• 한국농공학회논문집
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• 제56권5호
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• pp.11-19
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• 2014

The objective of this research was to investigate concentration and load of nutrients such as total nitrogen (TN), nitrate nitrogen ($NO_3$-N) total phosphorous (TP), and phosphate phosphorous ($PO_4$-P) in a 23.4-ha paddy fields watershed with river water source. Water samples for irrigation water, drainage water, ponded water and groundwater were collected, and irrigation and drainage water were measured at 5~10 day intervals during normal days and at 2~6 hours intervals during three storm events. The amount of irrigation water in the study area was over 2,000 mm, which is almost identical to that in the area irrigated from a large reservoir but much more than that in the area irrigated from a pumping station. Mean flow-weighted concentrations of TN and TP in irrigation water were 2.8 and 0.15 mg/L, respectively, higher than those in the area irrigated from a large reservoir or a pumping station. The ratios of irrigation load to total inflow load for TN and TP were 88 %, and the ratios of surface outflow load to total outflow load for TN and TP were over 90 %, indicating that total nutrient load may be greatly affected by water management. The nutrient loads per area in the study area were estimated as TN 21.1 kg/ha and TP 1.1 kg/ha. Especially, the TP load per area in the study area was smaller than that in the area irrigated from a large reservoir or a pumping station. This may be because outflow load is not high likely due to sedimentation of particulate P and irrigation water load is high due to high TP concentration in irrigation water and high amount of irrigation water.

• 약학회지
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• 제49권6호
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• pp.518-526
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• 2005

Hwanggumgung (HGG) is a hair-care product which is composed of several plant extracts used in oriental medicine. This study was carried out to investigate effect of HGG on hair regrowth in a shaving model of C57BL6 mice. Five-week-old mice were acclimated for 1 week under 23$\pm$3$^{\circ}C$, 50$\pm10\%$ relative humidity and 12 h of a light/dark cycle before beginning experiment. There were four experimental groups including distilled water (D.W., control), 10$\%$ ethanol (EtOH, vehicle control), a positive control of 3$\%$ minoxidil (MXD), and HGG for female and male mice, respectively; Six-weeks old mice were trimmed by electric clippers so as not to damage the skin. The next day; mice without visible scraches were selected, randomized and separated in groups of 11 mice. The test compounds were topically treated with 0.15ml per mouse per day for 21 days. The hair regrowth was photographically and histologically determined during the experimental period of 21 days. Enzyme activities of $\gamma$-glutamyl transpeptidase and alkaline phosphatase were also determined using a rate assay method. There were no clinical signs in all experimental groups. The topical application of 3$\%$ MXD and HGG in female mice promoted hair regrowth earlier and faster than the control groups. In male mice, the topical application of 3$\%$ MXD and HGG also accelerated hair growth compared with the controls. Ten percent ethanol also promoted hair growth faster than D.W group. The histology of hair growth in experimental groups was strongly associated with the hair regrowth. 3$\%$ MXD and HGG promoted elongation of hair follicles compared with the controls in both female and male mice. Activities of alkaline phosphatase and $\gamma$-glutamyl transpeptidase, enzymes related to hair growth, significantly increased after treatments of 3$\%$ MXD and HGG for 2 weeks in both female and male mice (p < 0.05). These results suggest that HGG has hair growth promoting activities and it can be for treatment for alopecia.

• Journal of Acupuncture Research
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• 제23권5호
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• pp.219-228
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• 2006

Objectives : To observe the effect of acupuncture treatment on Digital Infrared Thermographic Imaging(DITI) in frozen shoulder patients. Methods : 17 voluntary patients received acupuncture treatment on LI15, TE14, GB21 and Master Dong's acupuncture points, Shin-gwan and Gyun-joong, twice a week for 4 weeks. The patients were instructed to practice self exercise during their daily lives. Evaluations were made before treatment, after 1 week of treatment, after 2 weeks, 3 weeks and after 4 weeks of treatment. Constant Shoulder Assessment(CSA), Shoulder Pain and Disability Index(SPADI), Range of Motion(ROM) and the patient's satisfaction concerning the treatment was measured by Visual Analogue Scale(VAS). DITI was measured before treatment and after 4weeks of treatment. The obtained data was analyzed. Results : CSA, SPADI, VAS, adduction and extension showed significant(p<0.05) improvement. Abduction and flexion both improved after 4 weeks of treatment, but the improvement was statistically insignificant(p>0.05). DITI showed improvement but the improvement was insignificant(p>0.05). Conclusion : 4 weeks of acupuncture treatment significantly improved CSA, SPADI, VAS, adduction and extension in frozen shoulder patients(p<0.05). The improvement of abduction and flexion after 4 weeks of acupuncture treatment was insignificant(p>0.05). DITI results improved after 4 weeks of acupuncture treatment. But the change of thermal difference was insignificant(p>0.05).

