• Journal of Microbiology and Biotechnology
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• v.29 no.8
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• pp.1230-1239
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• 2019

Scutellaria baicalensis Georgi has been widely used in China for treatment of various diseases. This study investigated the effect of Scutellaria baicalensis Georgi extracts (SBE) against Coxsackievirus B3 (CVB3)-induced myocarditis in vitro and in vivo. In vitro, Hela cells and primary myocardial cells were infected with CVB3 and treated with SBE ($50-800{\mu}g/ml$) and ribavirin ($200{\mu}M$) for 48 h and then determined by CCK8 assay. Real-time PCR and western blotting assays were performed. In vivo, a myocarditis model was induced in male BALB/c mice by injecting CVB3 suspension intraperitoneally for three times, followed by treatment with SBE (400 and 200 mg/kg) and ribavirin (100 mg/kg) for 28 days. SBE ameliorated the cytotoxicity of CVB3 in Hela cells, especially at $400{\mu}g/ml$ (39.93% vs 65.67%, p < 0.05) without influencing cell growth and also significantly reduced CVB3 replication in primary myocardial cells. The levels of AKT, ERK, and p38 were increased after CVB3 infection. SBE could downregulate the expressions of AKT and p38. In vivo, the mortality rate from CVB3 reached to 66.67%, while 10.00% and 23.33% of this came after 400 and 200 mg/kg SBE treatment, respectively (p < 0.05). The CVB3 replication was obviously reduced after SBE administration from day 5. Similarly, the levels of AKT, ERK, and p38 mRNAs and proteins were increased, and SBE suppressed the expression of AKT and p38. Our study indicates that SBE is a promising potent antiviral agent against CVB3-induced myocarditis by inhibition of virus replication via depressing AKT and p38 expressions.

• Korean Journal of Acupuncture
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• v.21 no.2
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• pp.111-123
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• 2004

Objectives : It has been reported that Cordyceps militaris Mycelia(CMM) has an effect on deficiency allergic asthma(虛喘) clinically. The aim of this study was to determine an appropriate oriental treatment and the doses of CMM to treat asthma. Methods : In order to study the effect of herbal acupuncture solution of the CMM on allergic asthma, the mouse were pretreated by CMM herbal acupuncture at BL13, LU4 before antigen sensitization. 2 days later Mice were actively sensitized with a subcutaneous injection of ovalbumin(OA) and 13 days later they were provoked with OA aerosols. IL-4, lymphocyte, macrophage in bronchoalveolar lavage fluid(BALF), IgE in serum, WBC, RBC, HGB in blood, and in vitro isometric contractile responses of the isolated tracheal smooth muscle(TSM) to acetylcholine$(ACh,\;0.1-1000\;{\mu}M)$, KCl were measured. Results : Contractile responses of TSM to ACh were significantly increased in CMM herbal acupuncture 1 group $(Ach\;1000\;{\mu}M)$, CMM herbal acupuncture 2 group $(ACh\;1,\;10\;{\mu}M)$, CMM herbal acupuncture 3 group $(Ach\;0.3,\;1,\;30,\;300\;{\mu}M)$. The sensitivity of TSM to ACh was significantly decreased in CMM herbal acupuncture 3 group. The maximal contractile response of TSM to ACh was significantly decreased in CMM herbal acupuncture 1, 3 group. The maximal contractile response of TSM to KCl was significantly decreased in CMM herbal acupuncture 1, 2, 3 group. The counts of lymphocytes in BALF was significantly increased in CMM herbal acupuncture 3 group. The counts of macrophages in BALF was significantly decreased in CMM herbal acupuncture 3 group. Interleukin-4 level in BALF was significantly increased in CMM herbal acupuncture 1,3 group. and it was increased in CMM herbal acupuncture 2 group, but there was no significance. Serum IgE level was significantly decreased in CMM herbal acupuncture 1, 2, 3 group. The counts of WBC in blood was significantly increased in CMM herbal acupuncture 1, 3 group Conclusion : Based on the above results it is assumed that CMM herbal acupuncture at BL13, LU4 can help the treatment of deficiency allergic Asthm.

• School Mathematics
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• v.5 no.4
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• pp.507-520
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• 2003

