• Title/Summary/Keyword: LT4

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Anti-Oxidant and Hepato-protective Activities of the Stems of Acanthopanax senticosus

  • Son , Dong-Wook;Ryu , Ji-Young;Kang , Jun-Gil;Lee, Sang-Yun;Kim, Hyun-Su;Lee, Sang-Hyun;Hoon, Jung-Sang;Lee, Yeon-Sil;Shin, Kuk-Hyun
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.191.1-191.1
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    • 2003
  • The anti-oxidant activities of Acanthopanax senticosus stems were investigated. The n-BuOH fraction of A. senticosus stems exhibited a significant decrease in serum transaminase activities elevated by hepatic damage induced by CCl$_4$-intoxication in rats. The n-BuOH fraction inhibited the sGPT activities by 65.79%. The n-BuOH fraction showed the increase in the anti-oxidant enzymes such as hepatic cytoso1ic superoxide dismutase, catalase and glutathione peroxidase activities by 30.31, 19.82 and 155%, respectively, in CCl$_4$-intoxicated rats. These results suggest that the stems of A. senticosus possess not only the hepatoprotective, but also the anti-oxidant activities in rats.

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Initial steroid regimen in idiopathic nephrotic syndrome can be shortened based on duration to first remission

  • Baek, Hee Sun;Park, Ki-Soo;Kang, Hee Gyung;Ko, Cheol Woo;Cho, Min Hyun
    • Clinical and Experimental Pediatrics
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    • v.58 no.6
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    • pp.206-210
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    • 2015
  • Purpose: The use of a 12-week steroid regimen (long-term therapy, LT) for the first episode of idiopathic nephrotic syndrome (NS) reportedly induces a more sustained remission and lower relapse rate than previous regimens, including an 8-week steroid regimen (short-term therapy, ST). Here, we assessed the potential for selective application of 2 steroid regimens (LT vs. ST) based on the days to remission (early responders [ER] vs. late responders [LR]) for the first idiopathic NS episode in children. Methods: Patients were divided into 4 subgroups (ST+ER, ST+LR, LT+ER, and LT+LR) according to the initial steroid regimen used and rapidity of response; the baseline characteristics, relapse rates, and cumulative percentage of children with sustained remission were then compared among the 4 subgroups. Results: Fifty-four children received ST, and the remaining 45 children received LT. As observed in previous studies, children receiving LT showed significantly lower relapse rates during the first year after the first NS episode than those receiving ST. The ST+ER group showed significantly lower relapse rates during the first one year and two years after the first NS episode than the the ST+LR group, whereas there were no significant differences of the relapse rates and duration to the first relapse between the ST+ER and LT+ER groups. Conclusion: We suggest that the initial steroid regimen in idiopathic NS patients can be shortened according to the duration to remission i.e., LT in patients achieving remission after the first week of steroid therapy, and ST in those achieving remission within the first week of steroid therapy.

Enterotoxigenic Escherichia coli Isolated from Diarrheal Patients (환자대변에서 장관병원성 대장균의 분리 -독소원성 대장균의 검출에 대하여-)

  • Kim, Yung-Bu;Yang, Hak-Do
    • The Journal of the Korean Society for Microbiology
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    • v.19 no.1
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    • pp.65-71
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    • 1984
  • The author attempted serological typing with the slide agglutination and the production of heat-labile enterotoxin (LT) and heat-stable enterotoxin (ST) by the enterotoxingenic eschenchia coli 446 strains isolated from diarrheal patients. The enterotoxingenic E.coli, producing LT and/or St, were detected by use of assays in the reversed passive hemagglutination(RPHA) and the suckling mouse method. The results obstained were as follows: 1. Of 446 strains isolated, 88 strains(19.73%) produced LT, while 224 strains(50.22%) produced ST, 134(30.05%) produced both LT-ST simultaneously. Serological typing were typed into 06, 08, 020, 025, 027, 0126, 0148 and 0159. Serotype 06 had the highest incidence of 26.46% followed by 0148(18.16%), 027(14.57%); 025(10.99%), 0159(4.03%), 0126(3.59%), 020(1.12%) and 08(0.45%). 2. Serotype 06, 08 and 025 almost always produced both LT and ST, whereas serotypes 020, 027 and 0148 almost always produced only ST. And serotypes 06, 025, 0126 and 0159 almost always produced LT or ST. 3. Of 134 LT-ST positive strains, 115 strains were serotype 06, 3 strains were 025, 2 strains were 08, and 14 strains were 0 untypable. 4. Of 224 ST positive strains, 65 strains were serotype 027, 81 strains were 0148, 16 strains were 0159, and 42 strains were 0 untypable. 5. Of 88 LT positive strains, 45 strains were serotype 025, 5 strains were 0126, 2 strains were 0159, and 42 strains were 0 untypable.

