• Asian-Australasian Journal of Animal Sciences
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• 제32권4호
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• pp.485-493
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• 2019

Objective: This study was undertaken to investigate the genetic characteristics of Berkshire (BS), Landrace (LR), and Yorkshire (YS) pig breeds raised in the Great Grandparents pig farms using the single nucleotide polymorphisms (SNP) information. Methods: A total of 25,921 common SNP genotype markers in three pig breeds were used to estimate the expected heterozygosity ($H_E$), polymorphism information content, F-statistics ($F_{ST}$), linkage disequilibrium (LD) and effective population size ($N_e$). Results: The chromosome-wise distribution of $F_{ST}$ in BS, LR, and YS populations were within the range of 0-0.36, and the average $F_{ST}$ value was estimated to be $0.07{\pm}0.06$. This result indicated some level of genetic segregation. An average LD ($r^2$) for the BS, LR, and YS breeds was estimated to be approximately 0.41. This study also found an average $N_e$ of 19.9 (BS), 31.4 (LR), and 34.1 (YS) over the last 5th generations. The effective population size for the BS, LR, and YS breeds decreased at a consistent rate from 50th to 10th generations ago. With a relatively faster $N_e$ decline rate in the past 10th generations, there exists possible evidence for intensive selection practices in pigs in the recent past. Conclusion: To develop customized chips for the genomic selection of various breeds, it is important to select and utilize SNP based on the genetic characteristics of each breed. Since the improvement efficiency of breed pigs increases sharply by the population size, it is important to increase test units for the improvement and it is desirable to establish the pig improvement network system to expand the unit of breed pig improvement through the genetic connection among breed pig farms.

• 한국임상수의학회지
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• 제25권3호
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• pp.146-151
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• 2008

During the clinical decision making practitioners are often faced with performing diagnostic tests to solve the presenting problems seen in the patients. The diagnostic utility of a test has traditionally been described by technical terms such as sensitivity, specificity, and positive (PPV) and negative predictive value (NPV). Although well known, clinicians are frequently unclear about the concept and application of these terms in everyday evidence-based clinical decision making. Sensitivity and specificity, which are intrinsic properties of diagnostic tests, summarizes the characteristics of the test over a population. The PPV and NPV are greatly dependent on the population prevalence of disease, and thus they do not transferable to different patients or clinical settings. Besides, considering the fact that clinicians more often interested in knowing the extent to which a test result could confirm or exclude of a condition under consideration (posttest probability), these measures do not provide answers on this question. The likelihood ratios (LR) using the information contained in sensitivity and specificity are becoming increasingly popular for reporting the usefulness of diagnostic tests because this term provide an indication of posttest probability as a function of the pretest probability. In this article, clinical applications of LR are illustrated with some practical examples. Discussion is also included of the inherent limitations regarding diagnostic test characteristics.

• 동의생리병리학회지
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• 제26권4호
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• pp.462-468
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• 2012

The present study was conducted with the object of examining how ST36 and LR3 electro acupuncture affects the injured side and the intact side in rats with sciatic nerve injury. For this study, we divided rats into a control group that were injured but not treated, experimental group I that were injured and had electro acupuncture on the intact side, experimental group II that were injured and had electro-acupuncture on the injured side, and experimental group III that were injured and had electro-acupuncture on both the intact side and the injured side, and performed behavioral and immunohistochemical tests. The results of this study are as follows. In the results of hot plate test, on Day 1 of experiment, experimental group I did not show a statistically significant difference but experimental group II and III showed a statistically significant difference, and on Day 2 and 3, all of experimental group I, II and III showed a statistically significant difference. In the results of SFI test, on Day 7 of experiment, experimental group I did not show a statistically significant difference but experimental group II and III showed a statistically significant difference, and on Day 14 and 21, all of experimental group I, II and III showed a statistically significant difference. In the results of immunohistochemical test, the expression of c-fos decreased gradually on Day 1, 2 and 3 in all the experimental groups, and the decrease was larger in the experimental groups that had electro-acupuncture than in the control group. In the results of immunohistochemical test, the expression of BDNF increased gradually on Day 7, 14 and 21 in all the experimental groups, and the expression was higher in the experimental groups than in the control group. Summing up the results, ST36 and LR3 electro acupuncture was effective when it was applied to the injured side and to both sides after sciatic nerve injury, but it was also effective in pain relief and nerve regeneration when it was applied to the intact side.

• Restorative Dentistry and Endodontics
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• 제30권2호
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• pp.95-101
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• 2005

이 연구의 목적은 근단공의 크기가 다양한 치아에서 근단공 확대의 유무에 따른 근관성형시 치아의 미세누출을 평가하기 위함이다. 1근관 치아 60개를 치근첨 상방 5mm에서 절단후 각 치아의 근단공 크기에 따라 큰 근단공 (L) 작은 근단공 (S)으로 나누었다 이 두 군을 치근첨 상방 5mm의 횡단면상 근관의 형태로 원형 (R)과 난형 (O)으로 나누었다(SR, SO, LR, LO). 각 군은 Quantec series Nickel-Titanium (Ni-Ti) rotary file을 이용하여 .02 taper로 성형 후 측방가압법으로 충전하였다. 누출은 40 $cmH_2O$ 압력하에 fluid transport method로 측정하였다. 측정 후 누출이 있는 시편은 .04 taper와 .06 taper로 재근관치료 하여 다세 미세누출을 평가하였다. 통계학적으로 chi-square test와 fisher's exact test를 이용하였다. 결과는 다음과 같다. 1. .02 taper로 성형한 군에서는 근단공의 크기에 따른 미세누출은 통계적으로 유의성이 있었고 (p < 0.05) .04 taper로 성형한 군에서는 통계적으로 유의한 차이를 보이지 않았다 (p > 0.05) .2.근첨 상방 5 mm에서 근관단면의 형태에 따른 미세누출은 통계적으로 유의하지 않았다 (p > 0.05). 3. LR group과 LO group에서는 .02 taper로 성형한 군과 .04 taper로 성형한 군사이에 유의한 차이를 보였다 (p < 0.05).

