• 대한정형도수물리치료학회지
• /
• 제10권2호
• /
• pp.45-56
• /
• 2004

OBJECTIVE: The objective of this study was to know the effects of the postoperative lumbar extensor strengthening exercise program on back muscles strength and volume, pain, and the time of return to work. METHODS: A prospective controlled trial of lumbar extensor exercise program in patients who underwent microdiscectomy or percutaneous endoscopic discectomy for prolapsed lumbar intervertebral disc. Seventy-five patients were randomized into exercise group (20 male, 15 female) and non-exercise group (18 male, 22 female). Six weeks after surgery, patients in exercise group undertook a 12-week lumbar extension exercise (MedX) program. Assessment of spinal function was performed in all patients on postoperative 6 weeks, 18 weeks. The assessment included measures of lumbar extensor power, muscle mass of erector spinalis. All patients completed the visual analog scale (VAS) for evaluation of pain, and return to work. RESULTS: In muscle power, there were statistically significant improvements between pre and post test on muscle power in exercise group. But there were not statistically significant difference on muscle power in non-exercise group. In muscle mass, there were statistically significant difference between pre and post test on muscle mass in exercise group. But there were not statistically significant difference on muscle mass in non-exercise group. In the pain, there were statistically significant decrease between pre and post test on both group. But there were not statistically significant difference on fatty tissue and obesity in non-exercise group. The percentages of return to work in postoperative 4 months were significantly greater in the exercise group than in the non -exercise group. CONCLUSIONS: Postoperative lumbar extensor strengthening exercise program appears to be more beneficial to the patients who underwent operation for prolapsed lumbar intervertbral disc.

• 생체재료학회지
• /
• 제22권4호
• /
• pp.303-310
• /
• 2018

Background: Photodynamic therapy (PDT) is photo-treatment of malignant or benign diseases using photosensitizing agents, light, and oxygen which generates cytotoxic reactive oxygens and induces tumour regressions. Several photodynamic treatments have been extensively studied and the photosensitizers (PS) are key to their biological efficacy, while laser and oxygen allow to appropriate and flexible delivery for treatment of diseases. Introduction: In presence of oxygen and the specific light triggering, PS is activated from its ground state into an excited singlet state, generates reactive oxygen species (ROS) and induces apoptosis of cancer tissues. Those PS can be divided by its specific efficiency of ROS generation, absorption wavelength and chemical structure. Main body: Up to dates, several PS were approved for clinical applications or under clinical trials. $Photofrin^{(R)}$ is the first clinically approved photosensitizer for the treatment of cancer. The second generation of PS, Porfimer sodium ($Photofrin^{(R)}$), Temoporfin ($Foscan^{(R)}$), Motexafin lutetium, Palladium bacteriopheophorbide, $Purlytin^{(R)}$, Verteporfin ($Visudyne{(R)}$), Talaporfin ($Laserphyrin^{(R)}$) are clinically approved or under-clinical trials. Now, third generation of PS, which can dramatically improve cancer-targeting efficiency by chemical modification, nano-delivery system or antibody conjugation, are extensively studied for clinical development. Conclusion: Here, we discuss up-to-date information on FDA-approved photodynamic agents, the clinical benefits of these agents. However, PDT is still dearth for the treatment of diseases in specifically deep tissue cancer. Next generation PS will be addressed in the future for PDT. We also provide clinical unmet need for the design of new photosensitizers.

• Medical Lasers
• /
• 제10권2호
• /
• pp.96-105
• /
• 2021

Background and Objectives Skin aging is reportedly associated with regulation in collagen and elastin synthesis. This study investigated the potential of combining light-emitting diode (LED) treatments using a 630-nm and 850-nm LED with simultaneous microcurrent application. Materials and Methods The dorsal skin of female pigs was treated with a home-use device. We examined the treatment effects using photography, thermocamera, microscopic pathology, and histological examination to determine the mechanism of action, efficacy, and safety of the procedure. A histological observation was performed using hematoxylin and eosin, Masson's trichrome, Victoria blue, and immunohistochemical staining. We also used the Sircol soluble collagen and elastin assay kit to measure the amounts of collagen and elastin in the porcine back skin tissue after 2 and 6 weeks. Results Evaluation by visual inspection and devices showed no skin damage or heat-induced injury at the treatment site. Histological staining revealed that accurate treatment of the targeted dermis layer effectively enhanced collagen and elastin deposition. Collagen type I, a protein defined by immunohistochemical staining, was overexpressed in the early stages of weeks 2 and 6. Combined therapy findings showed the superior capability of the 630-nm and 850-nm LED procedures to induce collagen; in contrast, elastin induction was more pronounced after microcurrent treatments. Conclusion The home-use LED device, comprising a combination of 630-nm and 850-nm LEDs and microcurrent, is safe and can be used as an adjunctive treatment for self-administered facial rejuvenation.

