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Comparison of Quality of Life on the Stage of Cancer Survivorship for Breast and Gynecological Cancer Survivors (유방암 및 부인과 암 생존자의 삶의 질에 대한 생존단계별 비교 연구)

  • Lim, Jung-Won;Han, In-Young
    • Korean Journal of Social Welfare
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    • v.60 no.1
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    • pp.5-27
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    • 2008
  • Purpose: This study aims to better understand the quality of life (QOL) for Korean breast and gynecological cancer survivors by examining the differences in multi-dimensional QOL outcomes according to stage of cancer survivorship. Methods: To identify the multiple dimensions of health status and psychosocial outcomes, three standardized QOL and psychological distress measures were administered to 110 Korean breast and gynecological cancer survivors. These participants were divided into three groups based on the stage of cancer survivorship. Results: Analyses of covariance revealed that once important confounders were controlled for, QOL outcomes were partially different depending on the stage of cancer survivorship. Results for SF-36 measure showed significant differences between acute and long-term survival stages, indicating that QOL for cancer survivors had gradually improved in the physical domain. However, there were no significant group differences in the psychological domain of SF-36. Additionally, QOL-CS and BSI-18 measures did not show significant QOL differences according to the stage of cancer survivorship. Conclusions: Evidence that, for Korean survivors, QOL outcomes differ according to the stage of cancer survivorship serves as a rationale for developing discriminatory strategies and interventions that take into account survival stage.

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Membrane Transporter Genes in Cephabacin Biosynthetic Gene Cluster of Lysobacter lactamgenus

  • Nam, Doo-Hyun;Lim, Si-Kyu;Chung, Min-Ho;Lee, Eung-Seok;Sohn, Young-Sun;Dewey, D.Y. Ryu
    • Journal of Microbiology and Biotechnology
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    • v.11 no.1
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    • pp.153-159
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    • 2001
  • In order to clone the peptide synthetase gene form Lysobacter lactamgenus IFO 14,288, the gene fragments were amplified using primers for the adenylation domain and the thionylation domain of the peptide synthetase genes in other organisms by polymerase chain reaction (PCR). The resulting 0.5-kb fragment was cloned in a pGEM-T vector, and the nucleotide sequences were determined. Six different PCR products were obtained; three were identified to be a part of L-$\alpha$-aminoadipyl-L-cysteinyl-D-valine (ACV) synthetase and three to be other peptide synthetases. Using each of the two different classes of PCR products as mixed probes, a cosmid library of L. lactamgenus chromosomal DNA constructed in a pHC79 vector was screened by an in situ hybridization procedure, and one positive clone was selected which was bound by peptide synthetase gene fragments as well as ACV synthetase gene fragments. The partial sequence analysis formt he obtained pPTS-5 cosmid showed th presence of more than two open reading frames. These were for two putative membrane transporters, which were homologous with several integral membrane proteins including the ABC transporter ATP-binding protein of E. coli (YbjZ) and the metal ion uptake protein of Bacillus subtilis (YvrN). A 45% homology was also found between the two transporter proteins at the carboxy terminus. Through a hydropathy analysis and transmembrane analysis. 4-5 transmembrane domains were found in these two proteins. When the genes were expressed in Escherichia coli, the gene products inhibited the hose cell growth, probably due to the disturbance of the membrane transport system.

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Analysis of Lamb wave propagation on a plate using the spectral element method (스펙트럼 요소법을 이용한 판 구조물의 램파 전달 해석)

  • Lim, Ki-Lyong;Kim, Eun-Jin;Choi, Kwang-Kyu;Park, Hyun-Woo
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2008.11a
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    • pp.71-81
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    • 2008
  • This paper proposes a spectral element which can represent dynamic responses in high frequency domain such as Lamb waves on a thin plate. A two layer beam model under 2-D plane strain condition is introduced to simulate high-frequency dynamic responses induced by piezoelectric layer (PZT layer) bonded on a base plate. In the two layer beam model, a PZT layer is assumed to be rigidly bonded on a base beam. Mindlin-Herrmann and Timoshenko beam theories are employed to represent the first symmetric and anti-symmetric Lamb wave modes on a base plate, respectively. The Bernoulli beam theory and 1-D linear piezoelectricity are used to model the electro-mechanical behavior of a PZT layer. The equations of motions of a two layer beam model are derived through Hamilton's principle. The necessary boundary conditions associated with electro mechanical properties of a PZT layer are formulated in the context of dual functions of a PZT layer as an actuator and a sensor. General spectral shape functions of response field and the associated boundary conditions are formulated through equations of motions converted into frequency domain. A detailed spectrum element formulation for composing the dynamic stiffness matrix of a two layer beam model is presented as well. The validity of the proposed spectral element is demonstrated through comparison results with the conventional 2-D FEM and the previously developed spectral elements.

