• 대한한방내과학회지
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• 제28권1호
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• pp.133-148
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• 2007

Objectives : The purpose of our study was to investigate the effects of Injinchunggan-tang (Yinchenchinggan-tang) on DMN liver damage caused by applying proteomics. Materials and Methods: Sprague-Dawley rats were used in this experiment; the rats were divided into the normal group (normal saline), the control group (DMN) and the samplegroup (DMN+IJCGT). The DMN was induced 3 days a week for 3 weeks in the control group. The normal saline without DMN was induced by the same method in the normal group. Injinchunggan-tang extract was orally administered twice a day for 3 weeks after DMN was induced in the sample group. The livers of each group were processed and we investigated histology, OxyBlot, 2-dimensional electrophoresis, and western blot of liver of each group. Results : In the histological findings of the liver, the control group showed portal fibrosis with a few septa or without septa. The sample group showed no fibrosis or portal fibrosis without septa. In the OxyBlot finding, Injinchunggan-tang prevented liver damage by oxidation. In the 2-dimensional electrophoresis finding, formiminotransferase cyclodeaminase (FTCD), FYVE-finger containing protein, aldehyde dehydrogenase (ALDH), and ratio of predicted : hypothetical protein LOC68668 isoform 1 were changed. Conclusions : Injinchunggan-tang exerts an inhibitory effect against the fibrosis and oxidation induced by the DMN in the rat liver cell, and some proteins induced by the DMN were changed by Injinchunggan-tang.

• 한국지하수토양환경학회지:지하수토양환경
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• 제21권3호
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• pp.64-81
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• 2016

To analyze the influence of various groundwater flow rates (specific discharge) on BHE system with balanced and unbalanced energy loads under assuming same initial temperature (15℃) of ground and groundwater, numerical modeling using FEFLOW was used for this study. When groundwater flow is increased from 1 × 10⁻⁷ to 4 × 10⁻⁷m/s under balanced energy load, the performance of BHE system is improved about 26.7% in summer and 22.7% at winter time in a single BHE case as well as about 12.0~18.6% in summer and 7.6~8.7% in winter time depending on the number of boreholes in the grid, their array type, and bore hole separation in multiple BHE system case. In other words, the performance of BHE system is improved due to lower avT in summer and higher avT in winter time when groundwater flow becomes larger. On the contrary it is decreased owing to higher avT in summer and lower avT in winter time when the numbers of BHEs in an array are increased, Geothermal plume created at down-gradient area by groundwater flow is relatively small in balanced load condition while quite large in unbalanced load condition. Groundwater flow enhances in general the thermal efficiency by transferring heat away from the BHEs. Therefore it is highly required to obtain and to use adequate informations on hydrogeologic characterristics (K, S, hydraulic gradient, seasonal variation of groundwater temperature and water level) along with integrating groundwater flow and also hydrogeothermal properties (thermal conductivity, seasonal variation of ground temperatures etc.) of the relevant area for achieving the optimal design of BHE system.

• 한국산학기술학회논문지
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• 제19권9호
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• pp.288-297
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• 2018

보행은 사람들의 건강을 증진시키고 증가하는 교통 체증 해소에 중요한 역할을 한다. 기존 보행관련 연구는 유럽, 북미, 동아시아 등에서 진행하였으나, 베트남과 같은 덥고 습한 개발도상국 도시들의 경우, 걷기에 대한 연구가 비교적 많지않다. 따라서 본 연구는 베트남 호치민시 중심지구의 보행편의성과 건축 환경이 보행에 미치는 영향에 대하여 연구를 진행하였다. 본 연구는 대상지를 이용하는 사람들의 보행 빈도와 건축 환경 사이의 상관관계를 분석하고 있다. 기존 선행 연구에서 일반적으로 사용된 요소 외에도, 본 논문은 보행편의성 지수를 추정하기 위해 도시의 다른 특정한 건축 환경 요소를 사용하였다. 사용된 지표는 주거 밀도, 상업 비율, 혼합 토지이용, 교차로 간격, 블록 크기, 보행로 비율, 천장 유무, 온도 9가지를 사용하였으며, 이러한 지표는 지역 주민들을 대상으로 실시한 조사와 비교 분석을 실시하였다. 분석 결과 사람들은 보행편의성 지수가 높은 지역에서 더 많은 보행을 하는 것으로 분석되었다.

