• Title/Summary/Keyword: LMP2

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Influence of the supplementation of Achyranthes japonica extracts on the growth performance, nutrient digestibility, gas emission, fecal microbial, and meat quality traits of finishing pigs with different nutrition concentrations in the diet

  • Thamaraikannan, Mohankumar;Jae Hong, Park;Seyoung, Mun;In Ho, Kim
    • Korean Journal of Agricultural Science
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    • v.48 no.4
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    • pp.655-668
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    • 2021
  • The present study was conducted to investigate the effects of the supplementation of Achyranthes japonica extract (AJE) on overall performance levels with different nutrition concentrations in the diets of finishing pigs. Here, 140 finishing pigs with initial body weights of 50.18 ± 2.37 kg were used in a ten-week trial involving a 2 × 2 factorial design in two phases with the following factors: diet types with different nutrition concentrations (Positive control [PC] vs. Negative control [NC]) and 0 or 0.05% AJE supplementation to NC and PC diets. The PC diet was a basal diet, whereas the NC diet consisted of a 5% and 7% crude protein (CP) reduced basal diet during phase 1 (1 - 35 days) and phase 2 (36 - 70 days), respectively. A significant effect (p < 0.05) on the gain-to-feed ratio (G : F) was observed with interaction effects between the diets and AJE supplementation. However, during phase 1 and in all periods, the pigs fed the PC and NC diets with average daily feed intake (ADFI) tended to decrease compared to those fed diets with AJE. A significant effect (p = 0.0380) of E. coli was observed in pigs fed the PC and NC diets compared to AJE supplementation in phase 2 of the experiment. The backfat thickness (BFT) tended to decrease and the lean meat percentage (LMP) was significantly improved in phase 2 for pigs fed the PC and NC diets. In summary, BFT and LMP showed beneficial effects and fecal microbiota of E. coli counts were positively affected when pigs were fed diets with different nutrient concentrations.

Anti-tumor effect of Inonotus obliquus in xenograft animals with EBV+human gastric carcinoma (Inonotus obliquus (차가버섯) 추출물의 EBV 양성 인간위암에 대한 in vivo 항종양 효능 연구)

  • Lee, Seulki;Cho, Hyosun
    • Korean Journal of Microbiology
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    • v.52 no.4
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    • pp.482-486
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    • 2016
  • Inonotus obliquus is a medicinal mushroom with a variety of biological activities. It has reported to have strong anti-cancer, antioxidant and anti-inflammatory properties. EBV+ gastric carcinoma is one of the most common EBV-associated cancers that were caused by latent EBV infection. In this study, we investigated the anti-cancer effects of ethanol extract of I. obliquus using in vivo xenograft animal models implanted with EBV+ human gastric carcinoma (SNU719). We also explored the molecular mechanisms responsible for its anti-cancer activity. The result indicated that the extract of I. obliquus had an anti-cancer effect in in vivo xenograft mice with EBV+ gastric carcinoma (SNU719). Extract of I. obliquus also showed a great effect on inducing the expression of p53, p21 and Bax in tumor tissue derived from EBV+ human gastric carcinoma, and these were correlated with increased expressions of the cleaved forms of caspase-9 and Parp. Also, I. obliquus attenuated the expression of viral proteins, BZLF-1 and LMP-2 in tumor tissue from EBV+ human gastric carcinoma.