• Journal of Acupuncture Research
• /
• 제29권4호
• /
• pp.105-111
• /
• 2012

이 증례 보고를 통해, 수배부 피부 이식 환자에 대한 환측 및 건측 상지의 전침 자극이 자극 직후 이식 부위 및 건측 수배부의 피부 혈류 순환을 각각 다른 양상으로 변화시킴을 확인할 수 있었다. 향후 전침자극이 피부 이식 부위의 미세혈류 순환을 증가시키고, 이식 부위의 재활 및 괴사 방지에 대한 임상적 효과를 나타낼 수 있는지에 대한 추가적 연구가 필요하다.

• Journal of Oral Medicine and Pain
• /
• 제31권1호
• /
• pp.37-45
• /
• 2006

측두근의 근막동통으로 진단된 환자의 이환측과 비이환측 측두부에 대한 음악 청취 시의 혈액관류 변화를 비교 평가하고자 본 연구를 시행하였다. 경희대학교 치과대학 부속 치과병원 구강내과에 내원한 측두근 부위에서 촉진 시 통증을 호소하는 환자 중 근막동통장애로 진단된 환자에서 측두부 피하천부의 혈액관류를 미세혈류측정기로 음악 청취 전과 후에 비교 측정하여 혈구의 수, 혈류의 평균속도를 측정하고 평가한 결과 다음과 같은 결론을 얻었다. 1. 음악 청취 시 측두부 피하천부의 혈류는 이환측, 비이환측 모두 증가되었다. 2. 음악 청취 시 비이환측보다 이환측에서 피하천부의 혈류가 더욱 증가되었다. 3. 음악 청취 시 혈액관류량의 증가는 청취 전 관류량에 비례하여 증가되었다. 음악 청취 시 측두부 피하천부에서 혈액관류가 증가되었던 것은 자율신경계 반응에 의한 결과로 생각된다. 또한 측두근 부위에서 비이환측에 비하여 이환측에서 음악 청취 시에 혈류가 더욱 증가되었던 것은 자율신경계 반응으로 증가된 혈류가 수축 된 심층 근육으로 충분히 관류되지 못하고 표층으로 더 많은 혈액이 재관류 되었던 것으로 생각된다. 따라서 본 연구의 결과, 이환측과 비이환측에서 혈액관류의 변화정도가 차이가 있었으므로, 이것이 임상적 진단이나 감별 진단, 또는 치료 후의 예후 평가에 기여할 수 있는 자료가 될 수 있다고 생각되며, 근막통증환자에게 혈액관류를 평가해 보는 것이 효과적인 진단방법이 될 수 있으리라고 생각된다.

• 한방안이비인후피부과학회지
• /
• 제34권3호
• /
• pp.27-54
• /
• 2021

Objectives : This review was conducted to validate the effectiveness and safety of herbal medicine combined with conventional therapy for rosacea. Methods : Randomized controlled trials(RCTs) reporting the effects of herbal medicine treatment on rosacea were searched through eight electronic databases from 2016 to March 17, 2020. This study collection and data extraction were performed by two independent reviews. The Cochrane risk-of-bias tool was used for the evaluation of the risk of bias in all included RCTs. Mean differences(MD) and Risk ratio(RR) of 95% Confidence intervals(Cls) were calculated and data synthesis was conducted using Review Manager(RevMan, ver.5.4) Results : Eighteen RCTs were included and all trials compared the combined therapy of herbal medicine with conventional western therapy to conventional therapy alone. The effective rate of the combination of herbal medicine with western medicine(RR 1.20, 95% CI : 1.13-1.28, p<0.00001, I²=0%), the effective rate of the combination of herbal medicine with laser-based therapy(RR 1.12, 95% CI : 1.04-1.21, p=0.004, I²=18%) and the effective rate of the combination treatment group using herbal medicine, western medicine and external drugs were all statistically higher that of the control group(RR 1.19, 95% CI : 1.11-1.28, p<0.00001, I²=0%). The score of non transient erythema(MD -0.36, 95% CI : -1.01 0.29, p=0.27, I²=93%), flushing(MD -0.69, 95% CI : -0.97, 0.41, p<0.00001, I²=32%), papules or pustules(MD 0.10, 95% CI : -0.15, 0.35 p=0.44, I²=0%) were also seen in the herbal medicine and western medicine combination group. The overall risk of bias of the included studies was some concerns. No serious adverse effects were observed. Conclusions : This review found the safety and effectiveness of the combined therapy of herbal medicine with conventional western therapy for rosacea.