• Journal of Acupuncture Research
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• 제23권5호
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• pp.177-185
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• 2006

Objectives : To observe the effect of acupuncture treatment and western medical treatment on frozen shoulder patients. Methods : 39 voluntary patients were randomly assigned to the Eastern treatment group(E group, n=22) and the Western treatment group(W group, n=17). The E group received acupuncture treatment on LI15, TE14, GB21 and Master Dong's acupuncture points, Shin-gwan and Gyun-joong, twice a week for 4 weeks. The W group received suprascapular nerve block, subacromial injection and trigger point injection, twice a week for 4 weeks. Both groups were instructed to practice self exercise during their daily lives. Evaluations were made before treatment and after treatment using Constant Shoulder Assessment(CSA), Shoulder Pain and Disability Index(SPADI) and the patient's satisfaction concerning the treatment was measured by Visual Analogue Scale(VAS). The obtained data were analyzed and compared. Results : The E group showed significant improvement(p<0.05) according to the CSA and SPADI. The patient's satisfaction scored 5.67 on a scale of 10. The W group showed significant improvement(p<0.05) according to the CSA and SPADI. The patient's satisfaction scored 7.73. But the difference between the two groups were insignificant according to CSA and SPADI. Conclusion : Both acupuncture and nerve block treatment significantly improved frozen shoulder. But the difference of the two treatments was insignificant.

• World Technopolis Review
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• 제3권2호
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• pp.89-96
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• 2014

Center for Research of Science and Technology ("PUSPIPTEK") has 460 hectares land area, still maintained as a green area with more than 30% green space. There are 47 centers for research and testing technology, technology-based industries, and as well as public supporting facilities in PUSPIPTEK area. Based on the concepts developed to make this area as an ecological region, PUSPIPTEK can be seen as a model of eco-innovation. The purpose of this research is to develop a model of water, energy and waste management with eco-innovation concept. As a new approach in addressing environmental degradation and maintaining the sustainability of ecosystem, studies related to eco-innovation policy that combines the management of water, energy and waste in the region has not been done. In order to achieve the objectives of the research, a series of techniques for collecting data on PUSPIPTEK existing conditions will be carried out, which includes utilities data (water, electricity, sewage) and master plan of this area. The savings over the implementation of the concept of eco-innovation in water, energy, and waste management were calculated and analyzed using quatitative methods. The amount of cost savings and feasibility were then calculated. Eco innovation in water management among other innovations include the provision of alternative sources of water, overflow of rain water and water environments utilization, and use of gravity to replace the pumping function. Eco-innovation in energy management innovations include the use of LED and solar cell for air conditioning. Eco-innovation in waste management includes methods of composting for organic waste management. The research results: (1) The savings that can be achieved with the implementation of eco innovation in the water management is Rp. 3,032,640 daily, or Rp.1,106,913,600 annually; (2) The savings derived from the implementation of eco innovation through replacement of central AC to AC LiBr Solar Powered will be saved Rp.1,933,992,990 annually and the use of LED lights in the Public street lighting PUSPIPTEK saved Rp.163,454,433 annually; (3) Application of eco innovation in waste management will be able to raise awareness of the environment by sorting organic, inorganic and plastic waste. Composting and plastic waste obtained from the sale revenue of Rp. 44,016,000 per year; (4) Overall, implementation of the eco-innovation system in PUSPIPTEK area can saves Rp. 3,248,377,023 per year, compared to the existing system; and (5)The savings are obtained with implementation of eco-innovation is considered as income. Analysis of the feasibility of the implementation of eco-innovation in water, energy, and waste management in PUSPIPTEK give NPV at a 15% discount factor in Rp. 3,895,228,761; 23.20% of IRR and 4.48 years of PBP. Thus the model of eco-innovation in the area PUSPIPTEK is feasible to implement.

