• Title/Summary/Keyword: LSC 방법

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A study on the Means of Egress Codes for Interior Architecture in the United States - Focused on Evacuation Elements in the Interior Architectural Design - (미국의 실내건축 피난 규정에 관한 연구 - 실내건축계획에 있어 피난 요소를 중심으로 -)

  • Kim, Young-Sung;Cho, Sung-O
    • Korean Institute of Interior Design Journal
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    • v.27 no.3
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    • pp.24-32
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    • 2018
  • The law reflects the situation of the times, understands the society, and shows the will of the state and the community. The Means of Egress should be maintained from design to construction, supervision, as well as use, in order to protect the lives and property of the residents as well as the safe use of the facilities. However, Interior Architects are think that evacuation and safety regulations are complex elements that change frequently and may inhibit the idea of design. The purpose of this study is to propose a design method for the use of safe facilities in the interior architectural design on the evacuation regulations affecting the actual design by the IBC(the International Building Code) and NFPA(National Fire Protection Association) LSC (Life Safety Code). The research method is to investigate and analyze the provisions related to the evacuation of interior architecture in the US and to understand the current regulations and the evacuation regulations. We suggest to design method to the details of the hallway, corridors, aisle accessway, door way, exit path, In particular, the design of furniture, tables and chairs layout that could be obstacles to evacuation situations is presented.

The Precision Test Based on States of Bone Mineral Density (골밀도 상태에 따른 검사자의 재현성 평가)

  • Yoo, Jae-Sook;Kim, Eun-Hye;Kim, Ho-Seong;Shin, Sang-Ki;Cho, Si-Man
    • The Korean Journal of Nuclear Medicine Technology
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    • v.13 no.1
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    • pp.67-72
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    • 2009
  • Purpose: ISCD (International Society for Clinical Densitometry) requests that users perform mandatory Precision test to raise their quality even though there is no recommendation about patient selection for the test. Thus, we investigated the effect on precision test by measuring reproducibility of 3 bone density groups (normal, osteopenia, osteoporosis). Materials and Methods: 4 users performed precision test with 420 patients (age: $57.8{\pm}9.02$) for BMD in Asan Medical Center (JAN-2008 ~ JUN-2008). In first group (A), 4 users selected 30 patient respectively regardless of bone density condition and measured 2 part (L-spine, femur) in twice. In second group (B), 4 users measured bone density of 10 patients respectively in the same manner of first group (A) users but dividing patient into 3 stages (normal, osteopenia, osteoporosis). In third group (C), 2 users measured 30 patients respectively in the same manner of first group (A) users considering bone density condition. We used GE Lunar Prodigy Advance (Encore. V11.4) and analyzed the result by comparing %CV to LSC using precision tool from ISCD. Check back was done using SPSS. Results: In group A, the %CV calculated by 4 users (a, b, c, d) were 1.16, 1.01, 1.19, 0.65 g/$cm^2$ in L-spine and 0.69, 0.58, 0.97, 0.47 g/$cm^2$ in femur. In group B, the %CV calculated by 4 users (a, b, c, d) were 1.01, 1.19, 0.83, 1.37 g/$cm^2$ in L-spine and 1.03, 0.54, 0.69, 0.58 g/$cm^2$ in femur. When comparing results (group A, B), we found no considerable differences. In group C, the user_1's %CV of normal, osteopenia and osteoporosis were 1.26, 0.94, 0.94 g/$cm^2$ in L-spine and 0.94, 0.79, 1.01 g/$cm^2$ in femur. And the user_2's %CV were 0.97, 0.83, 0.72 g/$cm^2$ L-spine and 0.65, 0.65, 1.05 g/$cm^2$ in femur. When analyzing the result, we figured out that the difference of reproducibility was almost not found but the differences of two users' several result values have effect on total reproducibility. Conclusions: Precision test is a important factor of bone density follow up. When Machine and user's reproducibility is getting better, it’s useful in clinics because of low range of deviation. Users have to check machine's reproducibility before the test and keep the same mind doing BMD test for patient. In precision test, the difference of measured value is usually found for ROI change caused by patient position. In case of osteoporosis patient, there is difficult to make initial ROI accurately more than normal and osteopenia patient due to lack of bone recognition even though ROI is made automatically by computer software. However, initial ROI is very important and users have to make coherent ROI because we use ROI Copy function in a follow up. In this study, we performed precision test considering bone density condition and found LSC value was stayed within 3%. There was no considerable difference. Thus, patient selection could be done regardless of bone density condition.

