• Title/Summary/Keyword: LCH

검색결과 84건 처리시간 0.029초

BAV 모델을 적용한 소형 민수 헬기(LCH) 브랜드 커뮤니케이션 전략 (Brand Marketing Strategy for Light Civil Helicopter (LCH) with Brand Asset Valuator (BAV) Model)

  • 박지호;이하은;이상학
    • 한국항공운항학회지
    • /
    • 제32권2호
    • /
    • pp.48-64
    • /
    • 2024

  • This study established a marketing strategy for the KAI Light Civil Helicopter (LCH) market by applying a Brand Asset Valuator (BAV) model to the LCH project currently underway by Korea Aerospace industries (KAI). Through literature reviews, the global scale of LCH projects and the development status of KAI LCH were identified. Subsequently, four sub-items from the BAV model were applied, and an expert survey was conducted. The primary data underwent an analysis process following the completion of the validity and reliability verification stage. The analysis revealed that the highest value was in the knowledge indicator, while the lowest value was in differentiation. The analysis confirmed KAI LCH's position on the BAV Power gird, indication that brand vitality, particularly differentiation, was lower than brand knowledge. Accordingly, this study finally presents a new marketing strategy to enhance the brand vitality of KAI LCH.

  • https://doi.org/10.12985/ksaa.2024.32.2.048 인용 PDF

Licochalcone H Targets EGFR and AKT to Suppress the Growth of Oxaliplatin -Sensitive and -Resistant Colorectal Cancer Cells

  • Seung-On Lee;Mee-Hyun Lee;Ah-Won Kwak;Jin-Young Lee;Goo Yoon;Sang Hoon Joo;Yung Hyun Choi;Jin Woo Park;Jung-Hyun Shim
    • Biomolecules & Therapeutics
    • /
    • 제31권6호
    • /
    • pp.661-673
    • /
    • 2023

  • Treatment of colorectal cancer (CRC) has always been challenged by the development of resistance. We investigated the antiproliferative activity of licochalcone H (LCH), a regioisomer of licochalcone C derived from the root of Glycyrrhiza inflata, in oxaliplatin (Ox)-sensitive and -resistant CRC cells. LCH significantly inhibited cell viability and colony growth in both Ox-sensitive and Ox-resistant CRC cells. We found that LCH decreased epidermal growth factor receptor (EGFR) and AKT kinase activities and related activating signaling proteins including pEGFR and pAKT. A computational docking model indicated that LCH may interact with EGFR, AKT1, and AKT2 at the ATP-binding sites. LCH induced ROS generation and increased the expression of the ER stress markers. LCH treatment of CRC cells induced depolarization of MMP. Multi-caspase activity was induced by LCH treatment and confirmed by Z-VAD-FMK treatment. LCH increased the number of sub-G1 cells and arrested the cell cycle at the G1 phase. Taken together LCH inhibits the growth of Ox-sensitive and Ox-resistant CRC cells by targeting EGFR and AKT, and inducing ROS generation and ER stress-mediated apoptosis. Therefore, LCH could be a potential therapeutic agent for improving not only Ox-sensitive but also Ox-resistant CRC treatment.

  • https://doi.org/10.4062/biomolther.2023.155 인용 PDF

Lactobacillus salivarius LCH1230으로부터 생산된 Listeria 균 억제물질의 특성 (Characterization of Anti-Listerial Substance Produced by Lactobacillus salivarius LCH1227)

  • 신유리;임공분;채종표;강대경
    • 한국축산식품학회지
    • /
    • 제31권4호
    • /
    • pp.609-616
    • /
    • 2011

  • 전통발효식품으로부터 L. monocytogenes ATCC 19114에 강한 항균활성을 보이는 균주를 분리하였다. 분리된 균주의 형태학적 및 생화학적 특성과 16S rRNA 염기서열 분석을 통해 Lactobacillus salivarius LCH1227으로 동정되었다. L. salivarius LCH1227이 분비하는 항균물질은 L. monocytogenes 뿐만 아니라 vancomycin-resistant Enterococcus faecalis, Streptococcus agalactiae, Bacillus cereus, Lactobacillus fermentum 등과 같은 그람양성 세균에 대해 폭 넓은 항균 활성을 나타내었다. L. salivarius LCH1227의 생육에 따른 항균 활성을 측정한 결과, 생장정체기 초기에 최대 활성(300 AU/mL)을 나타내었고, 생장정체기 이후부터 활성이 점차 감소하였다. 항균물질의 활성은 pH 2-12 구간에서 비교적 안정하였으며, 열처리에 의해서도 활성이 소실되지 않아 열에 안정한 물질임을 알 수 있었다. L. salivarius LCH1227이 생산하는 항균물질은 단백질 분해효소 처리 후에 활성이 실활됨으로써 단백질성 물질인 것으로 추정되었으며, Tricine-SDS-PAGE 실험을 통하여 항균물질의 분자량은 약 5 kDa 정도임을 알 수 있었다.

  • https://doi.org/10.5851/kosfa.2011.31.4.609 인용 PDF KSCI

Licochalcone H Induces Cell Cycle Arrest and Apoptosis in Human Skin Cancer Cells by Modulating JAK2/STAT3 Signaling

  • Park, Kyung-Ho;Joo, Sang Hoon;Seo, Ji-Hye;Kim, Jumi;Yoon, Goo;Jeon, Young-Joo;Lee, Mee-Hyun;Chae, Jung-Il;Kim, Woo-Keun;Shim, Jung-Hyun
    • Biomolecules & Therapeutics
    • /
    • 제30권1호
    • /
    • pp.72-79
    • /
    • 2022

  • Licochalcone H (LCH) is a phenolic compound synthetically derived from licochalcone C (LCC) that exerts anticancer activity. In this study, we investigated the anticancer activity of LCH in human skin cancer A375 and A431 cells. The 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) cell viability assay was used to evaluate the antiproliferative activity of LCH. Cell cycle distribution and the induction of apoptosis were analyzed by flow cytometry. Western blotting assays were performed to detect the levels of proteins involved in cell cycle progression, apoptosis, and the JAK2/STAT3 signaling pathway. LCH inhibited the growth of cells in dose- and time-dependent manners. The annexin V/propidium iodide double staining assay revealed that LCH induced apoptosis, and the LCH-induced apoptosis was accompanied by cell cycle arrest in the G1 phase. Western blot analysis showed that the phosphorylation of JAK2 and STAT3 was decreased by treatment with LCH. The inhibition of the JAK2/STAT3 signaling pathway by pharmacological inhibitors against JAK2/STAT3 (cryptotanshinone (CTS) and S3I-201) simulated the antiproliferative effect of LCH suggesting that LCH induced apoptosis by modulating JAK2/STAT3 signaling.

  • https://doi.org/10.4062/biomolther.2021.149 인용 PDF KSCI