• 융합정보논문지
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• 제7권5호
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• pp.15-23
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• 2017

본 연구의 목적은 간호대학생의 학습몰입에 미치는 융합적인 요인을 파악하기 위함이다. 충청북도에 소재한 일개 대학의 간호대학생 200명을 대상으로 설문조사하였다. 자료는 기술통계와 t-test, 일원배치분산분석, Pearson correlation 및 다중회귀분석으로 분석하였다. 대상자의 셀프리더십, 사회적지지 및 학습몰입과의 관계를 보면 셀프 리더십이 높을수록(r=568, p<.001), 사회적지지가 높을수록(r=.412, p<.001) 학습몰입이 높은 것으로 나타났다. 대상자의 학습몰입에 영향을 미치는 변수는 셀프리더십으로 33.0%(${\beta}=.501$, p<.001)의 설명력이 있었다. 이처럼 셀프리더십이 간호대학생의 학습몰입에 매우 중요한 변수임을 확인할 수 있었다. 이 같은 이론적 근거를 바탕으로 간호대학생들의 셀프리더십 증진을 도모하여 학습몰입을 높일 수 있는 방안 모색이 필요하다.

• 통상정보연구
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• 제15권1호
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• pp.185-206
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• 2013

소비자의 제품에 대한 평가는 구매의도에 영향이 미친다는 연구 논문들이 이미 나오고 있다. 소비자의 제품 평가는 제품의 품질, 구매 후 만족도와 기타 유형적인 가치에 기초를 두고 있을 뿐만 아니라 원산지 이미지, 브랜드 이미지 등 같은 무형의 가치에 두기도 한다. 일반적으로 소비자의 제품평가는 실질적인 품질이나 구매 후 만족에 의해 편성된다. 이러한 편성은 원산지 이미지와 같은 사회심리적인 영향으로 나타나기도 한다. 본 연구에서는 소비자 자민중심주의와 더불어 과거 수입국 소비자들이 잊을 수 없는 경제적. 정치적이나 심지어 군사적인 활동에 관여됨에 의해 나타나는 제품 원산지에 대한 선입관의 일환인 적대감이 구매의도에 미치는 관계를 연구하고자 한다. 분석 결과, 제품 평가는 구매의도에 정(+)의 영향을 주고 있음을 확인하였으며 소비자 자민중심주의와 적대감은 제품평가와 구매의도에 부(-)의 영향을 주고 있음을 발견하였다. 중국 시장의 경우, 자민중심주의적인 소비자는 외국 제품 구매에 대해 부정적인 인식을 가지고 있으며 또한 중국 소비자들의 일본 제품에 대한 강한 적대감이 제품평가 및 구매의도에 부(-)의 영향을 미치고 있는 것으로 나타났다. 따라서 일본 기업들은 중국 기업과의 협력과 정부간 친밀감 증대를 위한 노력을 확대시킬 필요가 있다. 반면에 한국 제품의 경우, 제품 평가가 일차적으로 소비자의 구매의도에 영향을 미치고 있으므로 한국 기업들은 소비자의 제품평가의 개선을 위해서 제품의 품질, 구매 후 만족도, 브랜드 이미지와 무형의 요소들을 개선시킬 필요가 있다.

• 대한본초학회지
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• 제30권6호
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• pp.7-15
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• 2015

Objectives : Rosa laevigata Michx. has been used for the treatment of renal disease in traditional Korean medicine. In this study, we investigated cytoprotective effect of R. laevigata water extract (RLE) against oxidative stress induced by arachidonic acid (AA) + iron.Methods : To evaluate the protective effects of RLE against AA + iron-induced oxidative stress in HepG2 cell, cell viability and changes on apoptosis-related proteins were assessed by MTT and immunoblot analyses. The effects of RLE on reduced glutathione level, production of reactive oxygen species and mitochondrial membrane potential were also monitored. Furthermore, to verify underlying molecular mechanism, NF-E2-related factor 2 (Nrf2) was examined by immunoblot analysis. Additionally, Nrf2 transactivation and its downstream target genes expression were also determined by reporter gene and realtime RT-PCR analyses.Results : RLE pretreatment (30-300 μg/ml) prevented cells from AA + iron-mediated cell death in a concentration dependent manner. In addition, 100 μg/ml RLE inhibited AA + iron-induced glutathione depletion, reactive oxygen species production and mitochondrial dysfunction. RLE accumulated nuclear Nrf2 and also transactivated Nrf2, which was evidenced by antioxidant response element- and glutathione S-transferase A2-driven luciferase activities and mRNA level of glutamate-cysteine ligase catalytic subunit, NAD(P)H:quinone oxidoreductase 1 and sestrin 2. Moreover, protective effect of RLE against AA + iron was abolished in Nrf2 knockout cells.Conclusions : These results indicate that RLE has the ability to protect hepatocyte against oxidative stress through Nrf2 activation.