Expression of Epstein-Barr Virus Gene and Clonality of Infiltrated T Lymphocytes in Epstein-Barr Virus-associated Gastric Carcinoma

  • Lee, Jae-Myun;Kim, Ho-Guen;Noh, Sung-Hoon;Lee, Won-Young;Kim, Se-Jong;Park, Jeon-Han
    • IMMUNE NETWORK
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    • v.11 no.1
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    • pp.50-58
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    • 2011
  • Background: Epstein-Barr virus associated gastric lymphoepithelioma-like carcinoma (LELC) is characterized by the intensive infiltration of lymphoid cells, the presence of EBV, and the better prognosis over typical adenocarcinoma. Thus, it was assumable that viral latent proteins may be responsible for the recruitment of a certain T cell repertoire to EBV-associated gastric carcinoma. Methods: To examine above possibility, EBV gene expression in gastric carcinoma tissues and usage of TCR among the tumor infiltrating lymphocytes were analyzed. Results: EBV specific DNA and EBERs RNA were detected in 4 out of 30 patients. RT-PCR analysis revealed that all 4 of EBV-positive tumor tissues expressed EBNA1 mRNA and BARTs and LMP2a was detected only one sample out of 4. However, the EBNA2 and LMP-1 transcripts were not detected in these tissues. $CD8^+$ T cells were the predominant population of infiltrating lymphocytes in the EBV-positive gastric carcinoma. According to spectra type analysis of infiltrating T cells, 10 predominant bands were detected by TCR $V{\beta}$ CDR3 specific RT-PCR from 4 EBV-positive tumor tissues. Sequence analysis of these bands revealed oligoclonal expansion of T cells. Conclusion: These findings suggest that clonally expanded T cells in vivo might be a population of cytotoxic T cells reactive to EBV-associated gastric carcinoma.

Assessment of Residual Life for In-Service Fossil Power Plant Components Using Grain Boundary Etching Method (입계부식법에 의한 사용중인 화력발전소 요소의 잔여수명평가)

  • Han, Sang-In;Yoon, Kee-Bong;Chung, Se-Hi
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.21 no.1
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    • pp.22-31
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    • 1997
  • The grain boundary etching method as a method for assessing degradation of structural materials has received much attention because it is simple, inexpensive and easy to apply to real components. In this study, the effectiveness of the method is verified by successfully applying the technique to in-service components of aged fossil power plants such as main steam pipes, boiler headers an turbine rotors. A new degradation parameter, intersecting number ratio (N$_{1}$/N$_{0}$), is employed. The intersecting number ratio (N$_{1}$/N$_{0}$) is defined as the ratio of intersection number (N$_{1}$) obtained from 5-minute picric acid etched surface to the number (N$_{0}$) obtained from nital etched surface. Two kinds of test materials, 2.25Cr-1Mo steel and 1Cr-1Mo-0.25V steel, were artificially thermal-aged at 630.deg. C in different levels of degradation., (N$_{1}$/N$_{0}$) were measured. And, correlations between the measured values and LMP values calculated from aging temperature and aging time were sought. To check the validity of the correlations obtained in laboratory, similar data were measured from service components in four old Korean fossil power plants. These on-site measurement data were in good correlation with those obtained in the laboratory.oratory.

Long Time Creep Strength and Life Prediction of Steam Turbine Rotor Steel by Initial Strain Method (화력발전용 로터강의 초기 변형률법에 의한 장시간 크리프 수명 및 강도 예측)

  • 오세규;정순억
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.17 no.6
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    • pp.1321-1329
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    • 1993
  • Long time creep strength and life prediction of 1% Cr-Mo-V and 12% Cr rotor steel were performed by using round-bar type specimens under static load at 500-600.deg. C TTP (time temperature parameter), MCM (minimum commitment method) and ISM (initial strain method newly devised) as life prediction methods were investigated, and the results could be summarized as follows. (1) The minimum parameter of SEE (standard error) by TTP was proved as LMP (larson-miller parameter), and the minimum parameter of RMS (root mean squares), by data less than 10$^{3}$hrs was MHP (manson-haferd parameter). (2) The parameters of the minimum and the maximum strength values predicted in $10^{5}$hrs creep life of 1% Cr-Mo-V steel by TTP were LMP and MSP, respectively. In case of 12% Cr steel above $550^{\circ}C$ OSDP (orr-sherby-dorn parameter) was minimum and MSP (manson-succop parameter) was maximum, but below $550^{\circ}C$, the inverse phenomena was observed. On the other hand the creep strengths before $10^{3}hrs$ life by MCM were similar to those by TTP, but the strengths after $10^{3}hrs$ life were 10-25% lower than those by TTP. (3) Creep strengths by ISM were maximum 5% lower than those by TTP. Because $10^{5}hrs$ strengths were similar to those of the lower band by TTP, the ISM was safer than the TTP.

