• Asian-Australasian Journal of Animal Sciences
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• v.3 no.4
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• pp.337-341
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• 1990

An investigation was conducted to determine whether the rumen modifiers lasalocid and avoparcin, when included in molasses/urea based supplements, enhanced liveweight performance, in early weaned calves. As part of the study the broad-spectrum parasiticle Avermectin B1 was given to the calves to assess any undesirable side effects on animals of less than four months of age. There were no significant (p>0.05) liveweight responses to supplementation when the rumen modifiers lasalocid and avoparcin were included in supplement rations. Lasalocid reduced supplement intake, however, it had no adverse effect on liveweight gain. Avoparcin substantially improved growth when cottonseed meal was included in the ration. Weaners treated with Avermectin B1 tended to show a greater liveweight gain than untreated weaners during the experiment (p<0.10) and no adverse side effects were noted.

• Korean Journal of Veterinary Service
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• v.17 no.1
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• pp.44-53
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• 1994

The result that investigated aberage weekly oocyst nymbers in faeces from 16 broiler farms, Oocyst can be found in the highest during the 5 weeks age. The 3 of the 16 farms have clinical sign of the coccidiosis at the faeces collection. Anticoccidial drug sensitivity against Oocyst isolated in 2 farms to have clinical coccidiosis was tested for the drug susceptibility and resistance in order to prevention coccidiosis effectively. Maduramicin, Salynomicif Narasin Lasalocid, Monensin, Robenidine and Dicrazulir were used an anticoccidial drugs. The results ; Anticoccidial index(ACI) of the A farm were 201.50 in a chicken group treated with Dicrazulir, 194.84 with Robenidine. 172.79 with Maduramicin 6ppm 170.49 with Salynomicin, 168.02 with maduramicin 5ppm 165.77 with Lasalocid, 143.34 with Monensin and 140.63 with Narasin. ACI of the B farm were 193.40 in a chicken group treated Robenidine, 190.64 with Dicrazuril, 158.75 with Maduramic in 6ppm, 151.62 with Maduramicin 5ppm, 149.44 with Salynomicin, 143.10 with lasalocid, 138.11 with Monensin and 137.50 with Narasin. According to interpretation of ACI from Kawasae et al, the drug resistance(less than 120 of ACI) not appeared in two farms, vut the drug tolerance(120-160 of ACI) appeared in two group treated with Monesin and Nalacin in csae of A farm and in all group with treated anticoccidial drug in case of B farm.

• Asian-Australasian Journal of Animal Sciences
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• v.26 no.11
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• pp.1553-1561
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• 2013

Forty-eight crossbred heifers ($378.1{\pm}18$ kg) were used in a 56-d feeding trial (four pens per treatment in a randomised complete block design) to evaluate the influence of ionophore supplementation on growth performance, dietary energetics and carcass characteristics in finishing cattle during a period of heat stress. Heifers were fed a diet based on steam-flaked corn (2.22 Mcal $NE_m/kg$) with and without an ionophore. Treatments were: i) control, no ionophore; ii) 30 mg/kg monensin sodium (RUM30); iii) 20 mg/kg lasalocid sodium (BOV20), and iv) 30 mg/kg lasalocid sodium (BOV30). Both dry matter intake (DMI) and climatic variables were measured daily and the temperature humidity index (THI) was estimated. The maximum THI during the study averaged 93, while the minimum was 70 (THI average = $79.2{\pm}2.3$). Compared to controls, monensin supplementation did not influence average daily gain, the estimated NE value of the diet, or observed-to-expected DMI, but tended (p = 0.07) to increase (4.8%) gain to feed. Compared to controls, the group fed BOV30 increased ($p{\leq}0.03$) daily gain (11.8%), gain to feed (8.3%), net energy of the diet (5%), and observed-to-expected DMI (5.2%). Daily weight gain was greater (7.6%, p = 0.05) for heifers fed BOV30 than for heifers fed MON30. Otherwise, differences between the two treatments in DMI, gain to feed, and dietary NE were not statistically significant (p>0.11). Plotting weekly intakes versus THI, observed intake of controls was greater (p<0.05) at THI values ${\leq}77$ than ionophore groups. When THI values were greater than 79, DMI of control and MON30 were not different (p = 0.42), although less than that of groups fed lasalocid (p = 0.04). Variation in energy intake was lower (p>0.05) in the ionophores group (CV = 1.7%) than in the control group (CV = 4.5%). Inclusion of ionophores in the diet resulted in relatively minor changes in carcass characteristics. It is concluded that ionophore supplementation did not exacerbate the decline of DM intake in heat-stressed cattle fed a high-energy finishing diet; on the contrary, it stabilised feed intake and favoured feed efficiency. Ionophore supplementation reduced estimated maintenance coefficients around 10% in finishing cattle during a period of heat stress. This effect was greatest for heifers supplemented with 30 mg lasalocid/kg of diet.

• Proceedings of the Membrane Society of Korea Conference
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• 2002.11a
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• pp.174-176
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• 2002

• Asian-Australasian Journal of Animal Sciences
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• v.2 no.3
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• pp.357-358
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• 1989

• Microbiology and Biotechnology Letters
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• v.21 no.1
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• pp.54-58
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• 1993

During the screening of inhibitors against protein kinase CCPKC) and the bleb formation of K562 cell induced by phorbol ester from microbial secondary metabolites, MT-2007 was purified by solvent extraction, and chromatographic techniques from Actinomycetes isolate No. 2007-18. It showed completely suppression of bleb formation of K562 cell surface induced by phorbol 12.13dibutylate at the concentration of 503.9 11M and ICso on PKC was 31.4 11M. Its structure was postulated as lasalocid A sodium salt by physico-chemical properties and UV, IR. MS, IH-NMR.

