• Journal of Korean Medical classics
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• v.25 no.2
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• pp.141-168
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• 2012

Objective : The objective of this paper is to study the characteristics of the categorization of acupuncure points of the Lung Meridian(肺經) based on Hwangdineijingmingtang(黃帝內經明堂). Method : This paper examines several texts regarding the Lung Meridian. Result and Conclusion : Out of Yang Shangshan(楊上善)'s work, the theoretical aspects are presented in Hwangdineijingmingtang, whereas contents regarding acupuncture points are presented in Hwangdineijingmingtang. This is due to Yang's position as an imperial doctor(太醫侍御). In Hwangdineijingmingtang, Yang explains the characteristics of Metal(金) based on Hwangdineijingmingtang followed by an explanation of the acupuncture points of the Lung Meridian, which shows his emphasis on the relationship between the meridian as the main branch and the viscera. Along this medical logic, Yang must have included LU1(中府) into the Lung Meridian. This is Yang's unique point of view, distinguishing itself from other texts regarding the Lung Meridian. Apart from the means of explanation of the Lung Meridian by Yang, the verse 'made a volume for each 12 meridian' in the introduction of Hwangdineijingmingtang, discussion of the main treatable diseases of Hwangdineijingmingtang, contents on pathways of Lingshu Jingmai(靈樞 經脈), the start and end points of the meridians in Lingshu Maidu(靈樞 脈度) points to the assumption that each acupuncture point's belonging meridian known to us today was fixated by Yang.

• Asian-Australasian Journal of Animal Sciences
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• v.26 no.3
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• pp.334-342
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• 2013

Proteases and protease inhibitors play key roles in most physiological processes, including cell migration, cell signaling, and cell surface and tissue remodeling. Among these, the matrix metalloproteinase (MMPs) pathway is one of the most efficient biosynthetic pathways for controlling the activation of enzymes responsible for protein degradation. This also indicates the association of MMPs with the maturation of spermatozoa. In an attempt to investigate the effect of MMP activation and inhibitors in cultures with various hormones during sperm capacitation, we examined and monitored the localization and expression of MMPs (MMP-2 and MMP-9), tissue inhibitors of metalloproteinases (TIMP-2 and TIMP-3), as well as their expression profiles. Matured spermatozoa were collected from cultures with follicle-stimulating hormone (FSH), luteinizing hormone (LH), and Lutalyse at 1 h, 6 h, 18 h, and 24 h. ELISA detected the expression of MMP-2, MMP-9, TIMP-2, and TIMP-3 in all culture media, regardless of medium type (FSH-supplemented fertilization Brackett-Oliphant medium (FFBO), LH-supplemented FBO (LFBO), or Lutalyse-supplemented FBO (LuFBO)). TIMP-2 and TIMP-3 expression patterns decreased in LFBO and LuFBO. MMP-2 and MMP-9 activity in FBO and FFBO progressively increased from 1 h to 24 h but was not detected in LFBO and LuFBO. The localization and expression of TIMP-2 and TIMP-3 in sperm heads was also measured by immunofluorescence analysis. However, MMPs were not detected in the sperm heads. MMP and TIMP expression patterns differed according to the effect of various hormones. These findings suggest that MMPs have a role in sperm viability during capacitation. In conjunction with hormones, MMPs play a role in maintaining capacitation and fertilization by controlling extracellular matrix inhibitors of sperm.

