• Journal of Periodontal and Implant Science
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• v.50 no.6
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• pp.406-417
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• 2020

Purpose: This study investigated whether the placement of ribose cross-linked collagen (RCLC) membranes without primary soft tissue closure predictably resulted in sufficient alveolar ridge preservation in contained and non-contained extraction sockets. Methods: Membranes were positioned across extraction sockets, undermining full-thickness flaps, and the gingival margins were fixed by double-interrupted sutures without crossed horizontal mattress sutures for 1 week. In non-contained sockets, a bone substitute was used to support the membrane within the bony envelope. Radiographs and clinical images obtained 4 months later were analyzed by ImageJ software using non-parametric tests. Results: In 18 patients, 20 extraction sockets healed uneventfully and all sites received standard-diameter implants (4.1, 4.8, or 5.0 mm) without additional bone augmentation. Soft tissues and the muco-gingival border were well maintained. A retrospective analysis of X-rays and clinical photographs showed non-significant shrinkage in the vertical and horizontal dimensions (P=0.575 and P=0.444, respectively). The new bone contained vital bone cells embedded in mineralized tissues. Conclusions: Within the limitations of this pilot study, open healing of RCLC membranes may result in sufficient bone volume for implant placement without additional bone augmentation in contained and non-contained extraction sockets.

• Journal of Pharmacopuncture
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• v.18 no.2
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• pp.51-59
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• 2015

Objectives: This study was performed to analyze the toxicity and to find the lethal dose of the test substance Hominis placenta pharmacopuncture when used as a single-dose in 6 week old, male and female Sprague-Dawley (SD) rats. Methods: All experiments were conducted at Biotoxtech (Chungwon, Korea), an institution authorized to perform non clinical studies, under the regulations of Good Laboratory Practice (GLP). SD rats were chosen for the pilot study. Doses of Hominis placenta pharmacopuncture extracts, 0.125, 0.25 and 0.5 mL, were administered to the experimental group, and 0.5 mL doses of normal saline solution were administered to the control group. This study was conducted under the approval of the Institutional Animal Ethics Committee. Results: No deaths or abnormalities occurred in any of the groups. Also, no significant changes in body weights were observed among the groups, and no significant differences in hematology/biochemistry, necropsy, and histopathology results were noted. Hematologically, some changes in the male rats in two experimental groups were observed, but those changes had no clinical or toxicological meaning because they were not dose dependent. Histopathological tests on the injected parts showed cell infiltration in the male rats in one of the experimental groups; however, that result was due to spontaneous generation and had no toxicological meaning. Therefore, this study showed that Hominis placenta pharmacopuncture had no effect on the injected parts in terms of clinical signs, body weight, hematology, clinical chemistry, and necropsy. Conclusion: As a result of single-dose tests of the test substance Hominis placenta pharmacopuncture in 4 groups of rats, the lethal dose for both males and females exceeded 0.5 mL/animal. Therefore, the above findings suggest that treatment with Hominis placenta pharmacopuncture is relatively safe. Further studies on this subject are needed.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.4
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• pp.239-248
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• 2019

There are no published data on Gyeongokgo (GOK) safety or efficacy despite being commonly use. The Gyeongokgo (GOK) is commonly used in traditional Korean medicine to promote a health qi and blood, but their objective data was not sufficient in clinical field. To investigate the safety and efficacy of GOK with hematologic and serologic testing and the change of the quality of life in healthy individuals. Randomized, subject-assessor-blind, placebo-controlled, single-center pilot study Participants and Interventions 29 healthy volunteer subjects were randomly placed into the GOK group (n = 20) or placebo control group (n = 9) and instructed to take one treatment packet (GOK or placebo) twice daily for 4 weeks. Subjects were assessed using the Fatigue Severity Scale (FSS) and Short Form 36 Health Survey (SF-36) and underwent hematologic and serologic tests and body composition analysis. The FSS total score (p = 0.093) and SF-36 general health index (p = 0.002) were improved following treatment in the GOK group. Post-treatment thyroid-stimulating hormone levels were increased in the GOK group compared with pre-treatment levels (p = 0.0042). C-reactive protein levels decreased (p = 0.0256) in the GOK group compared with that the placebo group. In time-series tests, GOK did not affect post-prandial serum triglycerides, glucose, insulin, or C-peptide levels. Notably, elevations in serum fasting triglycerides at 2- (p = 0.0333) and 4-hours (p = 0.0414) post-prandial were lower than those in the placebo group. GOK reduced fatigue levels and did not significantly affect laboratory test results performed to measure safety, serum glucose, and lipid profiles. Post-meal triglyceride levels were effectively reduced with treatment.

• Journal of the Korean Geotechnical Society
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• v.26 no.1
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• pp.63-73
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• 2010

The supply of high quality filling materials for pavement base course or reclamation is getting harder. So, there is an attempt to use soft mudstones as an earth filling material in Pohang area. But the engineering properties of the soil deposit placed with soft mudstones have not been clearly evaluated yet. We investigated the water absorption and softening, the slaking behavior and the geological mechanism in order to obtain an effective way of estimating the magnitude of land subsidence and the reduction of soil strength. The applicability of soft mudstones is examined by a variety of laboratory tests and pilot-scale field tests. In addition, it is necessary to consider the environmental characteristics of soft mudstones as a reclaiming material, Consequently, the results from the current study can be used to prevent any construction defects due to the careless use of soft mudstones for the pavement base course or reclamation.

