• Childhood Kidney Diseases
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• v.22 no.1
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• pp.1-6
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• 2018

Rituximab (RTX) is a chimeric monoclonal antibody that inhibits CD20-mediated B-cell proliferation and differentiation. Several studies have examined its use in intractable nephrotic syndrome (NS) with some positive results. However, those studies examined such effects for a short-term period of 1 year, and some patients continued to relapse after a lapse in RTX treatment. Our use of RTX as a maintenance therapy (RTX injection when the CD19 cell count exceeded $100-200/{\mu}L$ before relapse) showed some noticeable efficacy. We used RTX in 19 patients with steroid-dependent NS (SDNS). In 12 patients treated with RTX maintenance therapy, only one relapse occurred. The mean treatment period was $23.4{\pm}12.7months$, and the mean number of RTX administrations was $3.9{\pm}1.6$. The relapse rates were decreased (from 2.68/year to 0.04/year), and the drug-free period also increased (from 22.5 days/year to 357.1 days/year) during maintenance therapy. The other seven patients were treated with one cycle of RTX or additional cycles in case of relapse (non-maintenance therapy). Relapse rates were significantly decreased after RTX treatment (from 1.76/year to 0.96/year, P=0.017). The relapse-free period was $15.55{\pm}7.38$ (range, 5.3-30.7) months. No severe side effects of RTX were found except for a hypersensitivity reaction such as fever and chills during its infusion. In conclusion, RTX is considered an effective and safe option to reduce the relapse rate by a single- or maintenance-interval therapy in SDNS.

• Nuclear Engineering and Technology
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• v.52 no.2
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• pp.296-307
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• 2020

Permanent magnet sodium flowmeter (PMSF) have been used to measure the sodium flow in fast breeder reactors. Due to the effects of irradiation, thermal cycling, time lapse, etc., the magnetic flux density of the PMSF will decrease after being used in the reactor for a period of time. Therefore, it must be calibrated regularly. But some flowmeters that immersed in sodium cannot be removed for an off-line calibration, so the on-line calibration is required. However, the best online calibration accuracy of PMSF using cross-correlation analysis method was 2.0-level without considering the repeatability. In order to further improve this work, the operational principle of the transducer in PMSF is analyzed and the design principle of the transducer is proposed. The transducers were tested on the sodium flow loop to collect the experimental data. The signal characteristics are analyzed from the time and frequency domains, respectively. The cross-correlation analysis method based on biased estimation is adopted to obtain the flow rate. The verification experimental results showed that the measurement accuracy is 1.0-level when the flow velocity is above 0.5 m/s, and the measurement accuracy is 3.0-level when the flow velocity is in the range of 0.2 m/s to 0.5 m/s.

• Korean Journal of Ecology and Environment
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• v.53 no.2
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• pp.195-207
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• 2020

In Korea, specific thermal elements such as annual mean temperature (AMT) 13℃, 14℃, and Kira's coldness index (CI) -10℃, have been suggested about the northernmost distribution of the warm-temperate evergreen broad-leaved forest zone. We reviewed the relationship between three thermal elements and the actual distribution of evergreen broad-leaved woody plants or its communities. Thiessen and Kriging method using point-data calibrated by seasonal lapse rate according to altitude were utilized for the spatial distribution pattern analysis. Several phytoclimatic maps were also produced in order to compare different thermal values. We identified that the AMT 13℃ was the best thermal element to demarcate the northern limit of the warm-temperate forest zone. Its area was estimated ca. 20,334 ㎢ and larger than those of other thermal elements. We concluded that an indirectly fabricated index i.e. CI -10℃ is useless and it was enough for a direct value of AMT 13℃ to represent the northern-limit distribution of warm-temperate forest zone, at least in Korea. Further researches on the reciprocity between floristic regions and phytoclimate zones are raised.

• Proceedings of the KSRS Conference
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• 2008.10a
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• pp.293-296
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• 2008

Land surface Temperature (LST) is a very useful surface parameter for the wide range of applications, such as agriculture, numerical and climate modelling community. Whereas operational observation of LST is far from the needs of application community in the spatial Itemporal resolution and accuracy. So, we developed split-window type LST retrieval algorithm to estimate the LST from MTSAT-IR data. The coefficients of split-window algorithm were obtained by means of a statistical regression analysis from the radiative transfer simulations using MODTRAN 4 for wide range of atmospheric profiles, satellite zenith angle and lapse rate conditions including the surface inversions. The sensitivity analysis showed that the LST algorithm reproduces the LST with a reasonable quality. However, the LST algorithm overestimates and underestimates for the strong surface inversion and superadiabatic conditions especially for the warm temperature, respectively. And the performance of LST algorithms is superior when satellite zenith angle is small. The accuracy of the retrieved LST has been evaluated with the Moderate Resolution Imaging Spectroradiometer (MODIS) LST data. The validation results showed that the correlation coefficients and RMSE are about 0.83${\sim}$0.98 and 1.38${\sim}$4.06, respectively. And the quality of LST is significantly better during night and winter time than during day and summer. The validation results showed that the LST retrieval algorithm could be used for the operational retrieval of LST from MTSAT-IR and COMS(Communication, Ocean and Meteorological Satellite) data with some modifications.