• Journal of Pharmaceutical Investigation
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• 제35권4호
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• pp.255-263
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• 2005

Research was undertaken to compare the pharmacological activity of Lithospermi radix (LR) reported as an oriental medicine for classical uses. LR contains naphthoquinone pigments : shikonin, acetylshikonin, isobutylshikonin, etc. LR is used for the treatment of excision wound, burn, eczema, blister, scarlatina and septicemia as antifebrile, antidotic and antiphlogistic. Gardeniae fructus (GF) has been used for the treatment to jaundice, hepatic disease, anti-inflammatory and analgesic effects, and it contains crocin, geniposide and its derivatives. The therapeutic effects of burn and excision wound healing from LR & GF hydrogel with $Nano-ATP^{\circledR}$ (GLN) were investigated. To evaluate the therapeutic value of various hydrogels, thermal burn model and excision wound mouse model were used. The burn and wound reduction rate and therapeutic period were measured to calculate the healing extent after 5 experiments. The 2nd degree burn was prepared on hairless mouse back skin and dressing with collagen. The burn and wound reduction rate of GLN hydrogel treated group decreased more rapidly than that of other gel group in animal model. Furthermore therapeutic periods of GLN hydrogel treated group was shorter than that of other gel group. In anti-inflammatory test, GLN hydrogel treated group decreased edema rapidly than that of other gel group. These results suggest that the GLN hydrogel treatment has an therapeutic effect on burn and excision wound healing.

• 터널과지하공간
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• 제27권5호
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• pp.333-342
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• 2017

본 연구에서는 국내의 다양한 화성암에 대해 내부구조의 불균질성을 정량화하고, 이와 탄성파속도 및 점하중강도간의 상관관계를 분석하였다. 3차원 X-ray Computed Tomography(CT)를 통해 암석 시편 내부 구조에 대한 정보를 획득하였으며, 3차원 영상에 통계적 기법을 적용하여 뷸균질성 대표계수(representative unit length, LR)를 계산하였다. 또한 암석의 탄성파 속도 및 점하중강도와 LR간의 상관관계로부터 암석의 역학적 특성치를 예측하는 추정식을 제안하였다. 본 연구에서 제안한 방법을 통해 3차원 X-ray 영상에 기반한 내부 특성 분석값을 이용해 실내실험을 수행하지 않고도 암석의 역학적 물성을 평가할 수 있는 간접적인 인자를 도출할 수 있는 가능성을 확인하였다.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2005년도 Proceedings of ISRS 2005
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• pp.197-200
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• 2005

Super resolution image reconstruction method refers to image processing algorithms that produce a high resolution(HR) image from observed several low resolution(LR) images of the same scene. This method is proved to be useful in many practical cases where multiple frames of the same scene can be obtained, such as satellite imaging, video surveillance, video enhancement and restoration, digital mosaicking, and medical imaging. In this paper we applied super resolution reconstruction method in spatial domain to video sequences. Test images are adjacently sampled images from continuous video sequences and overlapped for high rate. We constructed the observation model between the HR images and LR images applied by the Maximum A Posteriori(MAP) reconstruction method that is one of the major methods in the super resolution grid construction. Based on this method, we reconstructed high resolution images from low resolution images and compared the results with those from other known interpolation methods.

• Communications for Statistical Applications and Methods
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• 제10권3호
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• pp.749-764
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• 2003

In this paper we explain that normal theory likelihood-ratio tests(z, t, $x^2$. F) for mean(s) or variance(s) can be geometrically related to volume of difference of two joint pdf's. One is an estimated joint pdf under null parameter space $\omega$ and the other is an estimated joint pdf under full parameter space $\Omega$. For explanations, ‘distance between two distributions’ is defined. We study properties of it, and derive some results on the distance between two multivariate normal distributions.

• 한국음향학회지
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• 제11권1호
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• pp.14-21
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• 1992

본 연구에서는 통신망의 음성품질 기준을 설정하기 위하여, 음성품질 열화요인 중 음량정격 및 측음 마스킹 정격에 대한 일련의 주관평가를 실시하여, 음량정격과 평균 오피니언 점수 및 측음 마스킹 정격과 평균 오피니언 점수와의 상관을 구하였다. 또한 음성품질에 대한 사용자 백분율을 도출하여 사용자의 오피니언을 기본으로 하는 음성품질 기준을 제안하였다.

• Parasites, Hosts and Diseases
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• 제52권5호
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• pp.493-499
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• 2014

The determination of the accurate immune status of pregnant women is crucial in order to prevent congenital toxoplasmosis. Equivocal results with conventional serological techniques are not uncommon when IgG titers are close to the cut-off value of the test, so that a confirmatory technique is needed. For this purpose, we developed a homemade immunoblot (IB) using soluble extract of Toxoplasma gondii tachyzoites and assessed it by testing 154 positive, 100 negative, and 123 equivocal sera obtained from pregnant women. In order to select the more valuable bands in terms of sensitivity and specificity, we used the Youden Index (YI). The highest YIs were those given by the 32, 36, 98, 21, and 33 bands. The simultaneous presence on the same blot of at least 3 bands showed a much higher YI (0.964) and was adapted as the positivity criterion. The analysis of results showed that our homemade IB correlated well with the commercial LDBIO Toxo II $IgG^{(R)}$ kit recently recommended as a confirmatory test (96.7% of concordance).