• Korean Journal of Acupuncture
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• 제39권4호
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• pp.172-183
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• 2022

Objectives : An error was found in the recent standard by the World Health Organization (WHO) on the locations of the Upper arm Route of Lung Meridian (URLM) and its acupoints LU3 and LU4. This possible incorrect information is being taught throughout Korean medicine colleges nationwide, which follow WHO standards. Therefore, an investigation is required to sort out this discrepancy based on the evidence in historical documents. Methods : The location of WHO's URLM and LU3 and LU4 were compared with corresponding information in the classical literature. The anatomical structure mentioned in these classical documents was examined. Finally, an assessment was conducted on whether this structure is reflected in the WHO standards. Results : Classical literature prior to the early 20th century records the locations of the Lung Meridian and LU3 and LU4 of the upper arm to be in the artery on the medial aspect. This artery corresponds to the brachial artery. The location established by the WHO is on the anterolateral side of the upper arm, where no large arteries exist that can be found by haptic search or angiographically. The anterolateral side of the upper arm belongs to the Yang aspect, which does not coincide with the Yin aspect of Lung Meridian. Conclusions : The WHO's URLM and LU3-4 standards do not agree with the classical literature. The correct route must coincide with the brachial artery passing through the medial side of the humerus. The actual location of LU3-4 is on the medial aspect of the arm, just medial to the border of the biceps brachii muscle, on the brachial artery, 3-4 B-cun inferior to the anterior axillary fold.

• 한국세라믹학회지
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• 제53권4호
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• pp.463-467
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• 2016

$Si^{4+}-N^{3-}$ was incorporated into $Ce^{3+}-doped$ lutetium aluminum garnet ($Lu_{2.965}Ce_{0.035}Al_5O_{12}$, $LuAG:Ce^{3+}$) lattices, resulting in the formation of $Lu_{2.965}Ce_{0.035}Al_{5-x}Si_xO_{12-x}N_x$ [(Lu,Ce)AG:xSN]. For x = 0-0.25, the synthesized powders consisted of the LuAG single phase, and the lattice constant decreased owing to the smaller $Si^{4+}$ ions. However, for x > 0.25, a small amount of unknown impurity phases was observed, and the lattice constant increased. Under 450 nm excitation, the PL spectrum of $LuAG:Ce^{3+}$ exhibited the green band, peaking at 505 nm. The incorporation of $Si^{4+}-N^{3-}$ into the $Al^{3+}-O^{2-}$ sites of $LuAG:Ce^{3+}$ led to a red-shift of the emission peak wavelength from 505 to 570 nm with increasing x. Corresponding CIE chromaticity coordinates varied from the green to yellow regions. These behaviors were discussed based on the modification of the $5d^1$ split levels and crystal field surroundings of $Ce^{3+}$, which arose from the Ce-(O,N)8 bonds.

• 대한방사성의약품학회지
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• 제1권1호
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• pp.53-61
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• 2015

Lutetium-177 ($T_{1/2}=6.71day$) is an adequate radionuclide for therapy, which has both beta emission ($E_{max}=497keV$) for therapeutic effect and gamma emission (113 and 208 keV) for imaging. $^{177}Lu$ labeled ethylenediamine-N,N,N',N'-tetrakis (methylene phosphonic acid) (EDTMP) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminomethylenephosphonate (DOTMP) have been proposed as radiopharmaceuticals for bone pain palliation. In this study, we compared radiochemistry and biodistribution of $^{177}Lu$-EDTMP and $^{177}Lu$-DOTMP. EDTMP and DOTMP were synthesized, and 1 mg of each was labeled with $^{177}Lu$ at pH 7~8 with high efficiency (>98%). For comparative biodistribution studies, $^{177}Lu$-EDTMP or $^{177}Lu$-DOTMP were injected into ICR-mice through tail vein, and then biodistribution data were obtained as percentages of injected dose per gram of tissue (% ID/g). Urine excretions of both agents in mice were checked for 7 days. Rat images were also obtained after injection of $^{177}Lu$-EDTMP or $^{177}Lu$-DOTMP. $^{177}Lu$-DOTMP (100% at 1 min) showed faster labeling than $^{177}Lu$-EDTMP (100% at 30 min). Both of them were stable at least for 21 days at room temperature. High bone uptakes were found for both $^{177}Lu$-EDTMP and $^{177}Lu$-DOTMP: 38.0 and 34.1% ID/g at 3 hr, respectively; and 33.2 and 18.8% ID/g at 7 day, respectively. Rapid excretions to urine were found for both agents ($^{177}Lu$-EDTMP: 56%, $^{177}Lu$-DOTMP: 63% at 1 day). Other organs showed very low uptakes. Rat images of both $^{177}Lu$-EDTMP and $^{177}Lu$-DOTMP showed high bone uptakes and low soft tissue uptakes. In conclusion, both $^{177}Lu$-EDTMP and $^{177}Lu$-DOTMP showed high potential as bone pain palliation agents. $^{177}Lu$-EDTMP showed higher bone uptake and slower bone clearance in mice than those of $^{177}Lu$-DOTMP.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2020년도 춘계학술발표대회
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• pp.504-507
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• 2020

