• Journal of the Korean Society for Precision Engineering
• /
• v.28 no.4
• /
• pp.526-533
• /
• 2011

This research is about the pulsatile pump system utilized in the perfusion bioreactor for the in vitro human tissue culture. A pulsatile pump system which can be applied to the culture of the vascular tissues including blood vessel is developed by using the idea of human heart's blood pumping into organs as followings: culture chamber, a pressurizing device which generates laminar pulsatile flow by controlling the x-sectional area of the culture media delivering tubing, a compliance chamber which supplies the pressuring device with a constant pressure, and a peristaltic pump which circulates the culture media in a circuit ranging from the culture chamber to the compliance chamber. The developed pulsatile pump system shows that a physiology of the human heart's blood pumping including pulsatile pressure waveform of systolic-diastolic pressure is well represented. Not only time domain but also frequency domain characteristics of pulsatile pump system which are necessary for the vascular tissue culture such as pulsatile pressure waveform's shape, the frequency, and the magnitude can be easily generated and manipulated by using the proposed system.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
• /
• v.9 no.4
• /
• pp.561-571
• /
• 1997

In this paper, the fundamental equations are developed for the pulsatile laminar flow generated by changing the oscillatory flow with $0{\leq}f{\leq}48Hz$ into a steady one with $0{\leq}Re{\leq}2500$ in a rigid circular pipe. Analytical solutions for the wave propagation factor k, the axial distributions of cross-sectional mean velocity $u_m$ and pressure p are schematically derived and confirmed experimentally. The axial distributions of centerline velocity and pressure were measured by using Pitot-static tubes and strain gauge type pressure transducers, respectively. The cross-sectional mean velocity was calculated from the centerline velocity by applying the parabolic distribution of the laminar flow and it was confirmed by using the ultrasonic flowmeter. It was found that the axial distributions of cross-sectional mean velocity and pressure agree well with theoretical ones and depend only on the Reynolds number Re and angular velocity $\omega$.

• Journal of Biomedical Engineering Research
• /
• v.17 no.4
• /
• pp.515-524
• /
• 1996

The flow characteristics of developing unsteady laminar flow in a square-sectional $180^{\circ}$ curved duct are experimentally investigated by using laser doppler velocimerty (LDV) system with data acquisition and processing system of rotating machinery resolver(RMR) and PHASE software. The major flow characteristics of developing laminar pulsating flows are presented by mean velocity profilel velocity distribution of secondary flow, wall shear stress distributions, entrance lengths according to dimensionless angular frequency($\omega^+$), velocity amplitude ratio($A^1$), and time-averaged Dean number($De_ta$). The velocity profiles and wall shear stress distribution of laminar pulsating flow with dimensionlessangular frequency show the flow characteristics of the quasi-steady laminar flow in a curved duct. The developing region of laminar pulsatile flows in a square-sectional $180^{\circ}$ curved duct is extended to the curved duct angle of approximately $120^{\circ}$ under the present experimental condition.

• Membrane and Water Treatment
• /
• v.1 no.4
• /
• pp.253-271
• /
• 2010

A theoretical study for the flux enhancement by pulsation of transmembrane pressure is presented for osmotic pressure controlled ultrafiltration under laminar flow regime. The transient velocity profile is solved analytically using Green's function method. Time dependent convective diffusive equation is solved to quantify the membrane surface concentration and the permeate flux, numerically. The effects of the amplitude and frequency of pulsation on flux, surface concentration and observed retention are studied.

• 한국전산유체공학회:학술대회논문집
• /
• 2008.03b
• /
• pp.6-9
• /
• 2008

Analyzing the characteristics of blood flow in the blood vessels is very important to diagnose the circulatory diseases. In order to investigate the hemodynamic characteristics in vivo, the measurements of blood flows inside the extraembryonic arterial and venous blood vessels of chicken embryos were carried out using an in vivo micro-PIV technique. The circulatory diseases are closely related with the formation of abnormal hemodynamic shear stress regions, thereby it is important to get blood velocity and vessel's morphological information according to the vessel configuration and the flow conditions. In this study, the flow images of RBCs in blood vessels were obtained using a high-speed CMOS camera with a spatial resolution of approximately 14.6${\mu}$m${\times}$14.6${\mu}$m in the whole circulation network of blood vessels. The blood flows in the veins and arteries show steady laminar and unsteady pulsatile flow characteristics, respectively. The mean blood flows merged (in veins) and bifurcated (in arteries) smoothly into the main blood vessel and branches, respectively, without any flow separation or secondary flow which accompanying large variation of shear stress. Vorticity was high in the inner regions for both types of vessels, where the radius of curvature varied greatly. The instantaneous flows in the arterial blood vessels showed noticeable pulsatility due to the heart beat, and the main features of the velocity waveforms, including pulsatile shape, retrograde flow, mean velocity, maximum velocity and pulsatile frequency, were significantly dependent on the pulsatile condition which dominates the arterial blood flow. In near future, these in vivo experimental results of blood flow measured in various extraembryonic blood vessels would be very useful to understand the hemodynamic characteristics of human blood flows and various blood flow researches for clinically useful hemodynamic discoveries as well.