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Shopping Mall Avatar System Using Behavior and Motion Description Language (수준별 행위 표현 기법을 이용한 쇼핑몰도우미 아바타 시스템의 구현)

  • Kim, Jung-Hee;Lee, Gui-Hyun;Lim, Soon-Bum
    • Journal of Korea Multimedia Society
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    • v.8 no.4
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    • pp.566-574
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    • 2005
  • In spite of recent increase in the use of avatar in Web and Virtual Reality, there has not been a service that allows users to control directly the avatar behaviors. In addition, the conventional behavior control languages required a lot of complicated information for controlling the avatar motions. Moreover, in order to apply written languages to a different task domain, it was necessary to modify or rewrite the languages. In this paper, we define Task-Level Behavior Description Language and Motion Representation Language for more simple control of the avatar behavior. The first thing allows describing the avatar behaviors in each task domain, and The second thing enables writing detailed data for motion control. And in this paper, we developed an interpreter which can automatically change the Behavior Description Language to the Motion Representation Language. So this system allow users control the avatar behavior simply with only use the Behavior Description Language. The system was applied to shopping mall and the Task-level Behavior Description Language was compared with conventional languages to see how it was more effective in behavior description.

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Indoor Propagation Channel Modeling Using the Finite Difference Time Domain Method (시간영역 유한차분법을 이용한 실내 전파 채널 모델링)

  • Chung, Sun-Oh;Lim, Yeong-Seog
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.15 no.9
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    • pp.1847-1853
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    • 2011
  • Analysis of an indoor propagation channel has conventionally used the ray-tracing method. But, in this paper, we had modelling the channel for three dimensional indoor structure by the finite difference time domain method for three dimensional full wave analysis. An excitation signal of the FDTD method used plane wave. The plane wave was excited using the total field/scattered field method. And absorbing boundary condition used the perfectly matched layer method with 7 layers. An living room for the simulation of indoor channel modeling is surrounded the wall that be composed of the wood, the conductor, the glass and concrete. When there are furniture in the living room or not, it were simulated, respectively. As simulation results, we could identify the fading effect of multipath at indoor propagation environment, calculated mean excess delay and rms delay spread for the receiver design.

E-commerce data based Sentiment Analysis Model Implementation using Natural Language Processing Model (자연어처리 모델을 이용한 이커머스 데이터 기반 감성 분석 모델 구축)

  • Choi, Jun-Young;Lim, Heui-Seok
    • Journal of the Korea Convergence Society
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    • v.11 no.11
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    • pp.33-39
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    • 2020
  • In the field of Natural Language Processing, Various research such as Translation, POS Tagging, Q&A, and Sentiment Analysis are globally being carried out. Sentiment Analysis shows high classification performance for English single-domain datasets by pretrained sentence embedding models. In this thesis, the classification performance is compared by Korean E-commerce online dataset with various domain attributes and 6 Neural-Net models are built as BOW (Bag Of Word), LSTM[1], Attention, CNN[2], ELMo[3], and BERT(KoBERT)[4]. It has been confirmed that the performance of pretrained sentence embedding models are higher than word embedding models. In addition, practical Neural-Net model composition is proposed after comparing classification performance on dataset with 17 categories. Furthermore, the way of compressing sentence embedding model is mentioned as future work, considering inference time against model capacity on real-time service.