ISM에 의한 발전용 고온 배관재료 2.25Cr1Mo강의 고온 크리프 수명 예측에 관한 연구

  • Lee, Sang-Guk;Jeong, Min-Hwa;O, Se-Gyu;Song, Jeong-Geun
    • Journal of Ocean Engineering and Technology
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    • v.12 no.2 s.28
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    • pp.71-78
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    • 1998
  • In this report for the assessment of creep properties of high-temperature tube materials in power plants, the long-time($10^4$~105h) creep life prediction by ISM for 2.25Cr1Mo steel was studied. It was clarified experimentally and quantitatively that the newly developed long-time creep life prediction equation was very coincident with the actual experimental data with high confidence, and the model was $t_r=\alpha\varepsilon_0^{\beta}\sigma^{-1}$.

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Physical and mechanical properties of cement mortar with LLDPE powder and PET fiber wastes

  • Benimam, Samir;Bentchikou, Mohamed;Debieb, Farid;Kenai, Said;Guendouz, Mohamed
    • Advances in concrete construction
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    • v.12 no.6
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    • pp.461-467
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    • 2021
  • Polyethylene-terephthalate (PET) from bottle waste and linear low-density polyethylene (LLDPE) from barrels and tanks waste are widely available and need to be recycled. Recycling them in concrete and mortar is an alternative solution for their disposal. In this study various quantities of sand (5%, 10%, 15% and 20%) were substituted by powder from LLDPE waste. In addition, PET waste fibers (corrugated, straight) were added to the mortar with different percentages (0.5%, 1%, 1.5% and 2%) of cement mass. This paper evaluate the mechanical and physical properties of the composites in fresh (workability, air content and density) and hardened state (compressive and flexural strength, water absorption and total shrinkage). From the experimental results, it can be concluded that the strengthening in tensile of the mortar with plastic waste corrugated fibers is improved. Other important results are that the water absorption and the density rate are less than that of the ordinary mortar.

Creep Behavior of 9% Ni Alloy Steel at Elevated Temperatures

  • Suh, Chang-Min;Oh, Sang-Yeob
    • Journal of Ocean Engineering and Technology
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    • v.25 no.4
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    • pp.12-17
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    • 2011
  • Little design data is available for the creep life prediction of 9% Ni alloy in elevated temperatures. Therefore, in this study, a series of creep tests under 16 combined conditions with 4 kinds of stresses and 4 temperatures was performed to obtain creep design and life prediction data for 9% Ni alloy, with the following results. The stress exponents decreased as the test temperature increased. The creep activation energy gradually decreased as the stresses became larger. The Larson-Miller parameter (LMP) constant for this alloy was estimated to be about 2.

Creep Properties of Superalloy Udimet 720 in relation to Exposed (초내열합금 U720의 노출시험에 따른 크리프 특성)

  • Kong, Y.S.;Oh, S.K.
    • Journal of Power System Engineering
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    • v.5 no.2
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    • pp.57-62
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    • 2001
  • Gas turbine performance is highly dependent on the engine performance which is closely related to the engine materials since they are exposed to severe working environments, i.e, high temperature and high stresses. For this reason, advanced materials with improved properties are required for the engine. The purpose of this research is to develop key materials technologies for aircraft industry and to tester domestic production of related parts. In this paper, the real-time prediction of high temperature creep strength and creep life for nickel-based superalloy Udimet 720(high-temperature and high-pressure the gas turbine engine materials) was performed on round-bar type specimens under pure load at the temperatures of 538, 649 and $704^{\circ}C$.

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