• Journal of Mechanical Science and Technology
• /
• v.15 no.5
• /
• pp.613-622
• /
• 2001

Interaction of blood flow and leaflet behavior in a bileaflet mechanical heart valve was investigated using computational analysis. Blood flows of a Newtonian fluid and a non-Newtonian fluid with Carreau model were modeled as pulsatile, laminar, and incompressible. A finite volume computational fluid dynamics code and a finite element structure dynamics code were used concurrently to solve the flow and structure equations, respectively, where the two equations were strongly coupled. Physiologic ventricular and aortic pressure waveforms were used as flow boundary conditions. Flow fields, leaflet behaviors, and shear stresses with time were obtained for Newtonian and non-Newtonian fluid cases. At the fully opened phase three jets through the leaflets were found and large vortices were present in the sinus area. At the very final stage of the closing phase, the angular velocity of the leaflet was enormously large. Large shear stress was found on leaflet tips and in the orifice region between two leaflets at the final stage of closing phase. This method using fluid-structure interaction turned out to be a useful tool to analyze the different designs of existing and future bileaflet valves.

• Journal of the Korean Society of Visualization
• /
• v.3 no.1
• /
• pp.26-35
• /
• 2005

The combination of ultrasound echo images with digital particle image velocimetry (DPIV) method has resulted in a two-dimensional, two-component velocity field measurement technique appropriate for opaque flow conditions including blood flow in clinical applications. Advanced PIV processing algorithms including an iterative scheme and window of offsetting were used to increase spatial resolution. The optimum concentration of the ultrasound contrast agent used for seeding was explored. Velocity validation tests in fully developed laminar pipe flow and pulsatile flow showed good agreement with both optical PIV measurements and the known analytic solution. These studies indicate that echo PIV is a promising technique for the non-invasive measurement of velocity profiles and shear stress.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.29 no.1 s.232
• /
• pp.63-70
• /
• 2005

The main objective of the present study is to predict characteristics of three dimensional pulstitile flow by location of stenosis in blood vessel with the second order bifurcation. The present study simulates the incompressible non-Newtonian laminar blood flows using a Fluent V. 6.0. The Carreau model is employed as the constitutive equation for blood. The numerical simulation carried out at five cases without and with symmetry or asymmetry stenosis. It is found that the no stenosis and stenosis before first bifurcation do not have influence on flow at second bifurcated blood vessel. However, the stenosis after first biburcation has effect on flow at second bifurcated blood vessel.

• Journal of Biomedical Engineering Research
• /
• v.27 no.3
• /
• pp.94-100
• /
• 2006

The effectiveness of the treatment of intracranial aneurysms with endovascular coiling depends on coil packing density, the location of aneurysm, its neck dimensions with respect to the aneurysm dome, and its size with respect to the surrounding tissue. Clinical data also suggests that the aneurysm neck size is the main predictor of aneurysm recanalization. In this study, the force impinging on the aneurysm neck in an idealized aneurysm was calculated by using a three dimensional finite volume method for the non-Newtonian incompressible laminar flow. To quantify the effect of neck size on the impingement force, calculations were performed for aneurysm neck diameters (Da) varying from 10% to 100% of the parent artery diameter (Dp). Also, maximum impingement forces were represented by a function of the ratio of the aneurysm neck to the diameter of the parent vessel. The results show that the hemodynamic forces exerted on the coil mass at the aneurysm neck due to the pulsatile blood flow are larger for wide necked aneurysms.

• Journal of computational fluids engineering
• /
• v.6 no.2
• /
• pp.22-31
• /
• 2001

The two-dimensional unsteady incompressible viscous flow behind rectangular bluff bodies between two parallel plates was analyzed numerically. The steady state flow and the vortex flow behind rectangular bluff bodies in the channel were investigated for two regimes i.e., the laminar(Re = 100, 300, 500) and the turbulent flows(Re = 10⁴∼10/sup 6/). The vortex shedding was generated by a physical disturbance(6%) numerically imposed at the rear of the bluff bodies for a short time. It was observed that the perturbed flow became periodic after a transient period. And in the case of unsteady inflow, the sinusoidal pulsatile flow was applied as the inlet condition in the turbulent flow of Reynolds number of 1.0×10/sup 5/. FLUENT code was employed to solve the problems. The power-law scheme was used to get stable linearized equations and the PISO algorithm was applied to finding the solution of them.