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Selective Muscle Activation With Visual Electromyographic Biofeedback During Scapular Posterior Tilt Exercise in Subjects With Round-Shoulder Posture

  • Son, Jae-ik;Lim, One-bin;Han, Hae-rim;Cynn, Heon-seock;Yi, Chung-hwi
    • Physical Therapy Korea
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    • v.22 no.4
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    • pp.17-26
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    • 2015
  • The purpose of this study was to investigate the effects of visual electromyography (EMG) biofeedback on the EMG activity of the lower trapezius (LT), serratus anterior (SA), and upper trapezius (UT) muscles, the LT/UT and SA/UT EMG activity ratios, and the scapular upward rotation angle during scapular posterior tilting exercise (SPTE). Twenty-four subjects with round-shoulder posture participated in this study. The EMG activities of the LT, SA, and UT were collected during SPTE both without and with visual EMG biofeedback. The scapular upward rotation angle was measured at the baseline, after SPTE without visual EMG biofeedback, and after SPTE with visual EMG biofeedback. The LT, SA, and UT EMG activities, and the LT/UT and SA/UT EMG activity ratios were analyzed by paired t-test. The scapular upward rotation angle was statistically analyzed using one-way repeated analysis of variance. If a significant difference was found, a Bonferroni correction was performed (p=.05/3=.017). The EMG activities of LT and SA significantly increased, and the EMG activity of UT significantly decreased during SPTE with visual EMG biofeedback compared to SPTE without visual EMG biofeedback (p<.05). In addition, the LT/UT and SA/UT EMG activity ratios significantly increased during SPTE with visual EMG biofeedback compared to SPTE without visual EMG biofeedback (p<.05). Significant increases were found in the scapular upward rotation angle after SPTE without and with visual EMG biofeedback compared to baseline (p<.017), and no significant differences were observed in the scapular upward rotation angle between SPTE without and with visual EMG biofeedback. In conclusion, SPTE using visual EMG biofeedback may be an effective method for increasing LT and SA activities while reducing UT activity.

A Clinical Study about Soyangin Edema Patient (소양인(少陽人) 부종(浮腫) 환자(患者) 치험례(治驗例))

  • Ahn, Taek-Won;Bae, Na-Young
    • Journal of Sasang Constitutional Medicine
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    • v.17 no.3
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    • pp.163-171
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    • 2005
  • 1. Objectives The purpose of this study is to evaluate the effectivity of the Korean herbal medicine therapy which is based on the Sasang constitutional medicine for the Soyangin Edema Patient 2. Methods Patient who diagnosed as Soyangin by physical characteristic, posture and symptoms is evaluated with length of patient' Lt. calf, ankle, foot circumference after medication 3. Results After medicine, 1) Length of patient' Lt. calf was on the decrease from 37.2cm to 34.4cm 2) Length of patient' Lt. ankle was on the decrease from 27.8cm to 25.4cm 3) Length of patient' Lt. foot was on the decrease from 28.0cm to 25.7cm Edema of a Soyangin patient responded well to the treatment with Dojeokgangki-tang 4. Conclusions The case study shows an efficient results by using Dojeokgangki-tang in treatment of Soyangin edema patient.

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An application of LT method for Design-decisions to improve energy performance of non-domestic buildings during the early stage of Remodeling Process (비주거용 건물의 리모델링 계획 시 에너지 성능 향상을 위한 LT method의 적용 방법에 관한 연구)

  • Leigh, Seung-Bok;Byun, So-Hyung
    • KIEAE Journal
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    • v.3 no.4
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    • pp.3-14
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    • 2003
  • Remodeling for an aged building is emerging as a potential alternative towards the future of the building industry. It is a more effective method than the new construction in environmental friendly view. Most of remodeling were aimed at the improvement of the function of the deteriorated finishing materials. But, at the early stage of remodeling process, energy performance of a building can be improved by adopting passive design solutions such as daylighting and natural ventilation. The purpose of this study is to explain the passive design strategy in remodeling process and to suggest a application of LT method. LT method is an energy-design tool which responds to parameters available early in design development. It provides an output of annual primary energy for lighting, heating, cooling and ventilation in non-domestic buildings. LT method basically uses the concept of passive zone and non-passive zones and should be used to evaluate the energy performance of a number of options and to make comparisons. In this paper, the process of LT method is introduced and investigated an applicability in our office building.

A COMPUTER ANALYSIS ON THE CONDYLAR PATH OF BALANCING SIDE IN MANDIBULAR LATERAL MOVEMENT (하악 측방운동시 평형측 과두의 운동 궤적에 관한 컴퓨터 분석)