• Journal of the Korean Institute of Intelligent Systems
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• v.24 no.3
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• pp.251-258
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• 2014

The purpose of the neural image analysis is to trace the velocities and the directions of moving mitochondria migrating through axons. This paper proposes an automated technique for detecting axon structure. Previously, the detection process has been carried out using a partially automated technique combined with some human intervention. In our algorithm, a consolidated image is built by taking the maximum intensity value on the all image frames at each pixel Axon detection is performed through vessel enhancement filtering followed by a peak detection procedure. In order to remove errors contained in ridge points, a filtering process is devised using a local reliability measure. Experiments have been performed using real neural image sequences and ground truth data extracted manually. It has been turned out that the proposed algorithm results in high detection rate and precision.

• Journal of the Korea Fashion and Costume Design Association
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• v.21 no.4
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• pp.27-42
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• 2019

This paper tried a detailed approach to identify the correlation among basic elements that influenced the change of forms of the Po. To this end, the subjects were limited to the clothing from the 15th to the 18th century, which was found in the tombs of the period of Pyeonbokpo. The total number of excavated artifacts measured directly is 6 and other correctly described excavated artifacts for a total of 54 items. Per period and element, the types of collars and Seop were presented by classifying collars in 4 types, and Seop in 3 types. On the basis of the classification, the relics selected in this paper were analyzed considering the appearance, period, and rate per type of each element. The type and the change of forms of each element per period, with the focus on the appearance, were identified and the factors influencing the change of forms per element and the correlation between such factors were investigated. The representative type in the first period included dual collars, dual Seop and the representative type in the second period was characterized by a shawl collar and a dual Seop joining the pieces. The representative type in the third period was characterized by round collars and a short Seop. The elements determining the forms of Po, including collars and Seop, had a correlation to the lapse of time and had been systematically influencing each other. Furthermore, the overall change of form was caused due to the social functions as well as the supplementary function of keeping balance among the elements and accordingly, the change of forms was think characterized per period.

• Journal of Biosystems Engineering
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• v.26 no.1
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• pp.39-46
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• 2001

This research conducted to investigate the variation of the moisture content, crack ratio, and hardness of the whole and cracked brown rice after conditioning at the initial moisture content of 13, 14, and 15% with time lapse. The conditioning was conducted by increasing the moisture content of the sample to 0.4 and 0.8%. For basic information and conditioning characteristics for the development of a conditioning machine for the brown rice, predicted models of above three properties were developed using a nonlinear regression analysis of SAS with Gauss-Newton, Gradient, and DUD methods. Results of this research could be summarized as follows. 1. No moisture variation occurred after 0.5 hour conditioning. 2. The increasement of the crack ratio was 7.6 and 17.5% with the sample increased the moisture content of 0.4 and 0.8%, respectively, after 8 hours conditioning. 3. The hardness of the conditioned whole grain of the brown rice decreased 0.82 and 1,000kg$\_$f/ with the sample increased moisture content 0.4 and 0.8%, respectively, after 8 hours conditioning with respect to the non-conditioned sample. 4. The hardness of the conditioned cracked grain of the brown rice decreased 0.54 and 0.81kg$\_$f/ with the sample increased moisture content 0.4 and 0.8%, respectively, after 8 hours conditioning with respect to the non-conditioned sample. The hardness of the broken grain was about 0.81∼1.88kg$\_$f/ lower than whole grain. 5. The moisture content variation, increasing rate of the crack ratio, and hardness of the cracked and whole grain was predicted as a negative exponential function. 6. Each predicted model with the nonlinear regression analysis, which was very accurate and had a very small amount of sum of square of error between experimental value and predicted value, which could be used for predicting the physical variation after conditioning.