본 연구는 실질적인 의미에서 학생들로 하여금 수학을 더 잘 이해할 수 있도록 돕기 위해 테크놀로지를 학교 교실에서 직접 활용하는 방안에 대한 연구이다. 특히 여기서는 수학을 가르치고 배우는 과정에서 가상학습체계가 주요한 도구로서 적용되었다. 내용은 무게중심을 택했고 12명의 중학생을 대상으로 현직교사가 직접 지도하였다. 학생들은 수업초기에 교사에 의해 소개되는 학생중심 학습활동에 강한 관심과 호기심을 보였고 집중력이 아주 강했다. 전통적인 수업방식과는 달리 학생들이 참여하였고 테크놀로지를 이용하여 전통적인 방식의 교실에서 할 수 없었던 수업의 시작은 학생들의 호기심을 자극하는데 충분하였다. 전반적으로 테크놀로지 환경에서의 수업을 선호하였지만 아직 전통적인 방식인 칠판과 분필을 이용한 수업을 선호한 학생들도 있었다. 새로운 변화도 좋지만 새로운 환경에 친화적이지 않거나 테크놀로지를 이용한 수업의 빠른 진행이 학생을 오히려 혼란하게 만들기도 하였다. 마지막으로 교사는 가상학습체계를 교실에서 활용함에 있어서 현 교육과정과 교과서를 크게 개혁하지 않아도 잘 준비되고 계획된 테크놀로지의 활용에 대한 잠재력을 확인할 수 있었다. 우리는 현재 테크놀로지의 보급에 비해 그 활용도가 낮다는 것을 잘 알고 있고 기타 입학시험이라는 현실이 교육과정과 학습방법의 개혁을 현실적으로 추진하는 것이 어려운 일임을 잘 알고 있다. 그래서 현 상황에서 테크놀로지의 사용을 가능하게 할 수 있는 방법을 모색하였다. 이미 보급된 테크놀로지와 교사와 학생의 테크놀로지에 대한 이해가 앞으로 그 잠재력을 갖고 있다고 확인하였다.보다 낮은 일반세균수 값을 보여주었다. 봄철 시료에 있어서 소규모 도계장은 본 냉각 후 도계과정을 제외하곤 모든 도계공정 단계에서 대규모 도계장보다 높은 일반 세균수의 측정값을 보여주었다. 봄철 시료의 냉각말기의 냉각수 일반세균수는 소규모 도계장이 대규모 도계장보다 높은 측정값을 보여주었다.주었다.다.㏖/s/$m^2$에서는 이앙후 각각 18일로 두 품종 모두 늦어, 약광은 유묘기에 분화되었던 분얼아를 휴면으로 유도할 수 있음을 시사하였다. 4. 유효경비율은 1220~220 $\mu$㏖/s/$m^2$에서 다산벼는 47~55%, 화성벼는 100~72%로 다산벼가 화성벼보다 낮았다. 이것은 다산벼는 무효분얼이 많다는 것을 시사하는 것으로 품종 육성시 유효경비율을 높여야 할 것이다.타났고, \circled2 회복상태에서, 10 lu$\chi$인 경우 서간에 1.26 $\mu\textrm{V}$, 야간에 1.59 $\mu\textrm{V}$였고, 100 lu$\chi$인 경우 서간에 2.63 $\mu\textrm{V}$ 야간에 3.65 $\mu\textrm{V}$였으며, 400 lu$\chi$인 경우 서간에 2.52 $\mu\textrm{V}$, 야간에 3.67 $\mu\textrm{V}$로 나타났다.히, 흉선, F냥, 비장 등의 림프구에 초기 세포용해성 감염을 일으키는데, B

• Korean Journal of Acupuncture
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• v.30 no.3
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• pp.145-150
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• 2013

Objectives : The aim of this study is to review the acupoints used in cocaine studies and interpret the effectiveness in an aspect of meridian theory of Korean medicine. Methods : Authors searched 50 articles in PubMed, 16 in KISS, 9 in OASIS, 40 in NDSL, and 19 in DBPIA, with the keyword of 'cocaine' or 'acupuncture'. The articles written in English only were included. The articles related with cocaine(abuse, dependence, sensitization, intake, withdrawal sign, withdrawal syndrome, reinstatement, seeking) only were subjected. The articles which used manual- or electro-acupuncture were included, and auricular was excluded. Results : The most frequently used acupoint was HT7, while LI4, LU9, ST36, and SP6 were used once respectively. HT7 could be understood to be used from the meaning of the name as well as the theory that Heart Meridian is deeply related with the brain function. LU9 seems to be used to enhance the effect of HT7. LI4 is thought to control reverting yin that flows toward the top of head following the theory of Jang Bu Sang Tong. ST36 appears to be used because it could regulate stress reaction that reverting yin is associated with. SP6 seems to have effect on brain function due to its ability to control spiritual disorder. Conclusions : The acupoints used in the cocaine studies are thought to influence the brain function through diverse mechanism, and Jang Bu Sang Tong theory seems to be involved in the mechanism, at least in part.

• Journal of the Korean Institute of Landscape Architecture
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• v.49 no.2
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• pp.113-127
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• 2021

Although planning techniques linking parks, green areas, and waterways have become common, there are frequent disruptions in the operation and management of landscape-use artificial channels (LuAC). Therefore, this study examined a design to promote the sustainable management and operation of a LuAC using rainwater for the streamlets of the Jeonju-Wanju Innovative City. In order to accomplish the purpose of this study, scenarios were set up by dividing the design into waterhead and waterway portions. First, the scenario regarding the waterhead was analyzed to calculate the water supply and storage required for the waterway and waterhead. The analysis showed that the waterway requires a water supply of 676.8 tons/months, 3,018 tons to 5,512 tons of storage space, and a water depth of 0.75 m to 1.37 m considering the ecological and landscape aspects. The second scenario is to select an effective system of facilities for the operation and management of the LuAC. To accomplish this, a single-circulation system (SCS), which transports water to a highland location was compared to a multi-circulation system (MCS), which supplied water separately to each water space and operated independently. The results showed that the MCS, which was operated independently by small power units, was more effective owing to the vast difference in water supply operation times.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.3
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• pp.95-102
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• 2012