  • Lee Dong-Hyun;Choi Dae-Gyun;Park Nam-Soo
    • The Journal of Korean Academy of Prosthodontics
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    • v.31 no.4
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    • pp.549-564
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    • 1993
  • The purpose of this study was to research the condylar path and the anterior angle of glenoid fossae and classify the patterns of condylar path. Thirty male and female dental students with normal occlesion and masticatory system ranging in age from 21 to 30, without present symptoms and an)r history of TM joint disturbance, were selected for this study. Transcranial radiographs of TM joints under mandibular lateral movement were obtained. By the computer analysis on the radiographs, the angle of posterior slope of articular eminance, the sagittal condylar guidance angie, condylar movement patterns and the height of glenoid fossa was measured respectively, and studied their interrelationship comparatively. The results obtained were as follows : 1. The total distance of condylar movement on balancing side during mandibular lateral movement was 4.55mm for Lt. and 4.78mm for Rt. when mandible moved from C.R. to canine to canine relation and 7.86mm for the Lt. and 8.10mm for the Rt. when mandible moved from C.R. to 7.5mm. 2. The horizontal distance of condylar movement on balancing side during mandibular lateral movements was 3.16mm for the Lt. and 3.52mm for the Rt. when mandible moved from C.R. to canine to canine relation and 6.10mm for the Lt. and 6.30mm for the Rt. when mandible moved from C.R. to 7.5mm. 3. The sagittal condylar guidance angle on balancing side during mandibular lateral movements was $45.96^{\circ}$ for the Lt. and $43.22^{\circ}$ for the Rt. when mandible moved from C.R. from canine to canine relation and $41.14^{\circ}$ for the Lt. and $39.77^{\circ}$ for the Rt. when mandible moved from C.R. to 7.5mm. 4. The height of glenoid fossa was 8.23mm for the Lt. and 7.80mm for the Rt. and the angle of posterior slope of articular eminence was $38.30^{\circ}$ for the Lt. and $38.79^{\circ}$ for the Rt. by method-A and $55.61^{\circ}$ for the Lt. and $55.64^{\circ}$ for the Rt. by method-B. 5. The sequence of the frequency of condylar movement patterns on balancing side during mandibular lateral movement were concave type(30 cases), convex type(16 cases), reverse S shape curve(9 cases) and S shape curve(5 cases) when mandible moved from C.R. to canine to canine relation and concave type(27 cases), 5 shape curve(13 cases), convex type(11 cases) and reverse S shape curve(9 cases) when mandible moved from C.R. to 7.5mm.

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Production and Purification of Soluble Recombinant Human Lymphotoxin in Escherichia coli

  • Choi, Yoon-Ho;Na, Doe-Sun;Pan, Jae-Gu;Park, Seung-Kiel;Yoo, Hyang-Sook;Kang, Kook-Hee;Sung, Moon-Hee
    • Journal of Microbiology and Biotechnology
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    • v.2 no.1
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    • pp.21-25
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    • 1992
  • Human lymphotoxin (LT) was produced in E. coli as a soluble protein. The level of recombinant human LT production was about 4% of the total souble proteins of E. coli extracts. Recominant human LT was purified to apparant homogeneity by a simple procedure utilizing FPLC on Mono Q and Mono S columns. The specific activity of the purified LT was $10\times10^7\;units/mg$.

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Medical Complications of Lung Transplantation

  • Park, Moo Suk
    • Journal of Chest Surgery
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    • v.55 no.4
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    • pp.338-356
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    • 2022
  • Lung transplantation (LT) is now considered as an effective treatment option for end-stage lung diseases that improves the short and long-term survival rates and quality of life. As increasingly many LT procedures are being performed, the medical complications of LT are also increasing in frequency and emerging as a very important issue for transplant clinicians. Although chronic lung allograft dysfunction and infection are major causes of death after LT, many medical complications, several of which result from immunosuppressive treatment, contribute to increased mortality and morbidity. This article reviews the most frequent and important medical complications of LT, accompanied by a review of the literature and studies from South Korea, including lung allograft rejection, infection, and non-allograft organ systemic complications.

Eco-frendly Control of Culex pipiens (mosquito) Larvae by Acorus calamus (sweet flag) and Acorus gramineus (Grassy-leaved sweet flag) Extracts

  • Choi, Jeong-Keun;Lee, Ji-Yeon;Lee, Ja-Hyun;Lee, Seong-Gene;Han, Yeon-Soo;Han, Tae-Ho
    • Korean Journal of Plant Resources
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    • v.19 no.6
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    • pp.721-726
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    • 2006
  • Mosquitoes are carriers of malaria and encephalitis. This study performed for eco-friendly control of mosquitos by using genus Acorus. Several solvents were used for the extraction of genus Acorus; water, ethanol, and methanol. Grinded leaves and roots were also included. Acorus extracts killed mosquito larvae and the ethanol extract showed the best result. Autoclaved Acorus water needed long time to kill mosquito larvae. $LT_{50}$ of 1 % Acorus calamus decoction was 13.6 hrs and 1 % autoclaved Acorus water was 53.6 hrs. $LT_{50}$ of 0.05% Acorus calamus rhizome powder was 28.5 hrs. $LT_{50}$ of 0.5% Acorus calamus leaf powder was 10.8 hrs. $LT_{50}$ of 0.1 % Acorus calamus decoction was 63.4 hrs and 0.1 % Acorus calamus ethanol extracts was 48.6 hrs and 0.1% Acorus calamus methanol extracts was 53.9 hrs. $LT_{50}$ of 0.4% Acorus gramineus decoction was 45.5 hrs, 0.4% ethanol extracts was 10.9 hrs, 0.4% methanol extracts was 10.2 hrs. $LT_{50}$ of ethanol extracts was shorter than other extracts. Acorus calamus rhizome powder could be used for the eco-friendly control of the mosquito larvae.