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Appropriate image quality management method of bone mineral density measurement (골밀도 측정의 올바른 질 관리방법)

  • Kim, Ho-Sung;Dong, Kyung-Rae
    • Proceedings of the Korea Contents Association Conference
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    • 2009.05a
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    • pp.1141-1149
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    • 2009
  • In Bone Mineral Density(BMD) measurements, accuracy and precision must be superior in order to know the small changes in bone mineral density and actual biological changes. Therefore the purpose of this study is to increase the reliability of bone mineral density inspection through appropriate management of image quality from machines and inspectors. For the machine management method, the recommended phantom from each bone mineral density machine manufacturer was used to take 10~25 measurements to determine the standard amount and permitted limit. On each inspection day, measurements were taken everyday or at least three times per week to verify the whether or not change existed in the amount of actual bone mineral density. Also evaluations following Shewhart control chart and CUSUM control chart rules were made for the bone mineral density figures from the phantoms used for measurements. Various forms of management became necessary for machine installation and movement. For the management methods of inspectors, evaluation of the measurement precision was conducted by testing the reproducibility of the exact same figures without any real biological changes occurring during reinspection. There were two measurement methods followed: patients were either measured twice with 30 measurements or three times with 15 measurements. An important point to make regarding measurements is that after the first inspection and any other inspection following, the patient was required to come off the inspection table completely and then get back on for any further measurements. With a 95% confidence level, the precision error produced from the measurement bone mineral figures produced a precision error of 2.77 times the minimum of the biological bone mineral density change (Least significant change: LSC). In order to assure reliability in inspection, there needs to be good oversight of machine management and measurer for machine operation and inspection error. Accuracy error in machines needs to be reduced to under 1% for scientific development in bone mineral density machines.

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Development of Effective ${\gamma}$-ray and ${\beta}$-ray Detection Methods For Low-Level Radioactive Wastes (극저준위 방사성 폐기물을 위한 효율적인 ${\gamma}$-선 및 ${\beta}$-선 측정 방법 개발)

  • Kwak, Sung-Woo;Yeom, Yu-Sun;Kim, Ho-Kyung;Cho, Gyu-Seong;Park, Joo-Wan;Kim, Chang-Lak;Song, Myung-Jae
    • Journal of Radiation Protection and Research
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    • v.26 no.4
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    • pp.393-398
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    • 2001
  • The non-combustible RI wastes disposed of in hospital every year emit ${\gamma}$-ray or ${\beta}$-ray but their activities are very low to the extent of background. Development of more simple methods is needed because the conventional detection methods are so ineffective and complex. In this study, to solve this problem, detection method using efficiency curve for ${\gamma}$-ray emitting radioactive wastes measurement is proposed and experimental detection efficiency equation is also determined through HPGe's standard specimen measurement. For ${\beta}$-emitting radioisotopes detection, new measurement method using detection efficiency estimated by Monte Carlo simulation and SBD measurements is also proposed. According to the results of this paper, the unknown activity of low-level radioactive wastes without LSC requiring the preparation of standard sample and measurement for standard source detection efficiency could be determined efficiently and simply about ${\pm}17%$ in errors by using the theoretical detection efficiency and the SBD measurement result.

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Busulfan Inhibits PCNA Expression but Induces The Expression of pRB