• Journal of the Korean Society of Food Science and Nutrition
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• v.28 no.1
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• pp.126-131
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• 1999

We have got the following results from tests in the course of time retrogradation and taste change in bread with added flour of Angelica keiskei Koidz, which had been stored in room temperature (27±2oC), refrigerating(2±1oC) and freezing( 20±1oC), respectively. Bread with the added flour showed a little lower degree of retrogradation than control group, and every group in room temperature retrograded from the very first day. The degree of retrogradation of the group in refrigerating was far greater comparing with the group in room temperature. The longer bread was stored, the lower the degree of retrogradation was, and the higher the adding rate of the flour got, the later its retrogradation happened. Especially the flour of this vegetable's stem turned out to be the most effective in retarding its retrogradation. Group stored 30 days in freezing didn't show a wide difference in retrograde comparing with the group before storage. Preference for color and shape of the flour added bread stored in room temperatue, refrigerating and freezing did not change significantly from the group before storage. Although preference decreased for flavor, texture, mouth feel and overall quality with the lapse of time, flour added group improved in preference for these factors comparing with the control group. Above all, added flour of pretreated stem proved to be the most effective in the sensory tests. With respect to the storing method, the group stored in refrigerating showed greater preference for the texture and mouth feel over the groups in room temperature and freezing. Flavor preference of the group in freezing was the lowest of all.

• Korean journal of food and cookery science
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• v.32 no.2
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• pp.178-187
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• 2016

Purpose: This study investigated the quality characteristics of Jeungpyun prepared with brown rice and sea tangle powder. Methods: The pH, volume, and spreadability of the dough and moisture content, color, texture and sensory evaluation of the Jeungpyun were performed. Results: The results showed that the pH of the dough decreased in all sample groups with the lapse of fermentation time, and ultimately revealed a pH ranging from 4.55-4.65. The spreadability of the dough significantly decreased as the substitute amount of the brown rice flour increased; the sample group with 1% sea tangle powder showed a significantly larger spreadability than the sample group with 2% sea tangle powder (p<0.05). The moisture content in the Jeungpyun showed a significantly lower result as the substitute amount of brown rice flour increased (p<0.05). Lightness (L) was reduced as the substitute amount of brown rice flour increased, and redness (a) and yellowness (b) also appeared to increase. As a result of measuring the texture, the 50% sample group with a high substitute rate of brown rice flour was observed to have high characteristics of hardness, gumminess and chewiness, and was low in cohesiveness. The result of the acceptance test showed that the sample group that substituted 25% brown rice flour and added 1% sea tangle powder was evaluated to have a significantly higher acceptance than the sample group that added 2% sea tangle powder in terms of color, texture and overall acceptance. Conclusion: The result of the acceptance test showed that the sample group that substituted 25% of brown rice flour and added 1% of sea tangle powder showed higher tendency in all acceptance attributes than the sample group that did not substitute the brown rice flour to show the possibility of developing the Jeungpyun with brown rice.

• Journal of Pharmaceutical Investigation
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• v.16 no.2
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• pp.43-54
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• 1986

To increase the bioavailability of clonixin, clonixin argininate was prepared and compared with clonixin by determining solubility, pKa, lipid-water partition coefficient, dissolution rate and in vivo tests. The results are summerized as followings; 1) The solubility of clonixin argininate was increased by 20 times in water, about 1.2 times in pH 1.2 and pH 8.0 buffer solution, and about 1.8 times in pH 6.8 buffer solution compared with that of clonixin. 2) pKa values of clonixin, clonixin lysinate and clonixin argininate were 6.32, 7.20 and 7.45, respectively. 3) The lipid-water partition coefficient of clonixin argininate was increased more than that of the clonixin in n-hexane, carbon tetrachloride, chloroform, methylene chloride, and n-butanol, but the partition coefficient of clonixin was increased more than that of clonixin argininate in benzene/pH 1.2 buffer solution, ether/pH 8.0 buffer solution, and 3-methylbutyl acetate/pH 1.2, pH 8.0 buffer solution. 4) The time required to dissolve 60% $(T_{60%},\;min.)$ of clonixin argininate was about 1.5 min. in water and pH 1.2 buffer solution, and about 5 min. in pH 6.8 buffer solution. $T_{60%}$ of clonixin lysinate was about 1.5 min. in water, about 1.8 min. in pH 6.8 buffer solution, and about 8 min. in pH 1.2 buffer solution. But $T_{60%}$ of clonixin was about 96 min. in pH 6.8 buffer solution, over 2 hours in water and pH 1.2 buffer solution. 5) Anti-inflammatory effect of clonixin argininate was increased more than that of clonixin over 6 hours, and that of clonixin lysinate was followed by lapse of time. 6) Analgesic effect of clonixin argininate was increased by 1.5 times more than that of clonixin and the effect of clonixin argininate was nearly identical with that of clonixin lysinate. 7) The absorption rates (Ka) of clonixin, clonixin lysinate and clonixin argininate were $0.169\;hr^{-1},\;0.652\;hr^{-1}$ and $0.723\;hr^{-1}$ in situ, respectively.