멀티미디어학회논문지
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• 제18권1호
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• pp.65-70
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• 2015

Particle accelerator has mainly used in nuclear field only because of the large scale of the facility. However, since laser-plasma particle accelerator which has smaller size and spends less cost developed, the availability of this accelerator is expended to various research fields such as industrial and medical. This paper suggests a visualization system to control the laser-plasma particle accelerator efficiently. This system offers real-time 3D images via convert HDF file comes from plasma data obtained from PIC simulation into OpenGL texture type to analyse and modify plasma data. After that, it stores high-resolution rendering images of the data with external renderer hereafter.

• 한국항공우주학회지
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• 제36권6호
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• pp.587-593
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• 2008

본 연구의 목적은 신체 조직의 손상을 최소화할 수 있는 경피(transdermal) 및 국부적인(topical) 약물전달을 가능하게 하는 마이크로 입자가속시스템 개발에 있다. Ballistic 역학을 기반으로 하는 본 방법을 통하여 체순환을 위한 경피 및 국부적 약물 전달이 가능하다. 얇은 금속 포일의 한 쪽 면에 마이크로 입자들을 얹어놓고 뒷면에 레이저를 조사하면 충격파가 발생하고, 이 충격파는 포일을 통과하며 포일의 끝에서 금속-공기간의 acoustic impedance 차이로 expansion wave로 반사되어 포일이 반대 방향으로 변형을 일으키게 한다. 이 순간적인 변형으로 인해 포일에 붙어있던 마이크로 입자들이 가속되어 튕겨 나가게 된다. 입자들이 가속되는 속도가 굉장히 크기 때문에 이들은 신체 조직을 침투할 만한 충분한 운동량을 갖고 있다. 입자들의 침투 여부를 확인하기 위해 우리는 5${\mu}m$ 크기의 코발트 입자들을 연조직을 묘사하는 젤라틴에 가속시켰으며, 주목할 만한 침투 깊이를 얻으며 실험에 성공하였다.

• Journal of the Optical Society of Korea
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• 제13권1호
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• pp.8-14
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• 2009

In a laser-plasma wakefield accelerator, the ponderomotive force of an ultrashort high intensity laser pulse excites a longitudinal wave or plasma bubble in a way similar to the excitation of a wake wave behind a boat as it propagates on the water surface. Electric fields inside the plasma bubble can be several orders of magnitude higher than those available in conventional RF-based particle accelerator facilities which are limited by material breakdown. Therefore, if an electron bunch is properly phase-locked with the bubble's acceleration field, it can gain relativistic energies within an extremely short distance. Here, in the bubble regime we show the generation of stable and reproducible sub GeV, and GeV-class electron beams. Supported by three-dimensional particle-in-cell simulations, our experimental results show the highest acceleration gradients produced so far. Simulations suggested that the plasma bubble elongation should be minimized in order to achieve higher electron beam energies.

• 한국군사과학기술학회지
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• 제25권2호
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• pp.169-176
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• 2022

Laser ablation propulsion(LAP) is the method to create impulse by laser ablation. It can be used to deorbit the space debris(SD), as its long-range property and versatility on any material. In this paper, we find out several requirements of the LAP system(LAPS) to deorbit the SD by simple numerical calculations of the SD orbit and laser beam flux. As a result, minimum operable altitude angle turned out to be a crucial variable to the LAPS. Moreover, if minimum operable altitude angle is 10°, and if the minimum distance between the LAPS and the SD is below 450 km, 1 m/s² is sufficient to deorbit the SD by once. With 18 kJ/3 ns pulsed laser and cube shaped 100 kg SD, 1 m/s² acceleration can be achieved by increasing the pulse repetition rate over 34~53 Hz, depending on the size of the SD. This capability could compare with the conceptual design of the Japan Establishment for a Power-laser Community Harvest(J-EPoCH) facility, which include 8 kJ, 5 PW@100 Hz laser.

• 한국전산구조공학회논문집
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• 제30권3호
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• pp.249-254
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• 2017

본 논문에서는 가속도계와 속도계를 활용한 단기 동적변위 산정기법을 소개한다. 본 기법에서 변위는 측정된 가속도와 속도 데이터를 칼만필터 기반 실시간 융합 알고리즘에 적용하여 추정된다. 기존 변위센서(LVDT, LDV, Vision 등)는 고정된 지지점과 설치를 위해 별도의 가설물을 필요로 했기 때문에 지진 발생 시나 해상교량 적용에 한계가 있었다. 또한 Laser/Vision 기반 센서의 경우 시야확보가 어려운 경우 활용이 제한된다. 본 기법에서는 부착식 센서인 가속도계와 속도계를 활용하기 때문에, 고정된 지지점이 필요 없을뿐더러 부착만 되면 시야확보 여부로부터 자유롭다. 따라서, 지진, 해상교량뿐만 아니라 화재 시에도 적용 가능하다. 변위추정을 위해 누적되는 가속도의 이중적분 오차는 속도 계측치로 보정되며, 실험실 규모 테스트를 통해 해당 기법을 검증하였다.