  • 천영신;주학진;권득남;김진희
    • Proceedings of the KSAR Conference
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    • 2001.03a
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    • pp.21-21
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    • 2001
  • 일반적으로 세포는 방사능이나 항암제 등의 자극에 의해 DNA가 손상받았을 때 DNA를 합성하기 전, DNA변이를 복구하기 위해 cell cycle을 정지시키게 된다. pRB(retinoblatoma protein)는 이러한 cell cycle의 조절기작에서 중요한 역할을 담당하는 것으로 알려져 있다. G1기에서 S기로 진행하는 것을 조절하는 단백질인 pRB 은 E2F(cell cycle transcription factor)와 상호작용하여 cell cycle 진행에 필요한 전사활성을 억제, PCNA (proliferating cell nuclear antigen)의 합성을 저해한다. 또한, E2F와 결합된 pRB는 apoptosis를 제어하는 유전자를 조절하는 것으로 알려져 있다. Cell cycle에 영향을 미치는 항암제의 일종인 busulfan을 처리하면, 정소 내에 존재하는 대부분의 생식세포들은 사멸되고 spermatogonia만 남는 것으로 알려져 있다. 그러나 그 기작에 대해서는 자세히 연구된 바가 없다. 본 연구에서는 busulfan처리시 spermatogonial stem cell이 어떤 기작에 의해 손상받지 않고 유지되는지를 알아보고자 실험을 수행하였다. Busulfan을 처리한 마우스 (항암제 투여 후 5주)와 정상적인 13주령의 마우스의 정소로부터 각각 세포를 분리하였다. LSC (laser scanning cytometry)를 이용하여 처리군(busulfan treated mice)과 대조군(normal mature mice)에 대해 각각 DNA함량을 비교ㆍ분석한 결과 G0/G1(2N)에 머물러 있는 세포비율이 처리군에서 현저하게 증가했다 (79.3$\pm$5.5%:8.1$\pm$1.3%). Cell cycle의 G1/S check point인 pRB와 PCNA 발현을 Western blot과 면역조직학적인 방법(immunohisto-chemistry)을 이용하여 조사하였다 PCNA는 대조군과 비교해, 처리군에서 매우 낮은 수준으로 발현되었다. 면역염색된 정소단면을 살펴보면, 대조군에서는 모든 세정관에서 PCNA를 발현하는 세포가 높은 비율로 검출되었고, 처리군에서는 소수의 세정관에서 세포들이 낮은 수준으로 검출되었다. 반면에, pRB의 경우 PCNA와는 상반된 결과를 나타내어, 대조군에서는 거의 발현이 되지 않는 반면, 처리군에서는 대부분의 세정관내, 기저막을 따라 위치한 세포들에서 발현되었다. 이상의 결과는 busulfan에 의해 pRB의 인산화가 억제, pRB 와 결합된 E2F는 전사 활성이 억제되어, PCNA 합성을 저해하는 것으로 설명되어질 수 있다. 결론적으로, 인산화가 억제된 pRB (underphosphorylated RB protein)이 quiescent spermatogonial stem cell에서만 특이하게 발현하는 단백질이며, 이러한 pRB의 발현은 apoptosis를 제어하는 역할을 담당해 busulfan처리에 의해 손상받지 않고 남아있는 것으로 시사된다.

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Application of Biological Accelorator Mass Spectrometry by 6 MV in KIST

  • Lee, Gi-Su;Lee, Gyeong-Hui;Jo, Hye-Mi;Lee, Gwan-Ho;Kim, Jae-Yeol;Yu, Byeong-Yong
    • Proceedings of the Korean Vacuum Society Conference
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    • 2014.02a
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    • pp.146.2-146.2
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    • 2014
  • KIST 6MV 가속기는 이온빔 분석 그리고 가속기 질량 분석법(Accelerator mass spectrometry)으로 활용된다. 이온빔 분석으로는 RBS, TOF ERD, PIXE. ${\mu}$-Probe을 할 수 있으며 AMS(Accelerator mass spectrometry)는 액체섬광측정법(LSC)과 비교할때 민감도는 1,000배 정도로 3H, 14C, 26Al,41Ca 을 10-21 ~ 10-18 mole/mg 까지 검출 가능하여. 응용분야로는 BAMS(Biological AMS), 전통과학, 지구과학, 환경과학에 활용되고 있다. 이중 AMS의 생-의학분야(BAMS)의 응용은 최근 매우 중요하게 연구되고 있다. BAMS의 활용 연구에 사용하는 핵종으로는 주로 3H, 14C, 41Ca, 36Cl를 사용하며, 14C 화합물은 쉽게 구할 수 있고, 자연방사선 이하의 낮은 14C labeled drug 사용하기 때문에 1948년 이후 생물학 연구에 혁신적으로 활용되고 있다. 주 활용분야로는 (1) 신약개발은 임상실험 전(Phase 0) 이용되며, 14C로 표지된 bio-molecule을 자연수준의 방사선 농도에서 추적자로 사용하여 질량을 측정하는 방법을 활용. (2) 의과학분야는 인체 내에서의 추적자 연구수행 (3) 항암제 연구는 암조직 중 약물농도와 암효과의 상관성을 연구 (4) 바이오 기술 분야에서는 생약 유효물질의 체내 대사연구 등을 할 수 있어 전세계적으로 활발히 연구가 진행되고 있다. KIST에서는 6MV가속기를 BAMS 연구에 활용하기 위하여 전처리 단계의 Combustion, Gas transfer, Reduction 등을 자체 제작하여 테스트 중에 있으며, BAMS 샘플의 Gas는 호기중의 성분, 대기 성분이 있으며, Liquid는 혈액(혈장,혈청,적혈구), Solid는 DNA, 세포, 장기 뼈, 피부, 식물조직, 사료, Drug 및 그 대사 류가 있다. AMS 측정 결과는 14C/12C 비율로 나타나며 그 결과를 농도로 환산하여 분석하게 된다. 또한 분석 데이터 신뢰를 확보하기 위하여 표준시료 및 품질관리용 시료를 사용하여 BAMS분석법에 대한 검증을 실시하였다.