• Restorative Dentistry and Endodontics
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• v.41 no.1
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• pp.37-43
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• 2016

Objectives: The purpose of this study was to compare the marginal and internal fit of nano-composite CAD-CAM restorations. Materials and Methods: A full veneer crown and an mesio-occluso-distal (MOD) inlay cavity, which were prepared on extracted human molars, were used as templates of epoxy resin replicas. The prepared teeth were scanned and CAD-CAM restorations were milled using Lava Ultimate (LU) and experimental nano-composite CAD/CAM blocks (EB) under the same milling parameters. To assess the marginal and internal fit, the restorations were cemented to replicas and were embedded in an acrylic mold for sectioning at 0.5 mm intervals. The measured gap data were pooled according to the block types and measuring points for statistical analysis. Results: Both the block type and measuring point significantly affected gap values, and their interaction was significant (p = 0.000). In crowns and inlays made from the two blocks, gap values were significantly larger in the occlusal area than in the axial area, while gap values in the marginal area were smallest (p < 0.001). Among the blocks, the restorations milled from EB had a significantly larger gap at all measuring points than those milled from LU (p = 0.000). Conclusions: The marginal and internal gaps of the two nano-composite CAD/CAM blocks differed according to the measuring points. Among the internal area of the two nano-composite CAD/CAM restorations, occlusal gap data were significantly larger than axial gap data. The EB crowns and inlays had significantly larger gaps than LU restorations.

• Korean Journal of Acupuncture
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• v.33 no.2
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• pp.47-57
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• 2016

Objectives : Six command points are individual points that have strong and broad effects on their related part of the body, but there is a controversy about which acupoints are should be included in the six command points. This research was reviewed which acupoints are suitable for the construction of the six command points. Methods : We searched acupoints mentioned six command points in literatures, then investigated the effects of the acupoints to identify that they can be included in the six command points. And we deliberated which acupoints are suitable for the six command points. Results : Acupoints mentioned the six command points are LU7, LI4, ST36, BL40, PC6, TE6, GV26, ouch point, GB34 and SP6. Among the acupoints, LU7, LI4, ST36, BL40 and PC6 was included in the six command points in all of searched literatures. And GV26, ouch point, GB34 and SP6 were excluded because GV26 and ouch point were not fit the definition of the six command points, ST36 can be an alternative to SP6 based on their effects, and GB34 has a similar but little effect compared to TE6. Conclusions : Based on the definition of six command points and the effect of the acupoints, we suggest that the six command points should be composed of LU7, LI4, ST36, BL40, PC6 and TE6.

• Journal of the Korean Ceramic Society
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• v.48 no.5
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• pp.384-389
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• 2011

Gas pressure sintering (GPS) of reaction bonded silicon nitride (RBSN) was performed using $Lu_2O_3-SiO_2$ additive and the properties were compared with those of specimens prepared using high purity $Si_3N_4$ powder. The relative density of RBSN and compacted $Si_3N_4$ powder were 68.9 and 47.1%, and total linear shrinkage after sintering at $1900^{\circ}C$ were 14.8 and 42.9%, respectively. High nitrogen partial pressure (5MPa) was required during sintering at $1900^{\circ}C$ in order to prevent the decomposition of the nitride and to promote the formation of SiC. The relative density and 4-point bending strength of RBSN and $Si_3N_4$ powder compact were 97.7%, 954MPa and 98.2%, 792MPa, respectively, after sintering at $1900^{\circ}C$. The sintered RBSN also showed high fracture toughness of 9.2MPam$^{1/2}$.

• Journal of Korea Water Resources Association
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• v.46 no.5
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• pp.465-476
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• 2013

The outgoing longwave radiation (Rlu) for estimation of evapotranspiration is essential to understand energy balance of earth. However, the ground measurement based Rlu has a limitation that the observation can just stand for the exact site, not for an area. In this study, remote sensing technique is adopted to compensate the limitation of ground observation using the geostationary satellite. We calculated Rlu using Communication, Ocean and Meteorological Satellite (COMS). We validated Rlu from COMS with Cheongmicheon (CFK) and Sulmacheon (SMK) flux tower observations controlled by Hydrological Survey Center. The results showed that Rlu from COMS represented reasonable correlation with ground based measurement. Based on the results in this study, COMS will be able to be used for estimation of evapotranspiration.