• 대한두경부종양학회지
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• 제24권2호
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• pp.155-161
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• 2008

Head and neck squamous cell carcinoma(HNSCC) still has poor outcome, and laryngeal cancer is the most frequent subtype of HNSCC. Therefore, there is a need to develop novel treatments to improve the outcome of patients with HNSCC. It is critical to gain further understanding on the molecular and chromosomal alteration of HNSCC to identify novel therapeutic targets but genetic etiology of squamous cell carcinoma of the larynx is so complex that target genes have not yet been clearly identified. Array based CGH(array-CGH) allows investigation of general changes in target oncogenes and tumor suppressor genes, which should, in turn, lead to a better understanding of the cancer process. In this study, We used genomic wide array-CGH in tissue specimens to map genomic alterations found in laryngeal squamous cell carcinomas. As results, gains of MAP2, EPHA3, EVI1, LOC389174, NAALADL2, USP47, CTDP1, MASP1, AHRR, and KCNQ5, with losses of SRRM1L, ANKRD19, FLJ39303, ZNF141, DSCAM, GPR27, PROK2, ARPP-21, and B3GAT1 were observed frequently in laryngeal squamous cell carcinoma tissue specimens. These data about the patterns of genomic alterations could be a basic step for understanding more detailed genetic events in the carcinogenesis and also provide information for diagnosis and treatment in laryngeal squamous cell carcinoma. The high resolution of array-CGH combined with human genome database would give a chance to find out possible target genes which were gained or lost clones.

• Journal of Crop Science and Biotechnology
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• 제11권4호
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• pp.237-242
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• 2008

A liguleless mutant, which showed complete loss of lamina joint region at the junction between leaf blade and leaf sheath, was isolated from a Ds insertional mutants derived from the source cultivar, Dongjin. This mutant could not affect other developmental patterns like phyllotaxis. Southern blot analysis, using GUS as a probe, revealed that the liguleless mutant contained three Ds copies transposed in the rice genome. Among the four genomic sequences flanking the Ds, one was mapped in the intergenic region (31661640 - 31661759), and the other two predicted a protein kinase domain (12098980 - 12098667) as an original insertion site within a starter line used for massive production of Ds insertional mutant lines. Another predicted and inserted in first exon of liguleless 1 protein (OsLG1) that was mapped in coding region (LOC_Os04g56170) of chromosome 4. RT-PCR revealed that the OsLG1 gene was not expressed liguleless mutants. Structure analysis of OsLG1 protein revealed that it predicted transcription factor with a highly conserved SBP domain consisting of 79 amino acids that overlapped a nuclear localization signal (NLS). RT-PCR revealed that OsLG1 is mainly expressed in vegetative organs.

• 한국항공운항학회지
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• 제21권4호
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• pp.119-125
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• 2013

Since year 2001 to the present time, the aircraft accidents and serious incidents in our country have surpassed 150 occurrences. The Boeing has published the statistical summary of commercial jet airplane accidents annually for the past 10 years on the basis of the occurrence categories defined by the CICTT(CAST/ICAO Common Taxonomy Team), and the number of occurrences is in order of loss of control(LOC-I), controlled flight into terrain(CFIT) and runway excursion (RE). Like the NTSB and the EASA, when fatal and non-fatal accidents are aggregated, though fatality rate is low, abnormal runway contact(ARC), system/component failure(SCF-PP/NP), ground handling(RAMP) rank high in the CICTT occurrence categories. With the less occurrence frequency, it is difficult to statistically analyze the aircraft accidents in our country, thus customarily the accidents and the serious incidents on aggregate are consolidated, and the statistical analysis is performed. This study categorizes the accidents and serious incidents to the domestic transportation aircraft in the past 10 years according to the CICTT occurrence categories, that is compared with foreign practices, and the implications have been discussed. From years 2001 through 2010, the accidents to the domestic transportation aircraft occurred in order of system failure(SCF-NP), ARC and power plant failure(SCF-PP), and when the accidents and the serious incidents are consolidated and analyzed, it is verified that a distribution appears similar to the European accident occurrence categories defined from 300 accident occurrence data.

• Nuclear Engineering and Technology
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• 제42권5호
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• pp.568-575
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• 2010

Flow Accelerated Corrosion is an active degradation mechanism of CANDU feeder. The tight bend downstream to Gray loc weld connection, close to reactor face, suffers significant wall thinning by FAC. Extensive in-service inspection of feeder wall thinning is very difficult because of the intense radiation field, complex geometry, and space restrictions. Development of a knowledge-based inspection program is important in order to guarantee that adequate wall thickness is maintained throughout the whole life of feeder. Research results and plant experiences are reviewed, and the plant inspection databases from Wolsong Units One to Four are analyzed in order to support developing such a knowledge-based inspection program. The initial thickness before wall thinning is highly non-uniform because of bending during manufacturing stage, and the thinning rate is non-uniform because of the mass transfer coefficient distributed non-uniformly depending on local hydraulics. It is obvious that the knowledge-based feeder inspection program should focus on both fastest thinning locations and thinnest locations. The feeder wall thinning rate is found to be correlated proportionately with QV of each channel. A statistical model is proposed to assess the remaining life of each feeder using the QV correlation and the measured thicknesses. W-1 feeder suffered significant thinning so that the shortest remaining life barely exceeded one year at the end of operation before replacement. W-2 feeder showed far slower thinning than W-1 feeder despite the faster coolant flow. It is believed that slower thinning in W-2 is because of higher chromium content in the carbon steel feeder material. The average Cr content of W-2 feeder is 0.051%, while that value is 0.02% for W-1 feeder. It is to be noted that FAC is reduced substantially even though the Cr content of W-2 feeder is still very low.