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Physicochemical properties of dried Saururus chinensis and the antioxidative activities of water and 70% ethanol extracts (덖음온도를 달리하여 전저리한 삼백초 건조물의 이화학적 특성 및 물과 70% 에탄올 추출물의 항산화효과)

  • Kang, Myung-Hwa;An, Su-Mi;Kim, Do-Hee
    • Journal of Nutrition and Health
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    • v.52 no.4
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    • pp.399-407
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    • 2019
  • Purpose: This study was conducted to evaluate the physicochemical properties of different batches of Saururus chinensis using different roasting temperature that were dried at different using different roasting temperatures and their were determined the antioxidative activities of water and 70% ethanol extracts. Methods: Extracts were examined for the total phenolic acid content, the and flavonoids contents and the antioxidant properties, including DPPH radical scavenging activity, ABTs scavenging activity and, the reducing power. Results: Moisture content was significantly higher in the LSC and the crude ash content was significantly higher in the HSC. The crude protein content was higher in the LSC (although not significantly), and the crude fat and carbohydrate contents were higher in the HSC (although not significantly). The total phenolic content was lower in the samples extracted with water, but there was no significant difference. However, the extracts extracted with 70% ethanol at a high drying temperature were significantly higher. The low temperature and high drying temperature batches of Saururus chinensis were significantly higher in the samples extracted with 70% ethanol than those extracted with 70% ethanol. The total phenolic acid content, the total flavonoid content and the electron donating ability were highest in the ethanol extract of Saururuschinensis treated at a high temperature. However, the ABTs radical activity was highest in the water extracted, high-temperature treated Saururuschinensis. The 70% ethanol extract of high temperature roasted Saururuschinensis had the highest antioxidative activities of all the Saururuschinensis batches. Conclusion: The total phenolic acid contents, total flavonoid contents, electron donating activity and reducing power activity were highest in all the 70% ethanol extraction batches of the high-temperature treated samples.

Simultaneous Assay of $^{14}C$ and $^{3}H$ in Evaporator Bottom by Chemical Oxidation Method (화학적 산화 방법을 이용한 농축폐액 내 $^{14}C$$^{3}H$ 정략)

  • Ahn Hong-Joo;Lee Heung-Nae;Han Sun-Ho
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.3 no.3
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    • pp.193-200
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    • 2005
  • [ $^{14}C$ ] and $^{3}H$ in the evaporator bottom (EB) discharged from the Nuclear power plant (NPP) were extracted simultaneously into a gaseous $^{14}CO_{2}$ and liquefied HTO by using the chemical oxidation, which is the method to oxidize samples completely using potassium persulfate and sulfuric acid. The extracted $^{14}C$ and $^{3}H$ were counted by the liquid scintillation counter (LSC) after the quench correction. To examine the recovery of $^{14}C$ using the radioactive standards, $Na_{2}^{14}CO_{3}$, $^{14}C-alcohol$, and $^{14}C-toluene$ as $^{14}C$, and HTO as $^{3}H$ were used. Also, the most suitable method for oxidizing $^{14}C-toluene$, which is difficult to be oxidized, was investigated through FT-IR spectra according to the concentration of sulfuric acid. With the identical method, $^{14}C$ and $^{3}H$ in the EB generated in the NPP were assayed in the range of $8.35{\sim}l.38{\times}10^3$ Bq/g and $2.46{\times}10^2{\sim}1.40{\times}10^4$ Bq/g, respectively.