• Korean Journal of Poultry Science
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• v.21 no.2
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• pp.93-99
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• 1994

Chickens subjected to heat stress decrease their heat production by consuming less feed. The lowered feed intake naturally brings about decreased production performance of chicken. The only exception to this is the increased survivability. Birds drink less when they eat less. In hot enviror-mental temperature, chicken need more water for increased heat loss through evaporation an increased urine excretion. Thus, the increased water intake may alleviate the heat stress of chicken. Various electrolytes supplementation to feed or drinking water can alleviate the heat stress of chicken by their effect of increasing water intake. Lasalocid, an ionophorous coccidiostat, was found to have the effect of increasing water consumption of chicken, thereby improving the lowered production performance of heat-stressed chicken. Finally, dietary fiber could be another possible element which can exert beneficial effects on heat-stressed chicken.

• Korean Journal of Soil Science and Fertilizer
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• v.43 no.5
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• pp.734-740
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• 2010

Overuse of veterinary antibiotics threats public health and surrounding environment due to the occurrence of antibiotic resistant bacteria. The objective of this study was to evaluate the antibiotic's concentrations of tetracycline (TC), chlortetracycline (CTC), and oxytetracycline (OTC) in a tetracycline group (TCs), sulfamethazine (SMT), sulfamethoxazole (SMX), and sulfathiazole (STZ) in a sulfonamide group, lasalocid (LSL), monensin (MNS), and salinomycin (SLM) in a ionophore (IPs), and tylosin (TYL) in a macrolide (MLs) group from soil, water, and sediment samples adjacent to a cattle manure composting facility. For all samples of soil, water, and sediment, the highest concentrations were detected in TCs among the tested antibiotics because of its higher annual consumption in veterinary farms, Korea and its higher cohesiveness with divalent or trivalent cations in soil. Moreover, the concentrations of residual antibiotics in September were generally higher than in June because of heavier rainfall in June. We suggest that continual monitoring and developing guideline of antibiotics are needed to control residual antibiotics in the environment.

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.1
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• pp.123-135
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• 2001

Application of growth promoters by means of implantation or supplementation to the diets has been routine in the beef cattle industry of many countries for the better performance in growth and improvement of feed efficiency. Anabolic implants (zeranol, trenbolone acetate, and estradiol with testosterone or progesterone) have generated various positive effects. Zeranol implantation, in general, improved average daily gain (ADG), feed conversion (FC), dressing percentage (DP) and yield grade (YG) of cattle, and increased dry matter intake (DMI). Trenbolone acetate with or without estradiol also increased mean values of ADG and loin eye area (LEA) but reduced DMI and improved FC of cattle. Estradiol with testosterone or progesterone increased ADG and DMI. Anabolic implants, however, had minimal or negative effects on marbling or quality grade. The magnitude of the response to these anabolic implants in performance of beef cattle has varied depending on the type of implants, amount and duration of exposure, age of animals and combination of implants. Administration of bovine somatotropin improved ADG and FC, and decreased fat deposition. Ionophores improved FC in cattle from reduced DMI without great response to ADG. Supplementation of monensin and lasalocid reduced molar proportion of propionate. Monensin and lysocellin increased apparent absorption and retention of some minerals in cattle. Despite the improved cattle performance in growth and FC, results in beef quality from the application of the growth promoters appeared to vary or in conflict under a variety of environmental conditions.

• Asian-Australasian Journal of Animal Sciences
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• v.26 no.11
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• pp.1562-1568
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• 2013

This study was conducted to evaluate the effects of indigenous herbal supplements on growth, blood metabolites and carcass characteristics in the late fattening period of Hanwoo steers. In a 6 month feeding trial, thirty Hanwoo steers ($647{\pm}32$ kg) were allotted to one of 5 treatment groups, control (basal diet contained lasalocid), licorice, clove, turmeric and silymarin, with six steers per pen. All groups received ad libitum concentrate and 1 kg rice straw/animal/d throughout the feeding trial. Blood samples were collected at the beginning, middle, and the end of the experiment and the steers were slaughtered at the end. Blood glucose, triglyceride, total protein, and albumin concentrations were higher in the turmeric treatment compared with other treatments. Blood urea nitrogen and creatinine concentrations were highest (p<0.003 and p = 0.071, respectively) in steers treated with silymarin. Alanine aminotransferase activity was lower (p<0.06) for licorice and silymarin compared with the control group. There were no alterations in serum aspartate aminotransferase and gamma glutamyltransferase activities as a consequence of herb treatments (p = 0.203 and 0.135, respectively). Final body weight, body weight gain, average dairy gain and dry matter intake were not significantly different among treatments. Yield grade, marbling score and quality grade were higher for silymarin group than those of the control group (p<0.05). Therefore, the results suggest that silymarin can be used an effective dietary supplement as an alternative to antibiotic feed additive and a productivity enhancer, providing safe and more consumer acceptable alternative to synthetic compounds during the late fattening period of steers.