• 한국환경교육학회지:환경교육
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• 제22권3호
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• pp.15-30
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• 2009

This study focuses on the comparison of PBL and GBS. PBL is a famous model that emphasizes diversity of students and self directed learning within the theory of constructivism. GBS has not been studied that extensively. GBS is most similar to PBL but this model has not been actively applied to school education. This study focuses on how to enhance students' interest in an educational environment that is encompassing a new and changing teach-learn paradigm and the development of new technology. Furthermore, PBL and GBS methods were compare actively applied to "Environmental Education" to make the students learn self-directed education through the transformation of one's environmental awareness. Specifically, the models were applied to the "Ecology and Environment" subject taught in general high schools and the degree of 'environmental literacy' were measured, From March to May of 2007, the PBL and GBS models were applied to 3rd grade students at D high school and the subject was 'Ecology and Environment'. The students were divided according to age into groups of $5{\sim}7$. The PBL group attempted to solve the given problems and the GBS group carried out their missions. In conclusion, after analyzing the 'environmental literacy' survey results by SPSS 12.0, just 'Knowledge of Ecology (KEOC)' and 'Locus of Control (LOC)' were slightly significant in PBL. This shows that PBL enhances the students' problem solving ability and thinking power. This is a result of the enhancement of students' problem-solving and thinking abilities through PBL. Students can learn many things because they completed their projects based on their experience and knowledge, both individually and interpersonally. We have to study how to apply PBL and GBS to the education field in spite of the many limited conditions. Therefore, this study looks at the application of PBL and GBS in environmental education and suggests specific strategies for educators who want to apply GBS and PBL and adapt them into their education curricula.

• 정보처리학회논문지D
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• 제11D권3호
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• pp.597-604
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• 2004

정확한 소프트웨어 비용 추정은 개발자와 고객 모두에게 중요하다. 대부분의 비움 추정 모델들은 규모 추정으로부터 틴은 라인 수와 기능점수와 같을 규모 측도에 기반을 두고 있다. 규모 추정의 정확도는 비용 추정 정확도에 직접적으로 영향을 미친다. 이에 따라 대부분의 회귀기반 비용추정 모델들은 규모에 기반한 멱함수 형태를 적용하고 있다. 생물의 성장, 기술의 발전과 인간의 학습 능력 등 많은 성장 현상들은 S자 곡선을 따른다. 본 논문은 성장곡선을 이용하여 개발노력을 추정하는 모델을 제시하였다. 제시된 모델은 소프트웨어 규모가 증가함에 따라 소요되는 개발 비용이 성장곡선을 따른다고 가정한다. 일반적인 소프트웨어 규모 추정 기법인 기능점수, 완전기능점수와 유스케이스 점수에 기반하여 성장곡선 모델의 적합성을 검증하였다. 제안된 성장곡선 모델들은 멱함수 모델과 비교 시 상호 견줄만한 성능을 보여 소프트웨어 비용 추정분야에 석용 가능함을 보였다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제22권4호
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• pp.294-301
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• 2011

Objectives : This study investigated factors related to suicide in high school students and focused on perceived academic performance. Methods : We surveyed 293 grade 10 high-school students in Jeju and Gyeonggi provinces and gave them self-assessment questionnaires. To evaluate the suicide risk, the questionnaire included questions about suicidal thoughts, plans, threats, deliberate self-injury, and suicide attempts from the Scale for Suicide Ideation (SSI). Also, it included the Beck Depression Inventory (BDI), Beck Hopelessness Scale (BHS), Locus of Control Scale (LOC), Rosenberg's Self Esteem Scale (RSE) and Perceived Academic Performance (PAP) to identify factors related to suicide in high school students. Results : Depression, hopelessness, and low self-esteem were related with suicidal thoughts, plans, attempts, and severe suicidal ideation (SSI score${geq}$16). In the multivariate analysis, a low level of PAP (OR=3.796, 95%CI 1.280-11.257) was significantly associated with severe suicidal ideation (SSI score${geq}$16). Deliberate self-injury was most prevalent in failing the PAP group and also having a high level of PAP (OR=6.161, 95%CI 1.474-25.760). Conclusion : The authors found that the suicide risk of high school students is related to depression, hopelessness, low self-esteem and a low level of PAP. These results provide significant indicators in planning an adolescent suicide prevention program.