• Animal Bioscience
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• v.36 no.10
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• pp.1612-1618
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• 2023

Objective: In our previous study, we observed that the addition of waste cooking oil (WCO) reduced ammonia (NH₃) emissions during laboratory-scale composting of dairy cattle manure under low-aeration condition. Therefore, this study aimed to evaluate the effect of addition of WCO on NH₃ emissions reduction during pilot-scale composting of dairy cattle manure, which is close to the conditions of practical composting treatment. Methods: Composting tests were conducted using pilot-scale composting facilities (1.8 m³ of capacity). The composting mixtures were prepared from manure, sawdust, and WCO. Two treatments were set: without WCO (Control) and with WCO added to 3 wt% of manure (WCO3). Composting was conducted under continuous aeration at 40 L/min, corresponding to 22.2 L/(min·m³) of the mixture at the start of composting. The changes in temperatures, NH₃ concentrations in the exhaust gases, and contents of the composted mixtures were analyzed. Based on these analysis results, the effect of WCO addition on NH₃ emissions and nitrogen loss during composting was evaluated. Results: During composting, the temperature increase of the composting mixture became higher, and the decreases of weight and water content of the mixture became larger in WCO3 than in Control. In the decrease of weight, and the residual weight and water content of the mixture, significant differences (p<0.05) were detected between the two treatments at the end of composting. The NH₃ concentrations in the exhaust gases tended to be lower in WCO3 than in Control. Nitrogen loss was 21.5% lower in WCO3 than in Control. Conclusion: Reduction of NH₃ emissions by the addition of WCO under low aeration condition was observed in pilot-scale composting, as well as in laboratory-scale composting. This result suggests that this method is effective in reducing NH₃ emissions in practical-scale composting.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2000.05a
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• pp.84-89
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• 2000

Parametric studies based on laboratory pilot tests were performed to investigate the relationships between electrical resistivity and contaminated soil properties. Three kinds of sandy soils sampled and leachates from a industrial waste landfill were mixed to model the contaminated soils. Electrical resistivity of soils were measured by using a simulated resistivity cone penetrometer probe. In the experiments, the electrical resistivity were observed with changing the water content, void ratio, unit weight, degree of saturation, and concentration of the leachate. The test results show that the electrical resistivity of soils depends largely on the water content and the electrical property of pore water rather than unit weight and types of soils.

• Proceedings of the IEEK Conference
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• 2001.10a
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• pp.387-392
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• 2001

Kobe Steel, LTD. and Midrex Technologies Inc. jointly developed the FASTMET$\circledR$ process as a steel mill waste recycle technology in which the DRI product meets BF feed material or BOF/EAF feed material requirements. FASTMET(R) process turns value-less wastes into valuable DRI and sellable zinc oxide, and gives the solution for the steel mill wastes recycling from both economical and environmental viewpoints. During the development of the process, Laboratory, Pilot Plant and Demonstration Plant tests were carried out from 1990 to 1998. The first FASTMET(R) commercial plant began operation in April, 2000 and the second commercial plant started in April, 2001 Both commercial plants have proceeded successfully preying that FASTMET$\circledR$ is a suitable process for recycling steel mill waste and for producing DRI as an iron source.

• Proceedings of the Korea Concrete Institute Conference
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• 2003.05a
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• pp.1023-1028
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• 2003

The structure of Tower Palace III Sports Center building was designed as concrete Filled Steel Tube(CFT) Column and the filled-in concrete was designed as high compressive strength of 500kgf/$m_2$. The self compacting concrete(SCC, non-vibrating concrete) with 65$\pm$5cm flow must be applied to this case for filling the CFT by injecting the concrete from the column bottom. Laboratory tests and pilot productions of batcher plant were performed for optimum mix design and the full scale Mock-Up test was performed to check the appicability of the construction method. As a result, we observed that good quality SCC and the pressure change of concrete pump normally used domestically. Based on these results, we have constructed 20-40m height CFT columns successfully.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2003.10a
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• pp.24-29
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• 2003

Deep sea water has cold temperature, abundant nutrients and minerals, and good water quality that is pathogen-free and stable. Compared with surface water, deep sea water contains more nutrition salt, such as nitrogen and phosphor. Moreover, if has the good balance of minerals. Because of the ability of the spray drying process to produce a free-flowing power considering of spherical particles with a well-defined size distribution and the rapid drying times for heat-sensitive material, spray drying is attractive for a wide range of applications spray drying is a unique unit operation in which powders are produced from a liquid feed in a single processing step. Key component of the process are atomizer, spray chamber. Design of spray chamber should be based on the atomizer type, the production rate, and the particle size required. Because of the complex processes taking place during spray drying, traditional design method are based on pilot-plant tests and empirical scale-up rules. Modern technique such as CFD have a role to play in design and troubleshooting.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.47 no.9
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• pp.607-616
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• 2019

Free body diagram analysis is done for key parts of pilot stage of LLV (Load Limit Valve) which is used to protect overload for static structural test of aerospace flight vehicle. It is shown through the analysis that diameter ratio($D_2)^{ten}/D_2)^{comp}$) of two poppets in a pilot stage must be equal to piston area ratio($A_{comp}/A_{ten}$) of a hydraulic actuator for making a poppet open consistently at constant force applied by an actuator. The result of the analysis is verified by measuring geometries of the poppets in the four different LLVs which are corresponding to four actuators with different capacity and have been used after being imported in this laboratory. Results of "Adjuster resolution tests" with two different pilot stages show the max. deviation of Fi(actuator force in instant of opening poppet) from average Fi obtained for each turn of adjuster is 0.3KN and max. deviation of the Fi normalized by average Fi of each turn of adjuster is 3.7%. From the results, it is verified that the two pilot stages with same poppet diameter ratio make a poppet consistently open at Fis within ${\pm}3.7%$ deviation from the average Fi. The deviation is shown to be caused from frictional force of O-ring in the poppet. Additionally, design factors for poppet spring and adjuster, which are also key parts of the pilot stage, are distinguished and procedure for deciding the factors are also shown in this study.