Improvement of Field Uniformity in the Reverberation Chamber Using Diffusers Filled with Dielectric Material (유전체로 충진된 확산기를 이용한 전자파 잔향실 내의 전자기장 균일도 향상 연구)

  • Kim Hye-Kwang;Rhee Joong-Geun;Lim Wook-Chae
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.16 no.12 s.103
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    • pp.1222-1228
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    • 2005
  • Analysis on the field uniformity inside of a reverberation chamber was done at 2.45 GHz which is an operating frequency of MWO(Microwave Oven). The Schroeder's Quadratic Residue Diffuser was designed for the chamber, and 3 different types of diffusers have been investigated using the finite-difference time-domain(FDTD) method for the field characteristics of each type. Type 2 and 3 diffusers were filled with dielectric material, and the size of these could be designed smaller than Type 1, without degradation of field characteristic. Type 3 diffuser shows better results among the three types of diffusers in view of increased test region and better field uniformity.

Cell Death-Associated Ribosomal RNA Cleavage in Postmortem Tissues and Its Forensic Applications

  • Kim, Ji Yeon;Kim, Yunmi;Cha, Hyo Kyeong;Lim, Hye Young;Kim, Hyungsub;Chung, Sooyoung;Hwang, Juck-Joon;Park, Seong Hwan;Son, Gi Hoon
    • Molecules and Cells
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    • v.40 no.6
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    • pp.410-417
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    • 2017
  • Estimation of postmortem interval (PMI) is a key issue in the field of forensic pathology. With the availability of quantitative analysis of RNA levels in postmortem tissues, several studies have assessed the postmortem degradation of constitutively expressed RNA species to estimate PMI. However, conventional RNA quantification as well as biochemical and physiological changes employed thus far have limitations related to standardization or normalization. The present study focuses on an interesting feature of the subdomains of certain RNA species, in which they are site-specifically cleaved during apoptotic cell death. We found that the D8 divergent domain of ribosomal RNA (rRNA) bearing cell death-related cleavage sites was rapidly removed during postmortem RNA degradation. In contrast to the fragile domain, the 5' terminal region of 28S rRNA was remarkably stable during the postmortem period. Importantly, the differences in the degradation rates between the two domains in mammalian 28S rRNA were highly proportional to increasing PMI with a significant linear correlation observed in mice as well as human autopsy tissues. In conclusion, we demonstrate that comparison of the degradation rates between domains of a single RNA species provides quantitative information on postmortem degradation states, which can be applied for the estimation of PMI.

A Study on the assessment of stress using Wireless ECG (무선 심전도측정을 통한 스트레스 평가에 관한 연구)

  • Lim, Chae-Young;Kim, Kyung-Ho
    • Journal of the Korea Society of Computer and Information
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    • v.16 no.2
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    • pp.17-23
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    • 2011
  • In this paper, daily life stress monitoring system is proposed. The proposed wireless ECG module, reducing the noise and increasing the size of signal, amplification circuit was designed for. Using HRV(Heart Rate Variability), extracted by measuring R-wave, stress diagnostic algorithms to assess the stress of human emotion were developed. For monitoring the activities, the proposed system is consist of small rectangular size for portable and by simple measurement it is possible to measure at any time. Through experiments, the proposed approach to represent user's stress level can be confirmed. Through that, it can see appropriate structure to obtain R-wave for stress assess as well as high resemblance to the clinical electrocardiogram. In this paper, performed experiments was developed nonrestraint measuring and wearable wireless biometric scanner that is able to monitor the heart's electrical activity of everyday life.Using this, the algorithm system, that is able to assess stress index through time-domain and frequency-domain analysis of the front and the rear of performing stress load protocol, was developed,

Utilizing Local Bilingual Embeddings on Korean-English Law Data (한국어-영어 법률 말뭉치의 로컬 이중 언어 임베딩)

  • Choi, Soon-Young;Matteson, Andrew Stuart;Lim, Heui-Seok
    • Journal of the Korea Convergence Society
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    • v.9 no.10
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    • pp.45-53
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    • 2018
  • Recently, studies about bilingual word embedding have been gaining much attention. However, bilingual word embedding with Korean is not actively pursued due to the difficulty in obtaining a sizable, high quality corpus. Local embeddings that can be applied to specific domains are relatively rare. Additionally, multi-word vocabulary is problematic due to the lack of one-to-one word-level correspondence in translation pairs. In this paper, we crawl 868,163 paragraphs from a Korean-English law corpus and propose three mapping strategies for word embedding. These strategies address the aforementioned issues including multi-word translation and improve translation pair quality on paragraph-aligned data. We demonstrate a twofold increase in translation pair quality compared to the global bilingual word embedding baseline.