Purpose: The purpose of this study is to define the cut off values of cold hypersensitivity of hands by using digital infrared thermographic imaging(DITI). Methods: Thermographic images of 130 patients with cold hypersensitivity of hands(CHHG, n=65) and non-cold hypersensitivity of hands(NCHHG, n=65) were retrospectively reviewed. We used the temperature difference the palm(PC8) and the upper arm(LU4) for diagnosing cold hypersensitivity of hands. The temperature differences of between two groups were analysed using independent samples t-tests. The cut off values were calculated by ROC curve analysis. Analyses were undertaken using SPSS version 17.0. P value of < 0.05 was considered significant. Results: The temperature difference the palm(PC8) and the upper arm(LU4) were significantly different between groups(p < 0.001). Using receiver operating characteristic curve analysis, the sensitivity, specificity, and area under the curve were 70.8%, 73.8%, respectively both hands. The AUC was 0.822 on right hand and 0.818 on left hand. The optimum cut-off value was defined as $-0.05^{\circ}C$. Conclusions: These results suggest that DITI is a reliable instrument for estimating the cold hypersensitivity of hands.

• Journal of the Korean Ceramic Society
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• v.49 no.4
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• pp.318-324
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• 2012

Reaction-bonded silicon nitrides containing rare-earth oxide sintering additives were densified by gas pressure sintering. The sintering behavior, microstructure and mechanical properties of the resultant specimens were analyzed. For that purpose, $Lu_2O_3-SiO_2$ (US), $La_2O_3$-MgO (AM) and $Y_2O_3-Al_2O_3$ (YA) additive systems were selected. Among the tested compositions, densification of silicon nitride occurred at the lowest temperature when using the $La_2O_3$-MgO system. Since the $Lu_2O_3-SiO_2$ system has the highest melting temperature, full densification could not be achieved after sintering at $1950^{\circ}C$. However, the system had a reasonably high bending strength of 527 MPa at $1200^{\circ}C$ in air and a high fracture toughness of 9.2 $MPa{\cdot}m^{1/2}$. The $Y_2O_3-Al_2O_3$ system had the highest room temperature bending strength of 1.2 GPa.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.34 no.5
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• pp.1435-1442
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• 2014

This study presented numerical simulations of smooth-bed flows in the rectangular open-channel using the source code by OpenFOAM. For the analysis of the turbulent flow, Large Eddy Simulations were carried out and the dynamic sub-grid scale model proposed by Germano et al. (1991) is used to model the residual stress term. In order to analyze the coherent structure, the uw quadrant method proposed by Lu and Willmarth (1973) is used and the contribution rate and the fraction time of the instantaneous Reynolds stress are obtained in the Reynolds stress. The results by the present study are analyzed and compared with data from previous laboratory studies and direct numerical simulations. It is found that the contribution rate of the ejection events is larger than that of sweep events over the buffer layer in the open-channel flow over the smooth bed, however, the frequency of the sweep event is higher than that of the ejection events.

• The Journal of Korean Obstetrics and Gynecology
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• v.26 no.3
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• pp.85-92
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• 2013

Objectives: The purpose of this study is to find diagnostic points and define the cut off values of hot flashes by using digital infrared thermographic imaging. Methods: Thermographic images of 75 patients with hot flashes (HF, n=35) and non-hot flashes (NHF, n=40) were retrospectively reviewed. We used the temperature difference between Ex-HN3 and CV17, LU4, CV12, CV4 for diagnosing hot flashes. The temperature differences of between two groups were analysed using independent samples t-tests. The cut off values were calculated by received operating characteristic curve analysis. Analyses were undertaken using SPSS version 17.0. and p-value of <0.05 was considered significant. Results: The temperature difference Ex-HN3 and LU4 were the most significantly different between groups (p<0.001). Using receiver operating characteristic curve analysis, the sensitivity, specificity, and area under the curve were 65.7%, 72.5%, 0.729, respectively. The optimum cut off value was defined as $1.00^{\circ}C$. Conclusions: These results suggest that the digital infrared thermographic imaging is a reliable instrument for estimating hot flashes.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.1
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• pp.202-208
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• 2014

Friction force on robot systems is highly nonlinear and especially disturbs precise control of the robots at low speed. This paper deals with the dynamic friction compensation problem of a well-known one-link benchmark robot system. We consider the LuGre model because the model can successfully represent dynamic characteristics and various effects of friction phenomenon. The proposed controller is constructed as two parts. An adaptive controller based on dual observers is used to estimate and compensate the dynamic friction. In order to attenuate the friction estimation error and other disturbances, PI observer is additionally designed. Through the computer simulations with the benchmark system, this paper first examines the effects of nonlinear dynamic friction on the control performance of the benchmark robot system. Next, it is shown that the control performance against the dynamic friction is improved by using the proposed controller.