ReLU(Rectified Linear Unit) 함수는 제안된 이후로 대부분의 깊은 인공신경망 모델들에서 표준 활성함수로써 지배적으로 사용되었다. 이후에 ReLU 를 대체하기 위해 Leaky ReLU, Swish, Mish 활성함수가 제시되었는데, 이들은 영상 분류 과업에서 기존 ReLU 함수 보다 향상된 성능을 보였다. 따라서 초해상화(Super Resolution) 과업에서도 ReLU 를 다른 활성함수들로 대체하여 성능 향상을 얻을 수 있는지 실험해볼 필요성을 느꼈다. 본 연구에서는 초해상화 과업에서 안정적인 성능을 보이는 EDSR(Enhanced Deep Super-Resolution Network) 모델의 활성함수들을 변경하면서 성능을 비교하였다. 결과적으로 EDSR 의 활성함수를 변경하면서 진행한 실험에서 해상도를 2 배로 변환하는 경우, 기존 활성함수인 ReLU 가 실험에 사용된 다른 활성함수들 보다 비슷하거나 높은 성능을 보였다. 하지만 해상도를 4 배로 변환하는 경우에서는 Leaky ReLU 와 Swish 함수가 기존 ReLU 함수대비 다소 향상된 성능을 보임을 확인하였다. 구체적으로 Leaky ReLU 를 사용했을 때 기존 ReLU 보다 영상의 품질을 정량적으로 평가할 수 있는 PSNR 과 SSIM 평가지표가 평균 0.06%, 0.05%, Swish 를 사용했을 때는 평균 0.06%, 0.03%의 성능 향상을 확인할 수 있었다. 4 배의 해상도를 높이는 초해상화의 경우, Leaky ReLU 와 Swish 가 ReLU 대비 향상된 성능을 보였기 때문에 향후 연구에서는 다른 초해상화 모델에서도 성능 향상을 위해 활성함수를 Leaky ReLU 나 Swish 로 대체하는 비교실험을 수행하는 것도 필요하다고 판단된다.

• 한국재료학회지
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• 제29권9호
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• pp.559-566
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• 2019

$Lu(Nb,Ta)O_4:Eu^{3+}$ powders are synthesized by a solid-state reaction process using LiCl and $Li_2SO_4$ fluxes. The photoluminescence (PL) excitation spectra of the synthesized powders consist of broad bands at approximately 270 nm and sharp peaks in the near ultraviolet region, which are assigned to the $Nb^{5+}-O^{2-}$ charge transfer of $[NbO_4]^{3-}$ niobates and the f-f transition of $Eu^{3+}$, respectively. The PL emission spectra exhibit red peaks assigned to the $^5D_0{\rightarrow}^7F_J$ transitions of $Eu^{3+}$. The strongest peak is obtained at 614 nm ($^5D_0{\rightarrow}^7F_2$), indicating that the $Eu^{3+}$ ions are incorporated into the $Lu^{3+}$ asymmetric sites. The addition of fluxes causes the increase in emission intensity, and $Li_2SO_4$ flux is more effective for enhancement in emission intensity than is LiCl flux. The substitution of $Ta^{5+}$ for $Nb^{5+}$ results in an increase or decrease in the emission intensity of $LuNb_{1-x}Ta_xO_4:Eu^{3+}$ powders, depending on amount and kind of flux. The findings are explained using particle morphology, modification of the $[NbO_4]^{3-}$ structure, formation of substructure of $LuTaO_4$, and change in the crystal field surrounding the $Eu^{3+}$ ions.