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A study of activity ratios of uranium isotope in the groundwater using liquid scintillation counter (액체섬광계수기를 이용한 지하수 내 우라늄 동위원소 측정법에 관한 연구)

  • Cho, Soo-Young;Song, Kyung-Sun;Lee, Kil-Yong;Yoon, Yoon-Yeol;Kim, Won-Baek;Ko, Kyung-Sok
    • Analytical Science and Technology
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    • v.25 no.2
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    • pp.146-151
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    • 2012
  • An analytical method was developed for the measurement of uranium isotope in ground water using the liquid scintillation counting technique. A LKB Wallac Quantulus 1220 liquid scintillation counter (LSC) equipped with pulse shape analyzer (PSA) and a solvent extraction method were used for the measurement of uranium isotope in ground water samples. The effect of solution volume on the extraction efficiency was evaluated for 100 to 1000 mL solutions using a NIST standard reference material (NIST SRM 4321C). The effect of groundwater pH on the extraction efficiency was also investigated for pH ranging from 0.5 to 10. It was found that the extraction efficiency had a strong dependence on pH showing a maximum at pH 2. In contrast, the effect of groundwater volume on the extraction efficiency was negligible in the range investigated. According to the method, the extraction efficiency of uranium isotopes was near 96% and the lower detection limit for uranium was 0.018 Bq/L with the counting time of 300 min. The result of this study was also verified by the conventional ICP-MS measurement. It is demonstrated that the suggested method is valuable to the determination of the optimum extraction and measurement conditions for uranium in ground water. The method was successfully applied to the ground water at four locations near the Daejeon province. It was found that the uranium content and the isotopic ratio of $^{234}U/^{238}U$ at the locations ranged 0.59~6.69 Bq/L and 0.72~1.40, respectively.

Accurate Quality Control Method of Bone Mineral Density Measurement -Focus on Dual Energy X-ray Absorptiometry- (골밀도 측정의 정확한 정도관리방법 -이중 에너지 방사선 흡수법을 중심으로-)

  • Kim, Ho-Sung;Dong, Kyung-Rae;Ryu, Young-Hwan
    • Journal of radiological science and technology
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    • v.32 no.4
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    • pp.361-370
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    • 2009
  • The image quality management of bone mineral density is the responsibility and duty of radiologists who carry out examinations. However, inaccurate conclusions due to lack of understanding and ignorance regarding the methodology of image quality management can be a fatal error to the patient. Therefore, objective of this paper is to understand proper image quality management and enumerate methods for examiners and patients, thereby ensuring the reliability of bone mineral density exams. The accuracy and precision of bone mineral density measurements must be at the highest level so that actual biological changes can be detected with even slight changes in bone mineral density. Accuracy and precision should be continuously preserved for image quality of machines. Those factors will contribute to ensure the reliability in bone mineral density exams. Proper equipment management or control methods are set with correcting equipment each morning and after image quality management, a phantom, recommended from the manufacturer, is used for ten to twenty-five measurements in search of a mean value with a permissible range of ${\pm}1.5%$ set as standard. There needs to be daily measurement inspections on the phantom or at least inspections three times a week in order to confirm the existence or nonexistence of changes in values in actual bone mineral density. in addition, bone mineral density measurements were evaluated and recorded following the rules of Shewhart control chart. This type of management has to be conducted for the installation and movement of equipment. For the management methods of inspectors, evaluation of the measurement precision was conducted by testing the reproducibility of the exact same figures without any real biological changes occurring during reinspection. Bone mineral density inspection was applied as the measurement method for patients either taking two measurements thirty times or three measurements fifteen times. An important point when taking measurements was after a measurement whether it was the second or third examination, it was required to descend from the table and then reascend. With a 95% confidence level, the precision error produced from the measurement bone mineral figures came to 2.77 times the minimum of the biological bone mineral density change. The value produced can be stated as the least significant change (LSC) and in the case the value is greater, it can be stated as a section of genuine biological change. From the initial inspection to equipment moving and shifter, management must be carried out and continued in order to achieve the effects. The enforcement of proper quality control of radiologists performing bone mineral density inspections which brings about the durability extensions of equipment and accurate results of calculations will help the assurance of reliable inspections.

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