• Journal of Acupuncture Research
• /
• 제19권4호
• /
• pp.101-111
• /
• 2002

Objective : In order to review the studies related to the treatment of children by aupuncture or mo ibustion Methods : We referred to a Pubmed site by using searching word of "the terms of pediatrics(for e ample child children infant baby pediatrics etc and acupuncture" Results : 40 journals with 63 papers were searched 50 papers were reported Conclusion : 1 We found 63 articles in 40 journals which were Pediatrics J Tradit chin Med Am Fam Physician Anaesthesia linical research was the most of these studies and the pattern of the rest were review or clinical conferences 3 We analy ed articles and found many articles of nocturnal enuresis asthma bronchitis postoperative vomitting constipation etc 4 The result of clinical studies represented the significant cure rate owever the cases of sensorineural hearing loss vomitting after tonsillectomy e ercise induced asthma were not 5 It was ta en to research for laser acupressure bloodletting ear acupuncture etc as well as body acupuncture in the area of pediatric acupuncture treatment as alternative therapy which was composed of the lower stimulation than adult.

• 대한방사성의약품학회지
• /
• 제3권2호
• /
• pp.54-58
• /
• 2017

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS) is one of the powerful methods that enable analysis of small molecules as well as large molecules up to about 500,000 Da without severe fragmentation. MALDI-TOF MS, thus, has been a very useful an analytical tool for the confirmation of synthetic molecules, probing PTMs, and identifying structures of a given protein. In recent nuclear medicine, MALDI-TOF MS liner ion mode helps researcher calculate the average number of chelator(or linkage) per an antibody conjugate, such as DOTA-(or DFO-) trastuzumab for labeling a medical radioisotope. This simple technique can be utilized to improve the labeling method and control the quality at the development of antibody-based radiopharmaceuticals, which is very effected to diagnosis and therapy for in vivo tumor cells, with radioisotopes like $^{89}Zr$, $^{64}Cu$, and 177Lu. To minimize the error, MALDI-TOF MS measurement is repeatedly performed for each sample in this study, and external calibration is carried out after data collection.

• 한국환경성돌연변이발암원학회지
• /
• 제22권4호
• /
• pp.236-242
• /
• 2002

Using agarose-coupled methotrexate, we have successfully isolated two proteins, which have strong interactions with methotrexate. The two proteins were analyzed by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry and identified as carbamoyl-phosphate synthetase 2 and phosphoribosylglycinamide formyltransferase, respectively. Interestingly, both of these two proteins are essential key enzymes in nucleotide biosynthetic pathways, like dihydrofolate reductase, a well-known methotrexate target. We confirmed the specificity of their interactions between methotrexate and two target proteins by the methods of competition binding assay, which were followed by western blotting using antibody against carbamoyl-phosphate synthetase 2 and phosphoribosylglycinamide formyltransferase, respectively. Moreover, we could observe that carbamoyl-phosphate synthetase 2 is overexpressed in methotrexate-resistant MOLT-3 cells comparing with control MOLT-3 cells. This result indicates that carbamoyl-phosphate synthetase 2 may be a novel target of methotrexate in cancer therapy. We propose that chemical proteomics can be a powerful technique to identify target proteins of a chemical.

• 동의생리병리학회지
• /
• 제32권5호
• /
• pp.315-320
• /
• 2018

The purpose of this study is to investigate reasearch trend of acupuncture treatment on shoulder impingement syndrome. This study investigated the recent studies about acupuncture treatment for shoulder impingement syndrome via searching Korean and foreign electronic databases(Research Information Services, National Digital Science Library, Oriental Medicine Advanced Searching Integated Services, PubMed, China National Knowledge Infrastructure). The search term was searched by combining 'shoulder impingement sydrome', 'subacrominal pain', 'acupuncture', 'needle therapy', and was limited to the articles published from 2005 to 2017. 14 studies were found to be analyzed according to the type of study, the number of cases, the type of treatment, the instruments for assessment and published year. 14 studies were published since 2005, 6 case reports, 8 randomized controlled trials. In the treatment of shoulder impingement syndrome, treatments such as acupuncture, acupotomy, pharmacopuncture, laser acupuncture, combined treatment of exercise and rehabilitation were performed. Visual analogue scale(VAS), range of motion(ROM) and various questionnaires were used as primary assessments. In each study, acupuncture treatment was reported to have a significant effect in the pain, range of motion and disability of shoulder impingement syndrome. In order to ensure objective evidence on acupuncture treatment, large scale case reports and randomized controlled trials should be continued.