• 보건교육건강증진학회지
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• 제26권5호
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• pp.71-84
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• 2009

목적: 이 연구는 사회자본, 사회경제적 요인, 건강행동의 관계, 그리고 이 요인들이 한국인의 주관적 건강에 미치는 영향을 파악하고자 시도되었다. 방법: 통계청의 2006년 사회통계조사 원자료를 사용하여 분석하였다. 사회통계조사는 표본규모 33,000 가구내 15세 이상 가구원 약 7만명을 대상으로 수행되었다. 이 연구에서는 이 가운데에서 25세 이상 59세 이하 인구중 결혼 경험이 있는 37,928명을 추출하여 분석하였다. 사회자본, 사회경제적 요인, 건강행동의 관계, 그리고 이 요인들이 주관적 건강에 미치는 영향을 파악하고자 경로분석을 실시하였다. 결과: 교육 (0.069), 주관적 계층(0.108), 결혼(0.054), 가족관계 만족도(0.087), 기관신뢰(0.020), 시민참여(0.021), 운동(0.037), 그리고 금연(0.011)이 주관적 건강에 긍정적인 직접효과를 미치는 것으로 분석되었다. 그러나 절주 (-0.067)는 직접효과가 부정적인 것으로 나타났다. 결론: 사회자본이 건강에 긍정적 영향을 주는 것이 분명한 만큼, 건강증진사업 개발시 사회자본을 고려하여, 이의 유지 및 증진을 통해 건강수준의 긍정적인 변화를 유도하는 것이 필요하다. 특히 절주사업에서는 개인을 대상으로 하는 사업 이외에, 전반적인 사회 음주문화의 변화를 이끌어내는 사회적 문화에 대한 고려가 필요할 것으로 생각된다.

• 한국임상약학회지
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• 제12권2호
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• pp.91-95
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• 2002

The pharmacokinetics of intravenous paclitaxel (1 mg/kg) were investigated in rabbits with renal failure induced by folic acid. The area under the plasma concentration-time curve from time zero to time infinity (AUC) of paclitaxel was significantly (p<0.05) greater in rabbits with severe renal failure induced by folic acid $(1030\pm382)$ compared to that in rabbits with in moderate renal failure induced by folic acid $(780\pm209\;ng/ml{\cdot}hr)$. The apparent volume of distribution (Vd) $(0.008\pm0.002\;L/kg)$ and the elimination rate constant $(\beta)\;(0.09\pm0.025\;hr^{-1})$ of paclitaxel in rabbits with severe renal failure were significantly (p<0.05) smaller and slower respectively than those of control rabbits $(0.016\pm0.004\;L/kg,\;0.12\pm0.03\;hr^{-1})$, but not significantly different compared with that in rabbits with moderate renal failure $(0.010\pm0.003\;L/kg,\;0.10\pm0.026\;hr^{-1})$. total body clearance (CL) of paclitaxel in rabbits with severe renal failure $(0.97\pm0.183\;L/hr/kg)$ was significantly (p<0.05) slower than that in control rabbits $(1.68\pm0.440\;L/hr/kg)$, but not significantly different compared with that in rabbits with in moderate renal failure $(1.28\pm0.311\;L/hr/kg)$. The terminal half-life ($t_{1/2}$) of paclitaxel in rabbits with severe renal failure $(7.46\pm2.16\;hr)$ was significantly (p<0.05) longer than that in control rabbits $(5.75\pm1.44\;hr)$, but not significantly different compared to that in rabbits with moderate renal failure rabbits $(6.67\pm1.76\;hr)$. The above data could be at least partly decrease in due to paclitaxel excretion in rabbits with renal failure, since $7-15\%$ of interavenous paclitaxel was excreted via kidney as unchanged forms plus its metablites.