• Journal of The Korean Society of Agricultural Engineers
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• v.63 no.1
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• pp.11-25
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• 2021

The objective of this study was to analyze the impact of activation functions on flood forecasting model based on Artificial neural networks (ANNs). The traditional activation functions, the sigmoid and tanh functions, were compared with the functions which have been recently recommended for deep neural networks; the ReLU, leaky ReLU, and ELU functions. The flood forecasting model based on ANNs was designed to predict real-time runoff for 1 to 6-h lead time using the rainfall and runoff data of the past nine hours. The statistical measures such as R2, Nash-Sutcliffe Efficiency (NSE), Root Mean Squared Error (RMSE), the error of peak time (ETp), and the error of peak discharge (EQp) were used to evaluate the model accuracy. The tanh and ELU functions were most accurate with R2=0.97 and RMSE=30.1 (㎥/s) for 1-h lead time and R2=0.56 and RMSE=124.6~124.8 (㎥/s) for 6-h lead time. We also evaluated the learning speed by using the number of epochs that minimizes errors. The sigmoid function had the slowest learning speed due to the 'vanishing gradient problem' and the limited direction of weight update. The learning speed of the ELU function was 1.2 times faster than the tanh function. As a result, the ELU function most effectively improved the accuracy and speed of the ANNs model, so it was determined to be the best activation function for ANNs-based flood forecasting.

• Journal of the Korean Society of Propulsion Engineers
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• v.8 no.1
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• pp.27-37
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• 2004

The convergence characteristics of preconditioned Euler equations were studied. A perturbation analysis was conducted to understand the behavior of the preconditioned Euler equations. Various speed flows in a two-dimensional channel with a 10％ circular arc in the middle of the channel were calculated. Roe's FDS scheme was used for spatial discretization and the LU-SGS scheme was used for time integration. It is shown that the convergence characteristics of pressure and velocity were maintained regardless of the Mach numbers but that the convergence characteristics of temperature were strongly related to the Mach number and became worse as the Mach number decreased. The perturbation analysis well explained the trend of the convergence characteristics and showed that the convergence characteristics are strongly related with the behavior o( the Preconditioning matrix.

• Journal of computational fluids engineering
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• v.21 no.1
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• pp.10-18
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• 2016

Numerical boundary conditions are as important as the governing equations when analyzing the fluid flows numerically. An explicit boundary condition method updates the solutions at the boundaries with extrapolation from the interior of the computational domain, while the implicit boundary condition method in conjunction with an implicit time integration method solves the solutions of the entire computational domain including the boundaries simultaneously. The implicit boundary condition method, therefore, is more robust than the explicit boundary condition method. In this paper, steady compressible 2-Dimensional Navier-Stokes solver is developed. We present the implicit boundary condition method coupled with LU-SGS(Lower Upper Symmetric Gauss Seidel) method. Also, the explicit boundary condition method is implemented for comparison. The preconditioning Navier-Stokes equations are solved on unstructured meshes. The numerical computations for a number of flows show that the implicit boundary condition method can give accurate solutions.

• Bulletin of the Korean Chemical Society
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• v.35 no.7
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• pp.2097-2108
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• 2014

Chemical feature based quantitative pharmacophore models were generated using the HypoGen module implemented in DS2.5. The best hypothesis, Hypo1, which was characterized by the highest correlation coefficient (0.96), the highest cost difference (61.60) and the lowest RMSD (0.74), consisted of one hydrogen bond acceptor, one hydrogen bond donor, one hydrophobic and one ring aromatic. The reliability of Hypo1 was validated on the basis of cost analysis, test set, Fischer's randomization method and GH test method. The validated Hypo1 was used as a 3D search query to identify novel inhibitors. The screened molecules were further refined by employing ADMET, docking studies and visual inspection. Three compounds with novel scaffolds were selected as the most promising candidates for the designing of Mcl-1 antagonists. Finally, a 10 ns molecular dynamics simulation was carried out on the complex of receptor and the retrieved ligand to demonstrate that the binding mode was stable during the MD simulation.