• 건축역사연구
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• 제19권4호
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• pp.7-19
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• 2010

'Lu' is one of the Korean traditional building structure. The architectural characteristics of the 'Lu' can be classified two types with its use. One is single building type and the other is a part of building type within building complex. This study is about the two-storied 'Lu' that was built on part of building complex. 'Lu' built in building complex such like Sa-chal, Hyang-gyo, Seo-won, Jae-sil, has the similar characters. 1. It is built by taking slope site. 2. Ii is one of four buildings that forms court yard. 3. It uses simple building structure on the purpose of openness 4. It can control view with using window. The column type of 'Lu' can be classified with 3 style. These are $5{\times}2$ Kan style, $3{\times}2$ Kan style and $5{\times}3$ Kan style. It would be assumed with the result of study that $5{\times}2$ Kan style has its origin in Hoe-Rang structure, $3{\times}2$ Kan style is originated from Joong-Moon(middle gate) structure, and $5{\times}3$ Kan is originated from Kang-Dang structure.

• 방사선산업학회지
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• 제7권2_3호
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• pp.191-200
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• 2013

In this study, a novel bombesin (BBN) analogues, DOTA-Ala($SO_3H$)-4 aminobenzoyl-Gln-Trp-Ala-Val-Gly-His-Leu-Met-$NH_2$ (DOTA-sBBN) and DOTA-Lys(glucose)-4 aminobenzoyl-Gln-Trp-Ala-Val-Gly-His-Leu-Met-$NH_2$ (DOTA-gluBBN), were synthesized and radiolabeled, and their binding affinities were evaluated. Peptides were prepared by a solid phase synthesis method and their purities were over 98%. DOTA is the chelating agent for $^{177}Lu$-labeling, and the DOTA-conjugated peptides were radiolabeled with $^{177}Lu$ by a high radiolabeling yield (>98%). The Log P values of DOTA-sBBN and DOTA-gluBBN were -2.20 and -2.79, respectively. 50.41% of $^{177}Lu$-DOTA-sBBN and 72.97% of $^{177}Lu$-DOTA-gluBBN were left undegraded by the serum incubation at $37^{\circ}C$ for 48 hr. A competitive displacement of $^{125}I-[Tyr^4]$-BBN on the PC-3 human prostate carcinoma cells revealed that 50% inhibitory concentration ($IC_{50}$) were 1.46 nM of DOTA-sBBN and 4.67 nM of DOTA-gluBBN indicating a highly nanomolar binding affinity for GRPR. Therefore, it is concluded that $^{177}Lu$-DOTA-sBBN and $^{177}Lu$-DOTA-gluBBN can be potential candidates as a targeting modality for the Gastrin-releasing peptide receptor (GRPR)-over-expressing tumors, and further studies to evaluate their biological and pharmacological characteristics are needed.

• 반도체디스플레이기술학회지
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• 제18권4호
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• pp.51-56
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• 2019

LuAG:Ce(Lu₃Al₅O₁₂:Ce³⁺) nano phosphor were synthesized by applying the coprecipitation method. It is used to increase the color rendering of phosphor ceramic plate for high power LEDs and laser lighting. Internal quantum efficiency and absorption of LuAG:Ce nano phosphor are 51.5 % and 64.4 %, respectively, which is higher than the previously studied nano phosphors. The maximum absorption wavelength of this phosphor is 450 nm blue light, and the emission wavelength is 510 nm. The emission wavelength shifted to longer wavelength when the concentration of Ce increased in the heat treatment of the reducing atmosphere. Thermal quenching of LuAG nano phosphor was 70 % at 200 ℃, it was explained by their significant quenching of all raman scattering modes, implying the restriction of electron-phonon couplings caused by their defects.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제9권10호
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• pp.303-308
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• 2020

ReLU(Rectified Linear Unit) 함수는 제안된 이후로 대부분의 깊은 인공신경망 모델들에서 표준 활성함수로써 지배적으로 사용되었다. 이후에 ReLU를 대체하기 위해 Leaky ReLU, Swish, Mish 활성함수가 제시되었는데, 이들은 영상 분류 과업에서 기존 ReLU 함수 보다 향상된 성능을 보였다. 따라서 초해상화(Super Resolution) 과업에서도 ReLU를 다른 활성함수들로 대체하여 성능 향상을 얻을 수 있는지 실험해볼 필요성을 인지하였다. 본 연구에서는 초해상화 과업에서 안정적인 성능을 보이는 EDSR(Enhanced Deep Super-Resolution Network) 모델에 활성함수들을 변경하면서 성능을 비교하였다. 결과적으로 EDSR의 활성함수를 변경하면서 진행한 실험에서 해상도를 2배로 변환하는 경우, 기존 활성함수인 ReLU가 실험에 사용된 다른 활성함수들 보다 비슷하거나 높은 성능을 보였다. 해상도를 4배로 변환하는 경우에서는 Leaky ReLU와 Swish 함수가 기존 ReLU 함수 대비 다소 향상된 성능을 보임을 확인하였다. Leaky ReLU를 사용했을 때 기존 ReLU보다 영상의 품질을 정량적으로 평가할 수 있는 PSNR과 SSIM 평가지표가 평균 0.06%, 0.05%, Swish를 사용했을 때는 평균 0.06%, 0.03%의 성능 향상을 확인할 수 있었다. 또한 해상도를 8배로 변환하는 경우에서는 Mish 함수가 기존 ReLU 함수 대비 다소 향상된 성능을 보임을 확인하였다. Mish를 사용했을 때 기존 ReLU보다 PSNR과 SSIM 평가지표가 평균 0.06%, 0.02%의 성능 향상을 확인할 수 있었다. 결론적으로 해상도를 4배로 변환하는 초해상화의 경우는 Leaky ReLU와 Swish가, 해상도를 8배로 변환하는 초해상화의 경우는 Mish가 ReLU 대비 향상된 성능을 보였다. 향후 연구에서는 다른 초해상화 모델에서도 성능 향상을 위해 활성함수를 Leaky ReLU, Swish, Mish로 대체하는 비교실험을 수행하는 것도 필요하다고 판단된다.

• 한국재료학회지
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• 제28권6호
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• pp.355-360
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• 2018

$LuNbO_4:0.2Yb^{3+},xTm^{3+}$ powders were prepared using a solid-state reaction process. The effects of the amount of Tm on up-conversion(UC) and down-conversion(DC) luminescence properties are investigated. X-ray diffraction patterns confirm that $Yb^{3+}$ and $Tm^{3+}$ ions are successfully incorporated into Lu sites. Under 980 nm excitation, the UC spectra of the powders predominantly exhibit strong near-infrared emission bands that peak at 805 nm, whereas weak 480 nm emission bands are observed as well. The emission bands are assigned to the $^1G_4{\rightarrow}^3H_6$ (480 nm) and 3 $^3H_4{\rightarrow}^3H_6$ (805 nm) transitions of the $Tm^{3+}$ ions via an energy transfer from $Yb^{3+}$ to $Tm^{3+}$; two- and three-photon UC processes are responsible for the 805 and 480 nm emissions, respectively. The DC emission spectra exhibit blue emission ($^1D_2{\rightarrow}^3F_4$) of $Tm^{3+}$ at 458 nm. The amount of Tm affects the emission intensity with the strongest emissions at x = 0.007 and 0.02 for the UC and DC luminescence, respectively. The results demonstrate that $LuNbO_4:Yb^{3+},Tm^{3+}$ phosphors are suitable for bio-applications.